Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Amitriptyline hydrochloride 💬 Amitriptyline [3] 97, 226, 299 💬
2 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Amitriptyline 💬 Amitriptyline [3] 97, 226, 299 💬
3 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Amoxapine 💬 Amoxapine [1] 46 💬
4 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Ampreloxetine 💬 Ampreloxetine [2]  6 , 17 💬
5 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Citalopram hydrobromide 💬 Citalopram [5]  6 , 13, 46, 98, 127 💬
6 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Citalopram 💬 Citalopram [5]  6 , 13, 46, 98, 127 💬
7 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Desipramine hydrochloride 💬 Desipramine [1] 121 💬
8 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Desipramine 💬 Desipramine [1] 121 💬
9 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Doxepin hydrochloride 💬 Doxepin [1]  6  💬
10 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Doxepin 💬 Doxepin [1]  6  💬
11 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Duloxetine hydrochloride 💬 Duloxetine [2]  6 , 13 💬
12 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Duloxetine 💬 Duloxetine [2]  6 , 13 💬
13 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Escitalopram oxalate 💬 Escitalopram [5]  2 ,  6 , 13, 46, 77 💬
14 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Escitalopram 💬 Escitalopram [5]  2 ,  6 , 13, 46, 77 💬
15 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Fenfluramine hydrochloride 💬 Fenfluramine [4] 140, 144, 145, 149 💬
16 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
17 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Fluoxetine 💬 Fluoxetine [3] 13, 17, 86 💬
18 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Fluoxetine hydrochloride 💬 Fluoxetine [3] 13, 17, 86 💬
19 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Midomafetamine 💬 Midomafetamine [1] 72 💬
20 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Midomafetamine hydrochloride 💬 Midomafetamine [1] 72 💬
21 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Milnacipran hydrochloride 💬 Milnacipran [2] 46, 49 💬
22 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Milnacipran 💬 Milnacipran [2] 46, 49 💬
23 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Nortriptyline hydrochloride 💬 Nortriptyline [2]  6 , 226 💬
24 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Nortriptyline 💬 Nortriptyline [2]  6 , 226 💬
25 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Paroxetine hydrochloride hemihydrate 💬 Paroxetine [4]  6 , 13, 46, 85 💬
26 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Paroxetine 💬 Paroxetine [4]  6 , 13, 46, 85 💬
27 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Paroxetine hydrochloride 💬 Paroxetine [4]  6 , 13, 46, 85 💬
28 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Paroxetine mesylate 💬 Paroxetine [4]  6 , 13, 46, 85 💬
29 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Phentermine 💬 Phentermine [1] 97 💬
30 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Phentermine hydrochloride 💬 Phentermine [1] 97 💬
31 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Sertraline hydrochloride 💬 Sertraline [3]  6 , 158, 206 💬
32 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Sertraline 💬 Sertraline [3]  6 , 158, 206 💬
33 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Trazodone hydrochloride 💬 Trazodone [1]  2  💬
34 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Trazodone 💬 Trazodone [1]  2  💬
35 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Venlafaxine hydrochloride 💬 Venlafaxine [4]  6 , 13, 46, 97 💬
36 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Venlafaxine 💬 Venlafaxine [4]  6 , 13, 46, 97 💬
37 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Venlafaxine besylate monohydrate 💬 Venlafaxine [4]  6 , 13, 46, 97 💬
38 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Vortioxetine 💬 Vortioxetine [2]  6 , 127 💬
39 Neuroactive ligand signaling 💬
 [1] SLC6A4 💬 Vortioxetine hydrobromide 💬 Vortioxetine [2]  6 , 127 💬
40 Serotonergic synapse 💬
 [1] SLC6A4 💬 Amitriptyline hydrochloride 💬 Amitriptyline [3] 97, 226, 299 💬
41 Serotonergic synapse 💬
 [1] SLC6A4 💬 Amitriptyline 💬 Amitriptyline [3] 97, 226, 299 💬
42 Serotonergic synapse 💬
 [1] SLC6A4 💬 Amoxapine 💬 Amoxapine [1] 46 💬
43 Serotonergic synapse 💬
 [1] SLC6A4 💬 Ampreloxetine 💬 Ampreloxetine [2]  6 , 17 💬
44 Serotonergic synapse 💬
 [1] SLC6A4 💬 Citalopram hydrobromide 💬 Citalopram [5]  6 , 13, 46, 98, 127 💬
45 Serotonergic synapse 💬
 [1] SLC6A4 💬 Citalopram 💬 Citalopram [5]  6 , 13, 46, 98, 127 💬
46 Serotonergic synapse 💬
 [1] SLC6A4 💬 Desipramine hydrochloride 💬 Desipramine [1] 121 💬
47 Serotonergic synapse 💬
 [1] SLC6A4 💬 Desipramine 💬 Desipramine [1] 121 💬
48 Serotonergic synapse 💬
 [1] SLC6A4 💬 Doxepin hydrochloride 💬 Doxepin [1]  6  💬
49 Serotonergic synapse 💬
 [1] SLC6A4 💬 Doxepin 💬 Doxepin [1]  6  💬
50 Serotonergic synapse 💬
 [1] SLC6A4 💬 Duloxetine hydrochloride 💬 Duloxetine [2]  6 , 13 💬
51 Serotonergic synapse 💬
 [1] SLC6A4 💬 Duloxetine 💬 Duloxetine [2]  6 , 13 💬
52 Serotonergic synapse 💬
 [1] SLC6A4 💬 Escitalopram oxalate 💬 Escitalopram [5]  2 ,  6 , 13, 46, 77 💬
53 Serotonergic synapse 💬
 [1] SLC6A4 💬 Escitalopram 💬 Escitalopram [5]  2 ,  6 , 13, 46, 77 💬
54 Serotonergic synapse 💬
 [1] SLC6A4 💬 Fenfluramine hydrochloride 💬 Fenfluramine [4] 140, 144, 145, 149 💬
55 Serotonergic synapse 💬
 [1] SLC6A4 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
56 Serotonergic synapse 💬
 [1] SLC6A4 💬 Fluoxetine 💬 Fluoxetine [3] 13, 17, 86 💬
57 Serotonergic synapse 💬
 [1] SLC6A4 💬 Fluoxetine hydrochloride 💬 Fluoxetine [3] 13, 17, 86 💬
58 Serotonergic synapse 💬
 [1] SLC6A4 💬 Midomafetamine 💬 Midomafetamine [1] 72 💬
59 Serotonergic synapse 💬
 [1] SLC6A4 💬 Midomafetamine hydrochloride 💬 Midomafetamine [1] 72 💬
60 Serotonergic synapse 💬
 [1] SLC6A4 💬 Milnacipran hydrochloride 💬 Milnacipran [2] 46, 49 💬
61 Serotonergic synapse 💬
 [1] SLC6A4 💬 Milnacipran 💬 Milnacipran [2] 46, 49 💬
62 Serotonergic synapse 💬
 [1] SLC6A4 💬 Nortriptyline hydrochloride 💬 Nortriptyline [2]  6 , 226 💬
63 Serotonergic synapse 💬
 [1] SLC6A4 💬 Nortriptyline 💬 Nortriptyline [2]  6 , 226 💬
64 Serotonergic synapse 💬
 [1] SLC6A4 💬 Paroxetine hydrochloride hemihydrate 💬 Paroxetine [4]  6 , 13, 46, 85 💬
65 Serotonergic synapse 💬
 [1] SLC6A4 💬 Paroxetine 💬 Paroxetine [4]  6 , 13, 46, 85 💬
66 Serotonergic synapse 💬
 [1] SLC6A4 💬 Paroxetine hydrochloride 💬 Paroxetine [4]  6 , 13, 46, 85 💬
67 Serotonergic synapse 💬
 [1] SLC6A4 💬 Paroxetine mesylate 💬 Paroxetine [4]  6 , 13, 46, 85 💬
68 Serotonergic synapse 💬
 [1] SLC6A4 💬 Phentermine 💬 Phentermine [1] 97 💬
69 Serotonergic synapse 💬
 [1] SLC6A4 💬 Phentermine hydrochloride 💬 Phentermine [1] 97 💬
70 Serotonergic synapse 💬
 [1] SLC6A4 💬 Sertraline hydrochloride 💬 Sertraline [3]  6 , 158, 206 💬
71 Serotonergic synapse 💬
 [1] SLC6A4 💬 Sertraline 💬 Sertraline [3]  6 , 158, 206 💬
72 Serotonergic synapse 💬
 [1] SLC6A4 💬 Trazodone hydrochloride 💬 Trazodone [1]  2  💬
73 Serotonergic synapse 💬
 [1] SLC6A4 💬 Trazodone 💬 Trazodone [1]  2  💬
74 Serotonergic synapse 💬
 [1] SLC6A4 💬 Venlafaxine hydrochloride 💬 Venlafaxine [4]  6 , 13, 46, 97 💬
75 Serotonergic synapse 💬
 [1] SLC6A4 💬 Venlafaxine 💬 Venlafaxine [4]  6 , 13, 46, 97 💬
76 Serotonergic synapse 💬
 [1] SLC6A4 💬 Venlafaxine besylate monohydrate 💬 Venlafaxine [4]  6 , 13, 46, 97 💬
77 Serotonergic synapse 💬
 [1] SLC6A4 💬 Vortioxetine 💬 Vortioxetine [2]  6 , 127 💬
78 Serotonergic synapse 💬
 [1] SLC6A4 💬 Vortioxetine hydrobromide 💬 Vortioxetine [2]  6 , 127 💬
79 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Amitriptyline hydrochloride 💬 Amitriptyline [3] 97, 226, 299 💬
80 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Amitriptyline 💬 Amitriptyline [3] 97, 226, 299 💬
81 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Amoxapine 💬 Amoxapine [1] 46 💬
82 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Ampreloxetine 💬 Ampreloxetine [2]  6 , 17 💬
83 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Citalopram hydrobromide 💬 Citalopram [5]  6 , 13, 46, 98, 127 💬
84 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Citalopram 💬 Citalopram [5]  6 , 13, 46, 98, 127 💬
85 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Desipramine hydrochloride 💬 Desipramine [1] 121 💬
86 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Desipramine 💬 Desipramine [1] 121 💬
87 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Doxepin hydrochloride 💬 Doxepin [1]  6  💬
88 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Doxepin 💬 Doxepin [1]  6  💬
89 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Duloxetine hydrochloride 💬 Duloxetine [2]  6 , 13 💬
90 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Duloxetine 💬 Duloxetine [2]  6 , 13 💬
91 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Escitalopram oxalate 💬 Escitalopram [5]  2 ,  6 , 13, 46, 77 💬
92 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Escitalopram 💬 Escitalopram [5]  2 ,  6 , 13, 46, 77 💬
93 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Fenfluramine hydrochloride 💬 Fenfluramine [4] 140, 144, 145, 149 💬
94 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
95 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Fluoxetine 💬 Fluoxetine [3] 13, 17, 86 💬
96 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Fluoxetine hydrochloride 💬 Fluoxetine [3] 13, 17, 86 💬
97 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Midomafetamine 💬 Midomafetamine [1] 72 💬
98 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Midomafetamine hydrochloride 💬 Midomafetamine [1] 72 💬
99 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Milnacipran hydrochloride 💬 Milnacipran [2] 46, 49 💬
100 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Milnacipran 💬 Milnacipran [2] 46, 49 💬
101 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Nortriptyline hydrochloride 💬 Nortriptyline [2]  6 , 226 💬
102 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Nortriptyline 💬 Nortriptyline [2]  6 , 226 💬
103 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Paroxetine hydrochloride hemihydrate 💬 Paroxetine [4]  6 , 13, 46, 85 💬
104 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Paroxetine 💬 Paroxetine [4]  6 , 13, 46, 85 💬
105 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Paroxetine hydrochloride 💬 Paroxetine [4]  6 , 13, 46, 85 💬
106 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Paroxetine mesylate 💬 Paroxetine [4]  6 , 13, 46, 85 💬
107 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Phentermine 💬 Phentermine [1] 97 💬
108 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Phentermine hydrochloride 💬 Phentermine [1] 97 💬
109 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Sertraline hydrochloride 💬 Sertraline [3]  6 , 158, 206 💬
110 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Sertraline 💬 Sertraline [3]  6 , 158, 206 💬
111 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Trazodone hydrochloride 💬 Trazodone [1]  2  💬
112 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Trazodone 💬 Trazodone [1]  2  💬
113 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Venlafaxine hydrochloride 💬 Venlafaxine [4]  6 , 13, 46, 97 💬
114 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Venlafaxine 💬 Venlafaxine [4]  6 , 13, 46, 97 💬
115 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Venlafaxine besylate monohydrate 💬 Venlafaxine [4]  6 , 13, 46, 97 💬
116 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Vortioxetine 💬 Vortioxetine [2]  6 , 127 💬
117 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Vortioxetine hydrobromide 💬 Vortioxetine [2]  6 , 127 💬

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