75. Cushing disease Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 231 / Drugs : 224 - (DrugBank : 47) / Drug target genes : 63 - Drug target pathways : 145
Cushing disease and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 75 | Cushing disease | - |
| 96 | Crohn disease | 22.933 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 19.479 |
| 205 | Fragile X syndrome related disease | 17.290 |
| 152 | PCDH19-related syndrome | 16.000 |
| 6 | Parkinson disease | 15.946 |
| 46 | Malignant rheumatoid arthritis | 14.969 |
| 201 | Angelman syndrome | 14.196 |
| 2 | Amyotrophic lateral sclerosis | 14.151 |
| 145 | West syndrome | 13.742 |
| 231 | Alpha-1-antitrypsin deficiency | 12.976 |
| 158 | Tuberous sclerosis | 12.976 |
| 193 | Prader-Willi syndrome | 12.831 |
| 97 | Ulcerative colitis | 12.689 |
| 36 | Epidermolysis bullosa | 11.982 |
| 98 | Eosinophilic gastro-intestinal disorder | 11.929 |
| 272 | Fibrodysplasia ossificans progressiva | 11.434 |
| 22 | Moyamoya disease | 10.912 |
| 17 | Multiple system atrophy | 10.894 |
| 155 | Acquired aphasia with convulsive disorder | 10.679 |
| 84 | Sarcoidosis | 10.669 |
| 298 | Hereditary pancreatitis | 10.547 |
| 206 | Fragile X syndrome | 10.459 |
| 18 | Spinocerebellar degeneration | 10.335 |
| 21 | Mitochondrial disease | 10.118 |
| 8 | Huntington disease | 9.677 |
| 3 | Spinal muscular atrophy | 9.564 |
| 296 | Biliary atresia | 9.323 |
| 140 | Dorabe syndrome | 9.031 |
| 70 | Spinal stenosis | 8.710 |
| 34 | Neurofibromatosis | 8.700 |
| 144 | Lennox-Gastaut syndrome | 8.005 |
| 5 | Progressive supranuclear palsy | 7.888 |
| 156 | Rett syndrome | 7.385 |
| 74 | Prolactin secreting pituitary adenoma | 6.855 |
| 19 | Lysosomal storage disease | 6.101 |
| 299 | Cystic fibrosis | 5.406 |
| 67 | Polycystic kidney disease | 5.379 |
| 49 | Systemic lupus erythematosus | 4.492 |
| 78 | Hypopituitarism | 3.519 |
| 81 | Congenital adrenal hyperplasia | 3.290 |
| 86 | Pulmonary arterial hypertension | 2.947 |
| 113 | Muscular dystrophy | 2.480 |
| 94 | Primary sclerosing cholangitis | 2.292 |
| 72 | Pituitary ADH secretion disorder | 2.286 |
| 37 | Generalised pustular psoriasis | 2.206 |
| 77 | Growth hormone secreting pituitary adenoma | 2.000 |
| 225 | Congenital nephrogenic diabetes insipidus | 1.665 |
| 233 | Wolfram syndrome | 1.619 |
| 218 | Alport syndrome | 1.573 |
| 187 | Kabuki syndrome | 1.355 |
| 265 | Lipodystrophy | 1.287 |
| 65 | Primary immunodeficiency | 1.273 |
| 64 | Thrombotic thrombocytopenic purpura | 1.194 |
| 51 | Scleroderma | 1.175 |
| 222 | Primary nephrotic syndrome | 1.114 |
| 301 | Macular dystrophy | 1.097 |
| 288 | Autoimmune acquired coagulation factor deficiency | 1.090 |
| 66 | IgA nephropathy | 1.060 |
| 238 | Vitamin D-resistant rickets | 1.032 |
| 235 | Hypoparathyroidism | 1.032 |
| 191 | Werner syndrome | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |