Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 2,2-bis(4-hydroxy-3-tert-butylphenyl)propane 0件: ---5件: 19, 86, 90, 276, 299 💬
2 2-(aminomethyl)phenol 1件: 2-hoba---2件: 46, 86 💬
3 Acetaminophen 2件: Acetaminophen; Paracetamol1件: Acetaminophen 💬 2件: PTGS1,
PTGS2 💬 		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬18件: 3, 6, 11, 13, 19, 34, 35, 46, 49, 51, 70, 77, 86, 96, 222, 256, 300, 337 💬
4 Acetic acid C-11 1件: 11C-acetate---3件: 13, 86, 88 💬
5 Acetylsalicylic acid 2件: Acetylsalicylic acid; Aspirin1件: Aspirin 💬 2件: PTGS1,
PTGS2 💬 		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬15件: 13, 22, 34, 46, 49, 51, 64, 86, 96, 97, 113, 158, 210, 231, 271 💬
6 Activated charcoal 2件: Activated charcoal; Carbon1件: Charcoal, activated 💬 --11件: 6, 13, 51, 62, 85, 86, 97, 149, 158, 235, 298 💬
7 Albuterol 2件: Albuterol; Salbutamol2件: Albuterol sulfate ,
Albuterol 💬 		1件: ADRB2 💬 11件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬16件: 2, 3, 11, 12, 13, 85, 86, 89, 111, 113, 228, 231, 256, 273, 299, 340 💬
8 Alunacedase alfa 0件: ---1件: 86 💬
9 Ambrisentan 1件: Ambrisentan1件: Ambrisentan 💬 1件: EDNRA 💬 7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬8件: 51, 66, 84, 85, 86, 88, 210, 211 💬
10 Aminohippuric acid 1件: Aminohippurate2件: Aminohippurate sodium ,
Aminohippuric acid 💬 		--2件: 67, 86 💬
11 Anakinra 1件: Anakinra1件: Anakinra 💬 2件: IL1R1,
IL1R2 💬 		15件: Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬19件: 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 84, 86, 97, 106, 107, 266, 299 💬
12 Anastrozole 1件: Anastrozole1件: Anastrozole 💬 1件: CYP19A 💬 2件: Ovarian steroidogenesis, Steroid hormone biosynthesis 💬3件: 78, 86, 193 💬
13 Apabetalone 1件: Apabetalone1件: Apabetalone 💬 --1件: 86 💬
14 Apelin 1件: Apelin---1件: 86 💬
15 Artesunate 1件: Artesunate1件: Artesunate 💬 --5件: 18, 66, 85, 86, 96 💬
16 AV-101 1件: AV-101---2件: 6, 86 💬
17 Aviptadil 1件: Aviptadil1件: Aviptadil 💬 --4件: 49, 51, 84, 86 💬
18 Bardoxolone 0件: 1件: Bardoxolone 💬 --7件: 66, 67, 84, 85, 86, 218, 222 💬
19 Bardoxolone methyl 1件: Bardoxolone methyl1件: Bardoxolone methyl 💬 --7件: 66, 67, 84, 85, 86, 218, 222 💬
20 Benzbromarone 1件: Benzbromarone1件: Benzbromarone 💬 --1件: 86 💬
21 Beraprost 2件: Beraprost; Beraprost sodium2件: Beraprost sodium ,
Beraprost 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 86 💬
22 BIA 1件: BIA---3件: 6, 86, 299 💬
23 Bisoprolol 2件: Bisoprolol; Bisoprolol fumarate2件: Bisoprolol fumarate ,
Bisoprolol 💬 		1件: ADRB1 💬 13件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 58, 67, 86, 113 💬
24 Bosentan 2件: Bosentan; Bosentan monohydrate2件: Bosentan ,
Bosentan 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬11件: 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
25 Calcifediol 1件: Calcifediol1件: Calcifediol 💬 1件: VDR 💬 5件: Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬2件: 86, 113 💬
26 Capsaicin 1件: Capsaicin1件: Capsaicin 💬 1件: TRPV1 💬 2件: Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬4件: 2, 6, 86, 226 💬
27 Captopril 1件: Captopril1件: Captopril 💬 1件: ACE 💬 6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬7件: 17, 46, 86, 96, 97, 107, 271 💬
28 Carbon monoxide 1件: Carbon monoxide1件: Carbon monoxide 💬 --4件: 13, 85, 86, 298 💬
29 Carvedilol 1件: Carvedilol2件: Carvedilol ,
Carvedilol phosphate 💬 		5件: ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬 		15件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 6, 46, 57, 86, 113, 210 💬
30 Cetuximab 1件: Cetuximab1件: Cetuximab 💬 1件: EGFR 💬 47件: Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Virion - Hepatitis viruses 💬5件: 34, 51, 86, 89, 331 💬
31 Chlorhexidine 2件: Chlorhexidine; Chlorhexidine gluconate4件: Chlorhexidine gluconate ,
Chlorhexidine hydrochloride ,
Chlorhexidine ,
Chlorhexidine acetate 💬 		--2件: 86, 299 💬
32 Cicletanine 2件: Cicletanine; Cicletanine hydrochloride2件: Cicletanine ,
Cicletanine hydrochloride 💬 		--1件: 86 💬
33 Clopidogrel 1件: Clopidogrel4件: Clopidogrel bisulfate ,
Clopidogrel ,
Clopidogrel hydrochloride ,
Clopidogrel besilate 💬 		1件: P2RY12 💬 3件: Efferocytosis, Neuroactive ligand signaling, Platelet activation 💬4件: 40, 49, 51, 86 💬
34 CXA-10 1件: CXA-10---2件: 86, 222 💬
35 D-glucose 1件: D-glucose---2件: 86, 88 💬
36 Dapagliflozin 1件: Dapagliflozin1件: Dapagliflozin 💬 --13件: 6, 19, 28, 49, 66, 67, 86, 88, 97, 210, 215, 218, 222 💬
37 Dichloroacetic acid 1件: Dichloroacetate1件: Sodium dichloroacetate 💬 3件: PDK2_3_4,
PDK2_3_4,
PDK2_3_4 💬 		1件: Diabetic cardiomyopathy 💬2件: 21, 86 💬
38 Diltiazem 2件: Diltiazem; Diltiazem hydrochloride3件: Diltiazem hydrochloride ,
Diltiazem malate ,
Diltiazem 💬 		4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 51, 58, 86, 88 💬
39 Dimethyl fumarate 2件: Dimethyl fumarate; Dimethylfumarat1件: Dimethyl fumarate 💬 1件: KLHL19 💬 6件: Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬6件: 13, 20, 49, 51, 86, 296 💬
40 Diphenhydramine 2件: Diphenhydramine; Diphenhydramine hydrochloride4件: Diphenhydramine ,
Diphenhydramine hydrochloride ,
Diphenhydramine salicylate ,
Diphenhydramine citrate 💬 		1件: HRH1 💬 4件: Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction 💬11件: 11, 13, 19, 49, 51, 70, 86, 96, 222, 256, 300 💬
41 Dobutamine 2件: Dobutamin; Dobutamine3件: Dobutamine hydrochloride ,
Dobutamine ,
Dobutamine tartrate 💬 		1件: ADRB1 💬 13件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 57, 58, 86, 215 💬
42 Elafin 1件: Elafin---1件: 86 💬
43 Empagliflozin 1件: Empagliflozin1件: Empagliflozin 💬 --13件: 46, 58, 65, 67, 72, 77, 86, 96, 97, 113, 257, 298, 299 💬
44 Epicatechin 1件: Epicatechin---2件: 86, 113 💬
45 Epoprostenol 3件: Epoprostenol; Epoprostenol sodium; Prostacyclin2件: Epoprostenol ,
Epoprostenol sodium 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 86 💬
46 Esomeprazole 3件: Esomeprazole; Esomeprazole magnesium; Omeprazole5件: Esomeprazole magnesium ,
Esomeprazole sodium ,
Esomeprazole ,
Esomeprazole strontium ,
Esomeprazole magnesium dihydrate 💬 		2件: ATP4A,
ATP4B 💬 		3件: Collecting duct acid secretion, Gastric acid secretion, Oxidative phosphorylation 💬10件: 6, 13, 46, 86, 98, 107, 113, 234, 298, 299 💬
47 Esuberaprost 1件: Esuberaprost2件: Esuberaprost ,
Esuberaprost sodium 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 86 💬
48 Famotidine 2件: Famotidina; Famotidine1件: Famotidine 💬 1件: HRH2 💬 4件: Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction 💬7件: 6, 46, 61, 86, 98, 145, 300 💬
49 Ferric carboxymaltose 1件: Ferric carboxymaltose1件: Ferric carboxymaltose 💬 --4件: 86, 96, 97, 299 💬
50 Fluoxetine 3件: Fluoxetine; Fluoxetine hydrochloride; Fluoxétine2件: Fluoxetine ,
Fluoxetine hydrochloride 💬 		1件: SLC6A4 💬 3件: Neuroactive ligand signaling, Serotonergic synapse, Synaptic vesicle cycle 💬3件: 13, 17, 86 💬
51 Fulvestrant 1件: Fulvestrant1件: Fulvestrant 💬 2件: ESR1,
ESR2 💬 		10件: Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Estrogen signaling pathway, GnRH secretion, Hormone signaling, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬1件: 86 💬
52 Furosemide 1件: Furosemide1件: Furosemide 💬 1件: SLC12A2 💬 3件: Pancreatic secretion, Salivary secretion, Vibrio cholerae infection 💬3件: 6, 77, 86 💬
53 Gadolinium 1件: Gadolinium---7件: 13, 34, 46, 65, 77, 86, 305 💬
54 GSK2256098 1件: GSK2256098---1件: 86 💬
55 Human interleukin-6 2件: IL-6; Interleukin-6---6件: 46, 49, 51, 70, 86, 107 💬
56 Hydroxyurea 1件: Hydroxyurea1件: Hydroxyurea 💬 1件: RRM2 💬 5件: Drug metabolism - other enzymes, Glutathione metabolism, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway 💬10件: 3, 13, 19, 20, 46, 65, 85, 86, 107, 284 💬
57 IKT-001Pro 1件: IKT-001PRO---1件: 86 💬
58 Iloprost 1件: Iloprost2件: Iloprost ,
Iloprost tromethamine 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬4件: 51, 84, 85, 86 💬
59 Imatinib 2件: Imatinib; Imatinib mesylate2件: Imatinib mesylate ,
Imatinib 💬 		3件: ABL1,
KIT,
PDGFRA 💬 		31件: Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
60 JTT-251 1件: JTT-251---1件: 86 💬
61 Levocarnitine 3件: Carnitine; L-carnitine; Levocarnitine2件: Levocarnitine chloride ,
Levocarnitine 💬 		--11件: 2, 3, 13, 46, 53, 58, 86, 96, 97, 240, 265 💬
62 Lidocaine 2件: Lidocaine; Lidocaine hydrochloride3件: Lidocaine ,
Lidocaine hydrochloride ,
Lidocaine hydrochloride monohydrate 💬 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬 		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬14件: 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
63 Lisuride 1件: Lisuride1件: Lisuride 💬 3件: DRD2,
DRD3,
DRD4 💬 		10件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬2件: 6, 86 💬
64 Macitentan 1件: Macitentan1件: Macitentan 💬 2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬5件: 51, 85, 86, 88, 210 💬
65 Medical air 1件: Medical AIR1件: Air, medical 💬 --6件: 58, 85, 86, 97, 193, 299 💬
66 Melatonin 1件: Melatonin1件: Melatonin 💬 2件: MTNR1A,
MTNR1B 💬 		2件: Circadian entrainment, Neuroactive ligand-receptor interaction 💬17件: 2, 6, 8, 13, 37, 46, 49, 72, 78, 86, 90, 96, 97, 145, 149, 202, 265 💬
67 Metformin 3件: Metformin; Metformin hydrochloride; Metformina2件: Metformin hydrochloride ,
Metformin 💬 		2件: PRKAA,
PRKAA 💬 		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬28件: 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
68 Methylprednisolone 3件: Methylprednisolon; Methylprednisolone; Methylprednisolone acetate2件: Methylprednisolone ,
Methylprednisolone acetate 💬 		1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 127, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 💬
69 Morphine 3件: Morphine; Morphine hydrochloride; Morphine sulfate4件: Morphine sulfate ,
Morphine hydrochloride hydrate ,
Morphine ,
Morphine tartrate 💬 		1件: OPRM1 💬 5件: Estrogen signaling pathway, Hormone signaling, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction 💬6件: 36, 46, 70, 85, 86, 298 💬
70 Moxifloxacin 2件: Moxifloxacin; Moxifloxacin hydrochloride3件: Moxifloxacin hydrochloride ,
Moxifloxacin ,
Moxifloxacin hydrochloride monohydrate 💬 		--9件: 2, 6, 46, 49, 85, 86, 113, 240, 299 💬
71 Nicardipine 1件: Nicardipine2件: Nicardipine hydrochloride ,
Nicardipine 💬 		4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 70, 86 💬
72 Nilotinib 2件: Nilotinib; Nilotinib hydrochloride monohydrate1件: Nilotinib 💬 4件: ABL1,
KIT,
PDGFRA,
PDGFRB 💬 		32件: Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬5件: 6, 8, 34, 51, 86 💬
73 Nitric Oxide 1件: Nitric oxide1件: Nitric oxide 💬 --9件: 51, 85, 86, 88, 97, 210, 251, 294, 299 💬
74 Olaparib 1件: Olaparib1件: Olaparib 💬 2件: PARP1,
PARP2 💬 		5件: Apoptosis, Base excision repair, Diabetic cardiomyopathy, NF-kappa B signaling pathway, Necroptosis 💬2件: 86, 285 💬
75 Oxygen 1件: Oxygen1件: Oxygen 💬 --18件: 6, 19, 22, 49, 70, 85, 86, 88, 96, 97, 149, 168, 211, 235, 271, 298, 299, 330 💬
76 PF-00489791 1件: PF-00489791---1件: 86 💬
77 Pioglitazone 1件: Pioglitazone2件: Pioglitazone hydrochloride ,
Pioglitazone 💬 		1件: NR1C3 💬 12件: AMPK signaling pathway, Efferocytosis, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 81, 86, 96, 220, 229, 265, 298, 299 💬
78 PLX-PAD 1件: PLX-PAD---1件: 86 💬
79 Prasterone 3件: Dehydroepiandrosterone; Dhea; Prasterone1件: Prasterone 💬 3件: AR,
ESR1,
ESR2 💬 		12件: Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Estrogen signaling pathway, GnRH secretion, Hormone signaling, Oocyte meiosis, Pathways in cancer, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬6件: 49, 53, 83, 86, 96, 113 💬
80 Prednisone 2件: Prednisona; Prednisone1件: Prednisone 💬 1件: NR3C1 💬 1件: Neuroactive ligand-receptor interaction 💬54件: 2, 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 145, 162, 164, 205, 222, 224, 228, 251, 269, 283, 285, 288, 299, 300, 303, 307, 331 💬
81 Ralinepag 1件: Ralinepag1件: Ralinepag 💬 1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 86 💬
82 Ranolazine 1件: Ranolazine2件: Ranolazine ,
Ranolazine hydrochloride 💬 		--7件: 2, 58, 86, 96, 97, 113, 114 💬
83 Rifampin 2件: Rifampicin; Rifampin2件: Rifampin ,
Rifampicin sodium 💬 		--10件: 6, 13, 17, 46, 84, 86, 93, 97, 299, 338 💬
84 Riociguat 1件: Riociguat1件: Riociguat 💬 3件: GUCY1A,
GUCY1A,
GUCY1B 💬 		10件: Circadian entrainment, Gap junction, Long-term depression, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬6件: 51, 84, 86, 88, 225, 299 💬
85 Ritonavir 1件: Ritonavir1件: Ritonavir 💬 --3件: 2, 86, 265 💬
86 Rituximab 1件: Rituximab1件: Rituximab 💬 1件: MS4A1 💬 1件: Hematopoietic cell lineage 💬52件: 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 172, 220, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
87 Rodatristat 0件: 1件: Rodatristat 💬 1件: TPH1_2 💬 3件: Folate biosynthesis, Serotonergic synapse, Tryptophan metabolism 💬1件: 86 💬
88 Rodatristat ethyl 1件: Rodatristat ethyl1件: Rodatristat ethyl 💬 1件: TPH1_2 💬 3件: Folate biosynthesis, Serotonergic synapse, Tryptophan metabolism 💬1件: 86 💬
89 Sapropterin 4件: 6R-BH4; Sapropterin; Sapropterin dihydrochloride; Tetrahydrobiopterin2件: Sapropterin dihydrochloride ,
Sapropterin 💬 		--3件: 86, 124, 240 💬
90 Saquinavir 1件: Saquinavir2件: Saquinavir ,
Saquinavir mesylate 💬 		--2件: 86, 265 💬
91 Satralizumab 2件: Sapelizumab; Satralizumab1件: Satralizumab 💬 1件: IL6R 💬 11件: Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬4件: 11, 13, 86, 113 💬
92 Selexipag 1件: Selexipag1件: Selexipag 💬 1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬6件: 47, 51, 70, 84, 86, 88 💬
93 Selonsertib 1件: Selonsertib1件: Selonsertib 💬 1件: MAP3K5 💬 19件: Alcoholic liver disease, Alzheimer disease, Amyotrophic lateral sclerosis, Apoptosis, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Huntington disease, Lipid and atherosclerosis, MAPK signaling pathway, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Protein processing in endoplasmic reticulum, Sphingolipid signaling pathway, Spinocerebellar ataxia, TNF signaling pathway, Thermogenesis, Tight junction 💬1件: 86 💬
94 Seralutinib 1件: Seralutinib1件: Seralutinib 💬 2件: PDGFRA,
PDGFRB 💬 		20件: Calcium signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, Endocytosis, Focal adhesion, Gap junction, Glioma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton 💬1件: 86 💬
95 Serine 1件: Serine1件: Serine 💬 --1件: 86 💬
96 Sildenafil 3件: Sildenafil; Sildenafil citrate; Sildenafilo2件: Sildenafil citrate ,
Sildenafil 💬 		1件: PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway 💬14件: 6, 46, 51, 85, 86, 113, 210, 211, 212, 225, 226, 278, 294, 299 💬
97 Simvastatin 2件: Simvastatin; Simvastatine1件: Simvastatin 💬 1件: HMGCR 💬 3件: AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
98 Sirolimus 2件: Rapamycin; Sirolimus1件: Sirolimus 💬 1件: MTOR 💬 49件: AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬46件: 2, 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
99 Sitaxentan 3件: Sitaxentan; Sitaxentan sodium; Sitaxsentan2件: Sitaxentan ,
Sitaxentan sodium 💬 		1件: EDNRA 💬 7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 86 💬
100 Sodium dichloroacetate 1件: Dichloroacetate sodium---1件: 86 💬
101 Sorafenib 1件: Sorafenib2件: Sorafenib tosylate ,
Sorafenib 💬 		8件: BRAF,
FLT3,
FLT4,
KDR,
KIT,
PDGFRB,
RAF1,
RET 💬 		87件: Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, VEGF signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬2件: 34, 86 💬
102 Sotatercept 1件: Sotatercept1件: Sotatercept 💬 1件: ACVR2A 💬 4件: Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬2件: 86, 284 💬
103 Spironolactone 1件: Spironolactone1件: Spironolactone 💬 1件: NR3C2 💬 1件: Aldosterone-regulated sodium reabsorption 💬8件: 46, 58, 67, 86, 113, 210, 218, 225 💬
104 Sulfasalazine 4件: Salazosulfapyridine; Salicylazosulfapyridine; Sulfasalazin; Sulfasalazine1件: Sulfasalazine 💬 --8件: 46, 49, 54, 86, 94, 107, 270, 271 💬
105 Tadalafil 2件: Tadalafil; Tadalafilo1件: Tadalafil 💬 1件: PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway 💬8件: 6, 51, 75, 77, 84, 86, 113, 210 💬
106 Tamoxifen 2件: Tamoxifen; Tamoxifen citrate2件: Tamoxifen citrate ,
Tamoxifen 💬 		2件: ESR1,
ESR2 💬 		10件: Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Estrogen signaling pathway, GnRH secretion, Hormone signaling, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬4件: 2, 86, 113, 227 💬
107 Terguride 1件: Terguride1件: Terguride 💬 2件: DRD2,
PRL 💬 		14件: Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, Hormone signaling, JAK-STAT signaling pathway, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬2件: 51, 86 💬
108 Tezosentan 1件: Tezosentan---1件: 86 💬
109 Threonine 1件: Threonine1件: Threonine 💬 --3件: 86, 96, 97 💬
110 Tocilizumab 1件: Tocilizumab1件: Tocilizumab 💬 1件: IL6R 💬 11件: Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬24件: 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
111 Tolvaptan 1件: Tolvaptan1件: Tolvaptan 💬 1件: AVPR2 💬 4件: Hormone signaling, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬4件: 67, 72, 86, 225 💬
112 Treprostinil 3件: Treprostinil; Treprostinil diolamine; Treprostinil sodium3件: Treprostinil ,
Treprostinil monosodium salt ,
Treprostinil diolamine 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬5件: 51, 85, 86, 88, 210 💬
113 Treprostinil palmitil 1件: Treprostinil palmitil1件: Treprostinil palmitil 💬 1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 86 💬
114 Trimetazidine 2件: Trimetazidine; Trimetazidine dihydrochloride2件: Trimetazidine hydrochloride ,
Trimetazidine 💬 		--3件: 2, 58, 86 💬
115 Tyrosine 3件: Alanine; Propanoic acid; Tyrosine1件: Tyrosine 💬 --5件: 6, 75, 77, 86, 298 💬
116 Ubenimex 1件: Ubenimex1件: Ubenimex 💬 1件: ANPEP 💬 3件: Glutathione metabolism, Hematopoietic cell lineage, Renin-angiotensin system 💬1件: 86 💬
117 Ubidecarenone 2件: Coenzyme Q10; COQ101件: Ubidecarenone 💬 --14件: 2, 5, 6, 8, 10, 46, 57, 86, 96, 107, 113, 193, 214, 215 💬
118 Udenafil 1件: Udenafil1件: Udenafil 💬 1件: PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway 💬2件: 86, 210 💬
119 Ularitide 1件: Ularitide---1件: 86 💬
120 Valsartan 1件: Valsartan1件: Valsartan 💬 1件: AGTR1 💬 17件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hormone signaling, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬8件: 57, 58, 66, 75, 86, 210, 222, 224 💬
121 Vardenafil 1件: Vardenafil2件: Vardenafil ,
Vardenafil hydrochloride 💬 		1件: PDE5 💬 2件: Purine metabolism, cGMP-PKG signaling pathway 💬3件: 13, 86, 299 💬
122 Vasoactive intestinal peptide 0件: ---3件: 49, 51, 86 💬
123 Vasomera 0件: ---1件: 86 💬
124 Vericiguat 1件: Vericiguat1件: Vericiguat 💬 3件: GUCY1A,
GUCY1A,
GUCY1B 💬 		10件: Circadian entrainment, Gap junction, Long-term depression, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 86 💬
125 Warfarin 3件: Warfarin; Warfarin potassium; Warfarin sodium3件: Warfarin sodium ,
Warfarin potassium ,
Warfarin 💬 		2件: NQO1,
VKORC1 💬 		5件: Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬12件: 6, 8, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
126 Zamicastat 1件: Zamicastat---1件: 86 💬