Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	AGE-RAGE signaling pathway in diabetic complications 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 AGE-RAGE signaling pathway in diabetic complications × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
2	Amoebiasis 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Amoebiasis × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
3	Cell cycle 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Cell cycle × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
4	Cellular senescence 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Cellular senescence × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
5	Chagas disease 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Chagas disease × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
6	Chronic myeloid leukemia 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Chronic myeloid leukemia × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
7	Colorectal cancer 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Colorectal cancer × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
8	Cytokine-cytokine receptor interaction 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Cytokine-cytokine receptor interaction × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
9	Diabetic cardiomyopathy 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Diabetic cardiomyopathy × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
10	Dilated cardiomyopathy 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Dilated cardiomyopathy × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
11	FoxO signaling pathway 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 FoxO signaling pathway × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
12	Gastric cancer 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Gastric cancer × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
13	Hepatitis B 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Hepatitis B × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
14	Hepatocellular carcinoma 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Hepatocellular carcinoma × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
15	Hippo signaling pathway 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Hippo signaling pathway × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
16	Human T-cell leukemia virus 1 infection 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Human T-cell leukemia virus 1 infection × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
17	Hypertrophic cardiomyopathy 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Hypertrophic cardiomyopathy × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
18	Inflammatory bowel disease 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Inflammatory bowel disease × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
19	Leishmaniasis 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Leishmaniasis × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
20	Malaria 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Malaria × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
21	MAPK signaling pathway 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 MAPK signaling pathway × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
22	Pancreatic cancer 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Pancreatic cancer × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
23	Pathways in cancer 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Pathways in cancer × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
24	Renal cell carcinoma 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Renal cell carcinoma × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
25	Rheumatoid arthritis 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Rheumatoid arthritis × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
26	TGF-beta signaling pathway 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 TGF-beta signaling pathway × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
27	Toxoplasmosis 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Toxoplasmosis × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;
28	Tuberculosis 💬	[1] TGFB3 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TGFB3 transforming growth factor beta 3	Fresolimumab 💬 Tuberculosis × Name Other Names Fresolimumab Fresolimumab (USAN/INN)	Fresolimumab	[3] 51, 85, 222 💬 1. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 222 Primary nephrotic syndrome;

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