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Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Proximal tubule bicarbonate reclamation 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	sodium/potassium-transporting ATPase subunit alpha-1 isoform a
ATP1A2	sodium/potassium-transporting ATPase subunit alpha-2 precursor
ATP1A3	sodium/potassium-transporting ATPase subunit alpha-3 isoform 1
ATP1A4	sodium/potassium-transporting ATPase subunit alpha-4 isoform 1

Digitoxin 💬

Digitoxin

[1] 299 💬

Proximal tubule bicarbonate reclamation 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	sodium/potassium-transporting ATPase subunit alpha-1 isoform a
ATP1A2	sodium/potassium-transporting ATPase subunit alpha-2 precursor
ATP1A3	sodium/potassium-transporting ATPase subunit alpha-3 isoform 1
ATP1A4	sodium/potassium-transporting ATPase subunit alpha-4 isoform 1

Digoxin 💬

Digoxin

[7] 2 , 8 , 46, 57, 65, 67, 210 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
8	Huntington disease;Huntington chorea;Huntington syndrome;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
57	Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM;
65	Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Acetazolamide 💬

Acetazolamide

[8] 13, 67, 90, 115, 155, 222, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
90	Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy;
115	Hereditary periodic paralysis;Periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
222	Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Acetazolamide sodium 💬

Acetazolamide

[8] 13, 67, 90, 115, 155, 222, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
90	Retinitis pigmentosa;Rod dystrophy;Cone-rod dystrophy;Rod-Cone Dystrophy;
115	Hereditary periodic paralysis;Periodic paralysis;Hereditary hypokalemic periodic paralysis;Andersen-Tawil syndrome;Hereditary hyperkalemic periodic paralysis;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
222	Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Dorzolamide hydrochloride 💬

Dorzolamide

[1] 90 💬

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Dorzolamide 💬

Dorzolamide

[1] 90 💬

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
156	Rett syndrome;
193	Prader-Willi syndrome;

Proximal tubule bicarbonate reclamation 💬

[1] SLC9A3 💬

Tenapanor 💬

Tenapanor

[2] 6 , 299 💬

Proximal tubule bicarbonate reclamation 💬

[1] SLC9A3 💬

Tenapanor hydrochloride 💬

Tenapanor

[2] 6 , 299 💬