17. Multiple system atrophy Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 171 / Drugs : 202 - (DrugBank : 51) / Drug target genes : 58 - Drug target pathways : 114
Multiple system atrophy and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 17 | Multiple system atrophy | - |
| 6 | Parkinson disease | 56.028 |
| 2 | Amyotrophic lateral sclerosis | 42.107 |
| 5 | Progressive supranuclear palsy | 41.368 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 39.616 |
| 206 | Fragile X syndrome | 36.430 |
| 8 | Huntington disease | 34.119 |
| 46 | Malignant rheumatoid arthritis | 27.900 |
| 18 | Spinocerebellar degeneration | 27.605 |
| 97 | Ulcerative colitis | 27.480 |
| 140 | Dorabe syndrome | 26.929 |
| 156 | Rett syndrome | 25.596 |
| 3 | Spinal muscular atrophy | 24.672 |
| 96 | Crohn disease | 24.407 |
| 70 | Spinal stenosis | 24.163 |
| 22 | Moyamoya disease | 23.419 |
| 193 | Prader-Willi syndrome | 22.437 |
| 201 | Angelman syndrome | 22.000 |
| 21 | Mitochondrial disease | 19.334 |
| 144 | Lennox-Gastaut syndrome | 18.998 |
| 205 | Fragile X syndrome related disease | 18.797 |
| 152 | PCDH19-related syndrome | 16.000 |
| 296 | Biliary atresia | 14.811 |
| 158 | Tuberous sclerosis | 14.239 |
| 203 | 22q11.2 deletion syndrome | 14.000 |
| 98 | Eosinophilic gastro-intestinal disorder | 13.115 |
| 145 | West syndrome | 12.458 |
| 36 | Epidermolysis bullosa | 12.044 |
| 272 | Fibrodysplasia ossificans progressiva | 11.460 |
| 4 | Primary lateral sclerosis | 11.161 |
| 75 | Cushing disease | 10.894 |
| 155 | Acquired aphasia with convulsive disorder | 10.709 |
| 231 | Alpha-1-antitrypsin deficiency | 10.694 |
| 34 | Neurofibromatosis | 10.553 |
| 215 | Tetralogy of Fallot | 10.158 |
| 113 | Muscular dystrophy | 10.131 |
| 84 | Sarcoidosis | 9.836 |
| 169 | Menkes disease | 9.000 |
| 170 | Occipital horn syndrome | 9.000 |
| 127 | Frontotemporal lobar degeneration | 7.930 |
| 298 | Hereditary pancreatitis | 7.760 |
| 118 | Myelomeningocele | 6.225 |
| 86 | Pulmonary arterial hypertension | 6.085 |
| 57 | Idiopathic dilated cardiomyopathy | 5.623 |
| 85 | Idiopathic interstitial pneumonia | 4.739 |
| 78 | Hypopituitarism | 4.238 |
| 7 | Corticobasal degeneration | 4.197 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 3.902 |
| 299 | Cystic fibrosis | 3.566 |
| 11 | Myasthenia gravis | 3.497 |
| 49 | Systemic lupus erythematosus | 3.375 |
| 278 | Huge lymphatic malformation with cervicofacial lesion | 3.252 |
| 288 | Autoimmune acquired coagulation factor deficiency | 3.213 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 90 | Retinitis pigmentosa | 2.737 |
| 167 | Marfan syndrome | 2.705 |
| 67 | Polycystic kidney disease | 2.513 |
| 226 | Interstitial cystitis with Hunners ulcer | 2.407 |
| 309 | Progressive myoclonus epilepsy | 2.287 |
| 58 | Hypertrophic cardiomyopathy | 2.208 |
| 210 | Single Ventricle | 2.159 |
| 164 | Oculocutaneous albinism | 2.079 |
| 66 | IgA nephropathy | 2.043 |
| 120 | Hereditary dystonia | 2.000 |
| 179 | Williams syndrome | 1.923 |
| 157 | Sturge-Weber syndrome | 1.859 |
| 74 | Prolactin secreting pituitary adenoma | 1.844 |
| 254 | Porphyria | 1.618 |
| 218 | Alport syndrome | 1.574 |
| 19 | Lysosomal storage disease | 1.432 |
| 212 | Tricuspid atresia | 1.217 |
| 222 | Primary nephrotic syndrome | 1.122 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 111 | Congenital myopathy | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |