71. Idiopathic osteonecrosis of the femoral head Disease details / Clinical trials / Drug dev / DR info

Clinical trials : 45 /  Drugs : 49 - (DrugBank : 23) / Drug target genes : 15 - Drug target pathways : 40

Drugs, Primary sponsors and Trial info (Enrollment year, Phase, Trial ID, Countries)
15 ML bupivacaine HCL 0.25% injection
   Ataturk University
      2025   -   NCT07255768   Turkey (Türkiye)
20 ML bupivacaine 0.25% injection
   Ataturk University
      2025   -   NCT07255768   Turkey (Türkiye)
Acetate
   Asahikawa Medical University
      2012   -   JPRN-UMIN000009610   Japan
   Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University
      2014   Phase 2   JPRN-UMIN000008230   Japan
   Nakashima Yasuharu
      2014   Phase 2   JPRN-jRCTs071180052   -
Allogenic mesenchymal stem cells
   Enrique Gomez-Barrena
      2018   Phase 2   EUCTR2018-000886-35-ES   Spain
BM-mscs
   Enrique Gomez-Barrena
      2018   Phase 2   EUCTR2018-000886-35-ES   Spain
Bone marrow mononuclear cell infusion
   Jianming Tan
      2009   Phase 0   NCT00813267   China
Bupivacaine
   Dazhou Central Hospital
      2025   Phase 4   ChiCTR2500096425   China
Calcium
   Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University
      2014   Phase 2   JPRN-UMIN000008230   Japan
   Nakashima Yasuharu
      2014   Phase 2   JPRN-jRCTs071180052   -
Calcium carbonate
   the First Affiliated Hospital of Soochow University
      2024   Phase 0   ChiCTR2400084562   China
Calcium phosphate
   Chinese People's Liberation Army General Hospital
      2026   -   ChiCTR2600118059   China
      2026   Phase 0   ChiCTR2600117100   China
      2026   -   ChiCTR2600116823   China
Cholesterol
   Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School
      2016   -   JPRN-UMIN000020754   Japan
Clopidogrel
   Nakashima Yasuharu
      2014   Phase 2   JPRN-jRCTs071180052   -
Core decompression
   Affiliated Zhongshan Hospital of Dalian University
      2013   Phase 1 study   ChiCTR-TRC-13003238   China
   Ankara City Hospital Bilkent
      2025   -   NCT07560163   Turkey (Türkiye)
   Aviation General Hospital
      2020   Phase 0   ChiCTR2000034733   China
   Chinese People's Liberation Army General Hospital
      2026   Phase 0   ChiCTR2600117100   China
   West China Hospital, Sichuan University
      2023   -   ChiCTR2300073415   China
Core decompression/BMC implantation
   Erasme University Hospital
      2003   Phase 2   NCT02890537   Belgium
Core decompression/preob® implantation
   Bone Therapeutics S.A
      2011   Phase 3   NCT01529008   Belgium;France;Germany;Netherlands;United Kingdom
   Erasme University Hospital
      2003   Phase 2   NCT02890537   Belgium
Dexamethasone
   Dazhou Central Hospital
      2025   Phase 4   ChiCTR2500096425   China
Edoxaban
   Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
      2016   -   JPRN-UMIN000026819   Japan
Enoxaparin
   Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
      2016   -   JPRN-UMIN000026819   Japan
Gelatin
   Department of Orthopedic Surgery, Kyoto University Hospital
      2013   Phase 1,2   JPRN-UMIN000009250   Japan
   Haruhiko Akiyama, Gifu University Hospital
      2016   Phase 2   JPRN-UMIN000020340   Japan
Human mesenchymal stem cells
   Enrique Gomez-Barrena
      2018   Phase 2   EUCTR2018-000886-35-ES   Spain
Hyperbaric oxygen therapy
   Ankara City Hospital Bilkent
      2025   -   NCT07560163   Turkey (Türkiye)
   Yale University
      2026   -   NCT06931301   United States
Ixmyelocel-T
   Vericel Corporation
      2007   Phase 3   NCT00505219   United States
Lansoprazole
   Sapporo Medical University Hospital
      2016   Phase 2   JPRN-UMIN000032412   Japan
Magnesium
   Affiliated Zhongshan Hospital of Dalian University
      2013   Phase 1 study   ChiCTR-TRC-13003238   China
Mesenchymal stem cell infusion
   Jianming Tan
      2009   Phase 0   NCT00813267   China
Normal saline
   ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
      2023   Phase 1   NCT07545018   China
Ozone
   Aviation General Hospital
      2020   Phase 0   ChiCTR2000034733   China
      2013   -   ChiCTR1900023449   China
Parecoxib
   Peking Union Medical College Hospital
      2014   -   ChiCTR1800014846   China
Pitavastatin
   Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School
      2016   -   JPRN-UMIN000020754   Japan
   Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University
      2014   Phase 2   JPRN-UMIN000008230   Japan
   Nakashima Yasuharu
      2014   Phase 2   JPRN-jRCTs071180052   -
Preob® cells
   Bone Therapeutics S.A.
      2014   Phase 3   EUCTR2009-012929-11-GB   Belgium;Germany;United Kingdom
      2012   Phase 3   EUCTR2009-012929-11-DE   Belgium;Germany;United Kingdom
      2011   Phase 3   EUCTR2009-012929-11-BE   Belgium;Germany;United Kingdom
RAB001 400 µG/KG group
   ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
      2023   Phase 1   NCT07545018   China
RAB001 750 µG/KG group
   ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
      2023   Phase 1   NCT07545018   China
RAB001 high dose
   ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
      2024   Phase 2   NCT07471880   China
RAB001 LOW dose
   ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
      2024   Phase 2   NCT07471880   China
RAB001 medium dose
   ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
      2024   Phase 2   NCT07471880   China
Ropivacaine
   Dazhou Central Hospital
      2025   Phase 4   ChiCTR2500096425   China
Saline
   Peking Union Medical College Hospital
      2014   -   ChiCTR1800014846   China
Standard OF care only
   Vericel Corporation
      2007   Phase 3   NCT00505219   United States
Standard treatment
   Banc de Sang i Teixits
      2015   Phase 1/Phase 2   NCT01605383   Spain
Teriparatide
   Asahikawa Medical University
      2012   -   JPRN-UMIN000009610   Japan
Tocopherol
   Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University
      2014   Phase 2   JPRN-UMIN000008230   Japan
   Nakashima Yasuharu
      2014   Phase 2   JPRN-jRCTs071180052   -
Trafermin
   Haruhiko Akiyama, Gifu University Hospital
      2016   Phase 2   JPRN-UMIN000020340   Japan
XCEL-MT-osteo-alpha
   Banc de Sang i Teixits
      2015   Phase 1/Phase 2   NCT01605383   Spain