251. Urea cycle disorder Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 70 / Drugs : 76 - (DrugBank : 18) / Drug target genes : 2 - Drug target pathways : 4
Urea cycle disorder and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 251 | Urea cycle disorder | - |
| 300 | IgG4-related disease | 2.400 |
| 35 | Pemphigus | 2.352 |
| 271 | Ankylosing spondylitis | 2.305 |
| 78 | Hypopituitarism | 2.301 |
| 11 | Myasthenia gravis | 2.300 |
| 107 | Juvenile idiopathic arthritis | 2.293 |
| 298 | Hereditary pancreatitis | 2.292 |
| 3 | Spinal muscular atrophy | 2.292 |
| 113 | Muscular dystrophy | 2.288 |
| 222 | Primary nephrotic syndrome | 2.287 |
| 226 | Interstitial cystitis with Hunners ulcer | 2.285 |
| 70 | Spinal stenosis | 2.284 |
| 65 | Primary immunodeficiency | 2.275 |
| 299 | Cystic fibrosis | 2.273 |
| 86 | Pulmonary arterial hypertension | 2.272 |
| 51 | Scleroderma | 2.270 |
| 49 | Systemic lupus erythematosus | 2.270 |
| 97 | Ulcerative colitis | 2.266 |
| 96 | Crohn disease | 2.263 |
| 46 | Malignant rheumatoid arthritis | 2.262 |
| 6 | Parkinson disease | 2.262 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 2.258 |
| 337 | Homocystinuria | 2.000 |
| 22 | Moyamoya disease | 1.071 |
| 225 | Congenital nephrogenic diabetes insipidus | 1.067 |
| 256 | Muscle glycogenosis | 1.065 |
| 210 | Single Ventricle | 1.062 |
| 231 | Alpha-1-antitrypsin deficiency | 1.057 |
| 158 | Tuberous sclerosis | 1.057 |
| 296 | Biliary atresia | 1.044 |
| 21 | Mitochondrial disease | 1.043 |
| 58 | Hypertrophic cardiomyopathy | 1.042 |
| 206 | Fragile X syndrome | 1.037 |
| 5 | Progressive supranuclear palsy | 1.031 |
| 28 | Systemic amyloidosis | 1.030 |
| 34 | Neurofibromatosis | 1.023 |
| 2 | Amyotrophic lateral sclerosis | 1.012 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |
| 245 | Propionic acidemia | 1.000 |