Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Leukocyte transendothelial migration 💬

[1] CXCR4 💬

Plerixafor 💬

[5] 19, 20, 65, 285, 299 💬

2

Leukocyte transendothelial migration 💬

[1] ITGA4 💬

[2] 96, 97 💬

3

Leukocyte transendothelial migration 💬

[1] ITGA4 💬

Firategrast 💬

[1] 13 💬

4

Leukocyte transendothelial migration 💬

[1] ITGA4 💬

Natalizumab 💬

[6] 13, 15, 25, 46, 63, 96 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
96	Crohn disease;Terminal ileitis;

5

Leukocyte transendothelial migration 💬

[1] ITGA4 💬

Vedolizumab 💬

[3] 94, 96, 97 💬

6

Leukocyte transendothelial migration 💬

[1] ITGAL 💬

Efalizumab 💬

[9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
37	Generalised pustular psoriasis;Pustular psoriasis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
61	Autoimmune hemolytic anemia;AIHA;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;

7

Leukocyte transendothelial migration 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Losmapimod 💬

[2] 113, 222 💬

8

Leukocyte transendothelial migration 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Neflamapimod 💬

[1] 8 💬

9

Leukocyte transendothelial migration 💬

[1] PIK3CA 💬

[1] 138 💬

10

Leukocyte transendothelial migration 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

[2] 53, 65 💬

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