64. Thrombotic thrombocytopenic purpura Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 92 / Drugs : 85 - (DrugBank : 21) / Drug target genes : 18 - Drug target pathways : 76
Thrombotic thrombocytopenic purpura and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 64 | Thrombotic thrombocytopenic purpura | - |
| 63 | Idiopathic thrombocytopenic purpura | 9.800 |
| 60 | Aplastic anemia | 8.463 |
| 65 | Primary immunodeficiency | 7.983 |
| 49 | Systemic lupus erythematosus | 7.894 |
| 46 | Malignant rheumatoid arthritis | 7.767 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 7.705 |
| 285 | Fanconi anemia | 7.500 |
| 66 | IgA nephropathy | 6.075 |
| 283 | Acquired pure red cell aplasia | 5.778 |
| 53 | Sjogren syndrome | 5.707 |
| 299 | Cystic fibrosis | 5.432 |
| 51 | Scleroderma | 5.376 |
| 61 | Autoimmune hemolytic anemia | 5.280 |
| 96 | Crohn disease | 5.273 |
| 6 | Parkinson disease | 5.251 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 11 | Myasthenia gravis | 4.711 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 4.594 |
| 113 | Muscular dystrophy | 4.542 |
| 222 | Primary nephrotic syndrome | 4.525 |
| 151 | Rasmussen encephalitis | 4.427 |
| 85 | Idiopathic interstitial pneumonia | 4.323 |
| 284 | Diamond-Blackfan anemia | 4.315 |
| 39 | Toxic epidermal necrolysis | 4.295 |
| 2 | Amyotrophic lateral sclerosis | 4.186 |
| 55 | Relapsing polychondritis | 4.125 |
| 42 | Polyarteritis nodosa | 4.123 |
| 162 | Pemphigoid | 3.898 |
| 228 | Bronchiolitis obliterans | 3.898 |
| 41 | Giant cell arteritis | 3.898 |
| 274 | Osteogenesis Imperfecta | 3.857 |
| 93 | Primary biliary cholangitis | 3.850 |
| 56 | Behcet disease | 3.828 |
| 26 | HTLV-1-associated myelopathy | 3.788 |
| 38 | Stevens-Johnson syndrome | 3.750 |
| 269 | Pyogenic arthritis | 3.750 |
| 224 | Purpura nephritis | 3.750 |
| 286 | Hereditary sideroblastic anemia | 3.711 |
| 50 | Dermatomyositis | 3.637 |
| 226 | Interstitial cystitis with Hunners ulcer | 3.493 |
| 28 | Systemic amyloidosis | 3.480 |
| 19 | Lysosomal storage disease | 3.462 |
| 95 | Autoimmune hepatitis | 3.434 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 3.321 |
| 97 | Ulcerative colitis | 3.255 |
| 227 | Osler disease | 3.228 |
| 40 | Takayasu arteritis | 3.150 |
| 83 | Addison disease | 3.000 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 2.995 |
| 164 | Oculocutaneous albinism | 2.912 |
| 36 | Epidermolysis bullosa | 2.709 |
| 90 | Retinitis pigmentosa | 2.709 |
| 107 | Juvenile idiopathic arthritis | 2.683 |
| 326 | Osteopetrosis | 2.637 |
| 160 | Congenital ichthyosis | 2.517 |
| 288 | Autoimmune acquired coagulation factor deficiency | 2.517 |
| 20 | Adrenoleukodystrophy | 2.344 |
| 158 | Tuberous sclerosis | 2.054 |
| 58 | Hypertrophic cardiomyopathy | 1.921 |
| 76 | Pituitary gonadotropin secretion hyperthyroidism | 1.781 |
| 86 | Pulmonary arterial hypertension | 1.734 |
| 75 | Cushing disease | 1.194 |
| 72 | Pituitary ADH secretion disorder | 1.125 |
| 52 | Mixed connective tissue disease | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |