19. Lysosomal storage disease Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 990 / Drugs : 584 - (DrugBank : 126) / Drug target genes : 62 - Drug target pathways : 192
Lysosomal storage disease and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 19 | Lysosomal storage disease | - |
| 96 | Crohn disease | 23.620 |
| 13 | Multiple sclerosis | 22.227 |
| 46 | Malignant rheumatoid arthritis | 18.854 |
| 284 | Diamond-Blackfan anemia | 15.581 |
| 49 | Systemic lupus erythematosus | 15.449 |
| 65 | Primary immunodeficiency | 14.478 |
| 285 | Fanconi anemia | 13.952 |
| 60 | Aplastic anemia | 13.696 |
| 6 | Parkinson disease | 12.038 |
| 283 | Acquired pure red cell aplasia | 11.520 |
| 20 | Adrenoleukodystrophy | 11.265 |
| 53 | Sjogren syndrome | 10.962 |
| 41 | Giant cell arteritis | 10.788 |
| 66 | IgA nephropathy | 10.411 |
| 55 | Relapsing polychondritis | 10.229 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 10.069 |
| 326 | Osteopetrosis | 9.522 |
| 164 | Oculocutaneous albinism | 9.494 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 8.981 |
| 36 | Epidermolysis bullosa | 8.633 |
| 222 | Primary nephrotic syndrome | 8.622 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 8.575 |
| 224 | Purpura nephritis | 8.534 |
| 107 | Juvenile idiopathic arthritis | 8.377 |
| 95 | Autoimmune hepatitis | 8.348 |
| 93 | Primary biliary cholangitis | 8.292 |
| 286 | Hereditary sideroblastic anemia | 8.000 |
| 299 | Cystic fibrosis | 7.957 |
| 40 | Takayasu arteritis | 7.936 |
| 50 | Dermatomyositis | 7.807 |
| 42 | Polyarteritis nodosa | 7.725 |
| 51 | Scleroderma | 7.547 |
| 2 | Amyotrophic lateral sclerosis | 7.449 |
| 11 | Myasthenia gravis | 7.174 |
| 85 | Idiopathic interstitial pneumonia | 7.115 |
| 97 | Ulcerative colitis | 7.061 |
| 162 | Pemphigoid | 6.606 |
| 86 | Pulmonary arterial hypertension | 6.366 |
| 56 | Behcet disease | 6.259 |
| 75 | Cushing disease | 6.101 |
| 26 | HTLV-1-associated myelopathy | 6.059 |
| 226 | Interstitial cystitis with Hunners ulcer | 6.012 |
| 151 | Rasmussen encephalitis | 6.000 |
| 61 | Autoimmune hemolytic anemia | 5.822 |
| 28 | Systemic amyloidosis | 5.208 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 274 | Osteogenesis Imperfecta | 4.969 |
| 228 | Bronchiolitis obliterans | 4.836 |
| 39 | Toxic epidermal necrolysis | 4.713 |
| 38 | Stevens-Johnson syndrome | 4.700 |
| 35 | Pemphigus | 4.375 |
| 84 | Sarcoidosis | 4.122 |
| 113 | Muscular dystrophy | 4.103 |
| 160 | Congenital ichthyosis | 4.071 |
| 43 | Microscopic polyangiitis | 3.855 |
| 300 | IgG4-related disease | 3.645 |
| 269 | Pyogenic arthritis | 3.645 |
| 44 | Wegener granulomatosis | 3.622 |
| 98 | Eosinophilic gastro-intestinal disorder | 3.535 |
| 271 | Ankylosing spondylitis | 3.535 |
| 64 | Thrombotic thrombocytopenic purpura | 3.462 |
| 270 | Chronic recurrent multifocal osteomyelitis | 2.744 |
| 94 | Primary sclerosing cholangitis | 2.252 |
| 296 | Biliary atresia | 2.185 |
| 63 | Idiopathic thrombocytopenic purpura | 2.185 |
| 256 | Muscle glycogenosis | 2.130 |
| 331 | Idiopathic multicentric castleman disease | 2.130 |
| 58 | Hypertrophic cardiomyopathy | 2.106 |
| 257 | Hepatic glycogenosis | 2.000 |
| 139 | Congenital cerebral hypomyelination | 2.000 |
| 298 | Hereditary pancreatitis | 1.995 |
| 158 | Tuberous sclerosis | 1.968 |
| 227 | Osler disease | 1.951 |
| 16 | Crow-Fukase syndrome | 1.852 |
| 15 | Inclusion body myositis | 1.602 |
| 254 | Porphyria | 1.583 |
| 218 | Alport syndrome | 1.565 |
| 17 | Multiple system atrophy | 1.432 |
| 172 | Hypophosphatasia | 1.353 |
| 80 | Resistance to thyroid hormone | 1.353 |
| 90 | Retinitis pigmentosa | 1.193 |
| 57 | Idiopathic dilated cardiomyopathy | 1.087 |
| 106 | Cryopyrin-associated periodic syndrome | 1.029 |
| 91 | Budd-Chiari syndrome | 1.029 |
| 238 | Vitamin D-resistant rickets | 1.029 |
| 235 | Hypoparathyroidism | 1.029 |
| 5 | Progressive supranuclear palsy | 1.027 |
| 70 | Spinal stenosis | 1.020 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 191 | Werner syndrome | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |