Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ABL1 💬 11件: ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Chronic myeloid leukemia, Viral myocarditis Nilotinib 💬 Nilotinib 5件: 6, 8, 34, 51, 86 💬
2 ABL1 💬 11件: ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Chronic myeloid leukemia, Viral myocarditis Imatinib 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
3 ABL1 💬 11件: ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Chronic myeloid leukemia, Viral myocarditis Imatinib mesylate 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
4 ACE 💬 6件: Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Captopril 💬 Captopril 7件: 17, 46, 86, 96, 97, 107, 271 💬
5 ACVR2A 💬 4件: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Fluid shear stress and atherosclerosis Sotatercept 💬 Sotatercept 2件: 86, 284 💬
6 ADRA1A 💬 9件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol 6件: 6, 46, 57, 86, 113, 210 💬
7 ADRA1A 💬 9件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol phosphate 💬 Carvedilol 6件: 6, 46, 57, 86, 113, 210 💬
8 ADRA1B 💬 8件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol phosphate 💬 Carvedilol 6件: 6, 46, 57, 86, 113, 210 💬
9 ADRA1B 💬 8件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol 6件: 6, 46, 57, 86, 113, 210 💬
10 ADRA1D 💬 8件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol phosphate 💬 Carvedilol 6件: 6, 46, 57, 86, 113, 210 💬
11 ADRA1D 💬 8件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol 6件: 6, 46, 57, 86, 113, 210 💬
12 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Dobutamine tartrate 💬 Dobutamine 4件: 57, 58, 86, 215 💬
13 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Dobutamine 💬 Dobutamine 4件: 57, 58, 86, 215 💬
14 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Carvedilol 💬 Carvedilol 6件: 6, 46, 57, 86, 113, 210 💬
15 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Bisoprolol 💬 Bisoprolol 4件: 58, 67, 86, 113 💬
16 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Carvedilol phosphate 💬 Carvedilol 6件: 6, 46, 57, 86, 113, 210 💬
17 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Bisoprolol fumarate 💬 Bisoprolol 4件: 58, 67, 86, 113 💬
18 ADRB1 💬 13件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Dobutamine hydrochloride 💬 Dobutamine 4件: 57, 58, 86, 215 💬
19 ADRB2 💬 11件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Albuterol sulfate 💬 Albuterol 16件: 2, 3, 11, 12, 13, 85, 86, 89, 111, 113, 228, 231, 256, 273, 299, 340 💬
20 ADRB2 💬 11件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Carvedilol phosphate 💬 Carvedilol 6件: 6, 46, 57, 86, 113, 210 💬
21 ADRB2 💬 11件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Albuterol 💬 Albuterol 16件: 2, 3, 11, 12, 13, 85, 86, 89, 111, 113, 228, 231, 256, 273, 299, 340 💬
22 ADRB2 💬 11件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Carvedilol 💬 Carvedilol 6件: 6, 46, 57, 86, 113, 210 💬
23 AGTR1 💬 17件: Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease - COVID-19, Pathways in cancer, Diabetic cardiomyopathy Valsartan 💬 Valsartan 8件: 57, 58, 66, 75, 86, 210, 222, 224 💬
24 ANPEP 💬 3件: Glutathione metabolism, Renin-angiotensin system, Hematopoietic cell lineage Ubenimex 💬 Ubenimex 1件: 86 💬
25 AR 💬 4件: Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer Prasterone 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
26 ATP4A 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Esomeprazole strontium 💬 Esomeprazole 10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
27 ATP4A 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Esomeprazole magnesium 💬 Esomeprazole 10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
28 ATP4A 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Esomeprazole 💬 Esomeprazole 10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
29 ATP4A 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Esomeprazole sodium 💬 Esomeprazole 10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
30 ATP4A 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Esomeprazole magnesium dihydrate 💬 Esomeprazole 10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
31 ATP4B 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Esomeprazole sodium 💬 Esomeprazole 10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
32 ATP4B 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Esomeprazole magnesium dihydrate 💬 Esomeprazole 10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
33 ATP4B 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Esomeprazole 💬 Esomeprazole 10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
34 ATP4B 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Esomeprazole magnesium 💬 Esomeprazole 10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
35 ATP4B 💬 3件: Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion Esomeprazole strontium 💬 Esomeprazole 10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
36 AVPR2 💬 4件: Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vasopressin-regulated water reabsorption Tolvaptan 💬 Tolvaptan 4件: 67, 72, 86, 225 💬
37 BRAF 💬 42件: MAPK signaling pathway, ErbB signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, FoxO signaling pathway, mTOR signaling pathway, Vascular smooth muscle contraction, Focal adhesion, Natural killer cell mediated cytotoxicity, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Alcoholism, Hepatitis C, Hepatitis B, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer Sorafenib 💬 Sorafenib 2件: 34, 86 💬
38 BRAF 💬 42件: MAPK signaling pathway, ErbB signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, FoxO signaling pathway, mTOR signaling pathway, Vascular smooth muscle contraction, Focal adhesion, Natural killer cell mediated cytotoxicity, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Alcoholism, Hepatitis C, Hepatitis B, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
39 CACNA1C 💬 34件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem 💬 Diltiazem 4件: 51, 58, 86, 88 💬
40 CACNA1C 💬 34件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nicardipine 💬 Nicardipine 2件: 70, 86 💬
41 CACNA1C 💬 34件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nicardipine hydrochloride 💬 Nicardipine 2件: 70, 86 💬
42 CACNA1C 💬 34件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem hydrochloride 💬 Diltiazem 4件: 51, 58, 86, 88 💬
43 CACNA1C 💬 34件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem malate 💬 Diltiazem 4件: 51, 58, 86, 88 💬
44 CACNA1D 💬 35件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem hydrochloride 💬 Diltiazem 4件: 51, 58, 86, 88 💬
45 CACNA1D 💬 35件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem 💬 Diltiazem 4件: 51, 58, 86, 88 💬
46 CACNA1D 💬 35件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem malate 💬 Diltiazem 4件: 51, 58, 86, 88 💬
47 CACNA1D 💬 35件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nicardipine hydrochloride 💬 Nicardipine 2件: 70, 86 💬
48 CACNA1D 💬 35件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nicardipine 💬 Nicardipine 2件: 70, 86 💬
49 CACNA1F 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem malate 💬 Diltiazem 4件: 51, 58, 86, 88 💬
50 CACNA1F 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem hydrochloride 💬 Diltiazem 4件: 51, 58, 86, 88 💬
51 CACNA1F 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nicardipine 💬 Nicardipine 2件: 70, 86 💬
52 CACNA1F 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nicardipine hydrochloride 💬 Nicardipine 2件: 70, 86 💬
53 CACNA1F 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem 💬 Diltiazem 4件: 51, 58, 86, 88 💬
54 CACNA1S 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem malate 💬 Diltiazem 4件: 51, 58, 86, 88 💬
55 CACNA1S 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem 💬 Diltiazem 4件: 51, 58, 86, 88 💬
56 CACNA1S 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Diltiazem hydrochloride 💬 Diltiazem 4件: 51, 58, 86, 88 💬
57 CACNA1S 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nicardipine 💬 Nicardipine 2件: 70, 86 💬
58 CACNA1S 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nicardipine hydrochloride 💬 Nicardipine 2件: 70, 86 💬
59 CYP19A 💬 2件: Steroid hormone biosynthesis, Ovarian steroidogenesis Anastrozole 💬 Anastrozole 3件: 78, 86, 193 💬
60 DRD2 💬 10件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Lisuride 💬 Lisuride 2件: 6, 86 💬
61 DRD2 💬 10件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Terguride 💬 Terguride 2件: 51, 86 💬
62 DRD3 💬 4件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Dopaminergic synapse Lisuride 💬 Lisuride 2件: 6, 86 💬
63 DRD4 💬 4件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Dopaminergic synapse Lisuride 💬 Lisuride 2件: 6, 86 💬
64 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Bosentan 💬 Bosentan 11件: 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
65 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Macitentan 💬 Macitentan 5件: 51, 85, 86, 88, 210 💬
66 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Sitaxentan 💬 Sitaxentan 1件: 86 💬
67 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Ambrisentan 💬 Ambrisentan 8件: 51, 66, 84, 85, 86, 88, 210, 211 💬
68 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Bosentan 💬 Bosentan 11件: 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
69 EDNRA 💬 7件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Renin secretion, Pathways in cancer Sitaxentan sodium 💬 Sitaxentan 1件: 86 💬
70 EDNRB 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Macitentan 💬 Macitentan 5件: 51, 85, 86, 88, 210 💬
71 EDNRB 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Bosentan 💬 Bosentan 11件: 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
72 EDNRB 💬 6件: Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Melanogenesis, Relaxin signaling pathway, Pathways in cancer Bosentan 💬 Bosentan 11件: 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
73 EGFR 💬 47件: Virion - Hepatitis viruses, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Coronavirus disease - COVID-19, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Cetuximab 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
74 ESR1 💬 9件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Prasterone 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
75 ESR1 💬 9件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Tamoxifen citrate 💬 Tamoxifen 4件: 2, 86, 113, 227 💬
76 ESR1 💬 9件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Tamoxifen 💬 Tamoxifen 4件: 2, 86, 113, 227 💬
77 ESR1 💬 9件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Fulvestrant 💬 Fulvestrant 1件: 86 💬
78 ESR2 💬 7件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Prasterone 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
79 ESR2 💬 7件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Tamoxifen 💬 Tamoxifen 4件: 2, 86, 113, 227 💬
80 ESR2 💬 7件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Tamoxifen citrate 💬 Tamoxifen 4件: 2, 86, 113, 227 💬
81 ESR2 💬 7件: Hormone signaling, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Fulvestrant 💬 Fulvestrant 1件: 86 💬
82 FLT3 💬 8件: MAPK signaling pathway, Ras signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia, Central carbon metabolism in cancer Sorafenib 💬 Sorafenib 2件: 34, 86 💬
83 FLT3 💬 8件: MAPK signaling pathway, Ras signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia, Central carbon metabolism in cancer Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
84 FLT4 💬 8件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Pathways in cancer, Breast cancer Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
85 FLT4 💬 8件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Pathways in cancer, Breast cancer Sorafenib 💬 Sorafenib 2件: 34, 86 💬
86 GUCY1A 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Gap junction, Platelet activation, Circadian entrainment, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
87 GUCY1A 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Gap junction, Platelet activation, Circadian entrainment, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
88 GUCY1A 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Gap junction, Platelet activation, Circadian entrainment, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion Vericiguat 💬 Vericiguat 1件: 86 💬
89 GUCY1A 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Gap junction, Platelet activation, Circadian entrainment, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion Vericiguat 💬 Vericiguat 1件: 86 💬
90 GUCY1B 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Gap junction, Platelet activation, Circadian entrainment, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
91 GUCY1B 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Gap junction, Platelet activation, Circadian entrainment, Long-term depression, Oxytocin signaling pathway, Renin secretion, Salivary secretion Vericiguat 💬 Vericiguat 1件: 86 💬
92 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Simvastatin 💬 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
93 HRH1 💬 4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Inflammatory mediator regulation of TRP channels Diphenhydramine citrate 💬 Diphenhydramine 11件: 11, 13, 19, 49, 51, 70, 86, 96, 222, 256, 300 💬
94 HRH1 💬 4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Inflammatory mediator regulation of TRP channels Diphenhydramine hydrochloride 💬 Diphenhydramine 11件: 11, 13, 19, 49, 51, 70, 86, 96, 222, 256, 300 💬
95 HRH1 💬 4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Inflammatory mediator regulation of TRP channels Diphenhydramine 💬 Diphenhydramine 11件: 11, 13, 19, 49, 51, 70, 86, 96, 222, 256, 300 💬
96 HRH1 💬 4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Inflammatory mediator regulation of TRP channels Diphenhydramine salicylate 💬 Diphenhydramine 11件: 11, 13, 19, 49, 51, 70, 86, 96, 222, 256, 300 💬
97 HRH2 💬 4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Gastric acid secretion Famotidine 💬 Famotidine 7件: 6, 46, 61, 86, 98, 145, 300 💬
98 IL1R1 💬 13件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Hematopoietic cell lineage, Th17 cell differentiation, Inflammatory mediator regulation of TRP channels, Pathogenic Escherichia coli infection, Shigellosis, Amoebiasis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Fluid shear stress and atherosclerosis Anakinra 💬 Anakinra 19件: 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 84, 86, 97, 106, 107, 266, 299 💬
99 IL1R2 💬 7件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Amoebiasis, Human T-cell leukemia virus 1 infection, Transcriptional misregulation in cancer, Prostate cancer, Fluid shear stress and atherosclerosis Anakinra 💬 Anakinra 19件: 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 84, 86, 97, 106, 107, 266, 299 💬
100 IL6R 💬 11件: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Th17 cell differentiation, Non-alcoholic fatty liver disease, Human cytomegalovirus infection, Coronavirus disease - COVID-19, Pathways in cancer Satralizumab 💬 Satralizumab 4件: 11, 13, 86, 113 💬
101 IL6R 💬 11件: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Th17 cell differentiation, Non-alcoholic fatty liver disease, Human cytomegalovirus infection, Coronavirus disease - COVID-19, Pathways in cancer Tocilizumab 💬 Tocilizumab 24件: 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
102 KDR 💬 9件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Sorafenib 💬 Sorafenib 2件: 34, 86 💬
103 KDR 💬 9件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
104 KIT 💬 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
105 KIT 💬 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Nilotinib 💬 Nilotinib 5件: 6, 8, 34, 51, 86 💬
106 KIT 💬 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Sorafenib 💬 Sorafenib 2件: 34, 86 💬
107 KIT 💬 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Imatinib mesylate 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
108 KIT 💬 11件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Imatinib 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
109 KLHL19 💬 6件: Ubiquitin mediated proteolysis, Parkinson disease, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Dimethyl fumarate 💬 Dimethyl fumarate 6件: 13, 20, 49, 51, 86, 296 💬
110 MAP3K5 💬 19件: MAPK signaling pathway, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, Apoptosis, Tight junction, TNF signaling pathway, Thermogenesis, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease, Alcoholic liver disease, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - reactive oxygen species, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Selonsertib 💬 Selonsertib 1件: 86 💬
111 MS4A1 💬 1件: Hematopoietic cell lineage Rituximab 💬 Rituximab 52件: 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 172, 220, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
112 MTNR1A 💬 2件: Neuroactive ligand-receptor interaction, Circadian entrainment Melatonin 💬 Melatonin 17件: 2, 6, 8, 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 202, 265 💬
113 MTNR1B 💬 2件: Neuroactive ligand-receptor interaction, Circadian entrainment Melatonin 💬 Melatonin 17件: 2, 6, 8, 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 202, 265 💬
114 MTOR 💬 49件: ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Sirolimus 💬 Sirolimus 46件: 2, 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
115 NQO1 💬 5件: Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Warfarin 💬 Warfarin 12件: 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
116 NQO1 💬 5件: Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Warfarin sodium 💬 Warfarin 12件: 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
117 NQO1 💬 5件: Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Warfarin potassium 💬 Warfarin 12件: 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
118 NR1C3 💬 12件: PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Pioglitazone 💬 Pioglitazone 17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 81, 86, 96, 220, 229, 265, 298, 299 💬
119 NR1C3 💬 12件: PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Pioglitazone hydrochloride 💬 Pioglitazone 17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 81, 86, 96, 220, 229, 265, 298, 299 💬
120 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Methylprednisolone acetate 💬 Methylprednisolone 48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
121 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Methylprednisolone 💬 Methylprednisolone 48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
122 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Prednisone 💬 Prednisone 54件: 2, 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 145, 162, 164, 205, 222, 224, 228, 251, 269, 283, 285, 288, 299, 300, 303, 307, 331 💬
123 NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption Spironolactone 💬 Spironolactone 8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
124 OPRM1 💬 5件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Estrogen signaling pathway, Morphine addiction Morphine tartrate 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
125 OPRM1 💬 5件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Estrogen signaling pathway, Morphine addiction Morphine 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
126 OPRM1 💬 5件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Estrogen signaling pathway, Morphine addiction Morphine hydrochloride hydrate 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
127 OPRM1 💬 5件: Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Estrogen signaling pathway, Morphine addiction Morphine sulfate 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
128 P2RY12 💬 3件: Neuroactive ligand signaling, Efferocytosis, Platelet activation Clopidogrel hydrochloride 💬 Clopidogrel 4件: 40, 49, 51, 86 💬
129 P2RY12 💬 3件: Neuroactive ligand signaling, Efferocytosis, Platelet activation Clopidogrel besilate 💬 Clopidogrel 4件: 40, 49, 51, 86 💬
130 P2RY12 💬 3件: Neuroactive ligand signaling, Efferocytosis, Platelet activation Clopidogrel bisulfate 💬 Clopidogrel 4件: 40, 49, 51, 86 💬
131 P2RY12 💬 3件: Neuroactive ligand signaling, Efferocytosis, Platelet activation Clopidogrel 💬 Clopidogrel 4件: 40, 49, 51, 86 💬
132 PARP1 💬 5件: Base excision repair, NF-kappa B signaling pathway, Apoptosis, Necroptosis, Diabetic cardiomyopathy Olaparib 💬 Olaparib 2件: 86, 285 💬
133 PARP2 💬 2件: Base excision repair, Apoptosis Olaparib 💬 Olaparib 2件: 86, 285 💬
134 PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Sildenafil citrate 💬 Sildenafil 14件: 6, 46, 51, 85, 86, 113, 210, 211, 212, 225, 226, 278, 294, 299 💬
135 PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Vardenafil hydrochloride 💬 Vardenafil 3件: 13, 86, 299 💬
136 PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Tadalafil 💬 Tadalafil 8件: 6, 51, 75, 77, 84, 86, 113, 210 💬
137 PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Sildenafil 💬 Sildenafil 14件: 6, 46, 51, 85, 86, 113, 210, 211, 212, 225, 226, 278, 294, 299 💬
138 PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Udenafil 💬 Udenafil 2件: 86, 210 💬
139 PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway Vardenafil 💬 Vardenafil 3件: 13, 86, 299 💬
140 PDGFRA 💬 19件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Imatinib mesylate 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
141 PDGFRA 💬 19件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Seralutinib 💬 Seralutinib 1件: 86 💬
142 PDGFRA 💬 19件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Imatinib 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
143 PDGFRA 💬 19件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Nilotinib 💬 Nilotinib 5件: 6, 8, 34, 51, 86 💬
144 PDGFRB 💬 18件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Seralutinib 💬 Seralutinib 1件: 86 💬
145 PDGFRB 💬 18件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Nilotinib 💬 Nilotinib 5件: 6, 8, 34, 51, 86 💬
146 PDGFRB 💬 18件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
147 PDGFRB 💬 18件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer Sorafenib 💬 Sorafenib 2件: 34, 86 💬
148 PDK2_3_4 💬 1件: Diabetic cardiomyopathy Sodium dichloroacetate 💬 Dichloroacetic acid 2件: 21, 86 💬
149 PDK2_3_4 💬 1件: Diabetic cardiomyopathy Sodium dichloroacetate 💬 Dichloroacetic acid 2件: 21, 86 💬
150 PDK2_3_4 💬 1件: Diabetic cardiomyopathy Sodium dichloroacetate 💬 Dichloroacetic acid 2件: 21, 86 💬
151 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
152 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin hydrochloride 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
153 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin hydrochloride 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
154 PRKAA 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin 28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
155 PRL 💬 6件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin signaling pathway Terguride 💬 Terguride 2件: 51, 86 💬
156 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Iloprost 💬 Iloprost 4件: 51, 84, 85, 86 💬
157 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Esuberaprost 💬 Esuberaprost 1件: 86 💬
158 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Selexipag 💬 Selexipag 6件: 47, 51, 70, 84, 86, 88 💬
159 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil monosodium salt 💬 Treprostinil 5件: 51, 85, 86, 88, 210 💬
160 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Beraprost sodium 💬 Beraprost 1件: 86 💬
161 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Epoprostenol 💬 Epoprostenol 1件: 86 💬
162 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Ralinepag 💬 Ralinepag 1件: 86 💬
163 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil 💬 Treprostinil 5件: 51, 85, 86, 88, 210 💬
164 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Iloprost tromethamine 💬 Iloprost 4件: 51, 84, 85, 86 💬
165 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Esuberaprost sodium 💬 Esuberaprost 1件: 86 💬
166 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil diolamine 💬 Treprostinil 5件: 51, 85, 86, 88, 210 💬
167 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Beraprost 💬 Beraprost 1件: 86 💬
168 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Epoprostenol sodium 💬 Epoprostenol 1件: 86 💬
169 PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation Treprostinil palmitil 💬 Treprostinil palmitil 1件: 86 💬
170 PTGS1 💬 4件: Arachidonic acid metabolism, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes Aspirin 💬 Acetylsalicylic acid 15件: 13, 22, 34, 46, 49, 51, 64, 86, 96, 97, 113, 158, 210, 231, 271 💬
171 PTGS1 💬 4件: Arachidonic acid metabolism, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes Acetaminophen 💬 Acetaminophen 18件: 3, 6, 11, 13, 19, 34, 35, 46, 49, 51, 70, 77, 86, 96, 222, 256, 300, 337 💬
172 PTGS2 💬 22件: Arachidonic acid metabolism, NF-kappa B signaling pathway, Efferocytosis, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer Acetaminophen 💬 Acetaminophen 18件: 3, 6, 11, 13, 19, 34, 35, 46, 49, 51, 70, 77, 86, 96, 222, 256, 300, 337 💬
173 PTGS2 💬 22件: Arachidonic acid metabolism, NF-kappa B signaling pathway, Efferocytosis, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer Aspirin 💬 Acetylsalicylic acid 15件: 13, 22, 34, 46, 49, 51, 64, 86, 96, 97, 113, 158, 210, 231, 271 💬
174 RAF1 💬 81件: MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Cellular senescence, Vascular smooth muscle contraction, Axon guidance, VEGF signaling pathway, Apelin signaling pathway, Focal adhesion, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Alcoholism, Salmonella infection, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
175 RAF1 💬 81件: MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Cellular senescence, Vascular smooth muscle contraction, Axon guidance, VEGF signaling pathway, Apelin signaling pathway, Focal adhesion, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Alcoholism, Salmonella infection, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Sorafenib 💬 Sorafenib 2件: 34, 86 💬
176 RET 💬 7件: MAPK signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Thyroid cancer, Non-small cell lung cancer, Central carbon metabolism in cancer Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
177 RET 💬 7件: MAPK signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Thyroid cancer, Non-small cell lung cancer, Central carbon metabolism in cancer Sorafenib 💬 Sorafenib 2件: 34, 86 💬
178 RRM2 💬 5件: Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes, p53 signaling pathway Hydroxyurea 💬 Hydroxyurea 10件: 3, 13, 19, 20, 46, 65, 85, 86, 107, 284 💬
179 SCN1A 💬 1件: Dopaminergic synapse Lidocaine 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
180 SCN1A 💬 1件: Dopaminergic synapse Lidocaine hydrochloride 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
181 SCN1A 💬 1件: Dopaminergic synapse Lidocaine hydrochloride monohydrate 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
182 SCN2A 💬 1件: Taste transduction Lidocaine 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
183 SCN2A 💬 1件: Taste transduction Lidocaine hydrochloride 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
184 SCN2A 💬 1件: Taste transduction Lidocaine hydrochloride monohydrate 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
185 SCN3A 💬 1件: Taste transduction Lidocaine hydrochloride 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
186 SCN3A 💬 1件: Taste transduction Lidocaine hydrochloride monohydrate 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
187 SCN3A 💬 1件: Taste transduction Lidocaine 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
188 SCN5A 💬 1件: Adrenergic signaling in cardiomyocytes Lidocaine hydrochloride monohydrate 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
189 SCN5A 💬 1件: Adrenergic signaling in cardiomyocytes Lidocaine hydrochloride 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
190 SCN5A 💬 1件: Adrenergic signaling in cardiomyocytes Lidocaine 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
191 SCN9A 💬 1件: Taste transduction Lidocaine 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
192 SCN9A 💬 1件: Taste transduction Lidocaine hydrochloride 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
193 SCN9A 💬 1件: Taste transduction Lidocaine hydrochloride monohydrate 💬 Lidocaine 14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
194 SLC12A2 💬 3件: Salivary secretion, Pancreatic secretion, Vibrio cholerae infection Furosemide 💬 Furosemide 3件: 6, 77, 86 💬
195 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Fluoxetine 💬 Fluoxetine 3件: 13, 17, 86 💬
196 SLC6A4 💬 3件: Neuroactive ligand signaling, Synaptic vesicle cycle, Serotonergic synapse Fluoxetine hydrochloride 💬 Fluoxetine 3件: 13, 17, 86 💬
197 TPH1_2 💬 3件: Tryptophan metabolism, Folate biosynthesis, Serotonergic synapse Rodatristat ethyl 💬 Rodatristat ethyl 1件: 86 💬
198 TPH1_2 💬 3件: Tryptophan metabolism, Folate biosynthesis, Serotonergic synapse Rodatristat 💬 Rodatristat 1件: 86 💬
199 TRPV1 💬 2件: Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Capsaicin 💬 Capsaicin 4件: 2, 6, 86, 226 💬
200 VDR 💬 5件: Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Tuberculosis, Chemical carcinogenesis - receptor activation Calcifediol 💬 Calcifediol 2件: 86, 113 💬
201 VKORC1 💬 1件: Ubiquinone and other terpenoid-quinone biosynthesis Warfarin 💬 Warfarin 12件: 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
202 VKORC1 💬 1件: Ubiquinone and other terpenoid-quinone biosynthesis Warfarin sodium 💬 Warfarin 12件: 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
203 VKORC1 💬 1件: Ubiquinone and other terpenoid-quinone biosynthesis Warfarin potassium 💬 Warfarin 12件: 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬