Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alcoholic liver disease 💬
 [3] ADH1A, ADH1B, ADH1C 💬 Fomepizole 💬 Fomepizole [1] 301 💬
2 Alcoholic liver disease 💬
 [1] C3 💬 Pegcetacoplan 💬 Pegcetacoplan [4]  2 , 61, 62, 222 💬
3 Alcoholic liver disease 💬
 [1] C5 💬 Crovalimab 💬 Crovalimab [2] 62, 109 💬
4 Alcoholic liver disease 💬
 [1] C5 💬 Eculizumab 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
5 Alcoholic liver disease 💬
 [1] C5 💬 Nomacopan 💬 Nomacopan [3] 62, 109, 162 💬
6 Alcoholic liver disease 💬
 [1] C5 💬 Pozelimab 💬 Pozelimab [2] 11, 62 💬
7 Alcoholic liver disease 💬
 [1] C5 💬 Ravulizumab 💬 Ravulizumab [7]  2 , 11, 13, 50, 62, 66, 109 💬
8 Alcoholic liver disease 💬
 [1] C5 💬 Vilobelimab 💬 Vilobelimab [3] 43, 44, 269 💬
9 Alcoholic liver disease 💬
 [1] C5 💬 Zilucoplan 💬 Zilucoplan [3]  2 , 11, 62 💬
10 Alcoholic liver disease 💬
 [1] C5AR1 💬 Avacopan 💬 Avacopan [3] 43, 44, 222 💬
11 Alcoholic liver disease 💬
 [3] CPT1A, CPT1B, CPT1C 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
12 Alcoholic liver disease 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Rontalizumab 💬 Rontalizumab [1] 49 💬
13 Alcoholic liver disease 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Sifalimumab 💬 Sifalimumab [1] 49 💬
14 Alcoholic liver disease 💬
 [2] IL12A, IL12B 💬 Ustekinumab 💬 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
15 Alcoholic liver disease 💬
 [1] IL17A 💬 Bimekizumab 💬 Bimekizumab [3] 46, 97, 271 💬
16 Alcoholic liver disease 💬
 [1] IL17A 💬 Ixekizumab 💬 Ixekizumab [8] 36, 37, 46, 107, 160, 162, 269, 271 💬
17 Alcoholic liver disease 💬
 [1] IL17A 💬 Secukinumab 💬 Secukinumab [8] 13, 37, 41, 46, 107, 160, 269, 271 💬
18 Alcoholic liver disease 💬
 [1] IL17A 💬 Tibulizumab 💬 Tibulizumab [1] 53 💬
19 Alcoholic liver disease 💬
 [1] IL17RA 💬 Brodalumab 💬 Brodalumab [2] 37, 51 💬
20 Alcoholic liver disease 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
21 Alcoholic liver disease 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
22 Alcoholic liver disease 💬
 [1] IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬
23 Alcoholic liver disease 💬
 [3] IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
24 Alcoholic liver disease 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
25 Alcoholic liver disease 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
26 Alcoholic liver disease 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
27 Alcoholic liver disease 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
28 Alcoholic liver disease 💬
 [1] MAP3K5 💬 Selonsertib 💬 Selonsertib [1] 86 💬
29 Alcoholic liver disease 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
30 Alcoholic liver disease 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
31 Alcoholic liver disease 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
32 Alcoholic liver disease 💬
 [1] PPARA 💬 Bezafibrate 💬 Bezafibrate [7] 20, 93, 94, 160, 296, 316, 324 💬
33 Alcoholic liver disease 💬
 [1] PPARA 💬 Elafibranor 💬 Elafibranor [2] 93, 94 💬
34 Alcoholic liver disease 💬
 [1] PPARA 💬 Fenofibrate 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
35 Alcoholic liver disease 💬
 [1] PPARA 💬 Pemafibrate 💬 Pemafibrate [1] 93 💬
36 Alcoholic liver disease 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
37 Alcoholic liver disease 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
38 Alcoholic liver disease 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
39 Alcoholic liver disease 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
40 Alcoholic liver disease 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
41 Alcoholic liver disease 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
42 Alcoholic liver disease 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
43 Alcoholic liver disease 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
44 Alcoholic liver disease 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
45 Alcoholic liver disease 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
46 Alcoholic liver disease 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬