6. Parkinson disease Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 2,817 / Drugs : 2,606 - (DrugBank : 348) / Drug target genes : 185 - Drug target pathways : 205
Parkinson disease and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 6 | Parkinson disease | - |
| 13 | Multiple sclerosis/Neuromyelitis optica | 139.526 |
| 2 | Amyotrophic lateral sclerosis | 85.629 |
| 97 | Ulcerative colitis | 79.226 |
| 46 | Malignant rheumatoid arthritis | 70.881 |
| 8 | Huntington disease | 64.162 |
| 96 | Crohn disease | 60.766 |
| 5 | Progressive supranuclear palsy | 60.082 |
| 17 | Multiple system atrophy | 56.028 |
| 206 | Fragile X syndrome | 50.607 |
| 70 | Spinal stenosis | 50.043 |
| 21 | Mitochondrial disease | 47.000 |
| 140 | Dorabe syndrome | 46.266 |
| 156 | Rett syndrome | 43.883 |
| 193 | Prader-Willi syndrome | 42.594 |
| 3 | Spinal muscular atrophy | 41.411 |
| 144 | Lennox-Gastaut syndrome | 38.939 |
| 86 | Pulmonary arterial hypertension | 38.700 |
| 296 | Biliary atresia | 38.150 |
| 298 | Hereditary pancreatitis | 36.742 |
| 18 | Spinocerebellar degeneration | 36.501 |
| 226 | Interstitial cystitis with Hunners ulcer | 36.228 |
| 84 | Sarcoidosis | 35.677 |
| 158 | Tuberous sclerosis | 35.000 |
| 299 | Cystic fibrosis | 33.579 |
| 36 | Epidermolysis bullosa | 31.194 |
| 113 | Muscular dystrophy | 29.859 |
| 231 | Alpha-1-antitrypsin deficiency | 29.724 |
| 127 | Frontotemporal lobar degeneration | 28.239 |
| 22 | Moyamoya disease | 28.000 |
| 34 | Neurofibromatosis | 26.227 |
| 85 | Idiopathic interstitial pneumonia | 24.240 |
| 145 | West syndrome | 23.394 |
| 98 | Eosinophilic gastro-intestinal disorder | 23.236 |
| 201 | Angelman syndrome | 22.000 |
| 90 | Retinitis pigmentosa | 21.490 |
| 78 | Hypopituitarism | 20.639 |
| 51 | Scleroderma | 20.573 |
| 107 | Juvenile idiopathic arthritis | 20.545 |
| 205 | Fragile X syndrome related disease | 19.669 |
| 58 | Hypertrophic cardiomyopathy | 19.292 |
| 272 | Fibrodysplasia ossificans progressiva | 19.011 |
| 4 | Primary lateral sclerosis | 19.000 |
| 152 | PCDH19-related syndrome | 16.000 |
| 75 | Cushing disease | 15.946 |
| 11 | Myasthenia gravis | 15.366 |
| 256 | Muscle glycogenosis | 14.982 |
| 65 | Primary immunodeficiency | 14.888 |
| 215 | Tetralogy of Fallot | 14.374 |
| 203 | 22q11.2 deletion syndrome | 14.000 |
| 67 | Polycystic kidney disease | 13.821 |
| 49 | Systemic lupus erythematosus | 13.668 |
| 28 | Systemic amyloidosis | 13.337 |
| 19 | Lysosomal storage disease | 12.038 |
| 155 | Acquired aphasia with convulsive disorder | 11.826 |
| 222 | Primary nephrotic syndrome | 11.301 |
| 89 | Lymphangioleiomyomatosis | 11.273 |
| 63 | Idiopathic thrombocytopenic purpura | 11.051 |
| 233 | Wolfram syndrome | 11.000 |
| 26 | HTLV-1-associated myelopathy | 10.460 |
| 265 | Lipodystrophy | 10.370 |
| 66 | IgA nephropathy | 10.094 |
| 38 | Stevens-Johnson syndrome | 9.753 |
| 254 | Porphyria | 9.179 |
| 169 | Menkes disease | 9.000 |
| 170 | Occipital horn syndrome | 9.000 |
| 271 | Ankylosing spondylitis | 8.869 |
| 149 | Hemiconvulsion hemiplegia epilepsy syndrome | 8.696 |
| 50 | Dermatomyositis | 8.681 |
| 162 | Pemphigoid | 8.459 |
| 118 | Myelomeningocele | 8.000 |
| 53 | Sjogren syndrome | 7.821 |
| 164 | Oculocutaneous albinism | 7.286 |
| 57 | Idiopathic dilated cardiomyopathy | 7.149 |
| 179 | Williams syndrome | 7.149 |
| 102 | Rubinstein-Taybi syndrome | 7.000 |
| 283 | Acquired pure red cell aplasia | 6.973 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 6.973 |
| 288 | Autoimmune acquired coagulation factor deficiency | 6.973 |
| 81 | Congenital adrenal hyperplasia | 6.858 |
| 95 | Autoimmune hepatitis | 6.639 |
| 41 | Giant cell arteritis | 6.540 |
| 167 | Marfan syndrome | 6.468 |
| 225 | Congenital nephrogenic diabetes insipidus | 6.143 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 5.940 |
| 10 | Charcot-Marie-Tooth disease | 5.911 |
| 20 | Adrenoleukodystrophy | 5.822 |
| 224 | Purpura nephritis | 5.572 |
| 56 | Behcet disease | 5.269 |
| 236 | Pseudohypoparathyroidism | 5.266 |
| 285 | Fanconi anemia | 5.260 |
| 64 | Thrombotic thrombocytopenic purpura | 5.251 |
| 61 | Autoimmune hemolytic anemia | 5.200 |
| 42 | Polyarteritis nodosa | 5.025 |
| 157 | Sturge-Weber syndrome | 5.000 |
| 278 | Huge lymphatic malformation with cervicofacial lesion | 5.000 |
| 12 | Congenital myasthenic syndrome | 5.000 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 294 | Congenital diaphragmatic hernia | 5.000 |
| 1 | Spinal and bulbar muscular atrophy | 4.978 |
| 228 | Bronchiolitis obliterans | 4.851 |
| 35 | Pemphigus | 4.836 |
| 227 | Osler disease | 4.648 |
| 60 | Aplastic anemia | 4.645 |
| 93 | Primary biliary cholangitis | 4.618 |
| 40 | Takayasu arteritis | 4.319 |
| 331 | Idiopathic multicentric castleman disease | 4.318 |
| 210 | Single Ventricle | 4.204 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 4.192 |
| 151 | Rasmussen encephalitis | 4.189 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 4.103 |
| 168 | Ehlers-Danlos syndrome | 4.064 |
| 7 | Corticobasal degeneration | 4.064 |
| 309 | Progressive myoclonus epilepsy | 4.000 |
| 72 | Pituitary ADH secretion disorder | 4.000 |
| 246 | Methylmalonic acidemia | 3.945 |
| 284 | Diamond-Blackfan anemia | 3.936 |
| 274 | Osteogenesis Imperfecta | 3.630 |
| 39 | Toxic epidermal necrolysis | 3.360 |
| 74 | Prolactin secreting pituitary adenoma | 3.209 |
| 286 | Hereditary sideroblastic anemia | 3.175 |
| 55 | Relapsing polychondritis | 3.096 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 3.096 |
| 171 | Wilson disease | 3.000 |
| 310 | Congenital anomalies syndrome | 3.000 |
| 229 | Autoimmune pulmonary alveolar proteinosis | 3.000 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 114 | Non-dystrophic myotonia syndrome | 2.882 |
| 88 | Chronic thromboembolic pulmonary hypertension | 2.872 |
| 218 | Alport syndrome | 2.695 |
| 300 | IgG4-related disease | 2.515 |
| 269 | Pyogenic arthritis | 2.515 |
| 326 | Osteopetrosis | 2.370 |
| 87 | Pulmonary veno-occlusive disease | 2.262 |
| 251 | Urea cycle disorder | 2.262 |
| 202 | Smith-Magenis syndrome | 2.262 |
| 160 | Congenital ichthyosis | 2.128 |
| 212 | Tricuspid atresia | 2.043 |
| 77 | Growth hormone secreting pituitary adenoma | 2.000 |
| 337 | Homocystinuria | 2.000 |
| 263 | Cerebrotendinous xanthomatosis | 2.000 |
| 257 | Hepatic glycogenosis | 2.000 |
| 282 | Congenital dyserythropoietic anemia | 2.000 |
| 307 | Canavan disease | 2.000 |
| 120 | Hereditary dystonia | 2.000 |
| 43 | Microscopic polyangiitis | 1.871 |
| 124 | Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy | 1.524 |
| 15 | Inclusion body myositis | 1.509 |
| 230 | Alveolar hypoventilation syndrome | 1.485 |
| 94 | Primary sclerosing cholangitis | 1.414 |
| 187 | Kabuki syndrome | 1.340 |
| 44 | Wegener granulomatosis | 1.292 |
| 301 | Macular dystrophy | 1.032 |
| 333 | Hutchinson-Gilford syndrome | 1.011 |
| 91 | Budd-Chiari syndrome | 1.011 |
| 235 | Hypoparathyroidism | 1.011 |
| 71 | Idiopathic osteonecrosis of the femoral head | 1.011 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 111 | Congenital myopathy | 1.000 |
| 241 | Hypertyrosinemia type I | 1.000 |
| 52 | Mixed connective tissue disease | 1.000 |
| 290 | Chronic nonspecific multiple ulcers of the small intestine | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |