231. Alpha-1-antitrypsin deficiency Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 119 / Drugs : 126 - (DrugBank : 15) / Drug target genes : 33 - Drug target pathways : 42
Alpha-1-antitrypsin deficiency and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 231 | Alpha-1-antitrypsin deficiency | - |
| 6 | Parkinson disease | 29.724 |
| 97 | Ulcerative colitis | 28.225 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 26.198 |
| 70 | Spinal stenosis | 23.353 |
| 96 | Crohn disease | 23.333 |
| 298 | Hereditary pancreatitis | 22.594 |
| 46 | Malignant rheumatoid arthritis | 21.729 |
| 2 | Amyotrophic lateral sclerosis | 20.325 |
| 36 | Epidermolysis bullosa | 20.152 |
| 34 | Neurofibromatosis | 17.199 |
| 140 | Dorabe syndrome | 16.275 |
| 22 | Moyamoya disease | 16.208 |
| 144 | Lennox-Gastaut syndrome | 16.200 |
| 193 | Prader-Willi syndrome | 16.059 |
| 152 | PCDH19-related syndrome | 16.000 |
| 158 | Tuberous sclerosis | 15.029 |
| 156 | Rett syndrome | 14.891 |
| 84 | Sarcoidosis | 14.751 |
| 8 | Huntington disease | 14.700 |
| 201 | Angelman syndrome | 13.631 |
| 3 | Spinal muscular atrophy | 13.428 |
| 75 | Cushing disease | 12.976 |
| 205 | Fragile X syndrome related disease | 12.873 |
| 5 | Progressive supranuclear palsy | 12.853 |
| 296 | Biliary atresia | 12.754 |
| 272 | Fibrodysplasia ossificans progressiva | 12.659 |
| 21 | Mitochondrial disease | 12.605 |
| 145 | West syndrome | 12.461 |
| 206 | Fragile X syndrome | 12.171 |
| 155 | Acquired aphasia with convulsive disorder | 12.106 |
| 98 | Eosinophilic gastro-intestinal disorder | 10.704 |
| 17 | Multiple system atrophy | 10.694 |
| 18 | Spinocerebellar degeneration | 10.403 |
| 10 | Charcot-Marie-Tooth disease | 6.317 |
| 107 | Juvenile idiopathic arthritis | 5.934 |
| 1 | Spinal and bulbar muscular atrophy | 4.011 |
| 226 | Interstitial cystitis with Hunners ulcer | 3.973 |
| 256 | Muscle glycogenosis | 3.421 |
| 168 | Ehlers-Danlos syndrome | 3.095 |
| 86 | Pulmonary arterial hypertension | 2.916 |
| 51 | Scleroderma | 2.847 |
| 113 | Muscular dystrophy | 2.665 |
| 58 | Hypertrophic cardiomyopathy | 2.217 |
| 38 | Stevens-Johnson syndrome | 2.143 |
| 53 | Sjogren syndrome | 2.113 |
| 337 | Homocystinuria | 2.000 |
| 114 | Non-dystrophic myotonia syndrome | 1.905 |
| 28 | Systemic amyloidosis | 1.481 |
| 127 | Frontotemporal lobar degeneration | 1.250 |
| 251 | Urea cycle disorder | 1.057 |
| 111 | Congenital myopathy | 1.000 |