222. Primary nephrotic syndrome Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 576 / Drugs : 519 - (DrugBank : 130) / Drug target genes : 108 - Drug target pathways : 219
Primary nephrotic syndrome and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 222 | Primary nephrotic syndrome | - |
| 13 | Multiple sclerosis/Neuromyelitis optica | 26.997 |
| 46 | Malignant rheumatoid arthritis | 19.418 |
| 85 | Idiopathic interstitial pneumonia | 19.374 |
| 51 | Scleroderma | 18.802 |
| 66 | IgA nephropathy | 18.088 |
| 49 | Systemic lupus erythematosus | 16.573 |
| 65 | Primary immunodeficiency | 16.466 |
| 2 | Amyotrophic lateral sclerosis | 13.337 |
| 96 | Crohn disease | 12.441 |
| 58 | Hypertrophic cardiomyopathy | 12.158 |
| 164 | Oculocutaneous albinism | 12.029 |
| 6 | Parkinson disease | 11.301 |
| 50 | Dermatomyositis | 11.096 |
| 228 | Bronchiolitis obliterans | 11.055 |
| 113 | Muscular dystrophy | 10.131 |
| 97 | Ulcerative colitis | 10.098 |
| 107 | Juvenile idiopathic arthritis | 9.704 |
| 11 | Myasthenia gravis | 9.370 |
| 61 | Autoimmune hemolytic anemia | 9.254 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 9.103 |
| 284 | Diamond-Blackfan anemia | 8.815 |
| 19 | Lysosomal storage disease | 8.622 |
| 300 | IgG4-related disease | 8.596 |
| 224 | Purpura nephritis | 8.596 |
| 93 | Primary biliary cholangitis | 8.536 |
| 41 | Giant cell arteritis | 7.789 |
| 60 | Aplastic anemia | 7.728 |
| 86 | Pulmonary arterial hypertension | 7.595 |
| 283 | Acquired pure red cell aplasia | 7.494 |
| 84 | Sarcoidosis | 7.280 |
| 269 | Pyogenic arthritis | 7.213 |
| 95 | Autoimmune hepatitis | 7.204 |
| 285 | Fanconi anemia | 7.203 |
| 26 | HTLV-1-associated myelopathy | 7.187 |
| 34 | Neurofibromatosis | 7.134 |
| 55 | Relapsing polychondritis | 7.082 |
| 256 | Muscle glycogenosis | 7.060 |
| 102 | Rubinstein-Taybi syndrome | 7.000 |
| 162 | Pemphigoid | 6.800 |
| 53 | Sjogren syndrome | 6.773 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 6.284 |
| 274 | Osteogenesis Imperfecta | 6.260 |
| 331 | Idiopathic multicentric castleman disease | 6.092 |
| 151 | Rasmussen encephalitis | 6.000 |
| 89 | Lymphangioleiomyomatosis | 5.657 |
| 44 | Wegener granulomatosis | 5.621 |
| 90 | Retinitis pigmentosa | 5.484 |
| 20 | Adrenoleukodystrophy | 5.440 |
| 35 | Pemphigus | 5.440 |
| 271 | Ankylosing spondylitis | 5.182 |
| 160 | Congenital ichthyosis | 5.164 |
| 43 | Microscopic polyangiitis | 5.021 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 63 | Idiopathic thrombocytopenic purpura | 4.931 |
| 42 | Polyarteritis nodosa | 4.855 |
| 28 | Systemic amyloidosis | 4.785 |
| 233 | Wolfram syndrome | 4.747 |
| 39 | Toxic epidermal necrolysis | 4.747 |
| 56 | Behcet disease | 4.739 |
| 64 | Thrombotic thrombocytopenic purpura | 4.525 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 4.418 |
| 218 | Alport syndrome | 4.235 |
| 299 | Cystic fibrosis | 4.156 |
| 158 | Tuberous sclerosis | 4.028 |
| 127 | Frontotemporal lobar degeneration | 3.730 |
| 38 | Stevens-Johnson syndrome | 3.695 |
| 226 | Interstitial cystitis with Hunners ulcer | 3.533 |
| 36 | Epidermolysis bullosa | 3.346 |
| 286 | Hereditary sideroblastic anemia | 3.279 |
| 40 | Takayasu arteritis | 3.273 |
| 3 | Spinal muscular atrophy | 3.217 |
| 94 | Primary sclerosing cholangitis | 3.086 |
| 109 | Atypical hemolytic uremic syndrome | 3.000 |
| 210 | Single Ventricle | 2.787 |
| 227 | Osler disease | 2.689 |
| 5 | Progressive supranuclear palsy | 2.390 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 2.322 |
| 251 | Urea cycle disorder | 2.287 |
| 298 | Hereditary pancreatitis | 2.098 |
| 337 | Homocystinuria | 2.000 |
| 257 | Hepatic glycogenosis | 2.000 |
| 282 | Congenital dyserythropoietic anemia | 2.000 |
| 139 | Congenital cerebral hypomyelination | 2.000 |
| 98 | Eosinophilic gastro-intestinal disorder | 1.861 |
| 16 | Crow-Fukase syndrome | 1.859 |
| 326 | Osteopetrosis | 1.844 |
| 78 | Hypopituitarism | 1.789 |
| 215 | Tetralogy of Fallot | 1.685 |
| 225 | Congenital nephrogenic diabetes insipidus | 1.672 |
| 15 | Inclusion body myositis | 1.621 |
| 83 | Addison disease | 1.574 |
| 81 | Congenital adrenal hyperplasia | 1.508 |
| 67 | Polycystic kidney disease | 1.444 |
| 229 | Autoimmune pulmonary alveolar proteinosis | 1.355 |
| 80 | Resistance to thyroid hormone | 1.355 |
| 8 | Huntington disease | 1.320 |
| 212 | Tricuspid atresia | 1.217 |
| 17 | Multiple system atrophy | 1.122 |
| 75 | Cushing disease | 1.114 |
| 79 | Homozygous familial hypercholesterolemia | 1.098 |
| 288 | Autoimmune acquired coagulation factor deficiency | 1.093 |
| 106 | Cryopyrin-associated periodic syndrome | 1.033 |
| 71 | Idiopathic osteonecrosis of the femoral head | 1.033 |
| 167 | Marfan syndrome | 1.003 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 108 | TNF receptor-associated periodic syndrome | 1.000 |
| 267 | Hyper-IgD syndrome | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |