86. 肺動脈性肺高血圧症 Disease details / Clinical trials / Drug dev / DR info

(-)-Epicatechin
   University of California, San Francisco
      2013   Phase 1   NCT01880866   United States;
(Pyr1)apelin-13
   Imperial College London
      2012   Phase 1   NCT01590108   United Kingdom;
(S)-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoic acid
   GlaxoSmithKline Research and Development Ltd
      2019   Phase 1   EUCTR2019-001699-12-GB   United Kingdom;
(S)-3-((3-(1-((6-(3,4-DIMETHOXYPHENYL)PRYAZIN-2- YL)AMINO)ETHYL)PHENYL)CARBAMOYL)-5-METHYLPRIDIN-1-IUM
   GB002, Inc.
      2021   Phase 2   EUCTR2020-005169-15-ES   Australia;Austria;Belgium;Canada;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-005169-15-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
(S)-3-((3-(1-((6-(3,4-DIMETHOXYPHENYL)PRYAZIN-2-YL)AMINO)ETHYL)PHENYL)CARBAMOYL)-5-METHYLPRIDIN-1-IUM
   GB002, Inc.
      2021   Phase 2   EUCTR2019-002669-37-DE   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2019-002669-37-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2019-002669-37-BE   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002669-37-GB   Australia;Austria;Belgium;Canada;France;Germany;Israel;Serbia;Singapore;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002669-37-FR   Australia;Austria;Belgium;Canada;France;Germany;Israel;Serbia;Singapore;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002669-37-AT   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
/ml Treprostinil
   AOP Orphan Pharmaceuticals GmbH
      2021   Phase 2   EUCTR2021-004002-21-AT   Austria;
10-nitro-9(E)-octadec-9-enoic acid
   Complexa Inc.
      2019   Phase 2   EUCTR2019-002414-40-GB   United Kingdom;United States;
129Xe Hyperpolarized
   Bastiaan Driehuys
      2021   Phase 2   NCT04991454   United States;
171
   Pfizer, Inc.
      -   Phase 3   EUCTR2016-003978-41-Outside-EU/EEA   Japan;
2-(4-[5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy)-N-(methylsulfonyl)actamide
   Actelion Pharmaceuticals Ltd
      2008   -   EUCTR2007-003328-39-HU   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   -   EUCTR2007-003328-39-GB   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   -   EUCTR2007-003328-39-DE   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   -   EUCTR2007-003328-39-BE   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
   Nippon Shinyaku Co., LTD
      2009   -   EUCTR2007-003328-39-AT   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   Phase 2   EUCTR2007-003328-39-FR   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl) acetamide
   Actelion Pharmaceuticals Ltd
      2008   Phase 2   EUCTR2007-006453-12-GB   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
   Nippon Shinyaku Co., Ltd.
      2008   Phase 2   EUCTR2007-006453-12-FR   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
4AU76
   GlaxoSmithKline Research and Development Limited
      2011   -   EUCTR2011-002943-92-NL   Canada;Netherlands;United States;
66215-101
   ICIN
      2010   -   EUCTR2008-004533-21-NL   Netherlands;
: 2-{4-[(5,6-difenilpirazin-2-yl)(isopropil)amino]butoxi}-N-
   NIPPON SHINYAKU CO., LTD.
      2008   -   EUCTR2007-003328-39-IT   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
ABI-009, nab-rapamycin, albumin-bound rapamycin
   Aadi, LLC
      2017   Phase 1   NCT02587325   United States;
ACE-011
   ACCELERON PHARMA INC.
      2022   Phase 3   EUCTR2021-001498-21-IT   Australia;Belgium;Canada;France;Germany;Israel;Italy;Mexico;Netherlands;Spain;United Kingdom;United States;
      2022   Phase 3   EUCTR2021-000199-12-IT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Democratic People's Republic of;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;South Africa;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-IT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Democratic People's Republic of;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
   Acceleron Pharma Inc.
      2022   Phase 3   EUCTR2021-001498-21-DE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Mexico;Netherlands;Spain;United Kingdom;United States;
      2022   Phase 3   EUCTR2021-000199-12-HR   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 3   EUCTR2020-005061-13-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 3   EUCTR2020-005061-13-PL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 3   EUCTR2020-005061-13-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 2   EUCTR2021-003020-32-ES   Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Spain;Sweden;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-001498-21-NL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Mexico;Netherlands;Spain;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-001498-21-ES   Australia;Belgium;Canada;France;Germany;Israel;Italy;Mexico;Netherlands;Spain;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-000199-12-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;Colombia;Croatia;Czechia;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;South Africa;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-000199-12-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-000199-12-ES   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;Colombia;Croatia;Czechia;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;South Africa;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-000199-12-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-000199-12-CZ   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-005061-13-ES   Argentina;Australia;Austria;Belgium;Brazil;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-005061-13-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-PL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-BE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2019   Phase 2   EUCTR2017-004738-27-BE   Australia;Belgium;Brazil;France;Germany;Israel;Spain;United Kingdom;United States;
      2018   Phase 2   EUCTR2017-004738-27-GB   Australia;Belgium;Brazil;France;Germany;Israel;Spain;United Kingdom;United States;
      2018   Phase 2   EUCTR2017-004738-27-ES   Australia;Belgium;Brazil;France;Germany;Israel;Spain;United Kingdom;United States;
      2018   Phase 2   EUCTR2017-004738-27-DE   Australia;Belgium;Brazil;France;Germany;Israel;Spain;United Kingdom;United States;
ACT - 064992
   Actelion Pharmaceuticals Ltd.
      2008   -   EUCTR2007-002440-14-IT   Austria;Belgium;Bulgaria;Finland;France;Germany;Italy;Netherlands;Portugal;Sweden;United Kingdom;
ACT-050089
   Idorsia Pharmaceuticals Ltd.
      2010   Phase 2   NCT01094067   France;Japan;United States;
ACT-050089 (Ro 61-0612)
   Actelion Pharmaceuticals Ltd.
      2009   -   EUCTR2009-012450-20-FR   France;
ACT-064992
   ACTELION PHARMACEUTICALS LTD
      2019   Phase 3   EUCTR2014-004786-25-IT   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
   ACTELION PHARMACEUTICALS LTD.
      2013   Phase 3   EUCTR2012-004411-31-IT   Austria;Bulgaria;Canada;Chile;China;Czech Republic;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Philippines;Portugal;Romania;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-IT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Portugal;Russian Federation;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
   ACTELION Pharmaceuticals France
      2015   Phase 4   EUCTR2015-002078-19-FR   France;
   ACTELION Pharmaceuticals Ltd
      2017   Phase 3   EUCTR2016-001062-28-PT   Australia;Austria;Brazil;Canada;China;Colombia;Finland;France;Hungary;Israel;Korea, Republic of;Malaysia;Mexico;Philippines;Poland;Portugal;Russian Federation;South Africa;Spain;Thailand;Ukraine;United States;Viet Nam;
      2017   Phase 3   EUCTR2016-001062-28-HU   Argentina;Australia;Austria;Bulgaria;Canada;China;France;Germany;Hungary;Israel;Korea, Republic of;Mexico;Philippines;Poland;Portugal;Russian Federation;South Africa;Spain;Thailand;Ukraine;United States;Vietnam;
      2017   Phase 3   EUCTR2016-001062-28-ES   Argentina;Australia;Austria;Bulgaria;Canada;China;France;Germany;Hungary;Israel;Korea, Republic of;Mexico;Philippines;Poland;Portugal;Russian Federation;South Africa;Spain;Thailand;Ukraine;United States;Vietnam;
      2017   Phase 3   EUCTR2016-001062-28-AT   Australia;Austria;Brazil;Canada;China;Colombia;Finland;France;Hungary;Israel;Korea, Republic of;Malaysia;Mexico;Philippines;Poland;Portugal;Russian Federation;South Africa;Spain;Thailand;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2016-001062-28-FR   Australia;Austria;Canada;China;Colombia;Finland;France;Germany;Hungary;Israel;Korea, Republic of;Mexico;Philippines;Poland;Portugal;Russian Federation;South Africa;Spain;Thailand;Ukraine;United States;Vietnam;
   ACTELION Pharmaceuticals Ltd.
      2014   Phase 3   EUCTR2013-003489-15-ES   Italy;Spain;
      2014   -   EUCTR2013-003462-14-ES   Spain;
      2013   Phase 3   EUCTR2013-003489-15-IT   Italy;Spain;
      2013   Phase 3   EUCTR2013-003462-14-IT   Italy;Spain;
   Actelion Pharmaceuticals Ltd
      2021   Phase 3   EUCTR2017-003934-10-PL   Belarus;Belgium;France;Germany;Poland;Russian Federation;Turkey;Ukraine;
      2018   Phase 3   EUCTR2017-003934-10-FR   France;
      2018   Phase 3   EUCTR2015-003438-28-GB   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2018   Phase 3   EUCTR2015-003438-28-ES   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-NO   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-FR   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-DK   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-DE   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-BE   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-AT   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2015   Phase 3   EUCTR2012-004411-31-GB   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-004411-31-PT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2012   Phase 3   EUCTR2007-003694-27-BG   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2011   -   EUCTR2007-003694-27-GB   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2008   Phase 3   EUCTR2007-003694-27-IT   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Poland;Portugal;Slovakia;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2007-003694-27-DE   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2008   Phase 3   EUCTR2007-003694-27-AT   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
   Actelion Pharmaceuticals Ltd.
      2019   Phase 3   EUCTR2014-004786-25-PL   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-ES   Australia;Brazil;Bulgaria;Canada;China;Czech Republic;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-DE   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-BG   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
      2015   Phase 4   EUCTR2014-004066-20-NL   Australia;France;Germany;Hong Kong;Israel;Italy;Malaysia;Netherlands;Russian Federation;Singapore;United Kingdom;United States;
      2015   Phase 4   EUCTR2014-004066-20-GB   Australia;France;Germany;Hong Kong;Israel;Italy;Malaysia;Netherlands;Russian Federation;Singapore;United Kingdom;United States;
      2015   Phase 4   EUCTR2014-004066-20-DE   Australia;France;Germany;Hong Kong;Israel;Italy;Malaysia;Netherlands;Russian Federation;Singapore;United Kingdom;United States;
      2015   Phase 3   EUCTR2012-004411-31-GR   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2015   Phase 3   EUCTR2012-004411-31-CZ   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2014   Phase 3   EUCTR2012-004411-31-RO   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2014   Phase 3   EUCTR2012-004411-31-HU   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2014   Phase 3   EUCTR2012-003335-33-GR   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-004411-31-ES   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-004411-31-DE   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-004411-31-BG   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-004411-31-AT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-PT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-NL   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-HU   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-GB   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-ES   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Russian Federation;Serbia;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-DE   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-CZ   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-BG   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-BE   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-AT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2009   Phase 3   EUCTR2007-003694-27-DK   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Poland;Portugal;Slovakia;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2007-003694-27-SK   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Poland;Portugal;Slovakia;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2007-003694-27-SE   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2008   Phase 3   EUCTR2007-003694-27-PT   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Poland;Portugal;Slovakia;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2007-003694-27-NL   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2008   Phase 3   EUCTR2007-003694-27-FR   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Poland;Portugal;Slovakia;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2007-003694-27-FI   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Poland;Portugal;Slovakia;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2007-003694-27-BE   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2008   Phase 3   EUCTR2007-002440-14-SK   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Portugal;Slovakia;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2007-002440-14-GB   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Portugal;Slovakia;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2007-002440-14-FR   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Portugal;Slovakia;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2007-002440-14-BE   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Portugal;Slovakia;Sweden;United Kingdom;
      2008   -   EUCTR2007-002440-14-SE   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Norway;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2008   -   EUCTR2007-002440-14-PT   Austria;Belgium;Bulgaria;Finland;France;Germany;Italy;Netherlands;Portugal;Sweden;United Kingdom;
      2008   -   EUCTR2007-002440-14-NL   Austria;Belgium;Bulgaria;Finland;France;Germany;Italy;Netherlands;Portugal;Sweden;United Kingdom;
      2008   -   EUCTR2007-002440-14-FI   Austria;Belgium;Bulgaria;Finland;France;Germany;Italy;Netherlands;Portugal;Sweden;United Kingdom;
      2008   -   EUCTR2007-002440-14-DK   Austria;Belgium;Bulgaria;Denmark;Finland;France;Germany;Italy;Netherlands;Portugal;Sweden;United Kingdom;
      2008   -   EUCTR2007-002440-14-DE   Austria;Belgium;Bulgaria;Finland;France;Germany;Italy;Netherlands;Portugal;Sweden;United Kingdom;
      2008   -   EUCTR2007-002440-14-BG   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Norway;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2008   -   EUCTR2007-002440-14-AT   Austria;Belgium;Bulgaria;Finland;France;Germany;Italy;Netherlands;Portugal;Sweden;United Kingdom;
      -   Phase 3   EUCTR2012-004411-31-PL   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      -   Phase 3   EUCTR2007-003694-27-PL   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
   Nippon Shinyaku co.,LTD./Actelion Pharmaceuticals Japan Ltd.
      2012   Phase 2-3   JPRN-JapicCTI-121986   -
ACT-064992 / JNJ-67896062
   ACTELION Pharmaceuticals Ltd
      -   Phase 3   EUCTR2016-001062-28-PL   Australia;Austria;Brazil;Canada;China;Colombia;Finland;France;Hungary;Israel;Korea, Republic of;Malaysia;Mexico;Philippines;Poland;Portugal;Russian Federation;South Africa;Spain;Thailand;Ukraine;United States;Viet Nam;
ACT-064992/ JNJ-67896062
   ACTELION Pharmaceuticals Ltd
      2019   Phase 3   EUCTR2016-001062-28-FI   Australia;Austria;Brazil;Canada;China;Colombia;Finland;France;Hungary;Israel;Korea, Republic of;Malaysia;Mexico;Philippines;Poland;Portugal;Russian Federation;South Africa;Spain;Thailand;Ukraine;United States;Viet Nam;
ACT-064992D
   Actelion Pharmaceuticals Ltd.
      2019   Phase 3   EUCTR2014-004786-25-ES   Australia;Brazil;Bulgaria;Canada;China;Czech Republic;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;Spain;Taiwan;Turkey;United States;
   Janssen Pharmaceutical K.K.
      2020   Phase 3   JPRN-JapicCTI-194971   Japan, South America, Europe;
ACT-178418
   Actelion Pharmaceuticals Ltd.
      2019   Phase 3   EUCTR2014-004786-25-PL   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-DE   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-BG   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
ACT-293987
   ACTELION Pharmaceuticals Ltd.
      2020   Phase 4   EUCTR2019-004783-22-NL   Argentina;Brazil;China;France;Germany;Hong Kong;Israel;Korea, Republic of;Malaysia;Netherlands;Russian Federation;Saudi Arabia;Singapore;United Arab Emirates;United Kingdom;United States;
      2020   Phase 4   EUCTR2019-004783-22-GB   Argentina;Brazil;China;France;Germany;Hong Kong;Israel;Korea, Republic of;Netherlands;Russian Federation;Saudi Arabia;United Arab Emirates;United Kingdom;United States;
      2020   Phase 4   EUCTR2019-004783-22-DE   Argentina;Brazil;China;France;Germany;Hong Kong;Israel;Korea, Republic of;Malaysia;Netherlands;Russian Federation;Saudi Arabia;Singapore;United Arab Emirates;United Kingdom;United States;
   Actelion
      2010   Phase 3   NCT01112306   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
   Actelion Pharmaceuticals Ltd
      2018   Phase 4   EUCTR2017-000216-42-PT   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2018   Phase 4   EUCTR2017-000216-42-FR   Austria;France;Germany;Ireland;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2018   Phase 3   EUCTR2015-003438-28-GB   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2018   Phase 3   EUCTR2015-003438-28-ES   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2018   Phase 2   EUCTR2018-000145-39-HU   Belarus;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
      2018   Phase 2   EUCTR2018-000145-39-GB   Belarus;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
      2018   Phase 2   EUCTR2018-000145-39-DE   Belarus;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
      2017   Phase 4   EUCTR2017-000216-42-SE   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 4   EUCTR2017-000216-42-IE   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 4   EUCTR2017-000216-42-GB   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 4   EUCTR2017-000216-42-DE   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 4   EUCTR2017-000216-42-AT   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-004035-21-DE   Germany;United States;
      2016   Phase 3   EUCTR2015-003438-28-NO   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-FR   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-DK   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-DE   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-BE   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-AT   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2009-014992-31-GB   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2011   Phase 3   EUCTR2009-014992-31-SK   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2011   Phase 3   EUCTR2009-014992-31-NL   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2011   -   EUCTR2009-014490-41-SK   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Hungary;Ireland;Italy;Netherlands;Slovakia;Spain;Sweden;United Kingdom;
      2011   -   EUCTR2009-014490-41-NL   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-SE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-PL   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-IT   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Russian Federation;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-IE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-HU   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-GR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Hungary;Ireland;Italy;Netherlands;Poland;Slovakia;Spain;Sweden;United Kingdom;
      2010   Phase 3   EUCTR2009-014992-31-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Hungary;Ireland;Italy;Netherlands;Poland;Slovakia;Spain;Sweden;United Kingdom;
      2010   Phase 3   EUCTR2009-014992-31-ES   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Hungary;Ireland;Italy;Netherlands;Poland;Slovakia;Spain;Sweden;United Kingdom;
      2010   Phase 3   EUCTR2009-014992-31-DK   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-DE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-CZ   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-BE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-AT   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014490-41-BE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-SE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-IT   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Russian Federation;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-IE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-GR   Austria;Belgium;Denmark;France;Germany;Greece;Hungary;Ireland;Italy;Netherlands;Slovakia;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-014490-41-GB   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Hungary;Ireland;Italy;Netherlands;Slovakia;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-014490-41-ES   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Hungary;Ireland;Italy;Netherlands;Slovakia;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-014490-41-DE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-CZ   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-AT   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2009   -   EUCTR2009-014490-41-DK   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      -   Phase 2   EUCTR2018-000145-39-PL   Belarus;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
      -   Phase 2   EUCTR2018-000145-39-FR   Belarus;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
      -   Phase 2   EUCTR2018-000145-39-BE   Belarus;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
   Actelion Pharmaceuticals Ltd.
      2010   -   EUCTR2009-014490-41-HU   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
ACT-293987 (NS-304)
   Actelion Pharmaceuticals Ltd
      2008   Phase 2   EUCTR2007-006453-12-GB   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   -   EUCTR2007-003328-39-HU   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   -   EUCTR2007-003328-39-GB   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   -   EUCTR2007-003328-39-DE   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   -   EUCTR2007-003328-39-BE   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
ACT-385781A
   ACTELION Pharmaceuticals Ltd
      2011   -   EUCTR2010-018322-40-NL   Belgium;France;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-018320-10-NL   Belgium;Canada;France;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-018320-10-ES   Belgium;Canada;France;Italy;Netherlands;Spain;
      2010   Phase 3   EUCTR2010-018322-40-FR   Belgium;France;Italy;Netherlands;Spain;
      2010   Phase 3   EUCTR2010-018322-40-BE   Belgium;Canada;France;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-018320-10-BE   Belgium;Canada;France;Italy;Netherlands;Spain;
   Actelion Pharmaceuticals Japan Ltd.
      2015   Phase 3   JPRN-JapicCTI-142722   -
      2014   Phase 3   JPRN-JapicCTI-142721   -
      2013   Phase 4   JPRN-JapicCTI-132142   -
      2011   Phase 3   JPRN-JapicCTI-122017   -
   Actelion Pharmaceuticals Ltd
      2011   -   EUCTR2010-018322-40-ES   Belgium;Canada;France;Italy;Netherlands;Spain;
ACT-385781A (Actelion Epoprostenol)
   Actelion
      2010   Phase 4   NCT01105117   United States;
      2010   Phase 4   NCT01105091   United States;
ADCIRCA 20 mg film-coated tablets
   Bayer AG
      2019   Phase 4   EUCTR2016-001067-36-PL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-NL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-GR   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DK   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-BE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-ES   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-AT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
ADEMPAS - 0,5 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE
   BAYER AG
      2016   Phase 4   EUCTR2016-001067-36-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
ADEMPAS - 1 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE
   BAYER AG
      2016   Phase 4   EUCTR2016-001067-36-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
ADEMPAS - 1,5 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE
   BAYER AG
      2016   Phase 4   EUCTR2016-001067-36-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
ADEMPAS - 2 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE
   BAYER AG
      2016   Phase 4   EUCTR2016-001067-36-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
ADEMPAS - 2,5 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE
   BAYER AG
      2016   Phase 4   EUCTR2016-001067-36-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
AER-901 Solution for Nebulization
   Aerami Therapeutics
      2021   Phase 1   NCT04903730   Australia;
AIR001
   Aires Pharmaceuticals, Inc.
      2013   Phase 2   NCT01725269   Australia;Hungary;United States;
AIR001 (sodium nitrite inhalation solution)
   Aires Pharmaceuticals, Inc.
      2012   Phase 2   NCT01725256   Australia;Hungary;United States;
AIR001 Inhalation Solution
   Aires Pharmaceuticals Inc
      2013   -   EUCTR2012-000166-37-PL   Australia;Czech Republic;France;Germany;Hungary;Italy;Poland;Serbia;United States;
      2013   -   EUCTR2012-000166-37-HU   Australia;Czech Republic;France;Germany;Hungary;Italy;Poland;Serbia;United States;
      2013   -   EUCTR2012-000166-37-DE   Australia;Bulgaria;Czech Republic;France;Germany;Hungary;Italy;Poland;Romania;Serbia;United States;
      2013   -   EUCTR2012-000166-37-CZ   Australia;Czech Republic;France;Germany;Hungary;Italy;Poland;Serbia;United States;
   Aires Pharmaceuticals, Inc
      2013   Phase 2   EUCTR2012-000153-31-IT   Australia;Czech Republic;France;Germany;Hungary;Italy;Poland;Serbia;United States;
      2013   -   EUCTR2012-000153-31-PL   Australia;Czech Republic;France;Germany;Hungary;Italy;Poland;Serbia;United States;
      2013   -   EUCTR2012-000153-31-HU   Australia;Czech Republic;France;Germany;Hungary;Italy;Poland;Serbia;United States;
      2013   -   EUCTR2012-000153-31-DE   Australia;Bulgaria;Czech Republic;France;Germany;Hungary;Italy;Poland;Romania;Serbia;United States;
      2013   -   EUCTR2012-000153-31-CZ   Australia;Czech Republic;France;Germany;Hungary;Italy;Poland;Serbia;United States;
AIR001 Inhalation Solution (Expansion arm)
   Aires Pharmaceuticals, Inc.
      2008   Phase 1   NCT00814645   United States;
AMN107
   Novartis Pharma AG
      2010   -   EUCTR2010-019883-36-HU   Germany;Hungary;
   Novartis Pharma Services AG
      2011   -   EUCTR2010-019883-36-DE   Canada;Germany;Hungary;Italy;Korea, Republic of;Singapore;Switzerland;United States;
APD811
   Arena Pharmaceuticals, Inc.
      2019   Phase 3   EUCTR2018-001189-40-FR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Japan;Korea, Republic of;Mexico;Serbia;Singapore;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-HR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Japan;Korea, Republic of;Mexico;Netherlands;Serbia;Singapore;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2017   Phase 2   EUCTR2014-000667-40-SK   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2016   Phase 2   EUCTR2014-003042-27-SK   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-003042-27-PL   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-003042-27-HU   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-PL   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-HU   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-ES   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-CZ   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   -   EUCTR2014-003042-27-RO   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Spain;United States;
      2015   -   EUCTR2014-003042-27-ES   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Spain;United States;
      2015   -   EUCTR2014-000667-40-RO   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Spain;United States;
   UNITED THERAPEUTICS CORPORATION
      2020   Phase 3   EUCTR2019-003309-88-IT   Argentina;Australia;Austria;Belgium;Brazil;Czechia;Germany;Italy;Poland;Spain;United Kingdom;United States;
   United Therapeutic Corporation
      2019   Phase 3   EUCTR2018-001189-40-PT   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
   United Therapeutics
      2014   Phase 2   NCT02279160   Australia;Bulgaria;Czech Republic;Czechia;Hungary;Poland;Romania;Serbia;Spain;United States;
   United Therapeutics Corporation
      2020   Phase 3   EUCTR2019-003309-88-PL   Argentina;Australia;Austria;Belgium;Brazil;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003309-88-GB   Argentina;Australia;Austria;Belgium;Brazil;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003309-88-ES   Argentina;Australia;Austria;Belgium;Brazil;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003309-88-DE   Argentina;Australia;Austria;Belgium;Brazil;Germany;Italy;Poland;Spain;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003309-88-AT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Germany;Italy;Poland;Spain;United Kingdom;United States;
      2020   Phase 3   EUCTR2018-001189-40-NL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2018-001189-40-CZ   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czech Republic;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-SE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-PL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czech Republic;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-IT   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-HU   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-HR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czech Republic;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-GR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-GB   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-DK   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-BG   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-BE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-SE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-PT   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Japan;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-PL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-NL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-HU   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-GR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Japan;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-GB   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-DK   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-DE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-BG   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-BE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2015   Phase 2   EUCTR2014-003042-27-CZ   Australia;Bulgaria;Czech Republic;Czechia;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
AR392830
   Arena Pharmaceuticals, Inc.
      2017   Phase 2   EUCTR2014-000667-40-SK   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2016   Phase 2   EUCTR2014-003042-27-SK   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-003042-27-PL   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-003042-27-HU   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-PL   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-HU   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-ES   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-CZ   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   -   EUCTR2014-003042-27-RO   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Spain;United States;
      2015   -   EUCTR2014-003042-27-ES   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Spain;United States;
      2015   -   EUCTR2014-000667-40-RO   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Spain;United States;
   UNITED THERAPEUTICS CORPORATION
      2020   Phase 3   EUCTR2019-003309-88-IT   Argentina;Australia;Austria;Belgium;Brazil;Czechia;Germany;Italy;Poland;Spain;United Kingdom;United States;
   United Therapeutic Corporation
      2019   Phase 3   EUCTR2018-001189-40-PT   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
   United Therapeutics Corporation
      2020   Phase 3   EUCTR2019-003309-88-PL   Argentina;Australia;Austria;Belgium;Brazil;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003309-88-GB   Argentina;Australia;Austria;Belgium;Brazil;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003309-88-ES   Argentina;Australia;Austria;Belgium;Brazil;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003309-88-DE   Argentina;Australia;Austria;Belgium;Brazil;Germany;Italy;Poland;Spain;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003309-88-AT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Germany;Italy;Poland;Spain;United Kingdom;United States;
      2020   Phase 3   EUCTR2018-001189-40-NL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2018-001189-40-CZ   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czech Republic;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-PL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czech Republic;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-HU   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-HR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czech Republic;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-DK   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-BG   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-BE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-SE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-PL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-DK   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-DE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-BE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2015   Phase 2   EUCTR2014-003042-27-CZ   Australia;Bulgaria;Czech Republic;Czechia;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
AV-101
   Aerovate Therapeutics
      2021   Phase 2/Phase 3   NCT05036135   United States;
   Aerovate Therapeutics, Inc.
      2022   Phase 2;Phase 3   EUCTR2021-001910-13-FR   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Colombia;Czechia;France;Germany;Greece;Israel;Italy;Mexico;Netherlands;Poland;Portugal;Singapore;South Africa;Spain;Sweden;Turkey;United Kingdom;United States;
AZD4831
   University of Cologne
      2020   Phase 2   EUCTR2020-002788-80-DE   Germany;
Access program - sildenafil citrate, Viagra, Revatio
   Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
      2011   -   NCT01582438   India;
Acetaminophen
   National Institute of Allergy and Infectious Diseases (NIAID)
      2011   Phase 2   NCT01086540   United States;
ActRIIA-IgG1Fc
   ACCELERON PHARMA INC.
      2022   Phase 3   EUCTR2021-000199-12-IT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Democratic People's Republic of;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;South Africa;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
   Acceleron Pharma Inc.
      2022   Phase 3   EUCTR2021-001498-21-DE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Mexico;Netherlands;Spain;United Kingdom;United States;
      2022   Phase 3   EUCTR2021-000199-12-HR   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 3   EUCTR2020-005061-13-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 3   EUCTR2020-005061-13-PL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 3   EUCTR2020-005061-13-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-001498-21-NL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Mexico;Netherlands;Spain;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-001498-21-ES   Australia;Belgium;Canada;France;Germany;Israel;Italy;Mexico;Netherlands;Spain;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-000199-12-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;Colombia;Croatia;Czechia;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;South Africa;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-000199-12-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-000199-12-ES   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;Colombia;Croatia;Czechia;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;South Africa;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-000199-12-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2021-000199-12-CZ   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czech Republic;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-005061-13-ES   Argentina;Australia;Austria;Belgium;Brazil;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-005061-13-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-PL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-BE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2019   Phase 2   EUCTR2017-004738-27-BE   Australia;Belgium;Brazil;France;Germany;Israel;Spain;United Kingdom;United States;
      2018   Phase 2   EUCTR2017-004738-27-GB   Australia;Belgium;Brazil;France;Germany;Israel;Spain;United Kingdom;United States;
      2018   Phase 2   EUCTR2017-004738-27-ES   Australia;Belgium;Brazil;France;Germany;Israel;Spain;United Kingdom;United States;
      2018   Phase 2   EUCTR2017-004738-27-DE   Australia;Belgium;Brazil;France;Germany;Israel;Spain;United Kingdom;United States;
Adcirca
   ACTELION Pharmaceuticals France
      2015   Phase 4   EUCTR2015-002078-19-FR   France;
   Actelion Pharmaceuticals Ltd
      2018   Phase 3   EUCTR2015-003438-28-GB   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2018   Phase 3   EUCTR2015-003438-28-ES   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-NO   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-FR   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-DK   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-DE   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-BE   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-AT   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
Adcirca®
   ACTELION PHARMACEUTICALS LTD
      2019   Phase 3   EUCTR2014-004786-25-IT   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
   Actelion Pharmaceuticals Ltd.
      2019   Phase 3   EUCTR2014-004786-25-PL   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-ES   Australia;Brazil;Bulgaria;Canada;China;Czech Republic;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-DE   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-BG   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
Adempas
   Bayer AG
      2017   Phase 3   EUCTR2014-003952-29-BE   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;United States;
      2016   Phase 3   EUCTR2014-003952-29-PL   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 3   EUCTR2014-003952-29-DE   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Poland;Romania;Spain;Taiwan;Turkey;United Kingdom;United States;
      2015   Phase 3   EUCTR2014-003952-29-HU   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Taiwan;Turkey;United Kingdom;United States;
      2015   Phase 3   EUCTR2014-003952-29-GB   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;United States;
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-DE   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-CZ   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-PT   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2014-003952-29-Outside-EU/EEA   Japan;Turkey;
   Bayer HealthCare AG
      2013   Phase 2;Phase 3   EUCTR2013-001759-10-BE   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-DK   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-CZ   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-BE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-AT   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2008   Phase 3   EUCTR2008-003610-94-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
   Bayer Healthcare AG
      2016   Phase 3   EUCTR2014-003952-29-ES   Belgium;France;Germany;Hungary;Italy;Japan;Netherlands;Poland;Spain;Turkey;United Kingdom;
      2015   -   EUCTR2014-003952-29-IT   Australia;Austria;Canada;France;Germany;Hungary;Italy;Japan;Netherlands;Poland;Spain;Turkey;United Kingdom;
      -   Phase 3   EUCTR2014-003952-29-FR   Belgium;France;Germany;Hungary;Italy;Japan;Netherlands;Poland;Spain;Turkey;United Kingdom;
Adempas (Riociguat, BAY63-2521)
   Bayer
      2017   Phase 4   NCT02891850   Australia;Austria;Belgium;Brazil;Canada;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   NCT02759419   France;Italy;Korea, Republic of;Poland;Thailand;
Adempas (active agent riociguat)
   Thoraxklinik Heidelberg gGmbH
      2021   Phase 4   EUCTR2020-005462-34-DE   Germany;
Adempas 0.5 mg Film Coated Tablet
   Bayer AG
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-GB   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
Adempas 1 mg Film Coated Tablet
   Bayer AG
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-GB   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
Adempas 1.5 mg Film Coated Tablet
   Bayer AG
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-GB   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
Adempas 2 mg Film Coated Tablet
   Bayer AG
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-GB   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
Adempas 2.5 mg Film Coated Tablet
   Bayer AG
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-GB   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
Adempas®
   Justus Liebig Universität Gießen
      2016   Phase 2   EUCTR2015-002835-17-DE   Germany;
Adempas® 0.5 mg film-coated tablets
   Bayer AG
      2019   Phase 4   EUCTR2016-001067-36-PL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-NL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-GR   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DK   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-BE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-PT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-GB   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-ES   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-AT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
Adempas® 1.0 mg film-coated tablets
   Bayer AG
      2019   Phase 4   EUCTR2016-001067-36-PL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-NL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-GR   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DK   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-BE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-PT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-GB   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-ES   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-AT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
Adempas® 1.5 mg film-coated tablets
   Bayer AG
      2019   Phase 4   EUCTR2016-001067-36-PL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-NL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-GR   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DK   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-BE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-PT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-GB   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-ES   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-AT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
Adempas® 2.0 mg film-coated tablets
   Bayer AG
      2019   Phase 4   EUCTR2016-001067-36-PL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-NL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-GR   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DK   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-BE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-PT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-GB   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-ES   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-AT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
Adempas® 2.5 mg film-coated tablets
   Bayer AG
      2019   Phase 4   EUCTR2016-001067-36-PL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-NL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-GR   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DK   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-DE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2017   Phase 4   EUCTR2016-001067-36-BE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-PT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-GB   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-ES   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-AT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
Adempas¿
   BAYER AG
      2016   Phase 4   EUCTR2016-001067-36-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
Adempas¿ 0.5 mg compressa rivestita con film
   BAYER AG
      2016   Phase 4   EUCTR2016-001067-36-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
Adempas¿ 1.0
   BAYER AG
      2016   Phase 4   EUCTR2016-001067-36-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
Adipose derived mesenchymal stem cells
   Liaocheng People's Hospital
      2019   Phase 1/Phase 2   NCT04055415   China;
Aerosolized iloprost
   Hannover Medical School
      2004   Phase 4   NCT00120380   Germany;
Albuterol
   University of Miami
      2017   Phase 2   NCT03270332   United States;
Albuterol.
   American Medical Association Foundation
      2014   Phase 2   NCT02108743   United States;
Allogeneic Human Cardiosphere-Derived Stem Cells
   Cedars-Sinai Medical Center
      2017   Phase 1   NCT03145298   United States;
Ambrisentan
   Brigham and Women's Hospital
      2008   Phase 4   NCT01338636   United States;
   Gilead Sciences
      2008   Phase 4   NCT00617305   United States;
      2005   Phase 2   NCT00423592   -
      2004   Phase 3   NCT00578786   Argentina;Brazil;Chile;Mexico;
      2004   Phase 3   NCT00091598   Australia;Canada;United States;
      2003   Phase 3   NCT00423748   -
      2003   Phase 3   NCT00423202   -
      2003   Phase 2   NCT00424021   -
   GlaxoSmithKline
      2012   Phase 3   NCT01808313   China;
      2011   Phase 2   NCT01342952   Argentina;Brazil;Canada;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Russian Federation;Spain;United States;
      2010   Phase 3   NCT01178073   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   NCT01406327   -
   GlaxoSmithKline Research & Development, Ltd
      2011   -   EUCTR2010-021572-29-IT   Germany;Greece;Hungary;Italy;Netherlands;Spain;
   Hamamatsu University School of Medicine
      2011   -   JPRN-UMIN000005464   Japan;
   Heidelberg University
      2014   Phase 2   NCT02290613   Germany;
   MYOGEN INC.
      2005   -   EUCTR2005-000812-29-IT   Belgium;Germany;Hungary;Italy;Spain;
   Medical University of South Carolina
      2016   Phase 4   NCT02885012   United States;
   Myogen Inc.
      2005   Phase 2   EUCTR2005-001564-31-DE   Belgium;Germany;
      2005   -   EUCTR2005-001564-31-BE   Belgium;Germany;
   Myogen, Inc
      2005   Phase 3   EUCTR2005-000812-29-ES   Austria;Belgium;Germany;Hungary;Italy;Spain;
      2005   -   EUCTR2005-001193-28-AT   Austria;
      2005   -   EUCTR2005-000812-29-DE   Belgium;Germany;Hungary;Italy;Spain;
      2005   -   EUCTR2005-000812-29-BE   Belgium;Germany;Hungary;Italy;Spain;
      2005   -   EUCTR2005-000812-29-AT   Austria;Belgium;Germany;Hungary;Italy;Spain;
   Myogen, Inc.
      2005   Phase 3   EUCTR2005-000812-29-HU   Austria;Belgium;Germany;Hungary;Italy;Spain;
   Nanjing First Hospital, Nanjing Medical University
      2022   -   NCT04972656   -
   National Jewish Health
      2012   -   NCT02169752   United States;
   RenJi Hospital
      2020   Phase 1/Phase 2   NCT04528056   China;
   Shanghai Pulmonary Hospital
      2015   -   ChiCTR-OON-17013521   China;
   Thoraxklinik-Heidelberg gGmbH
      2014   Phase 2   EUCTR2014-001882-28-DE   Germany;
   University of Alabama at Birmingham
      2011   Phase 4   NCT01330108   United States;
Ambrisentan - high dose
   GlaxoSmithKline
      2011   Phase 2   NCT01332331   Argentina;Brazil;Canada;France;Germany;Greece;Hungary;Italy;Japan;Mexico;Netherlands;Russian Federation;Spain;United States;
Ambrisentan - low dose
   GlaxoSmithKline
      2011   Phase 2   NCT01332331   Argentina;Brazil;Canada;France;Germany;Greece;Hungary;Italy;Japan;Mexico;Netherlands;Russian Federation;Spain;United States;
Ambrisentan 5 mg film-coated tablets
   GlaxoSmithKline R&D Ltd
      2010   Phase 4   EUCTR2009-011150-17-GB   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-SE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-NL   Austria;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-GR   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-DE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-BE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-AT   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
   GlaxoSmithKline Research & Development Limited
      2010   Phase 4   EUCTR2009-011150-17-FR   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
Ambrisentan 5mg film-coated tablets [marketed product]
   GlaxoSmithKline Research and Development Ltd
      2019   Phase 1   EUCTR2019-001699-12-GB   United Kingdom;
Ambrisentan Tablet
   GlaxoSmithKline Research and Development Ltd
      2019   Phase 1   EUCTR2019-001699-12-GB   United Kingdom;
Ambrisentan plus Spironolactone
   Brigham and Women's Hospital
      2015   Phase 4   NCT02253394   United States;
Ammonia
   Ottawa Heart Institute Research Corporation
      2018   Phase 4   NCT03344159   Canada;
Anakinra
   Virginia Commonwealth University
      2016   Phase 1   NCT03057028   United States;
Anastrozole
   University of Pennsylvania
      2017   Phase 2   NCT03229499   United States;
      2012   Phase 2   NCT01545336   United States;
Apabetalone
   Laval University
      2022   Phase 2   NCT04915300   Canada;
   Steeve Provencher
      2019   Early Phase 1   NCT03655704   Canada;
Apelin
   Golden Jubilee National Hospital
      2012   -   NCT01457170   United Kingdom;
Aspirin
   Kawut, Steven, MD
      2002   Phase 2   NCT00105209   United States;
   University of Pennsylvania
      2006   Phase 2   NCT00384865   United States;
Assigned pulmonary hypertension medication
   Bayer
      2015   -   NCT02576002   United States;
Autologous EPCs transfected with human eNOS
   Northern Therapeutics
      2017   Phase 2/Phase 3   NCT03001414   Canada;
Aviptadil
   MONDOGEN AG
      2008   -   EUCTR2007-003621-24-IT   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
   MondoGEN AG
      2009   -   EUCTR2007-003621-24-AT   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   Phase 2   EUCTR2007-003621-24-GB   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   -   EUCTR2007-003621-24-NL   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   -   EUCTR2007-003621-24-FR   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   -   EUCTR2007-003621-24-ES   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   -   EUCTR2007-003621-24-DE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   -   EUCTR2007-003621-24-BE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
Axially Oscillating Sphere dry powder inhaler (AOS DPI)
   Respira Therapeutics, Inc.
      2020   Phase 2   NCT04266197   Serbia;United States;
B-lines SE
   Fatebenefratelli Hospital
      2016   -   NCT03049995   Italy;
BARDOXOLONE METHYL, CDDO-Me, CDDO-Methyl Ester, NSC 713200, Chemical Name: Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester
   Reata Pharmaceuticals, Inc.
      2016   Phase 3   EUCTR2016-000196-24-NL   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Philippines;Spain;United Kingdom;United States;
      2016   Phase 3   EUCTR2016-000196-24-GB   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Philippines;Spain;United Kingdom;United States;
      2016   Phase 3   EUCTR2016-000196-24-ES   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Spain;United Kingdom;United States;
      2016   Phase 3   EUCTR2016-000196-24-DE   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Philippines;Spain;United Kingdom;United States;
      2016   Phase 3   EUCTR2016-000196-24-CZ   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Philippines;Spain;United Kingdom;United States;
      2016   Phase 3   EUCTR2016-000196-24-BE   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Spain;United Kingdom;United States;
BAY 63-2521
   Bayer AG
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-GB   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
   Bayer HealthCare AG
      2009   -   EUCTR2008-003610-94-IT   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2006   Phase 1;Phase 2   EUCTR2006-003520-10-DE   Germany;
   Bayer Healthcare AG
      2009   -   EUCTR2008-003482-68-IT   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
   Thoraxklinik Heidelberg gGmbH
      2022   Phase 2   EUCTR2021-001633-40-DE   Austria;France;Germany;Italy;Norway;Switzerland;United Kingdom;
BAY 63-2521 IR tablets
   Bayer Health Care AG
      2011   -   EUCTR2010-018863-40-AT   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
   Bayer HealthCare AG
      2011   Phase 2   EUCTR2010-018863-40-GB   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2011   -   EUCTR2011-001893-24-DE   Germany;
      2011   -   EUCTR2010-018863-40-PL   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2011   -   EUCTR2010-018863-40-ES   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2010   -   EUCTR2010-018863-40-DE   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2010   -   EUCTR2010-018863-40-CZ   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
BAY 63-2521 Tablet
   Bayer AG
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-DE   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-CZ   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
   Bayer HealthCare AG
      2014   Phase 3   EUCTR2013-001759-10-IT   Belgium;Canada;Czech Republic;Germany;Italy;Switzerland;United Kingdom;United States;
      2014   Phase 2;Phase 3   EUCTR2013-001759-10-FR   Belgium;Canada;Czech Republic;France;Germany;Italy;Switzerland;United Kingdom;United States;
      2013   Phase 2;Phase 3   EUCTR2013-001759-10-BE   Belgium;Canada;Czech Republic;Germany;Switzerland;United Kingdom;United States;
BAY 63-2521 coated tablets
   Bayer AG
      2009   Phase 3   EUCTR2008-003610-94-PT   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-GB   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Democratic People's Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
   Bayer HealthCare AG
      2009   Phase 3   EUCTR2008-003610-94-DK   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-CZ   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-BE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-AT   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2008   Phase 3   EUCTR2008-003610-94-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
BAY 63-2521 tablets
   Bayer HealthCare AG
      2010   Phase 3   EUCTR2008-003610-94-GR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2008-003482-68-GR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003610-94-NL   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003610-94-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003482-68-IE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003482-68-ES   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003482-68-AT   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003610-94-IE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003610-94-ES   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003482-68-PT   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   -   EUCTR2008-003482-68-NL   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003482-68-CZ   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2008   Phase 3   EUCTR2008-003610-94-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2008   Phase 3   EUCTR2008-003482-68-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2008   -   EUCTR2008-003482-68-DE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
   Bayer HealthCare AG, D-51368 Leverkusen
      2009   Phase 3   EUCTR2008-003482-68-GB   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003482-68-BE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003482-68-DK   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2008   -   EUCTR2008-003482-68-SE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
BAY1237592
   Bayer
      2019   Phase 1   NCT03754660   Austria;Czechia;Germany;Poland;
BAY63-2521
   Bayer AG
      2017   Phase 3   EUCTR2014-003952-29-BE   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;United States;
      2016   Phase 3   EUCTR2014-003952-29-PL   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 3   EUCTR2014-003952-29-DE   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Poland;Romania;Spain;Taiwan;Turkey;United Kingdom;United States;
      2015   Phase 3   EUCTR2014-003952-29-HU   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Taiwan;Turkey;United Kingdom;United States;
      2015   Phase 3   EUCTR2014-003952-29-GB   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2014-003952-29-Outside-EU/EEA   Japan;Turkey;
   Bayer Healthcare AG
      2016   Phase 3   EUCTR2014-003952-29-ES   Belgium;France;Germany;Hungary;Italy;Japan;Netherlands;Poland;Spain;Turkey;United Kingdom;
      2015   -   EUCTR2014-003952-29-IT   Australia;Austria;Canada;France;Germany;Hungary;Italy;Japan;Netherlands;Poland;Spain;Turkey;United Kingdom;
      -   Phase 3   EUCTR2014-003952-29-FR   Belgium;France;Germany;Hungary;Italy;Japan;Netherlands;Poland;Spain;Turkey;United Kingdom;
BIA 5-1058
   BIAL-Portela & Ca, S.A.
      2019   Phase 2   EUCTR2018-002448-10-IT   Austria;Germany;Italy;Portugal;Spain;Ukraine;United Kingdom;
   Bial - Portela & Ca, S.A
      2019   Phase 2   EUCTR2018-002796-18-GB   Austria;Belgium;Germany;Netherlands;Portugal;Spain;Ukraine;United Kingdom;
      2019   Phase 2   EUCTR2018-002448-10-GB   Austria;Germany;Netherlands;Portugal;Spain;Ukraine;United Kingdom;
   Bial - Portela & Ca, S.A.
      2019   Phase 2   EUCTR2018-002796-18-PT   Austria;Belgium;Germany;Italy;Portugal;Spain;Ukraine;United Kingdom;
      2019   Phase 2   EUCTR2018-002796-18-ES   Austria;Portugal;Spain;Ukraine;United Kingdom;
      2019   Phase 2   EUCTR2018-002448-10-DE   Austria;Belgium;France;Germany;Italy;Portugal;Spain;Ukraine;United Kingdom;
      2018   Phase 2   EUCTR2018-002796-18-AT   Austria;Germany;Italy;Portugal;Spain;Ukraine;United Kingdom;
      2018   Phase 2   EUCTR2018-002448-10-PT   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Ukraine;United Kingdom;
      2018   Phase 2   EUCTR2018-002448-10-ES   Austria;Portugal;Spain;Ukraine;
      2018   Phase 2   EUCTR2018-002448-10-AT   Austria;Germany;Italy;Portugal;Spain;Ukraine;United Kingdom;
   Bial - Portela C S.A.
      2018   Phase 1   NCT04994860   Germany;
      2018   Phase 1   NCT04994119   Germany;
      2018   Phase 1   NCT04991207   Germany;
      2018   Phase 1   NCT03708146   United Kingdom;
      2018   Phase 1   NCT03489005   United Kingdom;
      2017   Phase 1   NCT04991181   Netherlands;
      2015   Phase 1   NCT04991194   -
      2015   Phase 1   NCT04991155   -
BIA-5-1058
   BIAL-Portela & Ca, S.A.
      2019   Phase 2   EUCTR2018-002796-18-IT   Austria;Germany;Italy;Portugal;Spain;Ukraine;United Kingdom;
   Bial - Portela & Ca, S.A.
      2019   Phase 2   EUCTR2018-002796-18-PT   Austria;Belgium;Germany;Italy;Portugal;Spain;Ukraine;United Kingdom;
      2019   Phase 2   EUCTR2018-002796-18-ES   Austria;Portugal;Spain;Ukraine;United Kingdom;
      2018   Phase 2   EUCTR2018-002796-18-AT   Austria;Germany;Italy;Portugal;Spain;Ukraine;United Kingdom;
BOSENTAN MONOHIDRATO
   Actelion Pharmaceuticals Ltd.
      2011   -   EUCTR2010-021793-12-ES   Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
      2010   Phase 3   EUCTR2010-021825-11-ES   Bulgaria;Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
BOSENTAN MONOHYDRATE
   Actelion Pharmaceuticals Ltd.
      2013   Phase 3   EUCTR2010-021825-11-BG   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021825-11-NL   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021793-12-NL   Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-021793-12-HU   Australia;Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021793-12-DE   Australia;Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021793-12-CZ   Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2010   -   EUCTR2010-021825-11-HU   Bulgaria;Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-021825-11-DE   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2010   -   EUCTR2010-021825-11-CZ   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2009   -   EUCTR2005-005068-97-CZ   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2005-005068-97-BE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2008   Phase 4   EUCTR2005-005068-97-SK   Belgium;Brazil;Czech Republic;Denmark;Germany;Greece;Portugal;Saudi Arabia;Slovakia;Spain;Sweden;United Kingdom;United States;
      -   Phase 3   EUCTR2010-021825-11-FR   Bulgaria;Czech Republic;France;Germany;Hungary;Italy;Netherlands;Spain;
      -   Phase 3   EUCTR2010-021793-12-PL   Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      -   Phase 3   EUCTR2010-021793-12-FR   Czech Republic;France;Germany;Hungary;Italy;Netherlands;Poland;Spain;
   Actelion pharmaceuticals Ltd
      2012   -   EUCTR2011-004612-31-PT   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
      2012   -   EUCTR2011-004106-16-PT   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
      2012   -   EUCTR2011-004106-16-BG   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2011-004612-31-NL   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2011-004612-31-FR   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2011-004106-16-NL   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;South Africa;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2011-004106-16-FR   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
BPS-314d-MR
   Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
      2013   Phase 2   NCT01966302   United States;
BPS-MR
   Lung LLC
      2010   Phase 2   EUCTR2009-014453-32-BE   Belgium;Czech Republic;Germany;Ireland;Romania;United States;
      2010   -   EUCTR2009-014453-32-CZ   Belgium;Czech Republic;Germany;Ireland;
      2009   Phase 2   EUCTR2008-006833-29-BE   Belgium;Ireland;United States;
      2009   -   EUCTR2008-006833-29-IE   Belgium;Ireland;
   Lung LLC Inc
      2010   -   EUCTR2009-014453-32-IE   Belgium;Czech Republic;Germany;Ireland;
   Lung RX
      -   Phase 2   EUCTR2009-014453-32-DE   Belgium;Czech Republic;Germany;Ireland;
   Lung Rx
      2010   Phase 2   EUCTR2009-014246-29-DE   Belgium;Czech Republic;Germany;Ireland;
      2010   -   EUCTR2009-014246-29-IE   Belgium;Czech Republic;Germany;Ireland;
      2009   -   EUCTR2008-003290-41-BE   Belgium;Ireland;
   Lung Rx Inc
      2010   -   EUCTR2009-014246-29-CZ   Belgium;Czech Republic;Germany;Ireland;
      2009   Phase 2   EUCTR2009-014246-29-BE   Belgium;Czech Republic;Germany;Ireland;
   LungRx
      2009   -   EUCTR2008-003290-41-IE   Belgium;Ireland;
BSF 208075
   Gilead Sciences
      2002   Phase 2   NCT00046319   Australia;Belgium;France;Germany;Italy;United States;
   Myogen Inc.
      2005   Phase 2   EUCTR2005-001564-31-DE   Belgium;Germany;
   Myogen, Inc
      2005   Phase 3   EUCTR2005-000812-29-ES   Austria;Belgium;Germany;Hungary;Italy;Spain;
      2005   -   EUCTR2005-001193-28-AT   Austria;
      2005   -   EUCTR2005-000812-29-DE   Belgium;Germany;Hungary;Italy;Spain;
      2005   -   EUCTR2005-000812-29-BE   Belgium;Germany;Hungary;Italy;Spain;
      2005   -   EUCTR2005-000812-29-AT   Austria;Belgium;Germany;Hungary;Italy;Spain;
   Myogen, Inc.
      2005   Phase 3   EUCTR2005-000812-29-HU   Austria;Belgium;Germany;Hungary;Italy;Spain;
BSF 208075 or LU 208075
   Myogen Inc.
      2005   -   EUCTR2005-001564-31-BE   Belgium;Germany;
Bardoxolone methyl
   Reata Pharmaceuticals, Inc.
      2016   Phase 3   JPRN-UMIN000025158   Japan,North America,South America,Australia,Europe;
      2014   Phase 2   NCT02036970   Germany;Spain;United Kingdom;United States;
Bardoxolone methyl capsules
   Reata Pharmaceuticals, Inc.
      2016   Phase 3   NCT02657356   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Czechia;Germany;Israel;Japan;Mexico;Netherlands;Philippines;Spain;United Kingdom;United States;
Beetroot juice
   Uppsala University
      2013   -   NCT02000856   Sweden;
Benzbromaron AL
   Medical University of Graz
      2015   Phase 2   EUCTR2015-000709-38-AT   Austria;
Benzbromarone
   Medical University of Graz
      2015   Phase 2   NCT02790450   Austria;
Beraprost
   Hamamatsu University School of Medicine
      2017   -   JPRN-UMIN000025176   Japan;
   Keio University
      2008   -   JPRN-UMIN000001350   Japan;
   Shanghai Pulmonary Hospital
      2009   -   ChiCTR-TCC-12002776   China;
Beraprost Sodium
   Dr. Soetomo General Hospital
      2017   Phase 4   NCT03431649   Indonesia;
Beraprost Sodium 314d Modified Release Tablets
   Lung Biotechnology Inc.
      2011   Phase 3   NCT01458236   -
   Lung Biotechnology PBC
      2013   Phase 3   NCT01908699   Israel;United States;
Beraprost Sodium Modified Release
   Lung Biotechnology PBC
      2010   Phase 2   NCT00989963   Belgium;Czech Republic;Czechia;Germany;Ireland;Romania;United States;
      2009   Phase 2   NCT00990314   Belgium;Czech Republic;Czechia;Germany;Ireland;Romania;United States;
      2009   Phase 2   NCT00792571   Belgium;Ireland;United States;
   Lung LLC
      2010   Phase 2   EUCTR2009-014453-32-BE   Belgium;Czech Republic;Germany;Ireland;Romania;United States;
      2010   -   EUCTR2009-014453-32-CZ   Belgium;Czech Republic;Germany;Ireland;
      2009   Phase 2   EUCTR2008-006833-29-BE   Belgium;Ireland;United States;
      2009   -   EUCTR2008-006833-29-IE   Belgium;Ireland;
   Lung LLC Inc
      2010   -   EUCTR2009-014453-32-IE   Belgium;Czech Republic;Germany;Ireland;
   Lung RX
      -   Phase 2   EUCTR2009-014453-32-DE   Belgium;Czech Republic;Germany;Ireland;
   Lung Rx
      2010   Phase 2   EUCTR2009-014246-29-DE   Belgium;Czech Republic;Germany;Ireland;
      2010   -   EUCTR2009-014246-29-IE   Belgium;Czech Republic;Germany;Ireland;
      2009   -   EUCTR2008-003290-41-BE   Belgium;Ireland;
   Lung Rx Inc
      2010   -   EUCTR2009-014246-29-CZ   Belgium;Czech Republic;Germany;Ireland;
      2009   Phase 2   EUCTR2009-014246-29-BE   Belgium;Czech Republic;Germany;Ireland;
   LungRx
      2009   -   EUCTR2008-003290-41-IE   Belgium;Ireland;
Beraprost sodium modified release
   Lung Biotechnology PBC
      2009   Phase 2   NCT00781885   Belgium;Ireland;United States;
Bevacizumab
   Brigham and Women's Hospital
      2018   Phase 1/Phase 2   NCT03166306   United States;
Biological DMARDs
   Hoffmann-La Roche
      2000   -   NCT02784808   -
Bisoprolol
   VU University Medical Center
      2011   Phase 1/Phase 2   NCT01246037   Netherlands;
   VU medical center
      2011   -   EUCTR2010-020424-21-NL   Netherlands;
Blood Test
   Universitätsklinikum Hamburg-Eppendorf
      2010   -   NCT01317134   Germany;
Bosentan
   ACTELION PHARMACEUTICALS ITALIA
      2005   -   EUCTR2004-005157-63-IT   Italy;United Kingdom;
      2005   -   EUCTR2004-000745-37-IT   Italy;Spain;United Kingdom;
   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
      2013   Phase 2   NCT01827059   Netherlands;
   Actelion
      2011   Phase 3   NCT01338415   Australia;Belarus;China;Czech Republic;Czechia;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   Phase 3   NCT01223352   Australia;Belarus;China;Czech Republic;Czechia;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2007   Phase 4   NCT00433329   United States;
      2006   Phase 4   NCT00595049   Australia;United States;
      2006   Phase 4   NCT00303459   Brazil;Czech Republic;Denmark;Germany;Greece;Portugal;Saudi Arabia;Slovakia;Spain;Sweden;United Kingdom;United States;
      2006   Phase 3   NCT00310830   France;Netherlands;United Kingdom;United States;
      2006   Phase 3   NCT00302211   United States;
      2005   Phase 3   NCT00319267   France;Germany;Italy;Netherlands;Switzerland;United Kingdom;United States;
      2005   Phase 3   NCT00319020   France;Germany;Italy;Netherlands;Switzerland;United Kingdom;United States;
      2004   Phase 3   NCT00091715   Australia;Austria;Belgium;Canada;China;Czech Republic;France;Germany;Italy;Netherlands;Spain;Switzerland;United Kingdom;United States;
      2003   Phase 4   NCT00317486   Australia;Austria;Belgium;Canada;France;Germany;Italy;Netherlands;Spain;United Kingdom;United States;
      2003   Phase 4   NCT00082186   Australia;Brazil;Czech Republic;Hungary;United States;
   Actelion Pharmaceuticals Japan Ltd.
      2013   Phase 3   JPRN-JapicCTI-132155   -
      2013   Phase 3   JPRN-JapicCTI-132154   -
      2009   Phase 3   JPRN-JapicCTI-121998   -
   Actelion Pharmaceuticals Ltd
      2005   -   EUCTR2005-001967-70-IT   Germany;Italy;United Kingdom;
      2004   -   EUCTR2004-000478-30-IT   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
   Actelion Pharmaceuticals Ltd.
      2011   -   EUCTR2010-021825-11-IT   Bulgaria;Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-021793-12-IT   Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
   Beijing Anzhen Hospital
      2011   -   ChiCTR-ONC-11001799   China;
   Bial - Portela C S.A.
      2018   Phase 1   NCT04991207   Germany;
   Fourth Military Medical University
      2012   Phase 3   NCT01712997   China;
   Hamamatsu University School of Medicine
      2011   -   JPRN-UMIN000005464   Japan;
   Hamilton Health Sciences Corporation
      2009   Phase 3   NCT00864201   Canada;
   Medical University of Graz
      2008   -   NCT00909337   Austria;
   NOVARTIS FARMA
      2011   -   EUCTR2010-021344-17-IT   Italy;
   Novartis Pharmaceuticals
      2011   Phase 3   NCT01392469   Australia;Belgium;Germany;Italy;Lithuania;Romania;Turkey;United Kingdom;United States;
   Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
      2006   Phase 4   NCT00323297   Australia;Belgium;Czech Republic;Czechia;France;Germany;Greece;Israel;Italy;Taiwan;United Kingdom;United States;
   Prof David S Celermajer
      2006   -   NCT01721564   -
   Rajan Saggar
      2007   Phase 4   NCT00625469   United States;
   Royal Brompton and Harefield NHS Trust
      2008   Phase 4   EUCTR2007-001643-21-GB   United Kingdom;
   Shanghai Pulmonary Hospital
      2015   -   ChiCTR-OON-17013521   China;
   Stanford University
      2008   Phase 2   NCT00825266   United States;
   Tokushima University
      2011   -   JPRN-UMIN000004369   Japan;
   University of Cincinnati
      2008   Phase 2/Phase 3   NCT00581607   United States;
   University of Edinburgh
      2009   Phase 0   NCT01100736   United Kingdom;
Bosentan administration
   Competence Network for Congenital Heart Defects
      2004   Phase 4   NCT00266162   Germany;
Bosentan and Sildenafil
   Rigshospitalet, Denmark
      2006   Phase 3   NCT00303004   Denmark;
Bosentan monohydrat
   Rigshospitalet
      2006   -   EUCTR2006-000021-57-DK   Denmark;
Bosentan monohydrate
   Actelion Pharmaceuticals Ltd.
      2007   -   EUCTR2005-005068-97-SE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2007   -   EUCTR2005-005068-97-GB   Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2007   -   EUCTR2005-005068-97-DK   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2006   -   EUCTR2004-004391-36-CZ   Czech Republic;Hungary;
      2006   -   EUCTR2004-000745-37-GB   Italy;Spain;United Kingdom;
      2005   Phase 3   EUCTR2005-001967-70-GB   Germany;Italy;United Kingdom;
      2005   Phase 3   EUCTR2004-005157-63-GB   Italy;United Kingdom;
      2005   Phase 3   EUCTR2004-000478-30-ES   Austria;Belgium;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2005   -   EUCTR2004-004391-36-HU   Czech Republic;Hungary;
      2004   Phase 4   EUCTR2004-000745-37-ES   Italy;Spain;United Kingdom;
      2004   Phase 3   EUCTR2004-000478-30-GB   Austria;Belgium;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-SE   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-DK   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-CZ   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-BE   Austria;Belgium;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-AT   Austria;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      -   -   EUCTR2005-005068-97-DE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      -   -   EUCTR2005-001967-70-DE   Germany;Italy;United Kingdom;
Bosentan, Ambrisentan
   West Penn Allegheny Health System
      2005   -   NCT00593905   United States;
Breelib nebulizer
   Bayer
      2018   -   NCT03293407   Germany;
Bromure d'Ipratropium
   ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
      2016   Phase 3   EUCTR2014-002590-10-FR   France;
C07AB07
   VU medical center
      2011   -   EUCTR2010-020424-21-NL   Netherlands;
C225
   VU University Medical Centre
      2006   -   EUCTR2006-002081-19-NL   Netherlands;
CIALIS
   GlaxoSmithKline R&D Ltd
      2010   -   EUCTR2009-011150-17-IT   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
CIALIS 20 mg comprimidos recubiertos con película
   GlaxoSmithKline,S.A.
      2010   -   EUCTR2009-011150-17-ES   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
CJNJ-68150420-ZZZ-G001 (ACT- 064992D)
   ACTELION PHARMACEUTICALS LTD
      2019   Phase 3   EUCTR2014-004786-25-IT   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
   Actelion Pharmaceuticals Ltd.
      2019   Phase 3   EUCTR2014-004786-25-DE   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
CJNJ-68150420-ZZZ-G001 (ACT-064992D)
   Actelion Pharmaceuticals Ltd.
      2019   Phase 3   EUCTR2014-004786-25-BG   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
CJNJ-68150420-ZZZ-G001(ACT-064992D)
   Actelion Pharmaceuticals Ltd.
      2019   Phase 3   EUCTR2014-004786-25-PL   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
CS1 Administration
   Cereno Scientific AB
      2022   Phase 2   NCT05224531   -
CXA-10
   Complexa Inc.
      2019   Phase 2   EUCTR2019-002414-40-GB   United Kingdom;United States;
   Complexa, Inc.
      2019   Phase 2   NCT04053543   United Kingdom;United States;
      2018   Phase 2   NCT03449524   United Kingdom;United States;
   Gladwin, Mark, MD
      2019   Phase 2   NCT04125745   United States;
Capsaicin
   Imperial College London
      2011   -   EUCTR2011-001312-59-GB   United Kingdom;
Carvedilol
   The Cleveland Clinic
      2012   -   NCT01586156   United States;
   The Hospital for Sick Children
      2012   Phase 1/Phase 2   NCT01723371   Canada;
   University of Minnesota
      2016   Phase 2   NCT02507011   United States;
      2014   Phase 1   NCT02120339   United States;
   Virginia Commonwealth University
      2010   Phase 1/Phase 2   NCT00964678   United States;
Cetuximab
   VU University Medical Centre
      2006   -   EUCTR2006-002081-19-NL   Netherlands;
Chlorhexidine
   Department of cardiology, Keio University School of Medicine
      2011   -   JPRN-UMIN000005438   Japan;
Cialis
   Eli Lilly and Company
      2006   -   EUCTR2005-002844-24-DE   Germany;Ireland;Italy;Spain;United Kingdom;
   Eli Lilly and Company Limited
      2006   Phase 3;Phase 4   EUCTR2005-002844-24-BE   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
   GlaxoSmithKline R&D Ltd
      2010   Phase 4   EUCTR2009-011150-17-GB   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-SE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-NL   Austria;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-GR   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-DE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-BE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-AT   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
   GlaxoSmithKline Research & Development Limited
      2010   Phase 4   EUCTR2009-011150-17-FR   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
   Lilly ICOS LLC
      2006   Phase 3   EUCTR2005-002844-24-GB   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2006   Phase 3   EUCTR2005-002692-33-IE   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2006   Phase 3   EUCTR2005-002692-33-GB   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2006   Phase 3   EUCTR2005-002692-33-ES   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2006   -   EUCTR2005-002844-24-IE   Germany;Ireland;Italy;Spain;United Kingdom;
      2006   -   EUCTR2005-002844-24-ES   Germany;Ireland;Italy;Spain;United Kingdom;
      2006   -   EUCTR2005-002692-33-DE   Germany;Ireland;Italy;Spain;United Kingdom;
      2006   -   EUCTR2005-002692-33-BE   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
Cialis 10 mg film-coated tablets
   Eli Lilly and Company
      2013   Phase 3   EUCTR2012-002354-23-NL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-IT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-FR   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-DE   Austria;Belgium;Brazil;France;Germany;Israel;Italy;Japan;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;
      2013   Phase 3   EUCTR2012-002354-23-BE   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-AT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   -   EUCTR2012-002354-23-RO   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2012   Phase 1;Phase 2   EUCTR2011-001873-24-GB   Canada;France;Poland;Spain;United Kingdom;United States;
      2012   Phase 1;Phase 2   EUCTR2011-001873-24-ES   Canada;France;Poland;Spain;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-PL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-GB   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 1;Phase 2   EUCTR2011-001873-24-PL   Canada;France;Poland;Spain;United Kingdom;United States;
   Lilly S.A.
      2013   Phase 3   EUCTR2012-002354-23-ES   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
Cialis 2.5 mg film-coated tablets
   Eli Lilly and Company
      2013   Phase 3   EUCTR2012-002354-23-NL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-IT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-FR   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-DE   Austria;Belgium;Brazil;France;Germany;Israel;Italy;Japan;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;
      2013   Phase 3   EUCTR2012-002354-23-BE   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-AT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   -   EUCTR2012-002354-23-RO   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2012   Phase 1;Phase 2   EUCTR2011-001873-24-GB   Canada;France;Poland;Spain;United Kingdom;United States;
      2012   Phase 1;Phase 2   EUCTR2011-001873-24-ES   Canada;France;Poland;Spain;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-PL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-GB   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 1;Phase 2   EUCTR2011-001873-24-PL   Canada;France;Poland;Spain;United Kingdom;United States;
   Lilly S.A.
      2013   Phase 3   EUCTR2012-002354-23-ES   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
Cialis 20 mg film-coated tablets
   Eli Lilly and Company
      2013   Phase 3   EUCTR2012-002354-23-NL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-IT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-FR   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-DE   Austria;Belgium;Brazil;France;Germany;Israel;Italy;Japan;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;
      2013   Phase 3   EUCTR2012-002354-23-BE   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-AT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   -   EUCTR2012-002354-23-RO   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2012   Phase 1;Phase 2   EUCTR2011-001873-24-GB   Canada;France;Poland;Spain;United Kingdom;United States;
      2012   Phase 1;Phase 2   EUCTR2011-001873-24-ES   Canada;France;Poland;Spain;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-PL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-GB   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 1;Phase 2   EUCTR2011-001873-24-PL   Canada;France;Poland;Spain;United Kingdom;United States;
   Lilly S.A.
      2013   Phase 3   EUCTR2012-002354-23-ES   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
Cialis 5 mg film-coated tablets
   Eli Lilly and Company
      2013   Phase 3   EUCTR2012-002354-23-NL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-IT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-FR   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-DE   Austria;Belgium;Brazil;France;Germany;Israel;Italy;Japan;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;
      2013   Phase 3   EUCTR2012-002354-23-BE   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-AT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   -   EUCTR2012-002354-23-RO   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2012   Phase 1;Phase 2   EUCTR2011-001873-24-GB   Canada;France;Poland;Spain;United Kingdom;United States;
      2012   Phase 1;Phase 2   EUCTR2011-001873-24-ES   Canada;France;Poland;Spain;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-PL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-GB   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 1;Phase 2   EUCTR2011-001873-24-PL   Canada;France;Poland;Spain;United Kingdom;United States;
   Lilly S.A.
      2013   Phase 3   EUCTR2012-002354-23-ES   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
Cicletanine
   Gilead Sciences
      2009   Phase 2   NCT00832507   Australia;Austria;Belgium;Canada;Germany;Israel;Mexico;Spain;United Kingdom;United States;
Cicletanine hydrochloride
   Gilead Sciences, Inc.
      2010   -   EUCTR2008-007455-26-AT   Austria;Belgium;Germany;Spain;United Kingdom;
      2009   Phase 2   EUCTR2008-007455-26-GB   Austria;Belgium;Germany;Spain;United Kingdom;
      2009   Phase 2   EUCTR2008-007455-26-BE   Austria;Belgium;Germany;Spain;United Kingdom;
      2009   -   EUCTR2008-007455-26-ES   Austria;Belgium;Germany;Spain;United Kingdom;
      2009   -   EUCTR2008-007455-26-DE   Australia;Austria;Belgium;Canada;Germany;Israel;Mexico;Spain;United Kingdom;United States;
Clopidogrel
   Kawut, Steven, MD
      2002   Phase 2   NCT00105209   United States;
Coenzyme Q-10 in Normal Control subjects
   The Cleveland Clinic
      2010   -   NCT01148836   United States;
Coenzyme Q-10 in Pulmonary Hypertension subjects
   The Cleveland Clinic
      2010   -   NCT01148836   United States;
Combination Product:
   Respira Therapeutics, Inc.
      2020   Phase 2   NCT04266197   Serbia;United States;
Combination Product: Implantable System for Remodulin (treprostinil)
   Medtronic Cardiac Rhythm and Heart Failure
      2020   -   NCT03833323   -
Combination Product: Treprostinil via implanted pump
   University Medicine Greifswald
      2020   -   NCT04309838   Germany;
Commercial Ventavis® (iloprost)
   Actelion
      2009   -   NCT00902603   United States;
Conventional drug therapy(expectorant,bronchodilator)
   Liaocheng People's Hospital
      2019   Phase 1/Phase 2   NCT04055415   China;
Coronary flow reserve SE
   Fatebenefratelli Hospital
      2016   -   NCT03049995   Italy;
Crono Five ambulatory pump
   United Therapeutics
      2007   Phase 4   NCT00439946   United States;
Current marketed FLOLAN (epoprostenol sodium)
   GlaxoSmithKline
      2011   Phase 4   NCT01462565   Canada;Netherlands;United States;
D.3.6.2 - dose massima specificare: giornaliera
   ACTELION PHARMACEUTICALS LTD
      2019   Phase 3   EUCTR2014-004786-25-IT   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
DHEA tablet
   Rhode Island Hospital
      2019   Phase 2   NCT03648385   United States;
Diastolic function SE
   Fatebenefratelli Hospital
      2016   -   NCT03049995   Italy;
Dichloroacetate Sodium
   University of Alberta
      2010   Phase 1   NCT01083524   Canada;United Kingdom;
Dietanolamina de treprostinilo
   United Therapeutics Corporation
      2007   Phase 3   EUCTR2006-000800-17-ES   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      2007   -   EUCTR2006-000804-18-ES   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
Diltiazem Hydrochloride
   University of South Florida
      2012   -   NCT01645826   United States;
Dimethyl Fumarate (DMF)
   Robert Lafyatis
      2016   Phase 1   NCT02981082   United States;
Diphenhydramine
   National Institute of Allergy and Infectious Diseases (NIAID)
      2011   Phase 2   NCT01086540   United States;
Duo-Therapy with Sildenafil + Bosentan
   Johns Hopkins University
      2022   Phase 3   NCT04039464   United States;
EFI/ACT-385781A
   Actelion
      2011   Phase 3   NCT01431716   Belgium;Canada;France;Italy;Netherlands;Spain;
ENOS transfected EPCs will be delivered via a PA line
   Northern Therapeutics
      2006   Phase 1   NCT00469027   Canada;
EPOPROSTENOL SODICO
   Actelion Pharmaceuticals Ltd
      2011   -   EUCTR2010-018322-40-ES   Belgium;Canada;France;Italy;Netherlands;Spain;
EPOPROSTENOL SODIUM
   ACTELION Pharmaceuticals Ltd
      2011   -   EUCTR2010-018322-40-NL   Belgium;France;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-018320-10-NL   Belgium;Canada;France;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-018320-10-ES   Belgium;Canada;France;Italy;Netherlands;Spain;
      2010   Phase 3   EUCTR2010-018322-40-FR   Belgium;France;Italy;Netherlands;Spain;
      2010   Phase 3   EUCTR2010-018322-40-BE   Belgium;Canada;France;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-018320-10-BE   Belgium;Canada;France;Italy;Netherlands;Spain;
   Actelion Pharmaceuticals Ltd
      2011   -   EUCTR2010-018322-40-ES   Belgium;Canada;France;Italy;Netherlands;Spain;
   Actelion Pharmaceuticals Ltd.
      2011   -   EUCTR2010-018320-10-IT   Belgium;Canada;Italy;Netherlands;Spain;
ERA and PDE-5I (Sildenafil, Tadalafil, Bosentan, Macitentan)
   VU University Medical Center
      2013   Phase 4   NCT03236818   Netherlands;
ERA as specific PAH treatment
   Eli Lilly and Company
      2014   Phase 3   NCT01824290   Austria;Belgium;Brazil;Canada;France;Germany;Israel;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;Turkey;United States;
ESR-specific PET scan
   Vanderbilt University Medical Center
      2021   Phase 2   NCT04280523   United States;
Elafin
   Roham T. Zamanian
      2019   Phase 1   NCT03522935   United States;
EndoPAT measurement
   Universitätsklinikum Hamburg-Eppendorf
      2010   -   NCT01317134   Germany;
Endothelin Receptor Antagonists
   Brigham and Women's Hospital
      2021   -   NCT05039086   United States;
Endothelin receptor antagonist therapy
   Actelion
      2015   -   NCT02309463   -
Endothelin-3
   University of Edinburgh
      2009   Phase 0   NCT01100736   United Kingdom;
Epoprostenol
   Actelion
      2011   Phase 3   NCT01470144   Belgium;Canada;France;Italy;Netherlands;Spain;
   Actelion Pharmaceuticals Japan Ltd.
      2015   Phase 3   JPRN-JapicCTI-142722   -
      2014   Phase 3   JPRN-JapicCTI-142721   -
      2013   Phase 4   JPRN-JapicCTI-132142   -
      2011   Phase 3   JPRN-JapicCTI-122017   -
Epoprostenol for injection
   ACTELION Pharmaceuticals Ltd
      2011   -   EUCTR2010-018322-40-NL   Belgium;France;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-018320-10-NL   Belgium;Canada;France;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-018320-10-ES   Belgium;Canada;France;Italy;Netherlands;Spain;
      2010   Phase 3   EUCTR2010-018322-40-BE   Belgium;Canada;France;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-018320-10-BE   Belgium;Canada;France;Italy;Netherlands;Spain;
   Actelion Pharmaceuticals Ltd
      2011   -   EUCTR2010-018322-40-ES   Belgium;Canada;France;Italy;Netherlands;Spain;
   Actelion Pharmaceuticals Ltd.
      2011   -   EUCTR2010-018322-40-IT   Belgium;Canada;France;Italy;Netherlands;Spain;
Epoprostenol-Actelion
   ACTELION Pharmaceuticals Ltd
      2010   Phase 3   EUCTR2010-018322-40-FR   Belgium;France;Italy;Netherlands;Spain;
Epoprostenolo per iniezione
   Actelion Pharmaceuticals Ltd.
      2011   -   EUCTR2010-018322-40-IT   Belgium;Canada;France;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-018320-10-IT   Belgium;Canada;Italy;Netherlands;Spain;
Equal
   BIOPROJET
      2004   -   EUCTR2004-003847-37-IT   Italy;
Erbitux
   VU University Medical Centre
      2006   -   EUCTR2006-002081-19-NL   Netherlands;
Esomeprazole
   United Therapeutics
      2009   Phase 1   NCT00963027   United States;
Esuberaprost
   Lung Biotechnology PBC
      2018   Phase 3   NCT03657095   Israel;United States;
Eutonic Treprostinil Solution
   Jewish General Hospital
      2012   Phase 4   NCT01615627   Canada;
FDC macitentan/tadalafil
   Actelion
      2019   Phase 3   NCT03904693   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
FK506 level 2-3 ng/ml
   Edda Spiekerkoetter
      2012   Phase 2   NCT01647945   United States;
FK506 level 3-5 ng/ml
   Edda Spiekerkoetter
      2012   Phase 2   NCT01647945   United States;
FK506 level < 2 ng/ml
   Edda Spiekerkoetter
      2012   Phase 2   NCT01647945   United States;
FLOLAN TM and Glycine Diluent
   GlaxoSmithKline Research and Development Limited
      2011   -   EUCTR2011-002943-92-NL   Canada;Netherlands;United States;
FLOLAN injection with currently marketed diluent
   GlaxoSmithKline
      2016   Phase 4   NCT02705807   Japan;
FLOLAN injection with reformulated diluent
   GlaxoSmithKline
      2016   Phase 4   NCT02705807   Japan;
FLOLAN™ and Glycine Diluent
   GlaxoSmithKline Research and Development Limited
      2011   -   EUCTR2011-002943-92-NL   Canada;Netherlands;United States;
Famotidine
   University of Washington
      2019   Phase 2   NCT03554291   United States;
Ferinject
   Imperial College Academic Healthsciences Centre
      2016   Phase 2   EUCTR2010-024585-22-DE   Germany;United Kingdom;
      2011   Phase 2   EUCTR2010-024585-22-GB   Germany;United Kingdom;
   VU university medical center
      2010   -   EUCTR2010-023233-30-NL   Netherlands;
Ferinject or CosmoFer
   Imperial College London
      2011   Phase 2   NCT01447628   China;Germany;United Kingdom;
Ferric carboxymaltose
   Imperial College Academic Healthsciences Centre
      2011   Phase 2   EUCTR2010-024585-22-GB   Germany;United Kingdom;
   VU university medical center
      2010   -   EUCTR2010-023233-30-NL   Netherlands;
Ferricarboxymaltose
   VU University Medical Center
      2011   Phase 4   NCT01288651   Netherlands;
Flolan®
   Actelion
      2010   Phase 4   NCT01105117   United States;
      2010   Phase 4   NCT01105091   United States;
Fluoxetine
   University of Texas Southwestern Medical Center
      2013   Phase 2   NCT03638908   United States;
      2009   Phase 2   NCT00942708   United States;
Fulvestrant
   University of Pennsylvania
      2017   Phase 2   NCT02911844   United States;
G04BE03
   Pfizer, Inc.
      -   Phase 3   EUCTR2016-003978-41-Outside-EU/EEA   Japan;
G04BE03- Sildenafil - sildenafil (citrato)
   PFIZER
      2006   -   EUCTR2006-001464-23-IT   Czech Republic;Germany;Greece;Italy;United Kingdom;
G04BE08
   ACTELION PHARMACEUTICALS LTD
      2019   Phase 3   EUCTR2014-004786-25-IT   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
GB002
   GB002, Inc., a wholly owned subsidiary of Gossamer Bio, Inc.
      2020   Phase 1   NCT03926793   United Kingdom;United States;
GB002 (seralutinib)
   GB002, Inc., a wholly owned subsidiary of Gossamer Bio, Inc.
      2021   Phase 2   NCT04816604   France;Germany;Spain;United States;
      2020   Phase 2   NCT04456998   Australia;Austria;Belgium;Canada;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
GB002 Capsules
   GB002, Inc.
      2021   Phase 2   EUCTR2020-005169-15-ES   Australia;Austria;Belgium;Canada;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-005169-15-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2019-002669-37-DE   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2019-002669-37-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2019-002669-37-BE   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002669-37-GB   Australia;Austria;Belgium;Canada;France;Germany;Israel;Serbia;Singapore;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002669-37-FR   Australia;Austria;Belgium;Canada;France;Germany;Israel;Serbia;Singapore;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002669-37-AT   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2019   Phase 1;Phase 2   EUCTR2018-003093-27-GB   Denmark;France;Netherlands;Sweden;United Kingdom;United States;
GLIVEC
   NOVARTIS FARMA
      2011   -   EUCTR2010-021960-14-IT   Germany;Italy;
      2011   -   EUCTR2010-021344-17-IT   Italy;
      2010   -   EUCTR2009-018167-26-IT   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2009   -   EUCTR2009-012057-38-IT   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
GLIVEC 100 mg comprimidos recubiertos con película
   Novartis Farmacéutica SA
      2009   -   EUCTR2009-012057-38-ES   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
   Novartis Farmacéutica, S.A.
      2013   -   EUCTR2013-001100-10-ES   Australia;Spain;Switzerland;United States;
GMA301 Injection
   Gmax Biopharm Australia Pty Ltd.
      2020   Phase 1   NCT04505137   Australia;
GS-4997
   Gilead Sciences, Inc.
      2015   Phase 2   EUCTR2014-002131-34-NL   Canada;France;Germany;Italy;Netherlands;Spain;United Kingdom;United States;
      2015   Phase 2   EUCTR2014-002131-34-IT   Canada;France;Germany;Italy;Netherlands;Spain;United Kingdom;United States;
      2015   Phase 2   EUCTR2014-002131-34-GB   Canada;France;Germany;Italy;Netherlands;Spain;United Kingdom;United States;
      2015   Phase 2   EUCTR2014-002131-34-ES   Canada;France;Germany;Italy;Netherlands;Spain;United Kingdom;United States;
      2015   Phase 2   EUCTR2014-002131-34-DE   Canada;France;Germany;Italy;Netherlands;Spain;United Kingdom;United States;
GSK1325760
   GlaxoSmithKline Research & Development Limited
      -   Phase 2   EUCTR2010-021572-29-FR   France;Germany;Greece;Hungary;Italy;Japan;Netherlands;Spain;United States;
      -   -   EUCTR2010-019547-19-Outside-EU/EEA   Argentina;Brazil;Canada;Japan;Mexico;Russian Federation;United States;
   GlaxoSmithKline Research & Development, Ltd
      2011   -   EUCTR2010-021572-29-NL   Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-021572-29-HU   Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-021572-29-DE   Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   Phase 2   EUCTR2010-019547-19-NL   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   Phase 2   EUCTR2010-019547-19-HU   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   Phase 2   EUCTR2010-019547-19-FR   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   Phase 2   EUCTR2010-019547-19-DE   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-021572-29-GR   Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-019547-19-IT   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-019547-19-GR   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
   GlaxoSmithKline Research and Development Ltd
      2019   Phase 1   EUCTR2019-001699-12-GB   United Kingdom;
   GlaxoSmithKline, S.A
      2011   -   EUCTR2010-021572-29-ES   Germany;Greece;Hungary;Italy;Netherlands;Spain;
   GlaxoSmithKline, S.A.
      2010   Phase 2   EUCTR2010-019547-19-ES   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
GSK1325760A
   GlaxoSmithKline
      2008   Phase 3   NCT00554619   Japan;
      2007   Phase 2   NCT00540436   Japan;
GSK2586881
   GlaxoSmithKline
      2018   Phase 2   NCT03177603   Germany;Spain;United States;
   GlaxoSmithKline Research & Development Ltd
      2017   Phase 2   EUCTR2017-000212-41-DE   Germany;Spain;United States;
   GlaxoSmithKline, S.A.
      2017   Phase 2   EUCTR2017-000212-41-ES   Germany;Spain;United States;
Gadolinium
   Ottawa Heart Institute Research Corporation
      2018   Phase 4   NCT03344159   Canada;
Generic Dry Powder Inhaler
   GB002, Inc., a wholly owned subsidiary of Gossamer Bio, Inc.
      2021   Phase 2   NCT04816604   France;Germany;Spain;United States;
      2020   Phase 2   NCT04456998   Australia;Austria;Belgium;Canada;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2020   Phase 1   NCT03926793   United Kingdom;United States;
Glivec
   Novartis Pharma Services AG
      2006   -   EUCTR2005-005569-12-GB   Austria;Germany;United Kingdom;
      2006   -   EUCTR2005-005569-12-AT   Austria;Germany;United Kingdom;
Glivec 100 mg Filmtabletten
   Novartis Pharma Services AG
      2006   -   EUCTR2005-005569-12-DE   Austria;Germany;United Kingdom;
Glivec 100 mg Hartkapsel
   Novartis Pharma Services AG
      2006   -   EUCTR2005-005569-12-DE   Austria;Germany;United Kingdom;
Glivec®
   Novartis Pharma AG
      2011   -   EUCTR2010-021960-14-DE   Germany;Italy;
      2010   Phase 3   EUCTR2009-018167-26-GB   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   Phase 3   EUCTR2009-018167-26-BE   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   -   EUCTR2009-018167-26-FR   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   -   EUCTR2009-018167-26-DE   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   -   EUCTR2009-012057-38-NL   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-FR   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
   Novartis Pharma Services AG
      2010   -   EUCTR2009-018167-26-AT   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2009   -   EUCTR2009-012057-38-SE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-GB   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-BE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-AT   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
Glivec® 100 mg Filmtabletten
   Novartis Pharma Services AG
      2009   -   EUCTR2009-012057-38-DE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
Gold
   Shanghai Pulmonary Hospital
      2020   Phase 0   ChiCTR2000036852   -
      2016   -   ChiCTR-DDD-16009406   China;
   Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
      2020   Phase 0   ChiCTR2000032622   China;
   Zhongda Hospital Affiliated to Southeast University
      2020   -   ChiCTR1900028152   China;
HGP1206
   Hanmi Pharmaceutical Company Limited
      2013   Phase 1   NCT01864863   Korea, Republic of;
Hydroxyurea
   National Heart, Lung, and Blood Institute (NHLBI)
      2013   Early Phase 1   NCT01950585   United States;
Hyperpolarized 129Xe
   Bastiaan Driehuys
      2022   Phase 2   NCT04778046   United States;
HypotonicTreprostinil Solution
   Jewish General Hospital
      2012   Phase 4   NCT01615627   Canada;
I-Neb AAD system
   Bayer
      2016   -   NCT02826252   Germany;
I.v. selexipag
   Actelion
      2017   Phase 3   NCT03187678   Germany;United States;
IMATINIB MESILATE
   Novartis Pharma AG
      2011   -   EUCTR2010-021960-14-DE   Germany;Italy;
IMATINIB MESYLATE
   NOVARTIS FARMA
      2011   -   EUCTR2010-021960-14-IT   Germany;Italy;
      2011   -   EUCTR2010-021344-17-IT   Italy;
   Novartis Pharma AG
      2010   Phase 3   EUCTR2009-018167-26-GB   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   Phase 3   EUCTR2009-018167-26-BE   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   -   EUCTR2009-018167-26-FR   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   -   EUCTR2009-018167-26-DE   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   -   EUCTR2009-012057-38-NL   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-FR   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
   Novartis Pharma Services AG
      2010   -   EUCTR2009-018167-26-AT   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2009   -   EUCTR2009-012057-38-SE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-GB   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-BE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-AT   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
INO
   BELLEROPHON PULSE TECHNOLOGIES LLC
      2016   Phase 3   EUCTR2015-005223-90-IT   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;Czechia;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
   Bellerophon Pulse Technologies
      2018   Phase 3   NCT03602781   Canada;United States;
   Bellerophon Pulse Technologies LLC
      2018   Phase 3   EUCTR2015-005223-90-BE   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-005223-90-NL   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-005223-90-HR   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-005223-90-AT   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-PT   Australia;Austria;Belgium;Canada;Croatia;Czech Republic;France;Germany;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-GB   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-DE   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-CZ   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
Ilomedin 20 [20 µg / ml]
   Bayer AG
      2013   Phase 1;Phase 2   EUCTR2013-002783-12-AT   Austria;Germany;
   Bayer HealthCare AG
      2014   Phase 1;Phase 2   EUCTR2013-002783-12-DE   Austria;Germany;
Iloprost
   Actelion
      2008   Phase 3   NCT00709098   Austria;Germany;United States;
      2004   Phase 2   NCT00086463   United States;
   Actelion Pharmaceuticals Ltd
      2009   -   EUCTR2009-010703-80-DE   Austria;Germany;
      2009   -   EUCTR2009-010703-80-AT   Austria;Germany;
   Actelion Pharmaceuticals Ltd.
      2009   -   EUCTR2009-011013-24-AT   Austria;
   Bayer
      2011   -   NCT01468545   Spain;
   COTHERIX, INC.
      2006   Phase 3   EUCTR2005-006192-13-IT   Austria;Germany;Italy;Portugal;Spain;United Kingdom;
   Fourth Military Medical University
      2012   Phase 3   NCT01712997   China;
   Gachon University Gil Medical Center
      2010   -   NCT01054105   Korea, Republic of;
   Royal Brompton and Harefield NHS Foundation Trust
      2014   Phase 4   EUCTR2014-000091-25-GB   United Kingdom;
   The University of Tokushima Graduate School of Health Biosciences
      2017   -   JPRN-UMIN000027284   Japan;
   University of California, Los Angeles
      2011   -   NCT01319045   United States;
   University of Cincinnati
      2006   Phase 4   NCT00403650   United States;
   University of Giessen
      2017   -   NCT03365479   Germany;
Iloprost (5 µg)
   Actelion
      2008   Phase 3   NCT00709956   Austria;Germany;United States;
Iloprost (Ventavis BAYQ6256)
   Bayer
      2006   -   NCT01062282   Korea, Republic of;
Iloprost (Ventavis inhaled, BAYQ6256)
   Bayer
      2012   Phase 3   NCT01469169   Japan;
Iloprost (Ventavis, BAYQ 6256)
   Bayer
      2013   -   NCT01894035   Portugal;
Iloprost (Ventavis, BAYQ6256)
   Bayer
      2018   -   NCT03293407   Germany;
Iloprost (Ventavis®)
   Actelion Pharmaceuticals US, Inc.
      2006   -   EUCTR2005-006192-13-GB   Austria;Germany;Italy;Portugal;Spain;United Kingdom;
      2006   -   EUCTR2005-006192-13-DE   Austria;Germany;Italy;Portugal;Spain;United Kingdom;
      2006   -   EUCTR2005-006192-13-AT   Austria;Germany;Italy;Portugal;Spain;United Kingdom;
   CoTherix, Inc
      2007   -   EUCTR2005-006192-13-PT   Austria;Germany;Italy;Portugal;Spain;United Kingdom;
      2006   Phase 3   EUCTR2005-006192-13-ES   Austria;Germany;Italy;Portugal;Spain;United Kingdom;
Iloprost Inhalation Solution (Ventavis)
   Actelion
      2006   Phase 2   NCT00453414   United States;
Iloprost PD-15
   Actelion
      2008   Phase 3   NCT00723554   United States;
Iloprost PD-6
   Actelion
      2008   Phase 3   NCT00723554   United States;
Iloprost,(Ventavis, BAYQ6256)
   Bayer
      2016   -   NCT02826252   Germany;
Imatinib
   Medical Education Center
      2008   -   JPRN-UMIN000001578   Japan;
   NOVARTIS FARMA
      2009   -   EUCTR2009-012057-38-IT   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
   Novartis Pharma K.K.
      2014   Phase 3   JPRN-JapicCTI-142462   -
   Novartis Pharma Services AG
      2006   -   EUCTR2005-005569-12-GB   Austria;Germany;United Kingdom;
      2006   -   EUCTR2005-005569-12-DE   Austria;Germany;United Kingdom;
      2006   -   EUCTR2005-005569-12-AT   Austria;Germany;United Kingdom;
   Novartis Pharmaceuticals
      2011   Phase 3   NCT01392495   Australia;Belgium;Germany;Italy;Lithuania;Turkey;United Kingdom;United States;
      2011   Phase 3   NCT01392469   Australia;Belgium;Germany;Italy;Lithuania;Romania;Turkey;United Kingdom;United States;
      2010   Phase 3   NCT01117987   Austria;Belgium;Canada;France;Germany;Italy;Japan;Korea, Republic of;Netherlands;Spain;Sweden;Switzerland;United Kingdom;United States;
Imatinib Mesylate
   Imperial College London
      2021   Phase 2   NCT04416750   United Kingdom;
Imatinib mesilate
   Imperial College London
      2020   Phase 2   EUCTR2020-001157-48-GB   United Kingdom;
   Novartis Pharma Services AG
      2009   -   EUCTR2009-012057-38-DE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
Imatinib mesylate
   Novartis Pharmaceuticals
      2009   Phase 3   NCT00902174   Austria;Belgium;Canada;France;Germany;Italy;Japan;Korea, Republic of;Netherlands;Spain;Sweden;Switzerland;United Kingdom;United States;
      2006   Phase 2/Phase 3   NCT00477269   Austria;Germany;United Kingdom;United States;
Inhaled Iloprost (5 µg)
   Actelion
      2006   Phase 3   NCT00302211   United States;
Inhaled NO with pulsed delivery
   BELLEROPHON PULSE TECHNOLOGIES LLC
      2016   Phase 3   EUCTR2015-005223-90-IT   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;Czechia;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
   Bellerophon Pulse Technologies LLC
      2018   Phase 3   EUCTR2015-005223-90-BE   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-005223-90-NL   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-005223-90-HR   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-005223-90-AT   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-PT   Australia;Austria;Belgium;Canada;Croatia;Czech Republic;France;Germany;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-GB   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-DE   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-CZ   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
Inhaled Nitric Oxide
   Bellerophon Pulse Technologies
      2016   Phase 3   NCT02652429   Canada;United States;
   Geno LLC
      2015   Phase 3   NCT02436512   United States;
      2011   Phase 2   NCT01265888   United States;
Inhaled Nitric Oxide 75 mcg/kg IBW/hr
   Bellerophon Pulse Technologies
      2016   Phase 3   NCT02725372   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czechia;France;Germany;Israel;Italy;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
Inhaled dry powder treprostinil (LIQ861)
   Liquidia Technologies, Inc.
      2019   Phase 2   NCT03884465   France;Germany;
Inhaled iloprost (Ventavis, BAYQ6256)
   Bayer
      2010   -   NCT01355380   Poland;
Inhaled nitric oxide & INOpulse delivery
   BELLEROPHON PULSE TECHNOLOGIES LLC
      2016   Phase 3   EUCTR2015-005223-90-IT   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;Czechia;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
   Bellerophon Pulse Technologies LLC
      2018   Phase 3   EUCTR2015-005223-90-BE   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-005223-90-NL   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-005223-90-HR   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-005223-90-AT   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-PT   Australia;Austria;Belgium;Canada;Croatia;Czech Republic;France;Germany;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-GB   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-DE   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-005223-90-CZ   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
Inhaled prostacyclin
   United Therapeutics
      2010   -   NCT01266265   United States;
Inhaled treprostinil
   United Therapeutics
      2012   Phase 3   NCT01557660   -
      2012   Phase 3   NCT01557647   -
      2008   Phase 4   NCT00741819   United States;
      2005   Phase 3   NCT00147199   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Spain;United Kingdom;United States;
Intestinal microbiota transplant (IMT)
   University of Minnesota
      2021   Phase 1   NCT04884971   United States;
Intravenous Treprostinil
   United Therapeutics
      2005   Phase 4   NCT03055221   -
Intravenous administration of ferric carboxymaltose
   University of Oxford
      2013   -   NCT01847352   United Kingdom;
Intravenous/Subcutaneous Treprostinil
   United Therapeutics
      2018   Phase 4   NCT03497689   United States;
Iron supplement
   The Cleveland Clinic
      2012   -   NCT01446848   United States;
JNJ-67896049
   Actelion
      2021   Phase 4   NCT04435782   Argentina;Brazil;China;France;Germany;Hong Kong;Israel;Korea, Republic of;Malaysia;Netherlands;Russian Federation;Saudi Arabia;Singapore;United Arab Emirates;United Kingdom;United States;
JNJ-67896049 (ACT-293987)
   ACTELION PHARMACEUTICALS LTD
      2020   Phase 3   EUCTR2019-002817-21-IT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
   Actelion Pharmaceuticals Ltd.
      2021   Phase 3   EUCTR2019-002817-21-FI   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-PT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-LT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-HU   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-ES   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-DE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-BG   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2019-002817-21-SE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2019-002817-21-PL   Australia;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Finland;France;Germany;Hungary;Ireland;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Viet Nam;
      -   Phase 3   EUCTR2019-002817-21-IE   Australia;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Finland;France;Germany;Hungary;Ireland;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2019-002817-21-FR   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2019-002817-21-BE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
JNJ-67896062 / ACT-064992
   ACTELION PHARMACEUTICALS LTD
      2020   Phase 3   EUCTR2019-004131-24-IT   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-002533-11-IT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
   ACTELION Pharmaceuticals Ltd.
      2020   Phase 3   EUCTR2019-004131-24-PL   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-LT   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-HU   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czech Republic;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Arab Emirates;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-GB   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czech Republic;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Arab Emirates;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-ES   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czech Republic;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Arab Emirates;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-DE   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
   ACTELION Pharmacteuticals Ltd.
      2021   Phase 3   EUCTR2019-002533-11-BG   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-SK   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-SE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-PT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-NO   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-NL   Argentina;Australia;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-002533-11-HU   Argentina;Australia;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-002533-11-GB   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-DK   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-DE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-CZ   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-AT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
JNJ-67896062/ ACT-064992
   ACTELION PHARMACEUTICALS LTD
      2020   Phase 3   EUCTR2019-004131-24-IT   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
JTT-251
   Akros Pharma Inc.
      2019   Phase 2   NCT03789643   -
KAR5585 Capsules
   Karos Pharmaceuticals
      2015   Phase 1   NCT02746237   United States;
L-Citrulline Malate
   Masih Daneshvari Hospital
      2012   Phase 0   NCT01683981   Iran, Islamic Republic of;
L606 (Liposomal Treprostinil) Inhalation Solution
   Pharmosa Biopharm Inc.
      2018   Phase 1   NCT04041648   United States;
L606 Inhalation System
   Pharmosa Biopharm Inc.
      2018   Phase 1   NCT04041648   United States;
LIQ861 100 µg
   Liquidia Technologies, Inc.
      2019   Phase 2   EUCTR2018-003414-40-FR   France;Germany;
LIQ861 106 µg
   Liquidia Technologies, Inc.
      2019   Phase 2   EUCTR2018-003414-40-DE   France;Germany;
LIQ861 25 µg
   Liquidia Technologies, Inc.
      2019   Phase 2   EUCTR2018-003414-40-FR   France;Germany;
LIQ861 26.5 µg
   Liquidia Technologies, Inc.
      2019   Phase 2   EUCTR2018-003414-40-DE   France;Germany;
LIQ861 50 µg
   Liquidia Technologies, Inc.
      2019   Phase 2   EUCTR2018-003414-40-FR   France;Germany;
LIQ861 53 µg
   Liquidia Technologies, Inc.
      2019   Phase 2   EUCTR2018-003414-40-DE   France;Germany;
LIQ861 75 µg
   Liquidia Technologies, Inc.
      2019   Phase 2   EUCTR2018-003414-40-FR   France;Germany;
LIQ861 79.5 µg
   Liquidia Technologies, Inc.
      2019   Phase 2   EUCTR2018-003414-40-DE   France;Germany;
LIQ861 Inhaled Treprostinil
   Liquidia Technologies, Inc.
      2019   Phase 3   NCT03992755   United States;
      2018   Phase 3   NCT03399604   United States;
LTP001
   Novartis Pharmaceuticals
      2022   Phase 2   NCT05135000   -
LY450190
   Eli Lilly and Company
      2013   Phase 3   EUCTR2012-002354-23-NL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-IT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-FR   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-DE   Austria;Belgium;Brazil;France;Germany;Israel;Italy;Japan;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;
      2013   Phase 3   EUCTR2012-002354-23-BE   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-AT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   -   EUCTR2012-002354-23-RO   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2012   Phase 1;Phase 2   EUCTR2011-001873-24-GB   Canada;France;Poland;Spain;United Kingdom;United States;
      2012   Phase 1;Phase 2   EUCTR2011-001873-24-ES   Canada;France;Poland;Spain;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-PL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-GB   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 1;Phase 2   EUCTR2011-001873-24-PL   Canada;France;Poland;Spain;United Kingdom;United States;
Left ventricular contractile reserve SE
   Fatebenefratelli Hospital
      2016   -   NCT03049995   Italy;
Left ventricular outflow tract gradient SE
   Fatebenefratelli Hospital
      2016   -   NCT03049995   Italy;
Levitra
   Rabin Medical Center
      2012   Phase 4   NCT01649739   Israel;
Lidocaine
   Jewish General Hospital
      2012   Phase 4   NCT01433328   Canada;
Lisuride
   Sinoxa Pharma GmbH
      2012   -   EUCTR2012-001675-37-DE   Austria;Germany;
      2012   -   EUCTR2012-001675-37-AT   Austria;Germany;
Lloprost(Ventavis,BAYQ6252, 10 µg/mL)
   Bayer
      2014   Phase 1/Phase 2   NCT02032836   Austria;Germany;
Lloprost(Ventavis,BAYQ6252, 20 µg/mL)
   Bayer
      2014   Phase 1/Phase 2   NCT02032836   Austria;Germany;
MACITENTAN COMPRESSE
   ACTELION PHARMACEUTICALS LTD
      2020   Phase 3   EUCTR2019-004131-24-IT   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
MD-711
   Mochida Pharmaceutical Co., Ltd.
      2019   Phase 2-3   JPRN-JapicCTI-194651   Japan;
MHealth Intervention
   Vanderbilt University Medical Center
      2018   Phase 2   NCT03617458   United States;
MK-4836
   Thoraxklinik Heidelberg gGmbH
      2022   Phase 2   EUCTR2021-001633-40-DE   Austria;France;Germany;Italy;Norway;Switzerland;United Kingdom;
MK-5475
   MERCK SHARP & DOHME CORP. UNA SUSSIDIARIA DI MERCK & CO. INC.
      2021   Phase 2;Phase 3   EUCTR2020-001108-40-IT   Argentina;Australia;Canada;Colombia;France;Germany;Israel;Italy;New Zealand;Poland;Portugal;Russian Federation;Sweden;Turkey;United Kingdom;United States;
   Merck Sharp & Dohme Corp.
      2021   Phase 2/Phase 3   NCT04732221   Argentina;Australia;Canada;Colombia;France;Germany;Greece;Israel;Italy;Mexico;New Zealand;Poland;Russian Federation;Turkey;United Kingdom;United States;
      2019   Phase 1   NCT03744637   Moldova, Republic of;
   Merck Sharp & Dohme Corp., a subsidiary of Merck &Co.,Inc
      2021   Phase 2;Phase 3   EUCTR2020-001108-40-PL   Argentina;Australia;Canada;Colombia;France;Germany;Israel;Italy;New Zealand;Poland;Portugal;Russian Federation;Sweden;Turkey;United Kingdom;United States;
      2021   Phase 2;Phase 3   EUCTR2020-001108-40-GR   Argentina;Australia;Canada;Colombia;France;Germany;Greece;Israel;Italy;Mexico;New Zealand;Poland;Russian Federation;Sweden;Turkey;United Kingdom;United States;
      2021   Phase 2;Phase 3   EUCTR2020-001108-40-DE   Argentina;Australia;Canada;Colombia;France;Germany;Greece;Israel;Italy;New Zealand;Poland;Portugal;Russian Federation;Sweden;Turkey;United Kingdom;United States;
MK-8892
   Merck Sharp & Dohme Corp.
      2013   Phase 1   NCT01934647   Germany;
      2013   Phase 1   NCT01926509   Bulgaria;Germany;Moldova, Republic of;
      2013   Phase 1   NCT01798849   Belgium;
MTD sodium nitrite inhalation solution
   Aires Pharmaceuticals, Inc.
      2011   Phase 1   NCT01409122   United States;
Macitentan
   ACTELION PHARMACEUTICALS LTD.
      2013   Phase 3   EUCTR2012-004411-31-IT   Austria;Bulgaria;Canada;Chile;China;Czech Republic;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Philippines;Portugal;Romania;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-IT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Portugal;Russian Federation;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
   Actelion
      2020   Phase 3   NCT04273945   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2018   Phase 3   NCT03422328   Belarus;Belgium;France;Poland;Russian Federation;Ukraine;
      2017   Phase 3   NCT02932410   Argentina;Australia;Austria;Brazil;Bulgaria;Canada;China;Colombia;Finland;France;Hungary;Israel;Korea, Republic of;Malaysia;Mexico;Philippines;Poland;Portugal;Russian Federation;South Africa;Spain;Thailand;Ukraine;United States;Vietnam;
      2016   Phase 3   NCT02558231   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2015   Phase 4   NCT02968901   France;
      2015   Phase 4   NCT02310672   Australia;France;Germany;Hong Kong;Israel;Italy;Malaysia;Netherlands;Russian Federation;Singapore;United Kingdom;United States;
      2014   Phase 3   NCT02112487   France;Italy;Spain;
      2014   Phase 3   NCT02081690   France;Italy;Spain;
      2013   Phase 3   NCT01847014   United States;
      2013   Phase 3   NCT01841762   United States;
      2013   Phase 3   NCT01743001   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2008   Phase 3   NCT00667823   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;Chile;China;Colombia;Croatia;Czech Republic;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
   Actelion Pharmaceuticals Ltd
      2012   Phase 3   EUCTR2007-003694-27-BG   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2011   -   EUCTR2007-003694-27-GB   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2008   Phase 3   EUCTR2007-003694-27-DE   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2008   Phase 3   EUCTR2007-003694-27-AT   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
   Actelion Pharmaceuticals Ltd.
      2014   Phase 3   EUCTR2012-003335-33-GR   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-PT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-NL   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-HU   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-GB   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-ES   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Russian Federation;Serbia;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-DE   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-CZ   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-BG   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-BE   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-AT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2008   Phase 3   EUCTR2007-003694-27-SE   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2008   Phase 3   EUCTR2007-003694-27-NL   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      2008   Phase 3   EUCTR2007-003694-27-BE   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
      -   Phase 3   EUCTR2007-003694-27-PL   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
   Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
      2019   -   JPRN-UMIN000035389   Japan;
   Janssen Pharmaceutical K.K.
      2022   Phase 3   NCT05167825   Japan;
      2020   Phase 3   JPRN-JapicCTI-194971   Japan, South America, Europe;
   Nakano Masayoshi
      2022   Phase 3   JPRN-jRCT2011210057   Japan;
      2021   Phase 3   JPRN-jRCT2061200058   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic Of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;
   Nippon Shinyaku co.,LTD./Actelion Pharmaceuticals Japan Ltd.
      2012   Phase 2-3   JPRN-JapicCTI-121986   -
Macitentan (ACT-064992)
   Actelion
      2008   Phase 3   NCT00660179   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;Chile;China;Colombia;Croatia;Czech Republic;Denmark;Finland;Former Serbia and Montenegro;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Norway;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
Macitentan 10 mg tablet, once daily.
   Actelion
      2013   Phase 3   NCT01739400   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
Macitentan Group
   University of Giessen
      2018   Phase 2   NCT03362047   Germany;
Macitentan tablets
   ACTELION PHARMACEUTICALS LTD
      2020   Phase 3   EUCTR2019-002533-11-IT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
   ACTELION Pharmaceuticals Ltd.
      2020   Phase 3   EUCTR2019-004131-24-PL   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-LT   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-HU   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czech Republic;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Arab Emirates;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-GB   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czech Republic;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Arab Emirates;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-ES   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czech Republic;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Arab Emirates;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-DE   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
   ACTELION Pharmacteuticals Ltd.
      2021   Phase 3   EUCTR2019-002533-11-BG   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-SK   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-SE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-PT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-NO   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-NL   Argentina;Australia;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-002533-11-HU   Argentina;Australia;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-002533-11-GB   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-DK   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-DE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-CZ   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-AT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
Metformin
   Nantes University Hospital
      2011   Phase 2   NCT01352026   France;
   Vanderbilt University Medical Center
      2018   Phase 2   NCT03617458   United States;
Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo
   Bayer Health Care AG
      2011   -   EUCTR2010-018863-40-AT   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
   Bayer HealthCare AG
      2011   Phase 2   EUCTR2010-018863-40-GB   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2011   -   EUCTR2010-018863-40-PL   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2011   -   EUCTR2010-018863-40-ES   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2010   -   EUCTR2010-018863-40-DE   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2010   -   EUCTR2010-018863-40-CZ   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridine-3-yl]-5-pyrimidinyl(methyl)carb
   Bayer HealthCare AG
      2010   Phase 3   EUCTR2008-003610-94-GR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2008-003482-68-GR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003610-94-NL   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003610-94-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003482-68-IE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003482-68-ES   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003482-68-AT   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003610-94-IE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003610-94-ES   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003482-68-PT   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   -   EUCTR2008-003482-68-NL   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003482-68-CZ   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2008   Phase 3   EUCTR2008-003610-94-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2008   Phase 3   EUCTR2008-003482-68-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2008   -   EUCTR2008-003482-68-DE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
   Bayer HealthCare AG, D-51368 Leverkusen
      2009   Phase 3   EUCTR2008-003482-68-GB   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003482-68-BE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003482-68-DK   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2008   -   EUCTR2008-003482-68-SE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
Methyl [4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]meth
   Bayer HealthCare AG
      2006   Phase 1;Phase 2   EUCTR2006-003520-10-DE   Germany;
Methylprednisolone
   National Institute of Allergy and Infectious Diseases (NIAID)
      2011   Phase 2   NCT01086540   United States;
Mitral regurgitation SE
   Fatebenefratelli Hospital
      2016   -   NCT03049995   Italy;
Mono-Therapy with Sildenafil
   Johns Hopkins University
      2022   Phase 3   NCT04039464   United States;
Morphine Sulfate
   John Granton
      2017   Phase 2   NCT03401476   Canada;
Moxifloxacin
   Bial - Portela C S.A.
      2018   Phase 1   NCT03489005   United Kingdom;
MultiHance
   Brigham and Women's Hospital
      2013   Phase 2   NCT01953965   United States;
NS-304
   NIPPON SHINYAKU CO., LTD.
      2008   Phase 2   EUCTR2007-006453-12-IT   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   -   EUCTR2007-003328-39-IT   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
   NIPPON SHINYAKU CO., LTD. / Actelion Pharmaceuticals Japan Ltd.
      2011   Phase 2   JPRN-JapicCTI-111532   -
   Nippon Shinyaku Co., LTD
      2009   -   EUCTR2007-003328-39-AT   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   Phase 2   EUCTR2007-003328-39-FR   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
   Nippon Shinyaku Co., Ltd.
      2020   Phase 2   JPRN-JapicCTI-205391   Japan;
      2008   Phase 2   EUCTR2007-006453-12-FR   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
NX1011
   NITROX, LLC
      2006   Phase 2   NCT00323024   United States;
Nebulized combination ipratropium bromide with salbutamol
   Assistance Publique - Hôpitaux de Paris
      2016   Phase 3   NCT02782052   -
Nebulized ipratropium bromide
   Assistance Publique - Hôpitaux de Paris
      2016   Phase 3   NCT02782052   -
New thermo stable formulation of epoprostenol sodium
   GlaxoSmithKline
      2011   Phase 4   NCT01462565   Canada;Netherlands;United States;
Nicardipine
   Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
      1999   -   JPRN-UMIN000020386   Japan;
Nilotinib
   NOVARTIS FARMA
      2010   -   EUCTR2010-019883-36-IT   Canada;Germany;Hungary;Italy;Korea, Republic of;Singapore;United States;
   Novartis Pharma AG
      2010   -   EUCTR2010-019883-36-HU   Germany;Hungary;
   Novartis Pharma Services AG
      2011   -   EUCTR2010-019883-36-DE   Canada;Germany;Hungary;Italy;Korea, Republic of;Singapore;Switzerland;United States;
   Novartis Pharmaceuticals
      2010   Phase 2   NCT01179737   Canada;Germany;Hungary;Italy;Korea, Republic of;Singapore;Switzerland;United States;
Nitric Oxide
   Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
      2016   Phase 2   NCT02734953   United States;
   Aurora Health Care
      2010   Phase 2   NCT01165047   United States;
   Bellerophon Pulse Technologies
      2012   Phase 2   NCT01457781   Canada;United States;
Nitric Oxide for inhalation
   Mallinckrodt
      2004   Phase 3   NCT00626028   France;Netherlands;Spain;United Kingdom;United States;
Nitric Oxide generated by the GeNO nitrosyl delivery system
   Geno LLC
      2010   Phase 2   NCT01092559   United States;
Nitric Oxide plus Oxygen
   Mallinckrodt
      2004   Phase 3   NCT00626028   France;Netherlands;Spain;United Kingdom;United States;
Non-Biologic DMARDs
   Hoffmann-La Roche
      2000   -   NCT02784808   -
Observational study with patients treated with Tracleer, Ventavis, Veletri, Opsumit and/or Uptravi
   Actelion
      2011   -   NCT01389206   Puerto Rico;United States;
Olaparib
   Laval University
      2019   Phase 1/Phase 2   NCT03782818   Canada;
      2018   Early Phase 1   NCT03251872   Canada;
Opsumit
   ACTELION Pharmaceuticals France
      2015   Phase 4   EUCTR2015-002078-19-FR   France;
   Actelion Pharmaceuticals Ltd
      2021   Phase 3   EUCTR2017-003934-10-PL   Belarus;Belgium;France;Germany;Poland;Russian Federation;Turkey;Ukraine;
      2018   Phase 3   EUCTR2017-003934-10-FR   France;
      2018   Phase 3   EUCTR2015-003438-28-GB   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2018   Phase 3   EUCTR2015-003438-28-ES   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-NO   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-FR   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-DK   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-DE   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-BE   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-AT   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2015   Phase 3   EUCTR2012-004411-31-GB   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-004411-31-PT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2012   Phase 3   EUCTR2007-003694-27-BG   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
   Actelion Pharmaceuticals Ltd.
      2015   Phase 4   EUCTR2014-004066-20-NL   Australia;France;Germany;Hong Kong;Israel;Italy;Malaysia;Netherlands;Russian Federation;Singapore;United Kingdom;United States;
      2015   Phase 4   EUCTR2014-004066-20-GB   Australia;France;Germany;Hong Kong;Israel;Italy;Malaysia;Netherlands;Russian Federation;Singapore;United Kingdom;United States;
      2015   Phase 4   EUCTR2014-004066-20-DE   Australia;France;Germany;Hong Kong;Israel;Italy;Malaysia;Netherlands;Russian Federation;Singapore;United Kingdom;United States;
      2015   Phase 3   EUCTR2012-004411-31-GR   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2015   Phase 3   EUCTR2012-004411-31-CZ   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2014   Phase 3   EUCTR2012-003335-33-GR   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-004411-31-DE   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-004411-31-BG   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-004411-31-AT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-PT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-NL   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-GB   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-DE   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-CZ   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-BG   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-BE   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      2013   Phase 3   EUCTR2012-003335-33-AT   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      -   Phase 3   EUCTR2012-004411-31-PL   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
      -   Phase 3   EUCTR2007-003694-27-PL   Argentina;Australia;Austria;Belarus;Belgium;Bulgaria;Canada;Chile;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hong Kong;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Peru;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;South Africa;Sweden;Taiwan;Thailand;Ukraine;United Kingdom;United States;
Opsumit (macitentan)
   Actelion
      2014   -   NCT02126943   Puerto Rico;United States;
Opsumit®
   ACTELION PHARMACEUTICALS LTD
      2020   Phase 3   EUCTR2019-004131-24-IT   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2014-004786-25-IT   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
   ACTELION Pharmaceuticals Ltd.
      2020   Phase 3   EUCTR2019-004131-24-PL   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-LT   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-HU   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czech Republic;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Arab Emirates;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-GB   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czech Republic;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Arab Emirates;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-ES   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czech Republic;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Arab Emirates;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-004131-24-DE   Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Lithuania;Mexico;Poland;Romania;Russian Federation;Saudi Arabia;Serbia;Singapore;Slovakia;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
   ACTELION Pharmacteuticals Ltd.
      2021   Phase 3   EUCTR2019-002533-11-BG   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-SK   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-SE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-PT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-NO   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-NL   Argentina;Australia;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-002533-11-HU   Argentina;Australia;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-002533-11-GB   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-DK   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-DE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-CZ   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002533-11-AT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Canada;China;Colombia;Czech Republic;Denmark;France;Germany;Hungary;Israel;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;Vietnam;
   Actelion Pharmaceuticals Ltd.
      2019   Phase 3   EUCTR2014-004786-25-PL   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-ES   Australia;Brazil;Bulgaria;Canada;China;Czech Republic;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-DE   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
      2019   Phase 3   EUCTR2014-004786-25-BG   Australia;Brazil;Bulgaria;Canada;China;Czechia;Germany;Hungary;Italy;Japan;Malaysia;Mexico;Poland;Russian Federation;South Africa;Spain;Taiwan;Turkey;United States;
      2014   Phase 3   EUCTR2012-004411-31-HU   Austria;Belgium;Bulgaria;Canada;Chile;China;Czech Republic;France;Germany;Greece;Hungary;India;Israel;Italy;Malaysia;Mexico;Netherlands;Philippines;Poland;Portugal;Romania;Russian Federation;Serbia;South Africa;Spain;Taiwan;Turkey;United Kingdom;United States;Vietnam;
   Justus Liebig Universität Gießen
      2016   Phase 2   EUCTR2015-002835-17-DE   Germany;
Oral ERA
   United Therapeutics
      2010   -   NCT01266265   United States;
Oral Ifetroban
   Cumberland Pharmaceuticals
      2017   Phase 2   NCT02682511   India;United States;
Oral PDE5 inhibitors
   United Therapeutics
      2010   -   NCT01266265   United States;
Oral Treprostinil
   United Therapeutics
      2018   Phase 4   NCT03497689   United States;
      2017   Phase 3   NCT02999906   -
      2017   Phase 2   NCT03016468   -
Oral anticoagulant treatment
   Centre Hospitalier Universitaire de Saint Etienne
      2017   -   NCT02800941   France;
Oral selexipag (Uptravi)
   Actelion
      2017   Phase 3   NCT03187678   Germany;United States;
Oral sildenafil
   University of Chile
      2003   Phase 4   NCT00483626   Chile;
Oral treprostinil
   United Therapeutics
      2017   -   NCT03045029   United States;
      2014   Phase 2   NCT02276872   United States;
Oral treprostinil (UT-15C) Sustained Release Tablets
   United Therapeutics
      2006   Phase 3   NCT00325403   Austria;Belgium;Canada;China;France;India;Israel;Italy;Mexico;Netherlands;Poland;Puerto Rico;United States;
Oral treprostinil (UT-15C) sustained release tablets
   United Therapeutics
      2006   Phase 3   NCT00325442   Australia;Austria;Belgium;Canada;France;Germany;Ireland;Israel;Italy;Netherlands;Poland;Spain;United Kingdom;United States;
Ossido Nitrico
   BELLEROPHON PULSE TECHNOLOGIES LLC
      2016   Phase 3   EUCTR2015-005223-90-IT   Australia;Austria;Belgium;Canada;Colombia;Croatia;Czech Republic;Czechia;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Netherlands;Portugal;Serbia;Spain;Ukraine;United Kingdom;United States;
Oxygen
   Federal University of São Paulo
      2012   -   NCT02661802   -
   Heidelberg University
      2019   Phase 2   NCT04207593   Germany;
Oxygen supplementation
   George Papanicolaou Hospital
      2018   -   NCT03683082   Greece;
Oxygen, liquid
   Thoraxklinik-Heidelberg gGmbH
      2019   Phase 2   EUCTR2018-001387-39-DE   Germany;
PAH Therapies
   Actelion
      2021   Phase 4   NCT04955990   Australia;Austria;Belgium;Brazil;Canada;China;Colombia;Germany;Italy;Japan;Korea, Republic of;Malaysia;Mexico;Netherlands;Poland;Russian Federation;Singapore;Spain;Sweden;Turkey;United Kingdom;United States;
PAH medication
   Bayer
      2019   -   NCT03863990   Argentina;
   Janssen-Cilag S.p.A.
      2020   -   NCT04567602   Italy;
PB1046 Subcutaneous Injection
   PhaseBio Pharmaceuticals Inc.
      2017   Phase 1   NCT03315507   United States;
PB1046, VIP-ELP1-120, Vasomera
   PhaseBio Pharmaceuticals, Inc.
      2021   Phase 2   EUCTR2019-001598-10-AT   Austria;Belgium;Bulgaria;Czech Republic;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
      2020   Phase 2   EUCTR2019-001598-10-PL   Austria;Belgium;Bulgaria;Czechia;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
      2020   Phase 2   EUCTR2019-001598-10-HU   Austria;Belgium;Bulgaria;Czech Republic;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
      2020   Phase 2   EUCTR2019-001598-10-GR   Austria;Belgium;Bulgaria;Czech Republic;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
      2020   Phase 2   EUCTR2019-001598-10-ES   Austria;Belgium;Bulgaria;Czech Republic;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
      2020   Phase 2   EUCTR2019-001598-10-BG   Austria;Belgium;Bulgaria;Czech Republic;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
PDE5 inhibitor
   Brigham and Women's Hospital
      2021   -   NCT05039086   United States;
PF-00489791
   Pfizer
      2009   Phase 2   NCT00853112   Belgium;Canada;Germany;India;Russian Federation;Spain;Sweden;Switzerland;United States;
   Pfizer Ltd,Ramsgate Road,Sandwich,Kent CT13 9NJ
      2009   -   EUCTR2008-003572-21-SE   Belgium;Germany;Spain;Sweden;
      2009   -   EUCTR2008-003572-21-BE   Belgium;Germany;Spain;Sweden;
   Pfizer Ltd.
      2009   -   EUCTR2008-003572-21-DE   Belgium;Germany;Spain;Sweden;
   Pfizer, S.A.
      2009   Phase 2   EUCTR2008-003572-21-ES   Belgium;Germany;Spain;Sweden;
PLX-PAD
   United Therapeutics
      2013   Phase 1   NCT01795950   Australia;
Parenteral Remodulin (treprostinil) injection
   United Therapeutics
      2017   Phase 2   NCT03016468   -
Pemziviptadil (PB1046)
   PhaseBio Pharmaceuticals Inc.
      2018   Phase 2   NCT03556020   United States;
Pemziviptadil (PB1046) Injection
   PhaseBio Pharmaceuticals Inc.
      2019   Phase 2   NCT03795428   United States;
Pioglitazone
   Stanford University
      2008   Phase 2   NCT00825266   United States;
Placebo
   Eli Lilly Japan K.K.
      2017   Phase 3   JPRN-JapicCTI-132356   Japan, Asia except Japan, North America, South America, Europe;
   Janssen Pharmaceutical K.K.
      2020   Phase 3   JPRN-JapicCTI-194971   Japan, South America, Europe;
Prednisone
   National Institute of Allergy and Infectious Diseases (NIAID)
      2011   Phase 2   NCT01086540   United States;
Prostacyclin
   Hamamatsu University School of Medicine
      2017   -   JPRN-UMIN000025176   Japan;
Pulmonary hemodynamics SE
   Fatebenefratelli Hospital
      2016   -   NCT03049995   Italy;
Puri-Nethol
   VU University Medical Center
      2017   Phase 2   EUCTR2017-000137-31-NL   Netherlands;
Q4W GMA301 IV injections (1000 mg)
   Gmax Biopharm LLC.
      2020   Phase 1   NCT04503733   China;United States;
Q4W GMA301 IV injections (300 mg)
   Gmax Biopharm LLC.
      2020   Phase 1   NCT04503733   China;United States;
Q4W GMA301 IV injections (600 mg)
   Gmax Biopharm LLC.
      2020   Phase 1   NCT04503733   China;United States;
QCC374
   Novartis Pharma AG
      2018   Phase 2   EUCTR2016-001411-20-GB   Germany;Korea, Republic of;Taiwan;United Kingdom;United States;
      2017   Phase 2   EUCTR2016-001412-38-DE   Germany;Korea, Republic of;Taiwan;United Kingdom;United States;
      2017   Phase 2   EUCTR2016-001411-20-DE   Germany;Korea, Republic of;Taiwan;United Kingdom;United States;
   Novartis Pharmaceuticals
      2018   Phase 2   NCT02939599   Germany;United Kingdom;United States;
      2017   Phase 2   NCT02927366   Germany;Korea, Republic of;Taiwan;United Kingdom;United States;
QTI571
   Novartis Farmacéutica, S.A.
      2013   -   EUCTR2013-001100-10-ES   Australia;Spain;Switzerland;United States;
   Novartis Pharma AG
      2011   -   EUCTR2010-021960-14-DE   Germany;Italy;
      2010   Phase 3   EUCTR2009-018167-26-GB   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   Phase 3   EUCTR2009-018167-26-BE   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   -   EUCTR2009-018167-26-FR   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   -   EUCTR2009-018167-26-DE   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2010   -   EUCTR2009-012057-38-NL   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-FR   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
   Novartis Pharma K.K.
      2014   Phase 3   JPRN-JapicCTI-142462   -
   Novartis Pharma Services AG
      2010   -   EUCTR2009-018167-26-AT   Austria;Belgium;France;Germany;Italy;Spain;United Kingdom;
      2009   -   EUCTR2009-012057-38-SE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-GB   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-DE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-BE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-012057-38-AT   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;Sweden;United Kingdom;
   Novartis Pharmaceuticals
      2014   Phase 3   NCT02042014   Japan;
Qutenza
   Imperial College London
      2011   Phase 2   NCT01393795   United Kingdom;
      2011   -   EUCTR2011-001312-59-GB   United Kingdom;
Qutenza ( capsaicin)
   University of Rochester
      2010   Phase 2   NCT01260454   United States;
REVATIO
   NOVARTIS FARMA
      2011   -   EUCTR2010-021344-17-IT   Italy;
REVATIO 20 mg, comprimidos recubiertos con película
   Pfizer, S.A.
      2009   Phase 2   EUCTR2008-003572-21-ES   Belgium;Germany;Spain;Sweden;
RT234 - vardenafil inhalation powder
   Respira Therapeutics, Inc.
      2020   Phase 2   NCT04266197   Serbia;United States;
RTA 402
   Reata Pharmaceuticals, Inc.
      2016   Phase 3   EUCTR2016-000196-24-NL   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Philippines;Spain;United Kingdom;United States;
      2016   Phase 3   EUCTR2016-000196-24-GB   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Philippines;Spain;United Kingdom;United States;
      2016   Phase 3   EUCTR2016-000196-24-ES   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Spain;United Kingdom;United States;
      2016   Phase 3   EUCTR2016-000196-24-DE   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Philippines;Spain;United Kingdom;United States;
      2016   Phase 3   EUCTR2016-000196-24-CZ   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Philippines;Spain;United Kingdom;United States;
      2016   Phase 3   EUCTR2016-000196-24-BE   Argentina;Australia;Belgium;Brazil;Canada;Chile;Czech Republic;Germany;Ireland;Israel;Japan;Mexico;Netherlands;Spain;United Kingdom;United States;
RVG 33865
   VU university medical center
      2010   -   EUCTR2010-023233-30-NL   Netherlands;
RVT-1201
   Altavant Sciences GmbH
      2021   Phase 2   EUCTR2020-004971-42-PL   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-LV   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-IT   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-ES   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-CZ   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czech Republic;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-BG   Austria;Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czech Republic;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-BE   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-AT   Austria;Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czech Republic;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2019   Phase 2   NCT03924154   Canada;United States;
Ralinepag
   Arena Pharmaceuticals, Inc.
      2019   Phase 3   EUCTR2018-001189-40-FR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Japan;Korea, Republic of;Mexico;Serbia;Singapore;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-HR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Japan;Korea, Republic of;Mexico;Netherlands;Serbia;Singapore;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2017   Phase 2   EUCTR2014-000667-40-SK   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2016   Phase 2   EUCTR2014-003042-27-SK   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-003042-27-PL   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-003042-27-HU   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-PL   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-HU   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-ES   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   Phase 2   EUCTR2014-000667-40-CZ   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
      2015   -   EUCTR2014-003042-27-RO   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Spain;United States;
      2015   -   EUCTR2014-003042-27-ES   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Spain;United States;
      2015   -   EUCTR2014-000667-40-RO   Australia;Bulgaria;Czech Republic;Hungary;Poland;Romania;Serbia;Spain;United States;
   United Therapeutic Corporation
      2019   Phase 3   EUCTR2018-001189-40-PT   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
   United Therapeutics
      2020   Phase 3   NCT04084678   Argentina;Australia;Austria;Belgium;Brazil;Canada;Germany;Italy;Poland;Spain;United States;
      2019   Phase 3   NCT03683186   Argentina;Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czechia;Denmark;France;Germany;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Romania;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2018   Phase 3   NCT03626688   Argentina;Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czechia;Denmark;France;Germany;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Romania;Serbia;Singapore;Spain;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2015   Phase 2   NCT02279745   Australia;Bulgaria;Czechia;Hungary;Poland;Romania;Serbia;Slovakia;Spain;United States;
   United Therapeutics Corporation
      2020   Phase 3   EUCTR2018-001189-40-NL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2020   Phase 3   EUCTR2018-001189-40-CZ   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czech Republic;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-SE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-PL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czech Republic;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-IT   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-HU   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-HR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Czech Republic;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-GR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-GB   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-DK   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-BG   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001189-40-BE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;France;Greece;Hungary;Israel;Korea, Republic of;Mexico;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-SE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-PT   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Japan;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-PL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-NL   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-HU   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-GR   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Japan;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-GB   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-DK   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-DE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-BG   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2018-001187-33-BE   Argentina;Australia;Belgium;Brazil;Bulgaria;Canada;Chile;China;Croatia;Denmark;European Union;Germany;Greece;Hungary;Israel;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Serbia;Singapore;Sweden;Taiwan;Turkey;Ukraine;United Kingdom;United States;
Ranolazine
   Northwestern University
      2010   Phase 3   NCT01174173   United States;
   University of Chicago
      2011   Phase 1   NCT01757808   United States;
Rapid Dose Titration Group of Subcutaneous Treprostinil
   United Therapeutics
      2017   Phase 4   NCT02893995   China;
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), APN01
   GlaxoSmithKline Research & Development Ltd
      2017   Phase 2   EUCTR2017-000212-41-DE   Germany;Spain;United States;
   GlaxoSmithKline, S.A.
      2017   Phase 2   EUCTR2017-000212-41-ES   Germany;Spain;United States;
Remodulin
   United Therapeutics
      2012   Phase 4   NCT02847260   -
Remodulin (treprostinil sodium)
   United Therapeutics
      2005   Phase 4   NCT00494533   India;
Remodulin® (treprostinil) 1 mg/ml solution for infusion
   United Therapeutics Corp.
      2012   -   EUCTR2011-004631-31-DE   Germany;
Remodulin® (treprostinil) 10 mg/ml solution for infusion
   United Therapeutics Corp.
      2012   -   EUCTR2011-004631-31-DE   Germany;
Remodulin® (treprostinil) 2.5 mg/ml solution for infusion
   United Therapeutics Corp.
      2012   -   EUCTR2011-004631-31-DE   Germany;
Remodulin® (treprostinil) 5 mg/ml solution for infusion
   United Therapeutics Corp.
      2012   -   EUCTR2011-004631-31-DE   Germany;
Revatio
   Actelion Pharmaceuticals Ltd.
      -   -   EUCTR2005-005068-97-DE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
   Deutsches Herzzentrum Berlin, Kompetenznetz Angeborene Herzfehler
      2007   -   EUCTR2007-002774-64-DE   Germany;
   PFIZER
      2008   -   EUCTR2006-006748-76-IT   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
   Pfizer Inc., 235 East 42nd Street, New York, NY 10017
      2014   Phase 4   EUCTR2013-004362-34-GR   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 4   EUCTR2013-004362-34-ES   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 3;Phase 4   EUCTR2013-004362-34-PL   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   -   EUCTR2013-004362-34-RO   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2009   -   EUCTR2008-005886-78-BG   Bulgaria;Czech Republic;
   Pfizer Japan Inc
      -   -   EUCTR2014-004167-20-Outside-EU/EEA   Japan;
   Pfizer Limited, Ramsgate Road, Sandwich, Kent UK
      2009   Phase 3   EUCTR2008-005886-78-SK   Bulgaria;Czech Republic;Slovakia;
   Pfizer Limited, Ramsgate Road, Sandwich, Kent, UK
      2009   Phase 3   EUCTR2008-005887-14-SK   Bulgaria;Czech Republic;Slovakia;
      2009   -   EUCTR2008-005887-14-BG   Bulgaria;Czech Republic;
      2007   Phase 3   EUCTR2005-000963-25-SK   Finland;Slovakia;Sweden;United Kingdom;
      2007   -   EUCTR2005-000963-25-FI   Finland;Sweden;United Kingdom;
      2006   Phase 3   EUCTR2005-000963-25-GB   Finland;Slovakia;Sweden;United Kingdom;
      2005   -   EUCTR2005-000963-25-SE   Brazil;Chile;Colombia;Costa Rica;Finland;Guatemala;Hungary;India;Italy;Malaysia;Mexico;Poland;Russian Federation;Sweden;Taiwan;Thailand;United Kingdom;
      -   -   EUCTR2005-000963-25-Outside-EU/EEA   Brazil;Chile;Colombia;Guatemala;India;Japan;Malaysia;Mexico;Russian Federation;Taiwan;United States;
   Pfizer Ltd, Ramsgate Rd, Sandwich, Kent, United Kingdom
      2007   Phase 3   EUCTR2006-002235-25-SK   Finland;Slovakia;United Kingdom;
      2007   -   EUCTR2006-002235-25-FI   Finland;United Kingdom;
      2006   Phase 3   EUCTR2006-002235-25-GB   Finland;Slovakia;United Kingdom;
      -   -   EUCTR2006-002235-25-Outside-EU/EEA   Brazil;Canada;Chile;Colombia;Guatemala;India;Japan;Malaysia;Mexico;Peru;Russian Federation;Taiwan;United States;
   Pfizer Ltd, Ramsgate Road, Sandwich, Kent UK
      2008   -   EUCTR2006-006748-76-DK   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
      2008   -   EUCTR2006-006748-76-BE   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
   Pfizer Ltd, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK
      2009   -   EUCTR2006-006748-76-BG   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
      2008   Phase 4   EUCTR2006-006748-76-GB   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
      2008   -   EUCTR2006-006748-76-LV   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
   Pfizer Ltd,Ramsgate Road,Sandwich,Kent CT13 9NJ
      2009   -   EUCTR2008-003572-21-SE   Belgium;Germany;Spain;Sweden;
   Pfizer Ltd.
      2010   Phase 3   EUCTR2008-005886-78-CZ   Bulgaria;Czech Republic;
      2010   -   EUCTR2008-005887-14-CZ   Bulgaria;Czech Republic;
   Pfizer Ltd. Ramsgate Road, Sandwich, Kent, UK
      2008   -   EUCTR2006-006748-76-NL   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
      2008   -   EUCTR2006-006748-76-GR   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
   Pfizer, Ltd.
      -   -   EUCTR2015-002238-37-Outside-EU/EEA   India;
Revatio 10 mg/ml powder for oral suspension
   Pfizer, Inc.
      -   Phase 3   EUCTR2016-003978-41-Outside-EU/EEA   Japan;
Revatio 20 mg Filmtabletten
   Pfizer Ltd.
      2009   -   EUCTR2008-003572-21-DE   Belgium;Germany;Spain;Sweden;
Revatio 20 mg film coated tablets
   Pfizer, Inc.
      -   Phase 3   EUCTR2016-003978-41-Outside-EU/EEA   Japan;
Revatio 20 mg film-coated tablets
   Bayer AG
      2017   Phase 4   EUCTR2016-001067-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-AT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
Revatio POS
   Pfizer, Inc.
      -   Phase 3   EUCTR2016-003978-41-Outside-EU/EEA   Japan;
Revatio Tablets
   Pfizer, Inc.
      -   Phase 3   EUCTR2016-003978-41-Outside-EU/EEA   Japan;
Revatio inyectable
   Fundacion para la investigación Biomédica del hospital Gregorio Marañón
      2014   -   EUCTR2011-002707-16-ES   Spain;
Revatio oral
   Fundacion para la investigación Biomédica del hospital Gregorio Marañón
      2014   -   EUCTR2011-002707-16-ES   Spain;
Revatio ® 20 mg film-coated tablets
   Imperial College London
      2007   Phase 4   EUCTR2006-004705-26-GB   United Kingdom;
Revatio®
   Pfizer Ltd
      2006   Phase 4   EUCTR2006-001464-23-GB   Czech Republic;Germany;Greece;Italy;United Kingdom;
   Pfizer Ltd, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK
      2006   -   EUCTR2006-001464-23-DE   Australia;Belgium;Czech Republic;France;Germany;Greece;Israel;Italy;Taiwan;United Kingdom;
   Pfizer Ltd,Ramsgate Road,Sandwich CT13 9NJ
      2008   -   EUCTR2006-001464-23-GR   Czech Republic;Germany;Greece;Italy;United Kingdom;
      2006   -   EUCTR2006-001464-23-CZ   Czech Republic;Germany;Greece;Italy;United Kingdom;
Riciguat Group
   University of Giessen
      2018   Phase 2   NCT03362047   Germany;
Rifampin
   Pfizer
      2010   Phase 1   NCT01251835   -
Riociguat
   Bayer AG
      2009   Phase 3   EUCTR2008-003610-94-PT   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
   Bayer Health Care AG
      2011   -   EUCTR2010-018863-40-AT   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2010   -   EUCTR2010-018863-40-IT   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
   Bayer HealthCare AG
      2011   Phase 2   EUCTR2010-018863-40-GB   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2011   -   EUCTR2011-001893-24-DE   Germany;
      2011   -   EUCTR2010-018863-40-PL   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2011   -   EUCTR2010-018863-40-ES   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2010   Phase 3   EUCTR2008-003610-94-GR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2010-018863-40-DE   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2010   -   EUCTR2010-018863-40-CZ   Austria;Czech Republic;Germany;Italy;Poland;Spain;United Kingdom;
      2010   -   EUCTR2008-003482-68-GR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003610-94-NL   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003610-94-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003610-94-DK   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-CZ   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-BE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003610-94-AT   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003482-68-IE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003482-68-ES   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2008-003482-68-AT   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003610-94-IT   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003610-94-IE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003610-94-ES   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003482-68-PT   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2009   -   EUCTR2008-003482-68-NL   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003482-68-CZ   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2008   Phase 3   EUCTR2008-003610-94-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2008   Phase 3   EUCTR2008-003610-94-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
      2008   Phase 3   EUCTR2008-003482-68-FR   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2008   -   EUCTR2008-003482-68-DE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2006   Phase 1;Phase 2   EUCTR2006-003520-10-DE   Germany;
   Bayer HealthCare AG, D-51368 Leverkusen
      2009   Phase 3   EUCTR2008-003482-68-GB   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Russian Federation;Singapore;Spain;Sweden;Switzerland;Taiwan;Thailand;United Kingdom;United States;
      2009   Phase 3   EUCTR2008-003482-68-BE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2008-003482-68-DK   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2008   -   EUCTR2008-003482-68-SE   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
   Bayer Healthcare AG
      2009   -   EUCTR2008-003482-68-IT   Austria;Belgium;Czech Republic;Denmark;France;Germany;Greece;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
   Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
      2019   -   JPRN-UMIN000035389   Japan;
   Heidelberg University
      2021   Phase 4   NCT04954742   Germany;
Riociguat (ADEMPAS, BAY63-2521)
   Bayer
      2015   -   NCT02428985   Japan;
Riociguat (Adempas, BAY63-2521)
   Bayer
      2021   -   NCT04813926   Puerto Rico;United States;
      2015   Phase 3   NCT02562235   Belgium;Brazil;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Taiwan;Turkey;United Kingdom;United States;
      2015   -   NCT02545465   Belgium;Canada;Colombia;Denmark;Germany;Japan;Sweden;Turkey;United Kingdom;
      2014   Phase 4   NCT02191137   Puerto Rico;United States;
      2014   Phase 3   NCT02007629   Belgium;Canada;Czech Republic;Czechia;France;Germany;Italy;Switzerland;United Kingdom;United States;
      2010   Phase 2   NCT01179334   Austria;Czech Republic;Germany;Italy;New Zealand;Poland;Spain;United Kingdom;United States;
      2008   Phase 3   NCT00810693   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
Riociguat (BAY63-2521)
   Bayer
      2009   Phase 3   NCT00863681   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Czech Republic;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Russian Federation;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;United Kingdom;United States;
Riociguat Oral Product
   University of Calgary
      2016   Phase 4   NCT03809156   Canada;
Riociguat Pill
   University of Arizona
      2019   Phase 3   NCT04062565   United States;
Riociguat granules for oral application
   Bayer AG
      2016   Phase 3   EUCTR2014-003952-29-DE   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Poland;Romania;Spain;Taiwan;Turkey;United Kingdom;United States;
      2015   Phase 3   EUCTR2014-003952-29-HU   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Taiwan;Turkey;United Kingdom;United States;
      2015   Phase 3   EUCTR2014-003952-29-GB   Belgium;Colombia;France;Germany;Hungary;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2014-003952-29-Outside-EU/EEA   Japan;Turkey;
   Bayer Healthcare AG
      2016   Phase 3   EUCTR2014-003952-29-ES   Belgium;France;Germany;Hungary;Italy;Japan;Netherlands;Poland;Spain;Turkey;United Kingdom;
      2015   -   EUCTR2014-003952-29-IT   Australia;Austria;Canada;France;Germany;Hungary;Italy;Japan;Netherlands;Poland;Spain;Turkey;United Kingdom;
      -   Phase 3   EUCTR2014-003952-29-FR   Belgium;France;Germany;Hungary;Italy;Japan;Netherlands;Poland;Spain;Turkey;United Kingdom;
Ritonavir
   Pfizer
      2011   Phase 1   NCT01251848   -
Rituximab
   National Institute of Allergy and Infectious Diseases (NIAID)
      2011   Phase 2   NCT01086540   United States;
   The University of Tokyo Hospital
      2014   -   JPRN-UMIN000016320   Japan;
Ro 47-0203
   Actelion Pharmaceuticals Ltd
      2005   -   EUCTR2005-001967-70-IT   Germany;Italy;United Kingdom;
   Actelion Pharmaceuticals Ltd.
      2006   -   EUCTR2004-004391-36-CZ   Czech Republic;Hungary;
      2006   -   EUCTR2004-000745-37-GB   Italy;Spain;United Kingdom;
      2005   Phase 3   EUCTR2005-001967-70-GB   Germany;Italy;United Kingdom;
      2005   Phase 3   EUCTR2004-005157-63-GB   Italy;United Kingdom;
      2005   Phase 3   EUCTR2004-000478-30-ES   Austria;Belgium;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2005   -   EUCTR2004-004391-36-HU   Czech Republic;Hungary;
      2004   Phase 4   EUCTR2004-000745-37-ES   Italy;Spain;United Kingdom;
      2004   Phase 3   EUCTR2004-000478-30-GB   Austria;Belgium;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-SE   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-DK   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-CZ   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-BE   Austria;Belgium;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-AT   Austria;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      -   -   EUCTR2005-001967-70-DE   Germany;Italy;United Kingdom;
Ro 47-0203 / ACT-050088
   Actelion Pharmaceuticals Japan Ltd.
      2013   Phase 3   JPRN-JapicCTI-132155   -
Ro-47-0203
   Actelion Pharmaceuticals Ltd.
      2008   Phase 4   EUCTR2005-005068-97-ES   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Slovakia;Spain;Sweden;United Kingdom;
      2007   -   EUCTR2005-005068-97-SE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2007   -   EUCTR2005-005068-97-GB   Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2007   -   EUCTR2005-005068-97-DK   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-DK   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      -   -   EUCTR2005-005068-97-DE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
Ro-47-0203/029
   Actelion Pharmaceuticals Ltd.
      2013   Phase 3   EUCTR2010-021825-11-BG   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021825-11-NL   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021793-12-NL   Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-021793-12-HU   Australia;Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021793-12-DE   Australia;Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021793-12-CZ   Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2010   -   EUCTR2010-021825-11-HU   Bulgaria;Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-021825-11-DE   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2010   -   EUCTR2010-021825-11-CZ   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2009   -   EUCTR2005-005068-97-CZ   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2005-005068-97-BE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2008   Phase 4   EUCTR2005-005068-97-SK   Belgium;Brazil;Czech Republic;Denmark;Germany;Greece;Portugal;Saudi Arabia;Slovakia;Spain;Sweden;United Kingdom;United States;
      2008   -   EUCTR2005-005068-97-PT   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2008   -   EUCTR2005-005068-97-GR   Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      -   Phase 3   EUCTR2010-021825-11-FR   Bulgaria;Czech Republic;France;Germany;Hungary;Italy;Netherlands;Spain;
      -   Phase 3   EUCTR2010-021793-12-PL   Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      -   Phase 3   EUCTR2010-021793-12-FR   Czech Republic;France;Germany;Hungary;Italy;Netherlands;Poland;Spain;
Ro47-0203
   Actelion Pharmaceuticals Japan Ltd.
      2009   Phase 3   JPRN-JapicCTI-121998   -
Ro47-0203 / ACT-050088
   Actelion Pharmaceuticals Japan Ltd.
      2013   Phase 3   JPRN-JapicCTI-132154   -
RoActemra
   Papworth Hospital NHS Foundation Trust
      2015   Phase 2   EUCTR2015-002799-26-GB   United Kingdom;
Rodatristat Ethyl 300 mg tablet
   Altavant Sciences GmbH
      2021   Phase 2   NCT04712669   United States;
Rodatristat ethyl
   Altavant Sciences GmbH
      2021   Phase 2   EUCTR2020-004971-42-PL   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-LV   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-IT   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-ES   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-CZ   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czech Republic;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-BG   Austria;Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czech Republic;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-BE   Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-004971-42-AT   Austria;Belgium;Bosnia and Herzegovina;Bulgaria;Canada;Czech Republic;Czechia;France;Germany;Italy;Latvia;Poland;Russian Federation;Serbia;Spain;Ukraine;United Kingdom;United States;
Rubidium
   Ottawa Heart Institute Research Corporation
      2018   Phase 4   NCT03344159   Canada;
SILDENAF
   Bayer AG
      2017   Phase 4   EUCTR2016-001067-36-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2016   Phase 4   EUCTR2016-001067-36-AT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;New Zealand;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
SILDENAFIL CITRATE
   ASSOCIAZIONE ITALIANA PNEUMOLOGI OSPEDALIERI
      2013   -   EUCTR2011-002018-35-IT   Italy;
   Fundacion para la investigación Biomédica del hospital Gregorio Marañón
      2014   -   EUCTR2011-002707-16-ES   Spain;
   Pfizer Inc., 235 East 42nd Street, New York, NY 10017
      2018   Phase 3;Phase 4   EUCTR2013-004362-34-LV   Australia;Austria;Belgium;Bosnia and Herzegovina;Croatia;Czech Republic;Germany;Greece;Hong Kong;Israel;Latvia;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Thailand;Turkey;Ukraine;United States;
      2015   Phase 3;Phase 4   EUCTR2013-004362-34-SE   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2015   Phase 3;Phase 4   EUCTR2013-004362-34-PT   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Czechia;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2015   Phase 3;Phase 4   EUCTR2013-004362-34-NL   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2015   -   EUCTR2013-004362-34-HR   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 4   EUCTR2013-004362-34-GR   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 4   EUCTR2013-004362-34-ES   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 3;Phase 4   EUCTR2013-004362-34-PL   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 3;Phase 4   EUCTR2013-004362-34-DE   Australia;Austria;Belgium;Bosnia and Herzegovina;Croatia;Czech Republic;Germany;Greece;Hong Kong;Israel;Latvia;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Thailand;Turkey;Ukraine;United States;
      2014   Phase 3;Phase 4   EUCTR2013-004362-34-CZ   Australia;Austria;Belgium;Bosnia and Herzegovina;Croatia;Czech Republic;Germany;Greece;Hong Kong;Israel;Latvia;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Thailand;Turkey;Ukraine;United States;
      2014   Phase 3;Phase 4   EUCTR2013-004362-34-AT   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 3   EUCTR2013-004362-34-BE   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   -   EUCTR2013-004362-34-RO   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
   Pfizer Japan Inc
      -   -   EUCTR2014-004167-20-Outside-EU/EEA   Japan;
   Pfizer, Inc.
      -   Phase 3   EUCTR2016-003978-41-Outside-EU/EEA   Japan;
SITAXSENTAN SODIUM
   Pfizer Inc., 235 East 42nd Street, New York, NY 10017
      2009   -   EUCTR2008-005885-30-BG   Bulgaria;Czech Republic;
   Pfizer Limited
      2009   Phase 3   EUCTR2008-005885-30-SK   Bulgaria;Czech Republic;Slovakia;
   Pfizer Ltd
      2010   -   EUCTR2008-005885-30-CZ   Bulgaria;Czech Republic;
STI571
   Novartis Pharma Services AG
      2006   -   EUCTR2005-005569-12-GB   Austria;Germany;United Kingdom;
      2006   -   EUCTR2005-005569-12-DE   Austria;Germany;United Kingdom;
      2006   -   EUCTR2005-005569-12-AT   Austria;Germany;United Kingdom;
Salbutamol
   ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
      2016   Phase 3   EUCTR2014-002590-10-FR   France;
Saline
   Imperial College London
      2012   Phase 1   NCT01590108   United Kingdom;
      2011   Phase 2   NCT01447628   China;Germany;United Kingdom;
Sapropterin dihydrochloride (6R-BH4)
   Vanderbilt University
      2008   Phase 1   NCT00435331   United States;
Saquinavir and ritonavir
   The Third Xiangya Hospital of Central South University
      2013   Phase 0   NCT02023450   China;
Sauerstoff
   Thoraxklinik-Heidelberg gGmbH
      2019   Phase 2   EUCTR2018-001387-39-DE   Germany;
Selexipag
   ACTELION PHARMACEUTICALS LTD
      2020   Phase 3   EUCTR2019-002817-21-IT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
   Academic Medical Center - Cardiology
      2016   Phase 3   EUCTR2016-003495-53-NL   Netherlands;
   Actelion
      2020   Phase 3   NCT04175600   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Croatia;Denmark;Finland;France;Germany;Hungary;Ireland;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2017   Phase 4   NCT03078907   Austria;France;Germany;Ireland;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   NCT02558231   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2015   Phase 3   NCT02471183   United States;
      2009   Phase 3   NCT01106014   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
   Actelion Pharmaceuticals Ltd
      2017   Phase 3   EUCTR2016-004035-21-DE   Germany;United States;
      2013   Phase 3   EUCTR2009-014992-31-GB   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2011   Phase 3   EUCTR2009-014992-31-SK   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2011   Phase 3   EUCTR2009-014992-31-NL   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2011   -   EUCTR2009-014490-41-NL   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-SE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-PL   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-IE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-HU   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-DK   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-DE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-CZ   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-BE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-AT   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014490-41-BE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-SE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-IT   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Russian Federation;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-IE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-GB   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-DE   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-CZ   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   -   EUCTR2009-014490-41-AT   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2009   -   EUCTR2009-014490-41-DK   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
   Actelion Pharmaceuticals Ltd.
      2010   -   EUCTR2009-014490-41-HU   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
   Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
      2019   -   JPRN-UMIN000035389   Japan;
   Hamamatsu University School of Medicine
      2017   -   JPRN-UMIN000025176   Japan;
   NIPPON SHINYAKU CO., LTD. / Actelion Pharmaceuticals Japan Ltd.
      2011   Phase 2   JPRN-JapicCTI-111532   -
   Nippon Shinyaku Co., Ltd.
      2020   Phase 2   JPRN-JapicCTI-205391   Japan;
   University of Sao Paulo General Hospital
      2020   Phase 2   NCT04589390   Brazil;
Selexipag (Uptravi)
   Actelion
      2018   Phase 2   NCT03492177   Belarus;Belgium;Canada;China;France;Germany;Hungary;Israel;Malaysia;Poland;Romania;Russian Federation;Serbia;Taiwan;Ukraine;United Kingdom;United States;
Selexipag, ACT-293987 (NS-304)
   Actelion Pharmaceuticals Ltd
      2008   Phase 2   EUCTR2007-006453-12-DE   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
      2008   Phase 2   EUCTR2007-006453-12-BE   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
   Actelion Pharmaceuticals Ltd.
      2009   Phase 2   EUCTR2007-006453-12-AT   Austria;Belgium;France;Germany;Hungary;Italy;United Kingdom;
Selonsertib
   Gilead Sciences
      2014   Phase 2   NCT02234141   Canada;France;Germany;Italy;Netherlands;Spain;United Kingdom;United States;
Seralutinib
   GB002, Inc.
      2021   Phase 2   EUCTR2020-005169-15-ES   Australia;Austria;Belgium;Canada;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2020-005169-15-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2019-002669-37-DE   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2019-002669-37-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2021   Phase 2   EUCTR2019-002669-37-BE   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002669-37-GB   Australia;Austria;Belgium;Canada;France;Germany;Israel;Serbia;Singapore;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002669-37-FR   Australia;Austria;Belgium;Canada;France;Germany;Israel;Serbia;Singapore;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002669-37-AT   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;France;Germany;Israel;Serbia;Spain;United Kingdom;United States;
Serine
   Medical Education Center, School of Medicine, Keio University
      2009   -   JPRN-UMIN000001709   Japan;
Sham O2 (medical air)
   George Papanicolaou Hospital
      2018   -   NCT03683082   Greece;
Sham PADN
   Nanjing First Hospital, Nanjing Medical University
      2014   Phase 4   NCT02284737   China;
Sildenafil
   ASSOCIAZIONE ITALIANA PNEUMOLOGI OSPEDALIERI
      2010   -   EUCTR2010-020917-97-IT   Italy;
   Actelion
      2007   Phase 4   NCT00433329   United States;
      2006   Phase 3   NCT00302211   United States;
   Actelion Pharmaceuticals Ltd
      2006   -   EUCTR2005-005066-37-IT   Germany;Italy;United Kingdom;
   Bayer
      2017   Phase 4   NCT02891850   Australia;Austria;Belgium;Brazil;Canada;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
      2010   Phase 2   NCT01179334   Austria;Czech Republic;Germany;Italy;New Zealand;Poland;Spain;United Kingdom;United States;
   Beijing Chaoyang Hospital affiliated to Capital Medical University
      2014   -   ChiCTR-TRC-14004894   -
   Bial - Portela C S.A.
      2018   Phase 1   NCT04994860   Germany;
   Competence Network for Congenital Heart Defects
      2007   Phase 3   NCT00586794   Germany;
   Division of cardiovascular internal medicine, The University of Tokyo Hospital
      2007   Phase 2,3   JPRN-C000000340   Japan;
   Gilead Sciences
      2008   Phase 4   NCT00617305   United States;
   Hamamatsu University School of Medicine
      2011   -   JPRN-UMIN000005464   Japan;
   Keio University
      2008   -   JPRN-UMIN000001350   Japan;
   Laval University
      2009   -   NCT01391104   Canada;
   NOVARTIS FARMA
      2011   -   EUCTR2010-021344-17-IT   Italy;
   Nanjing First Hospital, Nanjing Medical University
      2014   Phase 4   NCT02284737   China;
   Novartis Pharmaceuticals
      2011   Phase 3   NCT01392469   Australia;Belgium;Germany;Italy;Lithuania;Romania;Turkey;United Kingdom;United States;
   Osaka Medical College
      2010   -   JPRN-UMIN000012669   Japan;
   PFIZER
      2008   -   EUCTR2006-006748-76-IT   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
   Pfizer
      2017   -   NCT03364244   Japan;
      2013   -   NCT01897740   Russian Federation;
      2010   Phase 1   NCT01244620   Singapore;
      2009   Phase 2   NCT00853112   Belgium;Canada;Germany;India;Russian Federation;Spain;Sweden;Switzerland;United States;
   Pfizer Ltd
      2006   Phase 4   EUCTR2006-001464-23-GB   Czech Republic;Germany;Greece;Italy;United Kingdom;
   Pfizer Ltd, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK
      2006   -   EUCTR2006-001464-23-DE   Australia;Belgium;Czech Republic;France;Germany;Greece;Israel;Italy;Taiwan;United Kingdom;
   Pfizer Ltd,Ramsgate Road,Sandwich CT13 9NJ
      2008   -   EUCTR2006-001464-23-GR   Czech Republic;Germany;Greece;Italy;United Kingdom;
      2006   -   EUCTR2006-001464-23-CZ   Czech Republic;Germany;Greece;Italy;United Kingdom;
   Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
      2012   Phase 4   NCT01642407   Japan;
      2008   Phase 1   NCT00800592   Belgium;
      2006   -   NCT00946114   Poland;
      2002   Phase 3   NCT00644605   Australia;Belgium;Brazil;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Norway;Poland;Singapore;South Africa;Spain;Sweden;United Kingdom;United States;
   Rigshospitalet
      2006   -   EUCTR2006-000021-57-DK   Denmark;
   Shanghai Pulmonary Hospital
      2009   -   ChiCTR-TCC-12002776   China;
   The Hospital for Sick Children
      2008   Phase 3   NCT00742014   Canada;
   University Health Network, Toronto
      2012   Phase 2   NCT01517854   Canada;
      2008   Phase 3   NCT00780728   Canada;
   University of California, Los Angeles
      2007   Phase 4   NCT00625079   United States;
Sildenafil (REVATIO)
   Imperial College London
      2007   Phase 4   EUCTR2006-004705-26-GB   United Kingdom;
Sildenafil (Revatio) 20 mg TID
   Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
      2008   -   NCT00866983   Brazil;
Sildenafil (as citrate)
   Actelion Pharmaceuticals Ltd.
      -   -   EUCTR2005-005068-97-DE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
   Pfizer Limited, Ramsgate Road, Sandwich, Kent, UK
      2007   Phase 3   EUCTR2005-000963-25-SK   Finland;Slovakia;Sweden;United Kingdom;
      2007   -   EUCTR2005-000963-25-FI   Finland;Sweden;United Kingdom;
      2006   Phase 3   EUCTR2005-000963-25-GB   Finland;Slovakia;Sweden;United Kingdom;
      2005   -   EUCTR2005-000963-25-SE   Brazil;Chile;Colombia;Costa Rica;Finland;Guatemala;Hungary;India;Italy;Malaysia;Mexico;Poland;Russian Federation;Sweden;Taiwan;Thailand;United Kingdom;
      -   -   EUCTR2005-000963-25-Outside-EU/EEA   Brazil;Chile;Colombia;Guatemala;India;Japan;Malaysia;Mexico;Russian Federation;Taiwan;United States;
   Pfizer Ltd, Ramsgate Rd, Sandwich, Kent, United Kingdom
      2007   Phase 3   EUCTR2006-002235-25-SK   Finland;Slovakia;United Kingdom;
      2007   -   EUCTR2006-002235-25-FI   Finland;United Kingdom;
      2006   Phase 3   EUCTR2006-002235-25-GB   Finland;Slovakia;United Kingdom;
      -   -   EUCTR2006-002235-25-Outside-EU/EEA   Brazil;Canada;Chile;Colombia;Guatemala;India;Japan;Malaysia;Mexico;Peru;Russian Federation;Taiwan;United States;
Sildenafil 20mg and Bosentan
   Postgraduate Institute of Medical Education and Research
      2016   Phase 4   NCT03053739   India;
Sildenafil Citrate
   Dr. Soetomo General Hospital
      2017   Phase 4   NCT03431649   Indonesia;
   Pfizer Limited, Ramsgate Road, Sandwich, Kent, UK
      2009   Phase 3   EUCTR2008-005887-14-SK   Bulgaria;Czech Republic;Slovakia;
      2009   -   EUCTR2008-005887-14-BG   Bulgaria;Czech Republic;
      -   -   EUCTR2005-000963-25-Outside-EU/EEA   Brazil;Chile;Colombia;Guatemala;India;Japan;Malaysia;Mexico;Russian Federation;Taiwan;United States;
   Pfizer Ltd, Ramsgate Rd, Sandwich, Kent, United Kingdom
      2007   Phase 3   EUCTR2006-002235-25-SK   Finland;Slovakia;United Kingdom;
      2007   -   EUCTR2006-002235-25-FI   Finland;United Kingdom;
      2006   Phase 3   EUCTR2006-002235-25-GB   Finland;Slovakia;United Kingdom;
      -   -   EUCTR2006-002235-25-Outside-EU/EEA   Brazil;Canada;Chile;Colombia;Guatemala;India;Japan;Malaysia;Mexico;Peru;Russian Federation;Taiwan;United States;
   Pfizer Ltd,Ramsgate Road,Sandwich,Kent CT13 9NJ
      2009   -   EUCTR2008-003572-21-BE   Belgium;Germany;Spain;Sweden;
   Pfizer Ltd.
      2010   -   EUCTR2008-005887-14-CZ   Bulgaria;Czech Republic;
   Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
      2006   Phase 4   NCT00323297   Australia;Belgium;Czech Republic;Czechia;France;Germany;Greece;Israel;Italy;Taiwan;United Kingdom;United States;
Sildenafil Filmtabletten
   Pfizer Ltd.
      2009   -   EUCTR2008-003572-21-DE   Belgium;Germany;Spain;Sweden;
Sildenafil citrate
   Actelion Pharmaceuticals Ltd.
      2006   Phase 2   EUCTR2005-005066-37-GB   Belgium;Germany;Italy;United Kingdom;
      2006   -   EUCTR2005-005066-37-DE   Germany;Italy;United Kingdom;
      2006   -   EUCTR2005-005066-37-BE   Belgium;Germany;Italy;United Kingdom;
   Pfizer
      2014   Phase 4   NCT02060487   Australia;Austria;Belgium;Bosnia and Herzegovina;Croatia;Czech Republic;Czechia;Germany;Greece;Hong Kong;Israel;Latvia;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Thailand;Turkey;Ukraine;United States;
      2008   Phase 4   NCT00430716   Belgium;Brazil;Bulgaria;China;Denmark;Greece;India;Italy;Latvia;Malaysia;Netherlands;Panama;Philippines;Poland;Romania;Russian Federation;Thailand;United Kingdom;United States;
      2003   Phase 3   NCT00159913   Australia;Brazil;Canada;Chile;Colombia;Costa Rica;Guatemala;Hungary;India;Italy;Japan;Malaysia;Mexico;Panama;Peru;Poland;Russian Federation;Singapore;Sweden;Taiwan;United States;
   Pfizer Inc., 235 East 42nd Street, New York, NY 10017
      2009   -   EUCTR2008-005886-78-BG   Bulgaria;Czech Republic;
   Pfizer Limited, Ramsgate Road, Sandwich, Kent UK
      2009   Phase 3   EUCTR2008-005886-78-SK   Bulgaria;Czech Republic;Slovakia;
   Pfizer Ltd, Ramsgate Road, Sandwich, Kent UK
      2008   -   EUCTR2006-006748-76-DK   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
      2008   -   EUCTR2006-006748-76-BE   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
   Pfizer Ltd, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK
      2009   -   EUCTR2006-006748-76-BG   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
      2008   Phase 4   EUCTR2006-006748-76-GB   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
      2008   -   EUCTR2006-006748-76-LV   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
   Pfizer Ltd.
      2010   Phase 3   EUCTR2008-005886-78-CZ   Bulgaria;Czech Republic;
   Pfizer Ltd. Ramsgate Road, Sandwich, Kent, UK
      2008   -   EUCTR2006-006748-76-NL   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
      2008   -   EUCTR2006-006748-76-GR   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
   Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
      2011   -   NCT01365585   Germany;Ireland;
      2009   -   NCT00878943   India;
      2004   Phase 3   NCT00159874   Brazil;Canada;Chile;Colombia;Costa Rica;Guatemala;Hungary;India;Italy;Japan;Malaysia;Mexico;Panama;Poland;Russian Federation;Singapore;Sweden;Taiwan;United States;
      2003   Phase 3   NCT00159861   Belgium;Canada;Czech Republic;Czechia;Denmark;France;Israel;Italy;Netherlands;Spain;United Kingdom;United States;
      2002   Phase 3   NCT00159887   Australia;Belgium;Brazil;Czech Republic;Czechia;Denmark;France;Germany;Hong Kong;Hungary;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Poland;Singapore;South Africa;Spain;Sweden;United Kingdom;United States;
Sildenafil citrate (UK-92,480)
   Pfizer
      2007   Phase 3   NCT00454207   Japan;
Sildenafil singly or in association with Bosentan
   University of Sao Paulo General Hospital
      2011   -   NCT01548950   Brazil;
Simvastatin
   University of Pennsylvania
      2006   Phase 2   NCT00384865   United States;
Simvastatin 40 mg tablets
   Dept. of Internal Medicine II, University Hospital Giessen
      2006   -   EUCTR2005-004863-41-DE   Germany;
Sitaxentan
   Pfizer
      2011   Phase 1   NCT01251848   -
      2010   Phase 3   NCT01210443   Japan;
      2010   Phase 3   NCT01204853   Japan;
      2010   Phase 1   NCT01244620   Singapore;
Sitaxentan sodium
   Pfizer
      2010   -   NCT00995566   Belgium;France;Germany;Sweden;
      2009   -   NCT01445873   -
   Pfizer Japan Inc.
      2010   Phase 3   JPRN-JapicCTI-101370   -
      2010   Phase 3   JPRN-JapicCTI-101369   -
Sitaxsentan
   Pfizer
      2011   Phase 1   NCT01251848   -
      2010   Phase 1   NCT01244620   Singapore;
      2008   Phase 3   NCT00795639   Argentina;Bulgaria;Chile;China;Colombia;Costa Rica;Czech Republic;Dominican Republic;Egypt;Guatemala;India;Jordan;Lebanon;Malaysia;Mexico;Peru;Philippines;Romania;Russian Federation;Saudi Arabia;Serbia;Slovakia;South Africa;Thailand;Turkey;Ukraine;United Arab Emirates;United States;
      2003   Phase 3   NCT00811018   Argentina;Australia;Austria;Belgium;Brazil;Canada;France;Germany;Israel;Italy;Mexico;Netherlands;Poland;Spain;United Kingdom;United States;
   University of Edinburgh
      2009   Phase 0   NCT01100736   United Kingdom;
   West Penn Allegheny Health System
      2005   -   NCT00593905   United States;
Sitaxsentan Sodium
   Pfizer Inc., 235 East 42nd Street, New York, NY 10017
      2009   -   EUCTR2008-005886-78-BG   Bulgaria;Czech Republic;
   Pfizer Limited, Ramsgate Road, Sandwich, Kent UK
      2009   Phase 3   EUCTR2008-005886-78-SK   Bulgaria;Czech Republic;Slovakia;
   Pfizer Limited, Ramsgate Road, Sandwich, Kent, UK
      2009   Phase 3   EUCTR2008-005887-14-SK   Bulgaria;Czech Republic;Slovakia;
      2009   -   EUCTR2008-005887-14-BG   Bulgaria;Czech Republic;
   Pfizer Ltd.
      2010   Phase 3   EUCTR2008-005886-78-CZ   Bulgaria;Czech Republic;
      2010   -   EUCTR2008-005887-14-CZ   Bulgaria;Czech Republic;
Sitaxsentan alone
   Pfizer
      2010   Phase 1   NCT01251835   -
Sitaxsentan and Sildenafil
   Pfizer
      2010   Phase 3   NCT00796510   Argentina;Bulgaria;Chile;China;Colombia;Costa Rica;Czech Republic;Dominican Republic;India;Mexico;Peru;Philippines;Romania;Russian Federation;Saudi Arabia;Serbia;Slovakia;South Africa;Thailand;Ukraine;United States;
      2009   Phase 3   NCT00796666   Argentina;Bulgaria;Chile;China;Colombia;Costa Rica;Czech Republic;Dominican Republic;India;Malaysia;Mexico;Peru;Philippines;Romania;Russian Federation;Saudi Arabia;Serbia;Slovakia;South Africa;Thailand;Turkey;Ukraine;United States;
Sitaxsentan sodium
   Encysive Pharmaceuticals
      2003   Phase 3   NCT00080457   United States;
   ICOS-Texas Biotechnology
      2002   Phase 2/Phase 3   NCT00034307   Canada;United States;
Slow Dose Titration Group of Subcutaneous Treprostinil
   United Therapeutics
      2017   Phase 4   NCT02893995   China;
Sodium Nitrite Inhalation Solution
   Aires Pharmaceuticals, Inc.
      2008   Phase 1   NCT00814645   United States;
Sodium tanshinone IIA sulfonate diluted with glucose solution,20mg sildenafil citrate by mouth
   The First Affiliated Hospital of Guangzhou Medical University
      2013   Phase 2/Phase 3   NCT01637675   China;
Sorafenib
   Medical Education Center, School of Medicine, Keio University
      2009   -   JPRN-UMIN000001709   Japan;
   University of Chicago
      2007   Phase 1   NCT00452218   United States;
Sotatercept
   ACCELERON PHARMA INC.
      2022   Phase 3   EUCTR2021-001498-21-IT   Australia;Belgium;Canada;France;Germany;Israel;Italy;Mexico;Netherlands;Spain;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-004142-11-IT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Czechia;France;Germany;Ireland;Israel;Italy;Korea, Democratic People's Republic of;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
   Acceleron Pharma Inc.
      2021   Phase 3   NCT04896008   United States;
      2021   Phase 3   NCT04811092   Israel;United States;
      2021   Phase 3   NCT04796337   Australia;Brazil;France;Germany;Israel;Spain;United States;
      2021   Phase 3   NCT04576988   Argentina;Australia;Belgium;Brazil;Canada;Czechia;France;Germany;Israel;Mexico;New Zealand;Poland;Serbia;Spain;Sweden;Switzerland;United Kingdom;United States;
      2019   Phase 2   NCT03738150   United States;
      2018   Phase 2   NCT03496207   Australia;Brazil;France;Germany;Israel;Spain;United Kingdom;United States;
Sotatercept - 45 mg/vial
   Acceleron Pharma Inc.
      2022   Phase 3   EUCTR2020-005061-13-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 3   EUCTR2020-005061-13-PL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 3   EUCTR2020-005061-13-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-005061-13-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
Sotatercept - 60 mg/vial
   Acceleron Pharma Inc.
      2022   Phase 3   EUCTR2020-005061-13-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 3   EUCTR2020-005061-13-PL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2022   Phase 3   EUCTR2020-005061-13-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
      2021   Phase 3   EUCTR2020-005061-13-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Colombia;Croatia;Czechia;Denmark;France;Germany;Greece;Ireland;Israel;Italy;Korea, Republic of;Mexico;Netherlands;New Zealand;Poland;Portugal;Serbia;Spain;Sweden;Switzerland;Taiwan;United Kingdom;United States;
Spironolactone
   Baylor College of Medicine
      2011   Phase 4   NCT01468571   United States;
   National Institutes of Health Clinical Center (CC)
      2014   Phase 2   NCT01712620   United States;
   Ottawa Heart Institute Research Corporation
      2018   Phase 4   NCT03344159   Canada;
Spironolactone and conivaptan
   University of Colorado, Denver
      2009   -   NCT00811486   United States;
Spironolactone captopril carvedilol
   Hebei Medical University
      2005   Phase 1   NCT00240656   China;
Subcutaneous Treprostinil
   United Therapeutics
      2017   Phase 4   NCT02882126   China;
Subcutaneous and intravenous prostacyclin
   United Therapeutics
      2010   -   NCT01266265   United States;
Sugar Pill
   Laval University
      2009   -   NCT01391104   Canada;
   University of South Florida
      2012   -   NCT01645826   United States;
Sulfasalazine
   RenJi Hospital
      2020   Phase 1/Phase 2   NCT04528056   China;
TBD
   Novartis Pharma AG
      2018   Phase 2   EUCTR2016-001411-20-GB   Germany;Korea, Republic of;Taiwan;United Kingdom;United States;
      2017   Phase 2   EUCTR2016-001412-38-DE   Germany;Korea, Republic of;Taiwan;United Kingdom;United States;
      2017   Phase 2   EUCTR2016-001411-20-DE   Germany;Korea, Republic of;Taiwan;United Kingdom;United States;
TPN171H
   Vigonvita Life Sciences
      2020   Phase 2   NCT04483115   China;
TPN171H single dose
   Vigonvita Life Sciences
      2022   Phase 1   NCT05208814   -
TRACLEER
   Actelion Pharmaceuticals Ltd.
      2011   -   EUCTR2010-021825-11-IT   Bulgaria;Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-021793-12-IT   Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
   NOVARTIS FARMA
      2011   -   EUCTR2010-021344-17-IT   Italy;
TRACLEER 62,5 mg comprimidos recubiertos con película
   Actelion Pharmaceuticals Ltd.
      2011   -   EUCTR2010-021793-12-ES   Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
      2010   Phase 3   EUCTR2010-021825-11-ES   Bulgaria;Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
TRACLEER 62,5MG 56CPR RIV.
   ACTELION PHARMACEUTICALS ITALIA
      2005   -   EUCTR2004-005157-63-IT   Italy;United Kingdom;
TRACLEER*125MG 56CPR RIV.
   ACTELION PHARMACEUTICALS ITALIA
      2005   -   EUCTR2004-000745-37-IT   Italy;Spain;United Kingdom;
TRACLEER*56CPR RIV
   Actelion Pharmaceuticals Ltd
      2004   -   EUCTR2004-000478-30-IT   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
TRE
   United Therapeutics Corporation
      2005   -   EUCTR2004-003236-59-IT   Germany;Ireland;Italy;Spain;United Kingdom;
TREPROSTINIL SODIUM, UT-15
   United Therapeutics Corp.
      2012   -   EUCTR2011-004631-31-DE   Germany;
TRK-100STP
   Lung LLC
      2010   Phase 2   EUCTR2009-014453-32-BE   Belgium;Czech Republic;Germany;Ireland;Romania;United States;
      2010   -   EUCTR2009-014453-32-CZ   Belgium;Czech Republic;Germany;Ireland;
      2009   Phase 2   EUCTR2008-006833-29-BE   Belgium;Ireland;United States;
      2009   -   EUCTR2008-006833-29-IE   Belgium;Ireland;
   Lung LLC Inc
      2010   -   EUCTR2009-014453-32-IE   Belgium;Czech Republic;Germany;Ireland;
   Lung RX
      -   Phase 2   EUCTR2009-014453-32-DE   Belgium;Czech Republic;Germany;Ireland;
   Lung Rx
      2009   -   EUCTR2008-003290-41-BE   Belgium;Ireland;
   Lung Rx Inc
      2010   -   EUCTR2009-014246-29-CZ   Belgium;Czech Republic;Germany;Ireland;
      2009   Phase 2   EUCTR2009-014246-29-BE   Belgium;Czech Republic;Germany;Ireland;
   LungRx
      2009   -   EUCTR2008-003290-41-IE   Belgium;Ireland;
Tadalafil
   Actelion
      2016   Phase 3   NCT02558231   Australia;Austria;Belgium;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2015   Phase 4   NCT02968901   France;
   Bayer
      2017   Phase 4   NCT02891850   Australia;Austria;Belgium;Brazil;Canada;Czechia;Denmark;France;Germany;Greece;Italy;Japan;Korea, Republic of;Mexico;Netherlands;Poland;Portugal;Spain;Switzerland;Taiwan;Turkey;United Kingdom;United States;
   ELI LILLY
      2006   -   EUCTR2005-002844-24-IT   Germany;Ireland;Italy;Spain;United Kingdom;
      2006   -   EUCTR2005-002692-33-IT   Germany;Ireland;Italy;Spain;United Kingdom;
   Eli Lilly Japan K.K.
      2017   Phase 3   JPRN-JapicCTI-132356   Japan, Asia except Japan, North America, South America, Europe;
   Eli Lilly and Company
      2014   Phase 3   NCT01824290   Austria;Belgium;Brazil;Canada;France;Germany;Israel;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;Turkey;United States;
      2010   -   NCT01066845   -
      2006   -   EUCTR2005-002844-24-DE   Germany;Ireland;Italy;Spain;United Kingdom;
      2005   Phase 3   NCT00549302   Belgium;Canada;France;Germany;Ireland;Italy;Japan;Spain;United Kingdom;United States;
      2005   Phase 3   NCT00125918   Belgium;Canada;France;Germany;Ireland;Italy;Japan;Spain;United Kingdom;United States;
   Eli Lilly and Company Limited
      2006   Phase 3;Phase 4   EUCTR2005-002844-24-BE   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
   Gilead Sciences
      2008   Phase 4   NCT00617305   United States;
   GlaxoSmithKline
      2010   Phase 3   NCT01178073   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
   GlaxoSmithKline R&D Ltd
      2010   -   EUCTR2009-011150-17-IT   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
   Govind Ballabh Pant Hospital
      2008   Phase 2   NCT01200732   India;
   Hamamatsu University School of Medicine
      2011   -   JPRN-UMIN000005464   Japan;
   Janssen Pharmaceutical K.K.
      2020   Phase 3   JPRN-JapicCTI-194971   Japan, South America, Europe;
   Lilly ICOS LLC
      2006   Phase 3   EUCTR2005-002844-24-GB   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2006   Phase 3   EUCTR2005-002692-33-IE   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2006   Phase 3   EUCTR2005-002692-33-GB   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2006   Phase 3   EUCTR2005-002692-33-ES   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2006   -   EUCTR2005-002844-24-IE   Germany;Ireland;Italy;Spain;United Kingdom;
      2006   -   EUCTR2005-002844-24-ES   Germany;Ireland;Italy;Spain;United Kingdom;
      2006   -   EUCTR2005-002692-33-DE   Germany;Ireland;Italy;Spain;United Kingdom;
      2006   -   EUCTR2005-002692-33-BE   Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
   National Cerebral and Cardiovascular Center
      2011   -   JPRN-UMIN000005973   Japan;
   Pfizer
      2010   Phase 1   NCT01244620   Singapore;
   Rabin Medical Center
      2008   Phase 4   NCT00705588   Israel;
   Rhode Island Hospital
      2011   Phase 4   NCT01302444   United States;
   Stanford University
      2010   Phase 4   NCT01305252   United States;
   Vigonvita Life Sciences
      2020   Phase 2   NCT04483115   China;
Tadalafil 20 mg film-coated tablets
   GlaxoSmithKline R&D Ltd
      2010   Phase 4   EUCTR2009-011150-17-GB   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-SE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-NL   Austria;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-GR   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-DE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-BE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-AT   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
   GlaxoSmithKline Research & Development Limited
      2010   Phase 4   EUCTR2009-011150-17-FR   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
Tadalafil and ambrisentan upfront combination therapy
   Johns Hopkins University
      2010   Phase 4   NCT01042158   United States;
Tadalafil oral suspension
   Eli Lilly and Company
      2013   Phase 3   EUCTR2012-002354-23-NL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-IT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-FR   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-DE   Austria;Belgium;Brazil;France;Germany;Israel;Italy;Japan;Netherlands;Poland;Romania;Spain;Turkey;United Kingdom;
      2013   Phase 3   EUCTR2012-002354-23-BE   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002354-23-AT   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      2013   -   EUCTR2012-002354-23-RO   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-PL   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2012-002354-23-GB   Austria;Belgium;Brazil;Canada;France;Germany;Italy;Japan;Mexico;Netherlands;Poland;Romania;Spain;Switzerland;United Kingdom;United States;
Tadalafil- Tablet or Oral suspension
   Eli Lilly and Company
      2012   Phase 1/Phase 2   NCT01484431   Canada;France;Poland;Spain;United Kingdom;United States;
Tamoxifen
   Vanderbilt University Medical Center
      2018   Phase 2   NCT03528902   United States;
Tasigna®
   Novartis Pharma AG
      2010   -   EUCTR2010-019883-36-HU   Germany;Hungary;
   Novartis Pharma Services AG
      2011   -   EUCTR2010-019883-36-DE   Canada;Germany;Hungary;Italy;Korea, Republic of;Singapore;Switzerland;United States;
Tegaderm
   Imperial College London
      2011   Phase 2   NCT01393795   United Kingdom;
Terguride 0,5mg tablet
   Ergonex Pharma GmbH
      2008   -   EUCTR2007-003975-38-NL   Austria;Czech Republic;Germany;Netherlands;
      2007   -   EUCTR2007-003975-38-DE   Austria;Czech Republic;Germany;Netherlands;
Terguride 0.5 mg tablet
   Ergonex Pharma GmbH
      2010   -   EUCTR2007-003975-38-AT   Austria;Czech Republic;Germany;Netherlands;
      2009   -   EUCTR2007-003975-38-CZ   Austria;Czech Republic;Germany;Netherlands;
Tezosentan
   Actelion Pharmaceuticals Ltd.
      2009   -   EUCTR2009-012450-20-FR   France;
   Idorsia Pharmaceuticals Ltd.
      2010   Phase 2   NCT01077297   France;Switzerland;United States;
The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
   Duke University
      2020   -   NCT04278404   Canada;United States;
The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
   Daniel Benjamin
      2011   -   NCT01431326   Australia;Canada;Israel;Singapore;United Kingdom;United States;
Thelin
   Pfizer Inc., 235 East 42nd Street, New York, NY 10017
      2009   -   EUCTR2008-005886-78-BG   Bulgaria;Czech Republic;
      2009   -   EUCTR2008-005885-30-BG   Bulgaria;Czech Republic;
   Pfizer Limited
      2009   Phase 3   EUCTR2008-005885-30-SK   Bulgaria;Czech Republic;Slovakia;
   Pfizer Limited, Ramsgate Road, Sandwich, Kent UK
      2009   Phase 3   EUCTR2008-005886-78-SK   Bulgaria;Czech Republic;Slovakia;
   Pfizer Limited, Ramsgate Road, Sandwich, Kent, UK
      2009   Phase 3   EUCTR2008-005887-14-SK   Bulgaria;Czech Republic;Slovakia;
      2009   -   EUCTR2008-005887-14-BG   Bulgaria;Czech Republic;
   Pfizer Ltd
      2010   -   EUCTR2008-005885-30-CZ   Bulgaria;Czech Republic;
   Pfizer Ltd.
      2010   Phase 3   EUCTR2008-005886-78-CZ   Bulgaria;Czech Republic;
      2010   -   EUCTR2008-005887-14-CZ   Bulgaria;Czech Republic;
Threonine
   Medical Education Center, School of Medicine, Keio University
      2009   -   JPRN-UMIN000001709   Japan;
Thrombin
   National and Kapodistrian University of Athens
      2015   -   NCT03195543   Greece;
Tocilizumab
   Papworth Hospital NHS Foundation Trust
      2016   Phase 2   NCT02676947   United Kingdom;
      2015   Phase 2   EUCTR2015-002799-26-GB   United Kingdom;
Traclear
   Hanmi Pharmaceutical Company Limited
      2013   Phase 1   NCT01864863   Korea, Republic of;
Tracleer
   Actelion Pharmaceuticals Ltd.
      2013   Phase 3   EUCTR2010-021825-11-BG   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021825-11-NL   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021793-12-NL   Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-021793-12-HU   Australia;Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021793-12-DE   Australia;Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2011   -   EUCTR2010-021793-12-CZ   Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2010   -   EUCTR2010-021825-11-HU   Bulgaria;Czech Republic;Germany;Hungary;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-021825-11-DE   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2010   -   EUCTR2010-021825-11-CZ   Australia;Belarus;Bulgaria;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      2009   -   EUCTR2005-005068-97-CZ   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2005-005068-97-BE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2008   Phase 4   EUCTR2005-005068-97-SK   Belgium;Brazil;Czech Republic;Denmark;Germany;Greece;Portugal;Saudi Arabia;Slovakia;Spain;Sweden;United Kingdom;United States;
      2008   Phase 4   EUCTR2005-005068-97-ES   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Slovakia;Spain;Sweden;United Kingdom;
      2008   -   EUCTR2005-005068-97-PT   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2008   -   EUCTR2005-005068-97-GR   Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2007   -   EUCTR2005-005068-97-SE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2007   -   EUCTR2005-005068-97-GB   Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2007   -   EUCTR2005-005068-97-DK   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
      2006   -   EUCTR2004-004391-36-CZ   Czech Republic;Hungary;
      2006   -   EUCTR2004-000745-37-GB   Italy;Spain;United Kingdom;
      2005   Phase 3   EUCTR2005-001967-70-GB   Germany;Italy;United Kingdom;
      2005   Phase 3   EUCTR2004-000478-30-ES   Austria;Belgium;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2005   -   EUCTR2004-004391-36-HU   Czech Republic;Hungary;
      2004   Phase 4   EUCTR2004-000745-37-ES   Italy;Spain;United Kingdom;
      2004   Phase 3   EUCTR2004-000478-30-GB   Austria;Belgium;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-SE   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-DK   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-CZ   Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-BE   Austria;Belgium;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      2004   -   EUCTR2004-000478-30-AT   Austria;Czech Republic;Denmark;Italy;Spain;Sweden;United Kingdom;
      -   Phase 3   EUCTR2010-021825-11-FR   Bulgaria;Czech Republic;France;Germany;Hungary;Italy;Netherlands;Spain;
      -   Phase 3   EUCTR2010-021793-12-PL   Belarus;China;Czech Republic;France;Germany;Hungary;India;Israel;Italy;Mexico;Netherlands;Poland;Russian Federation;Serbia;South Africa;Spain;Ukraine;United States;
      -   Phase 3   EUCTR2010-021793-12-FR   Czech Republic;France;Germany;Hungary;Italy;Netherlands;Poland;Spain;
      -   -   EUCTR2005-005068-97-DE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
   Actelion pharmaceuticals Ltd
      2012   -   EUCTR2011-004612-31-PT   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
      2012   -   EUCTR2011-004106-16-PT   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
      2012   -   EUCTR2011-004106-16-BG   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2011-004612-31-NL   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2011-004612-31-FR   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2011-004106-16-NL   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;South Africa;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2011-004106-16-FR   Argentina;Bulgaria;Chile;China;Colombia;Croatia;France;Guatemala;India;Malaysia;Mexico;Netherlands;Peru;Philippines;Portugal;Russian Federation;Serbia;Singapore;South Africa;Taiwan;Ukraine;United States;Vietnam;
   ICIN
      2010   -   EUCTR2008-004533-21-NL   Netherlands;
   Rigshospitalet
      2006   -   EUCTR2006-000021-57-DK   Denmark;
   Royal Brompton and Harefield NHS Trust
      2008   Phase 4   EUCTR2007-001643-21-GB   United Kingdom;
      2007   -   EUCTR2007-001645-17-GB   United Kingdom;
Tracleer®
   Actelion
      2004   Phase 4   NCT00367770   Australia;Austria;Belgium;Canada;France;Germany;Italy;Netherlands;Spain;United Kingdom;United States;
Transdihydrolisuride
   Ergonex Pharma GmbH
      2010   -   EUCTR2007-003975-38-AT   Austria;Czech Republic;Germany;Netherlands;
      2009   -   EUCTR2007-003975-38-CZ   Austria;Czech Republic;Germany;Netherlands;
      2008   -   EUCTR2007-003975-38-NL   Austria;Czech Republic;Germany;Netherlands;
      2007   -   EUCTR2007-003975-38-DE   Austria;Czech Republic;Germany;Netherlands;
Treprosinil Diethanolamine
   United Therapeutics Corporation
      2007   Phase 3   EUCTR2006-000800-17-GB   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
Treprostin
   United Therapeutics Corporation
      2014   Phase 3   EUCTR2012-000097-26-BE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Peru;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-000097-26-IT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000098-21-GB   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
Treprostinil
   Los Angeles Biomedical Research Institute
      2010   Phase 4   NCT01268553   United States;
   Magdi H. Yacoub
      2019   Phase 4   NCT03835676   Egypt;
   Mochida Pharmaceutical Co., Ltd.
      2019   Phase 2-3   JPRN-JapicCTI-194651   Japan;
   Rajan Saggar
      2008   Phase 2   NCT00705133   United States;
   United Therapeutics
      2011   -   NCT01028651   United States;
      2007   Phase 4   NCT00439946   United States;
   United Therapeutics Corporation
      2007   -   EUCTR2006-000801-50-BE   Austria;Belgium;France;Italy;Netherlands;
      2007   -   EUCTR2006-000800-17-BE   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
Treprostinil Diethanolamine
   UNITED THERAPEUTICS
      2007   -   EUCTR2006-000800-17-IT   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
   United Therapeutics Corporation
      2008   -   EUCTR2006-000800-17-DE   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      2007   -   EUCTR2006-000801-50-AT   Austria;Belgium;France;Italy;Netherlands;
Treprostinil Diolamine
   United Therapeutics
      2012   Phase 3   NCT01560624   Argentina;Australia;Austria;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
Treprostinil Inhalation Powder
   Mannkind Corporation
      2018   Phase 1   NCT03464864   United States;
   United Therapeutics
      2019   Phase 1   NCT03950739   United States;
Treprostinil Injectable Product
   University of Arizona
      2019   Phase 3   NCT04062565   United States;
Treprostinil Palmitil
   Insmed Incorporated
      2022   Phase 2   NCT05147805   United States;
      2021   Phase 2   NCT04791514   United States;
Treprostinil Sodium Solution for Inhalation
   Lung Rx Inc.
      2005   -   EUCTR2004-003236-59-IE   Germany;Ireland;Italy;Spain;United Kingdom;
   United Therapeutics Corporation
      2007   -   EUCTR2004-003236-59-ES   Germany;Ireland;Italy;Spain;United Kingdom;
      2005   Phase 3   EUCTR2004-003236-59-GB   Austria;Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2005   Phase 3   EUCTR2004-003236-59-BE   Austria;Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2005   -   EUCTR2004-003236-59-IT   Germany;Ireland;Italy;Spain;United Kingdom;
      2005   -   EUCTR2004-003236-59-AT   Austria;Germany;Ireland;Italy;Spain;United Kingdom;
      -   -   EUCTR2004-003236-59-DE   Germany;Ireland;Italy;Spain;United Kingdom;
Treprostinil dietanolamina
   United Therapeutics Corporation
      2009   Phase 3   EUCTR2009-009366-13-ES   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
Treprostinil diethanolamine
   UNITED THERAPEUTICS
      2013   -   EUCTR2012-000098-21-IT   Australia;Austria;Brazil;Canada;Germany;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Taiwan;United Kingdom;United States;
      2009   -   EUCTR2009-009366-13-IT   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2007   -   EUCTR2006-000801-50-IT   Austria;Belgium;France;Italy;Netherlands;
   United Therapeutics
      2013   Phase 3   NCT01934582   United States;
      2010   Phase 1   NCT01172496   United States;
      2010   Phase 1   NCT01165476   United States;
      2010   Phase 1   NCT01153386   United States;
      2009   Phase 1   NCT00963027   United States;
      2009   Phase 1   NCT00963001   United States;
      2006   Phase 3   NCT01027949   Australia;Austria;Belgium;Canada;Czech Republic;France;Germany;India;Ireland;Israel;Italy;Mexico;Netherlands;Poland;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;United States;
   United Therapeutics Corporation
      2016   Phase 3   EUCTR2012-000098-21-PL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2016   Phase 3   EUCTR2012-000097-26-PL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2015   Phase 3   EUCTR2012-000098-21-FR   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000098-21-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000098-21-GR   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Peru;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000098-21-DK   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000097-26-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000097-26-GR   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Peru;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000097-26-DK   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000097-26-BE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Peru;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   -   EUCTR2012-000098-21-BE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Peru;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-000098-21-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-000097-26-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-000097-26-IT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000098-21-GB   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000098-21-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000098-21-AT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000097-26-GB   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000097-26-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000097-26-AT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2010   Phase 3   EUCTR2006-000804-18-SE   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2010   Phase 3   EUCTR2006-000804-18-PT   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-009366-13-PT   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2009-009366-13-FR   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-009366-13-SE   Austria;Belgium;France;Germany;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-009366-13-NL   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-009366-13-GB   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-009366-13-BE   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-009366-13-AT   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2006-000804-18-DE   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-NL   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-IE   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-GB   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-FR   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-BE   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-AT   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000800-17-ES   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      -   -   EUCTR2009-009366-13-DE   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
Treprostinil inhalations
   Stanford University
      2010   Phase 4   NCT01305252   United States;
Treprostinil sodium
   United Therapeutics
      2008   Phase 4   NCT00643604   United States;
      2007   Phase 4   NCT00458042   United States;
      2006   Phase 4   NCT00373360   United States;
      2002   Phase 4   NCT00058929   United States;
Treprostinil, UT-15, LRX-15, 15AU81, BW A15AU, U-62, 840
   Lung Rx Inc.
      2005   -   EUCTR2004-003236-59-IE   Germany;Ireland;Italy;Spain;United Kingdom;
   United Therapeutics Corporation
      2007   -   EUCTR2004-003236-59-ES   Germany;Ireland;Italy;Spain;United Kingdom;
      2005   Phase 3   EUCTR2004-003236-59-GB   Austria;Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2005   Phase 3   EUCTR2004-003236-59-BE   Austria;Belgium;Germany;Ireland;Italy;Spain;United Kingdom;
      2005   -   EUCTR2004-003236-59-AT   Austria;Germany;Ireland;Italy;Spain;United Kingdom;
      -   -   EUCTR2004-003236-59-DE   Germany;Ireland;Italy;Spain;United Kingdom;
Trimetazidine
   Indonesia University
      2017   Phase 2/Phase 3   NCT03273387   Indonesia;
Trisuva(r)
   AOP Orphan Pharmaceuticals GmbH
      2021   Phase 2   EUCTR2021-004002-21-AT   Austria;
Tyrosine
   Medical Education Center
      2008   -   JPRN-UMIN000001578   Japan;
   Medical Education Center, School of Medicine, Keio University
      2009   -   JPRN-UMIN000001709   Japan;
Tyvaso Inhalation Solution
   United Therapeutics
      2011   Phase 2   NCT01477333   United States;
UK 092480
   Pfizer Inc., 235 East 42nd Street, New York, NY 10017
      2018   Phase 3;Phase 4   EUCTR2013-004362-34-LV   Australia;Austria;Belgium;Bosnia and Herzegovina;Croatia;Czech Republic;Germany;Greece;Hong Kong;Israel;Latvia;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Thailand;Turkey;Ukraine;United States;
      2015   Phase 3;Phase 4   EUCTR2013-004362-34-SE   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2015   Phase 3;Phase 4   EUCTR2013-004362-34-PT   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Czechia;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2015   Phase 3;Phase 4   EUCTR2013-004362-34-NL   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2015   -   EUCTR2013-004362-34-HR   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 4   EUCTR2013-004362-34-GR   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 4   EUCTR2013-004362-34-ES   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 3;Phase 4   EUCTR2013-004362-34-PL   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 3;Phase 4   EUCTR2013-004362-34-DE   Australia;Austria;Belgium;Bosnia and Herzegovina;Croatia;Czech Republic;Germany;Greece;Hong Kong;Israel;Latvia;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Thailand;Turkey;Ukraine;United States;
      2014   Phase 3;Phase 4   EUCTR2013-004362-34-CZ   Australia;Austria;Belgium;Bosnia and Herzegovina;Croatia;Czech Republic;Germany;Greece;Hong Kong;Israel;Latvia;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Thailand;Turkey;Ukraine;United States;
      2014   Phase 3;Phase 4   EUCTR2013-004362-34-AT   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   Phase 3   EUCTR2013-004362-34-BE   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Latvia;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
      2014   -   EUCTR2013-004362-34-RO   Australia;Austria;Belgium;Brazil;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Hong Kong;Hungary;Israel;Italy;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Singapore;South Africa;Spain;Sweden;Taiwan;Thailand;Ukraine;United States;
UK-92,480
   Pfizer Limited, Ramsgate Road, Sandwich, Kent, UK
      2007   Phase 3   EUCTR2005-000963-25-SK   Finland;Slovakia;Sweden;United Kingdom;
      2007   -   EUCTR2005-000963-25-FI   Finland;Sweden;United Kingdom;
      2006   Phase 3   EUCTR2005-000963-25-GB   Finland;Slovakia;Sweden;United Kingdom;
      2005   -   EUCTR2005-000963-25-SE   Brazil;Chile;Colombia;Costa Rica;Finland;Guatemala;Hungary;India;Italy;Malaysia;Mexico;Poland;Russian Federation;Sweden;Taiwan;Thailand;United Kingdom;
   Pfizer Ltd
      2006   Phase 4   EUCTR2006-001464-23-GB   Czech Republic;Germany;Greece;Italy;United Kingdom;
   Pfizer Ltd, Ramsgate Rd, Sandwich, Kent, United Kingdom
      2007   Phase 3   EUCTR2006-002235-25-SK   Finland;Slovakia;United Kingdom;
      2007   -   EUCTR2006-002235-25-FI   Finland;United Kingdom;
      2006   Phase 3   EUCTR2006-002235-25-GB   Finland;Slovakia;United Kingdom;
   Pfizer Ltd, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK
      2006   -   EUCTR2006-001464-23-DE   Australia;Belgium;Czech Republic;France;Germany;Greece;Israel;Italy;Taiwan;United Kingdom;
   Pfizer Ltd,Ramsgate Road,Sandwich CT13 9NJ
      2008   -   EUCTR2006-001464-23-GR   Czech Republic;Germany;Greece;Italy;United Kingdom;
      2006   -   EUCTR2006-001464-23-CZ   Czech Republic;Germany;Greece;Italy;United Kingdom;
   Pfizer Ltd. Ramsgate Road, Sandwich, Kent, UK
      2008   -   EUCTR2006-006748-76-NL   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
      2008   -   EUCTR2006-006748-76-GR   Belgium;Bulgaria;Denmark;Greece;Italy;Latvia;Netherlands;United Kingdom;
   Pfizer, Ltd.
      -   -   EUCTR2015-002238-37-Outside-EU/EEA   India;
UK-92,480-10
   Pfizer Limited, Ramsgate Road, Sandwich, Kent, UK
      -   -   EUCTR2005-000963-25-Outside-EU/EEA   Brazil;Chile;Colombia;Guatemala;India;Japan;Malaysia;Mexico;Russian Federation;Taiwan;United States;
   Pfizer Ltd, Ramsgate Rd, Sandwich, Kent, United Kingdom
      -   -   EUCTR2006-002235-25-Outside-EU/EEA   Brazil;Canada;Chile;Colombia;Guatemala;India;Japan;Malaysia;Mexico;Peru;Russian Federation;Taiwan;United States;
UT-15C
   UNITED THERAPEUTICS
      2013   -   EUCTR2012-000098-21-IT   Australia;Austria;Brazil;Canada;Germany;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Taiwan;United Kingdom;United States;
   United Therapeutics
      2008   Phase 3   NCT00760916   Australia;Mexico;United States;
   United Therapeutics Corporation
      2016   Phase 3   EUCTR2012-000098-21-PL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2016   Phase 3   EUCTR2012-000097-26-PL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2015   Phase 3   EUCTR2012-000098-21-FR   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Greece;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000098-21-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000098-21-GR   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Peru;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000098-21-DK   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000097-26-SE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000097-26-GR   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Peru;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000097-26-DK   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   Phase 3   EUCTR2012-000097-26-BE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Peru;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2014   -   EUCTR2012-000098-21-BE   Argentina;Australia;Austria;Belgium;Brazil;Canada;China;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Peru;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-000098-21-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-000097-26-NL   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-000097-26-IT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000098-21-GB   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000098-21-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000098-21-AT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000097-26-GB   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000097-26-DE   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
      2012   Phase 3   EUCTR2012-000097-26-AT   Argentina;Australia;Austria;Belgium;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
UT-15C (treprostinil diethanolamine)
   United Therapeutics
      2012   Phase 3   NCT01560637   Argentina;Australia;Austria;Brazil;Canada;Chile;China;Denmark;France;Germany;Greece;India;Israel;Italy;Korea, Republic of;Mexico;Netherlands;Poland;Singapore;Sweden;Taiwan;United Kingdom;United States;
UT-15C LP
   United Therapeutics Corporation
      2007   Phase 3   EUCTR2006-000800-17-ES   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      2007   -   EUCTR2006-000804-18-ES   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
UT-15C SR
   UNITED THERAPEUTICS
      2009   -   EUCTR2009-009366-13-IT   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-IT   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2007   -   EUCTR2006-000801-50-IT   Austria;Belgium;France;Italy;Netherlands;
      2007   -   EUCTR2006-000800-17-IT   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
   United Therapeutics
      2013   Phase 3   NCT01934582   United States;
      2012   Phase 2   NCT01588405   United States;
      2011   Phase 2   NCT01477333   United States;
      2009   Phase 3   NCT00887978   Belgium;Canada;France;Germany;Ireland;Israel;Italy;Netherlands;Norway;Portugal;Spain;Sweden;United Kingdom;United States;
   United Therapeutics Corporation
      2010   Phase 3   EUCTR2006-000804-18-SE   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2010   Phase 3   EUCTR2006-000804-18-PT   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-009366-13-PT   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2009-009366-13-FR   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   Phase 3   EUCTR2009-009366-13-ES   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-009366-13-SE   Austria;Belgium;France;Germany;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-009366-13-NL   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-009366-13-GB   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-009366-13-BE   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2009   -   EUCTR2009-009366-13-AT   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2008   Phase 3   EUCTR2006-000804-18-DE   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2008   -   EUCTR2006-000800-17-DE   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-NL   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-IE   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-GB   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-FR   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-BE   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000804-18-AT   Austria;Belgium;France;Germany;Ireland;Israel;Italy;Mexico;Netherlands;Portugal;Puerto Rico;Spain;Sweden;United Kingdom;
      2007   Phase 3   EUCTR2006-000801-50-FR   Austria;Belgium;France;Italy;Netherlands;
      2007   Phase 3   EUCTR2006-000800-17-GB   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      2007   Phase 3   EUCTR2006-000800-17-FR   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      2007   -   EUCTR2006-000801-50-NL   Austria;Belgium;France;Italy;Netherlands;
      2007   -   EUCTR2006-000801-50-BE   Austria;Belgium;France;Italy;Netherlands;
      2007   -   EUCTR2006-000801-50-AT   Austria;Belgium;France;Italy;Netherlands;
      2007   -   EUCTR2006-000800-17-NL   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      2007   -   EUCTR2006-000800-17-IE   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      2007   -   EUCTR2006-000800-17-BE   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      2007   -   EUCTR2006-000800-17-AT   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
      -   -   EUCTR2009-009366-13-DE   Austria;Belgium;France;Germany;Italy;Netherlands;Portugal;Spain;Sweden;United Kingdom;
UT-15C SR (treprostinil diethanolamine)
   United Therapeutics
      2010   Phase 1   NCT01131845   United States;
UT-15C-SR
   United Therapeutics Corporation
      2007   Phase 3   EUCTR2006-000800-17-GB   Austria;Belgium;France;Germany;Ireland;Italy;Netherlands;Spain;United Kingdom;
Ubenimex
   Eiger BioPharmaceuticals
      2016   Phase 2   NCT02736149   Canada;United States;
      2016   Phase 2   NCT02664558   Canada;United States;
Udenafil
   Dong-A ST Co., Ltd.
      2014   Phase 2/Phase 3   NCT02304198   Korea, Republic of;
      2011   Phase 2   NCT01553721   Korea, Republic of;
Uptravi
   ACTELION PHARMACEUTICALS LTD
      2020   Phase 3   EUCTR2019-002817-21-IT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
   ACTELION Pharmaceuticals Ltd.
      2020   Phase 4   EUCTR2019-004783-22-NL   Argentina;Brazil;China;France;Germany;Hong Kong;Israel;Korea, Republic of;Malaysia;Netherlands;Russian Federation;Saudi Arabia;Singapore;United Arab Emirates;United Kingdom;United States;
      2020   Phase 4   EUCTR2019-004783-22-GB   Argentina;Brazil;China;France;Germany;Hong Kong;Israel;Korea, Republic of;Netherlands;Russian Federation;Saudi Arabia;United Arab Emirates;United Kingdom;United States;
      2020   Phase 4   EUCTR2019-004783-22-DE   Argentina;Brazil;China;France;Germany;Hong Kong;Israel;Korea, Republic of;Malaysia;Netherlands;Russian Federation;Saudi Arabia;Singapore;United Arab Emirates;United Kingdom;United States;
   Actelion Pharmaceuticals Ltd
      2018   Phase 4   EUCTR2017-000216-42-PT   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2018   Phase 4   EUCTR2017-000216-42-FR   Austria;France;Germany;Ireland;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2018   Phase 3   EUCTR2015-003438-28-GB   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2018   Phase 2   EUCTR2018-000145-39-HU   Belarus;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
      2018   Phase 2   EUCTR2018-000145-39-GB   Belarus;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
      2018   Phase 2   EUCTR2018-000145-39-DE   Belarus;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
      2017   Phase 4   EUCTR2017-000216-42-SE   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 4   EUCTR2017-000216-42-IE   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 4   EUCTR2017-000216-42-GB   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 4   EUCTR2017-000216-42-DE   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 4   EUCTR2017-000216-42-AT   Austria;France;Germany;Ireland;Netherlands;Norway;Portugal;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-DK   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-DE   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-BE   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-003438-28-AT   Australia;Austria;Belgium;Brazil;Canada;Denmark;France;Germany;Ireland;Italy;Netherlands;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-PL   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-CZ   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      2010   Phase 3   EUCTR2009-014992-31-AT   Argentina;Australia;Austria;Belarus;Belgium;Canada;Chile;China;Colombia;Czech Republic;Denmark;France;Germany;Greece;Hungary;India;Ireland;Israel;Italy;Korea, Republic of;Malaysia;Mexico;Netherlands;Peru;Poland;Romania;Russian Federation;Serbia;Singapore;Slovakia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United Kingdom;United States;
      -   Phase 2   EUCTR2018-000145-39-PL   Belarus;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
      -   Phase 2   EUCTR2018-000145-39-FR   Belarus;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
      -   Phase 2   EUCTR2018-000145-39-BE   Belarus;Belgium;Canada;China;France;Germany;Hungary;Israel;Italy;Malaysia;Netherlands;Poland;Romania;Russian Federation;Serbia;Singapore;Taiwan;Ukraine;United Kingdom;United States;Vietnam;
   Actelion Pharmaceuticals Ltd.
      2021   Phase 3   EUCTR2019-002817-21-FI   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-PT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-LT   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-HU   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-ES   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-DE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      2020   Phase 3   EUCTR2019-002817-21-BG   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2019-002817-21-SE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2019-002817-21-PL   Australia;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Finland;France;Germany;Hungary;Ireland;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Viet Nam;
      -   Phase 3   EUCTR2019-002817-21-IE   Australia;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Finland;France;Germany;Hungary;Ireland;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2019-002817-21-FR   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Netherlands;Poland;Portugal;Romania;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
      -   Phase 3   EUCTR2019-002817-21-BE   Argentina;Australia;Austria;Belarus;Belgium;Brazil;Bulgaria;Canada;China;Colombia;Denmark;Finland;France;Germany;Hungary;Israel;Italy;Korea, Republic of;Lithuania;Malaysia;Mexico;Poland;Portugal;Russian Federation;Serbia;Spain;Sweden;Switzerland;Taiwan;Thailand;Turkey;Ukraine;United States;Vietnam;
Urodilatin
   Cardiorentis AG
      2021   Phase 2   EUCTR2020-004815-29-DE   Germany;
Usual Care
   Vanderbilt University Medical Center
      2018   Phase 2   NCT03617458   United States;
VIP
   MONDOGEN AG
      2008   -   EUCTR2007-003621-24-IT   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
   MondoGEN AG
      2009   -   EUCTR2007-003621-24-AT   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   Phase 2   EUCTR2007-003621-24-GB   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   -   EUCTR2007-003621-24-NL   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   -   EUCTR2007-003621-24-FR   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   -   EUCTR2007-003621-24-ES   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   -   EUCTR2007-003621-24-DE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
      2008   -   EUCTR2007-003621-24-BE   Austria;Belgium;France;Germany;Italy;Netherlands;Spain;United Kingdom;
VOLIBRIS 10 mg comprimidos recubiertos con película
   GlaxoSmithKline, S.A
      2011   -   EUCTR2010-021572-29-ES   Germany;Greece;Hungary;Italy;Netherlands;Spain;
   GlaxoSmithKline, S.A.
      2010   Phase 2   EUCTR2010-019547-19-ES   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
VOLIBRIS 5 mg comprimidos recubiertos con película
   GlaxoSmithKline, S.A
      2011   -   EUCTR2010-021572-29-ES   Germany;Greece;Hungary;Italy;Netherlands;Spain;
   GlaxoSmithKline, S.A.
      2010   Phase 2   EUCTR2010-019547-19-ES   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
   GlaxoSmithKline,S.A.
      2010   -   EUCTR2009-011150-17-ES   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
VOLIBRIS® (ambrisentan)
   GlaxoSmithKline Research & Development Limited
      -   Phase 2   EUCTR2010-021572-29-FR   France;Germany;Greece;Hungary;Italy;Japan;Netherlands;Spain;United States;
VOLIBRIS™ tablets
   GlaxoSmithKline Research & Development Limited
      -   -   EUCTR2010-019547-19-Outside-EU/EEA   Argentina;Brazil;Canada;Japan;Mexico;Russian Federation;United States;
Vardenafil
   Rabin Medical Center
      2008   Phase 4   NCT00705588   Israel;
   Tongji University
      2008   Phase 3   NCT00718952   China;
Vasomera (PB1046) Injection
   PhaseBio Pharmaceuticals, Inc.
      2021   Phase 2   EUCTR2019-001598-10-AT   Austria;Belgium;Bulgaria;Czech Republic;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
      2020   Phase 2   EUCTR2019-001598-10-PL   Austria;Belgium;Bulgaria;Czechia;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
      2020   Phase 2   EUCTR2019-001598-10-HU   Austria;Belgium;Bulgaria;Czech Republic;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
      2020   Phase 2   EUCTR2019-001598-10-GR   Austria;Belgium;Bulgaria;Czech Republic;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
      2020   Phase 2   EUCTR2019-001598-10-ES   Austria;Belgium;Bulgaria;Czech Republic;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
      2020   Phase 2   EUCTR2019-001598-10-BG   Austria;Belgium;Bulgaria;Czech Republic;Germany;Greece;Hungary;Italy;Poland;Romania;Serbia;Spain;United States;
Ventavis
   Actelion Pharmaceuticals Ltd
      2009   -   EUCTR2009-010703-80-DE   Austria;Germany;
      2009   -   EUCTR2009-010703-80-AT   Austria;Germany;
   Actelion Pharmaceuticals Ltd.
      2009   -   EUCTR2009-011013-24-AT   Austria;
   COTHERIX, INC.
      2006   Phase 3   EUCTR2005-006192-13-IT   Austria;Germany;Italy;Portugal;Spain;United Kingdom;
   Royal Brompton and Harefield NHS Foundation Trust
      2014   Phase 4   EUCTR2014-000091-25-GB   United Kingdom;
Ventavis (Iloprost, BAYQ6256)
   Bayer
      2016   -   NCT02825160   Japan;
      2013   -   NCT01781052   France;
Ventavis 10
   Bayer AG
      2013   Phase 1;Phase 2   EUCTR2013-002783-12-AT   Austria;Germany;
   Bayer HealthCare AG
      2014   Phase 1;Phase 2   EUCTR2013-002783-12-DE   Austria;Germany;
Ventavis(Iloprost)
   Univ.Clinic of Internal Medicine II, Department of Cardiology, Medical University of Vienna, Austria
      2008   -   EUCTR2007-002803-42-AT   Austria;
Viagra
   Actelion Pharmaceuticals Ltd.
      2006   Phase 2   EUCTR2005-005066-37-GB   Belgium;Germany;Italy;United Kingdom;
      2006   -   EUCTR2005-005066-37-BE   Belgium;Germany;Italy;United Kingdom;
      -   -   EUCTR2005-005068-97-DE   Belgium;Czech Republic;Denmark;Germany;Greece;Portugal;Spain;Sweden;United Kingdom;
Volibris
   GlaxoSmithKline R&D Ltd
      2010   Phase 4   EUCTR2009-011150-17-GB   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-SE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-NL   Austria;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-GR   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
      2010   -   EUCTR2009-011150-17-DE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-BE   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
      2010   -   EUCTR2009-011150-17-AT   Australia;Austria;Belgium;Canada;France;Germany;Greece;Italy;Japan;Netherlands;Spain;Sweden;United Kingdom;United States;
   GlaxoSmithKline Research & Development Limited
      2010   Phase 4   EUCTR2009-011150-17-FR   Austria;Belgium;France;Germany;Greece;Italy;Netherlands;Spain;Sweden;United Kingdom;
   GlaxoSmithKline Research & Development, Ltd
      2011   -   EUCTR2010-021572-29-NL   Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-021572-29-HU   Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2011   -   EUCTR2010-021572-29-DE   Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   Phase 2   EUCTR2010-019547-19-NL   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   Phase 2   EUCTR2010-019547-19-HU   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   Phase 2   EUCTR2010-019547-19-FR   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   Phase 2   EUCTR2010-019547-19-DE   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-021572-29-GR   Germany;Greece;Hungary;Italy;Netherlands;Spain;
      2010   -   EUCTR2010-019547-19-GR   France;Germany;Greece;Hungary;Italy;Netherlands;Spain;
   GlaxoSmithKline Research and Development Ltd
      2019   Phase 1   EUCTR2019-001699-12-GB   United Kingdom;
   Thoraxklinik-Heidelberg gGmbH
      2014   Phase 2   EUCTR2014-001882-28-DE   Germany;
Warfarin
   Bial - Portela C S.A.
      2018   Phase 1   NCT04994119   Germany;
Zamicastat
   BIAL-Portela & Ca, S.A.
      2019   Phase 2   EUCTR2018-002796-18-IT   Austria;Germany;Italy;Portugal;Spain;Ukraine;United Kingdom;
      2019   Phase 2   EUCTR2018-002448-10-IT   Austria;Germany;Italy;Portugal;Spain;Ukraine;United Kingdom;
   Bial - Portela & Ca, S.A
      2019   Phase 2   EUCTR2018-002796-18-GB   Austria;Belgium;Germany;Netherlands;Portugal;Spain;Ukraine;United Kingdom;
      2019   Phase 2   EUCTR2018-002448-10-GB   Austria;Germany;Netherlands;Portugal;Spain;Ukraine;United Kingdom;
   Bial - Portela C S.A.
      2019   Phase 2   NCT04316143   Spain;
[11C]-GSK2256098 500 MBq
   GlaxoSmithKline
      2015   Phase 1   NCT02551653   United Kingdom;
[18F] FES
   University of Pennsylvania
      2016   -   NCT02899533   United States;
[18F]Fluoro-2-deoxy-2-D-glucose
   Brigham and Women's Hospital
      2013   Phase 2   NCT01953965   United States;