28. Systemic amyloidosis Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 335 / Drugs : 274 - (DrugBank : 86) / Drug target genes : 47 - Drug target pathways : 165
Systemic amyloidosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 28 | Systemic amyloidosis | - |
| 46 | Malignant rheumatoid arthritis | 32.822 |
| 51 | Scleroderma | 26.066 |
| 85 | Idiopathic interstitial pneumonia | 25.587 |
| 34 | Neurofibromatosis | 22.759 |
| 2 | Amyotrophic lateral sclerosis | 20.774 |
| 13 | Multiple sclerosis | 19.622 |
| 49 | Systemic lupus erythematosus | 17.943 |
| 56 | Behcet disease | 16.296 |
| 26 | HTLV-1-associated myelopathy | 15.825 |
| 42 | Polyarteritis nodosa | 15.357 |
| 65 | Primary immunodeficiency | 14.795 |
| 96 | Crohn disease | 13.610 |
| 6 | Parkinson disease | 13.337 |
| 38 | Stevens-Johnson syndrome | 13.265 |
| 11 | Myasthenia gravis | 12.256 |
| 228 | Bronchiolitis obliterans | 12.050 |
| 331 | Idiopathic multicentric castleman disease | 11.300 |
| 127 | Frontotemporal lobar degeneration | 10.800 |
| 86 | Pulmonary arterial hypertension | 10.560 |
| 93 | Primary biliary cholangitis | 10.509 |
| 60 | Aplastic anemia | 9.487 |
| 266 | Familial mediterranean fever | 9.036 |
| 113 | Muscular dystrophy | 8.903 |
| 58 | Hypertrophic cardiomyopathy | 8.849 |
| 107 | Juvenile idiopathic arthritis | 8.505 |
| 227 | Osler disease | 8.461 |
| 53 | Sjogren syndrome | 8.280 |
| 61 | Autoimmune hemolytic anemia | 7.989 |
| 210 | Single Ventricle | 7.795 |
| 164 | Oculocutaneous albinism | 7.512 |
| 283 | Acquired pure red cell aplasia | 7.435 |
| 97 | Ulcerative colitis | 7.267 |
| 285 | Fanconi anemia | 7.084 |
| 36 | Epidermolysis bullosa | 6.957 |
| 226 | Interstitial cystitis with Hunners ulcer | 6.909 |
| 162 | Pemphigoid | 6.673 |
| 41 | Giant cell arteritis | 6.673 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 6.635 |
| 284 | Diamond-Blackfan anemia | 6.417 |
| 35 | Pemphigus | 6.417 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 6.229 |
| 39 | Toxic epidermal necrolysis | 6.083 |
| 151 | Rasmussen encephalitis | 6.000 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 5.657 |
| 20 | Adrenoleukodystrophy | 5.372 |
| 19 | Lysosomal storage disease | 5.208 |
| 16 | Crow-Fukase syndrome | 5.000 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 95 | Autoimmune hepatitis | 4.909 |
| 222 | Primary nephrotic syndrome | 4.785 |
| 224 | Purpura nephritis | 4.719 |
| 66 | IgA nephropathy | 4.714 |
| 286 | Hereditary sideroblastic anemia | 4.636 |
| 50 | Dermatomyositis | 4.636 |
| 84 | Sarcoidosis | 4.216 |
| 168 | Ehlers-Danlos syndrome | 4.182 |
| 8 | Huntington disease | 4.176 |
| 40 | Takayasu arteritis | 4.025 |
| 70 | Spinal stenosis | 3.967 |
| 89 | Lymphangioleiomyomatosis | 3.818 |
| 300 | IgG4-related disease | 3.663 |
| 269 | Pyogenic arthritis | 3.663 |
| 256 | Muscle glycogenosis | 3.484 |
| 64 | Thrombotic thrombocytopenic purpura | 3.480 |
| 326 | Osteopetrosis | 3.480 |
| 299 | Cystic fibrosis | 3.409 |
| 55 | Relapsing polychondritis | 3.273 |
| 298 | Hereditary pancreatitis | 3.116 |
| 57 | Idiopathic dilated cardiomyopathy | 2.946 |
| 63 | Idiopathic thrombocytopenic purpura | 2.782 |
| 1 | Spinal and bulbar muscular atrophy | 2.689 |
| 158 | Tuberous sclerosis | 2.577 |
| 10 | Charcot-Marie-Tooth disease | 2.479 |
| 25 | Progressive multifocal leukoencephalopathy | 2.390 |
| 160 | Congenital ichthyosis | 2.364 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 2.304 |
| 87 | Pulmonary veno-occlusive disease | 2.284 |
| 274 | Osteogenesis Imperfecta | 2.029 |
| 169 | Menkes disease | 1.912 |
| 170 | Occipital horn syndrome | 1.912 |
| 67 | Polycystic kidney disease | 1.895 |
| 114 | Non-dystrophic myotonia syndrome | 1.662 |
| 288 | Autoimmune acquired coagulation factor deficiency | 1.662 |
| 15 | Inclusion body myositis | 1.609 |
| 193 | Prader-Willi syndrome | 1.601 |
| 94 | Primary sclerosing cholangitis | 1.595 |
| 231 | Alpha-1-antitrypsin deficiency | 1.481 |
| 43 | Microscopic polyangiitis | 1.316 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 1.316 |
| 90 | Retinitis pigmentosa | 1.213 |
| 144 | Lennox-Gastaut syndrome | 1.213 |
| 118 | Myelomeningocele | 1.210 |
| 22 | Moyamoya disease | 1.204 |
| 5 | Progressive supranuclear palsy | 1.049 |
| 106 | Cryopyrin-associated periodic syndrome | 1.030 |
| 251 | Urea cycle disorder | 1.030 |
| 235 | Hypoparathyroidism | 1.030 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |