Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease - COVID-19, Pathways in cancer, Diabetic cardiomyopathy Valsartan 💬 Valsartan [8] 57, 58, 66, 75, 86, 210, 222, 224 💬
2 AVPR2 💬 [4] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vasopressin-regulated water reabsorption Desmopressin 💬 Desmopressin [6] 6, 64, 72, 75, 225, 288 💬
3 AVPR2 💬 [4] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Vasopressin-regulated water reabsorption Desmopressin acetate 💬 Desmopressin [6] 6, 64, 72, 75, 225, 288 💬
4 CRHR1 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Long-term depression, Cushing syndrome Corticorelin 💬 Corticorelin [2] 75, 205 💬
5 CRHR2 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Cushing syndrome Corticorelin 💬 Corticorelin [2] 75, 205 💬
6 CYP11A 💬 [5] Steroid hormone biosynthesis, Ovarian steroidogenesis, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome Levoketoconazole 💬 Levoketoconazole [1] 75 💬
7 CYP11B1 💬 [3] Steroid hormone biosynthesis, Cortisol synthesis and secretion, Cushing syndrome Levoketoconazole 💬 Levoketoconazole [1] 75 💬
8 CYP11B1 💬 [3] Steroid hormone biosynthesis, Cortisol synthesis and secretion, Cushing syndrome Metyrapone 💬 Metyrapone [1] 75 💬
9 CYP11B2 💬 [2] Steroid hormone biosynthesis, Aldosterone synthesis and secretion Osilodrostat 💬 Osilodrostat [1] 75 💬
10 CYP11B2 💬 [2] Steroid hormone biosynthesis, Aldosterone synthesis and secretion Osilodrostat phosphate 💬 Osilodrostat [1] 75 💬
11 CYP17A 💬 [5] Steroid hormone biosynthesis, Ovarian steroidogenesis, Prolactin signaling pathway, Cortisol synthesis and secretion, Cushing syndrome Levoketoconazole 💬 Levoketoconazole [1] 75 💬
12 CYP17A 💬 [5] Steroid hormone biosynthesis, Ovarian steroidogenesis, Prolactin signaling pathway, Cortisol synthesis and secretion, Cushing syndrome Abiraterone acetate 💬 Abiraterone [2] 75, 81 💬
13 DPP4 💬 [2] Virion - Hepatitis viruses, Protein digestion and absorption Sitagliptin phosphate 💬 Sitagliptin [5] 6, 75, 77, 233, 299 💬
14 DPP4 💬 [2] Virion - Hepatitis viruses, Protein digestion and absorption Sitagliptin 💬 Sitagliptin [5] 6, 75, 77, 233, 299 💬
15 DPP4 💬 [2] Virion - Hepatitis viruses, Protein digestion and absorption Sitagliptin phosphate 💬 Sitagliptin [5] 6, 75, 77, 233, 299 💬
16 DRD2 💬 [10] Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Cabergoline 💬 Cabergoline [4] 6, 74, 75, 77 💬
17 EGFR 💬 [47] Virion - Hepatitis viruses, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Coronavirus disease - COVID-19, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Lapatinib ditosylate 💬 Lapatinib [3] 34, 74, 75 💬
18 EGFR 💬 [47] Virion - Hepatitis viruses, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Coronavirus disease - COVID-19, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
19 EGFR 💬 [47] Virion - Hepatitis viruses, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Coronavirus disease - COVID-19, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Gefitinib 💬 Gefitinib [1] 75 💬
20 ERBB2 💬 [19] MAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Tight junction, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer, Breast cancer, Gastric cancer, Central carbon metabolism in cancer Lapatinib ditosylate 💬 Lapatinib [3] 34, 74, 75 💬
21 ERBB2 💬 [19] MAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Tight junction, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer, Breast cancer, Gastric cancer, Central carbon metabolism in cancer Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
22 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Dabigatran etexilate mesylate 💬 Dabigatran etexilate [2] 51, 75 💬
23 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Dabigatran 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
24 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Dabigatran etexilate 💬 Dabigatran etexilate [2] 51, 75 💬
25 F8 💬 [1] Complement and coagulation cascades Desmopressin acetate 💬 Desmopressin [6] 6, 64, 72, 75, 225, 288 💬
26 F8 💬 [1] Complement and coagulation cascades Desmopressin 💬 Desmopressin [6] 6, 64, 72, 75, 225, 288 💬
27 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronic acid 💬 Zoledronic acid [16] 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
28 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronate trisodium 💬 Zoledronic acid [16] 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
29 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronic acid hemipentahydrate 💬 Zoledronic acid [16] 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
30 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronic acid 💬 Zoledronic acid [16] 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
31 FDPS 💬 [3] Terpenoid backbone biosynthesis, Influenza A, Human T-cell leukemia virus 1 infection Zoledronate disodium 💬 Zoledronic acid [16] 5, 6, 13, 17, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
32 GABRA 💬 [7] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
33 GABRA 💬 [7] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
34 GABRA 💬 [7] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
35 GABRA 💬 [7] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
36 GABRA 💬 [7] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
37 GABRA 💬 [7] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
38 GABRB 💬 [7] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
39 GABRB 💬 [7] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
40 GABRB 💬 [7] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
41 GABRD 💬 [6] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
42 GABRE 💬 [6] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
43 GABRG 💬 [6] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
44 GABRG 💬 [6] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
45 GABRG 💬 [6] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
46 GABRP 💬 [6] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
47 GABRQ 💬 [6] Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Alprazolam 💬 Alprazolam [2] 8, 75 💬
48 GHR 💬 [6] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Somatropin 💬 Somatotropin [28] 2, 3, 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
49 GLP1R 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Insulin secretion Liraglutide 💬 Liraglutide [5] 6, 13, 75, 77, 193 💬
50 HDAC10 💬 [3] Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat [2] 75, 96 💬
51 HDAC10 💬 [3] Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Fimepinostat 💬 Fimepinostat [1] 75 💬
52 HDAC11 💬 [3] Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat [2] 75, 96 💬
53 HDAC1_2 💬 [18] ATP-dependent chromatin remodeling, Polycomb repressive complex, Cell cycle, Longevity regulating pathway - multiple species, Notch signaling pathway, TGF-beta signaling pathway, Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Huntington disease, Amphetamine addiction, Alcoholism, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Chronic myeloid leukemia Vorinostat 💬 Vorinostat [2] 75, 96 💬
54 HDAC1_2 💬 [18] ATP-dependent chromatin remodeling, Polycomb repressive complex, Cell cycle, Longevity regulating pathway - multiple species, Notch signaling pathway, TGF-beta signaling pathway, Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Huntington disease, Amphetamine addiction, Alcoholism, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Chronic myeloid leukemia Vorinostat 💬 Vorinostat [2] 75, 96 💬
55 HDAC1_2 💬 [18] ATP-dependent chromatin remodeling, Polycomb repressive complex, Cell cycle, Longevity regulating pathway - multiple species, Notch signaling pathway, TGF-beta signaling pathway, Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Huntington disease, Amphetamine addiction, Alcoholism, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Chronic myeloid leukemia Fimepinostat 💬 Fimepinostat [1] 75 💬
56 HDAC1_2 💬 [18] ATP-dependent chromatin remodeling, Polycomb repressive complex, Cell cycle, Longevity regulating pathway - multiple species, Notch signaling pathway, TGF-beta signaling pathway, Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Huntington disease, Amphetamine addiction, Alcoholism, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Chronic myeloid leukemia Fimepinostat 💬 Fimepinostat [1] 75 💬
57 HDAC3 💬 [4] Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat [2] 75, 96 💬
58 HDAC3 💬 [4] Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Alcoholism, Viral carcinogenesis Fimepinostat 💬 Fimepinostat [1] 75 💬
59 HDAC4_5 💬 [5] Apelin signaling pathway, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, MicroRNAs in cancer Vorinostat 💬 Vorinostat [2] 75, 96 💬
60 HDAC4_5 💬 [5] Apelin signaling pathway, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, MicroRNAs in cancer Vorinostat 💬 Vorinostat [2] 75, 96 💬
61 HDAC4_5 💬 [5] Apelin signaling pathway, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, MicroRNAs in cancer Fimepinostat 💬 Fimepinostat [1] 75 💬
62 HDAC4_5 💬 [5] Apelin signaling pathway, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, MicroRNAs in cancer Fimepinostat 💬 Fimepinostat [1] 75 💬
63 HDAC6 💬 [4] Neutrophil extracellular trap formation, Amyotrophic lateral sclerosis, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat [2] 75, 96 💬
64 HDAC6 💬 [4] Neutrophil extracellular trap formation, Amyotrophic lateral sclerosis, Alcoholism, Viral carcinogenesis Fimepinostat 💬 Fimepinostat [1] 75 💬
65 HDAC7 💬 [3] Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat [2] 75, 96 💬
66 HDAC7 💬 [3] Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Fimepinostat 💬 Fimepinostat [1] 75 💬
67 HDAC8 💬 [4] Cell cycle, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat [2] 75, 96 💬
68 HDAC8 💬 [4] Cell cycle, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Fimepinostat 💬 Fimepinostat [1] 75 💬
69 HDAC9 💬 [3] Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat [2] 75, 96 💬
70 HDAC9 💬 [3] Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Fimepinostat 💬 Fimepinostat [1] 75 💬
71 MC2R 💬 [6] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome Corticotropin, repository 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
72 MC2R 💬 [6] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome Corticotropin 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
73 NR1C3 💬 [12] PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Rosiglitazone maleate 💬 Rosiglitazone [6] 46, 75, 77, 97, 222, 265 💬
74 NR1C3 💬 [12] PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Rosiglitazone 💬 Rosiglitazone [6] 46, 75, 77, 97, 222, 265 💬
75 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Dexamethasone sodium phosphate 💬 Dexamethasone [25] 13, 14, 16, 19, 28, 35, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 296, 299, 331 💬
76 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Dexamethasone phosphate 💬 Dexamethasone [25] 13, 14, 16, 19, 28, 35, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 296, 299, 331 💬
77 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Dexamethasone 💬 Dexamethasone [25] 13, 14, 16, 19, 28, 35, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 296, 299, 331 💬
78 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Hydrocortisone 💬 Hydrocortisone [11] 6, 41, 46, 53, 75, 78, 81, 83, 97, 98, 299 💬
79 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Relacorilant 💬 Relacorilant [1] 75 💬
80 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Mifepristone 💬 Mifepristone [1] 75 💬
81 NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption Eplerenone 💬 Eplerenone [4] 75, 113, 210, 215 💬
82 PDE5 💬 [2] Purine metabolism, cGMP-PKG signaling pathway Tadalafil 💬 Tadalafil [8] 6, 51, 75, 77, 84, 86, 113, 210 💬
83 PGR 💬 [5] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical carcinogenesis - receptor activation, Breast cancer Mifepristone 💬 Mifepristone [1] 75 💬
84 PIK3C3 💬 [15] Inositol phosphate metabolism, Phosphatidylinositol signaling system, Autophagy - other, Autophagy - animal, Phagosome, Apelin signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Salmonella infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection Fimepinostat 💬 Fimepinostat [1] 75 💬
85 PML 💬 [7] Ubiquitin mediated proteolysis, Endocytosis, Influenza A, Herpes simplex virus 1 infection, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia Tretinoin 💬 Tretinoin [6] 2, 62, 63, 75, 94, 231 💬
86 PRKAA 💬 [20] FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin hydrochloride 💬 Metformin [28] 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
87 PRKAA 💬 [20] FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin [28] 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
88 PRKAA 💬 [20] FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin hydrochloride 💬 Metformin [28] 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
89 PRKAA 💬 [20] FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin [28] 2, 6, 8, 13, 46, 49, 60, 65, 66, 67, 75, 77, 81, 84, 86, 97, 113, 127, 158, 206, 218, 222, 225, 265, 285, 298, 299, 301 💬
90 PRL 💬 [6] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin signaling pathway Cabergoline 💬 Cabergoline [4] 6, 74, 75, 77 💬
91 RARA 💬 [5] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia Tretinoin 💬 Tretinoin [6] 2, 62, 63, 75, 94, 231 💬
92 RARB 💬 [4] Pathways in cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer Tretinoin 💬 Tretinoin [6] 2, 62, 63, 75, 94, 231 💬
93 RXRA 💬 [18] PPAR signaling pathway, Efferocytosis, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis Bexarotene 💬 Bexarotene [2] 13, 75 💬
94 RXRB 💬 [13] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis Bexarotene 💬 Bexarotene [2] 13, 75 💬
95 RXRG 💬 [13] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis Bexarotene 💬 Bexarotene [2] 13, 75 💬
96 SSTR1 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide diaspartate 💬 Pasireotide [4] 67, 74, 75, 77 💬
97 SSTR1 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide [4] 67, 74, 75, 77 💬
98 SSTR1 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide pamoate 💬 Pasireotide [4] 67, 74, 75, 77 💬
99 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide 💬 Octreotide [8] 67, 75, 77, 84, 85, 89, 193, 227 💬
100 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide pamoate 💬 Octreotide [8] 67, 75, 77, 84, 85, 89, 193, 227 💬
101 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Pasireotide 💬 Pasireotide [4] 67, 74, 75, 77 💬
102 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Edotreotide gallium Ga-68 💬 Dotatate gallium Ga-68 [4] 19, 75, 84, 238 💬
103 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide acetate 💬 Octreotide [8] 67, 75, 77, 84, 85, 89, 193, 227 💬
104 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Pasireotide diaspartate 💬 Pasireotide [4] 67, 74, 75, 77 💬
105 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Pasireotide pamoate 💬 Pasireotide [4] 67, 74, 75, 77 💬
106 SSTR2 💬 [5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide acetate 💬 Octreotide [8] 67, 75, 77, 84, 85, 89, 193, 227 💬
107 SSTR3 💬 [3] Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide diaspartate 💬 Pasireotide [4] 67, 74, 75, 77 💬
108 SSTR3 💬 [3] Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide [4] 67, 74, 75, 77 💬
109 SSTR3 💬 [3] Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide pamoate 💬 Pasireotide [4] 67, 74, 75, 77 💬
110 SSTR5 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide pamoate 💬 Pasireotide [4] 67, 74, 75, 77 💬
111 SSTR5 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide [4] 67, 74, 75, 77 💬
112 SSTR5 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Growth hormone synthesis, secretion and action Pasireotide diaspartate 💬 Pasireotide [4] 67, 74, 75, 77 💬
113 TNFSF11 💬 [8] Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Prolactin signaling pathway, Parathyroid hormone synthesis, secretion and action, Chemical carcinogenesis - receptor activation, Breast cancer, Rheumatoid arthritis Denosumab 💬 Denosumab [10] 46, 50, 70, 75, 77, 93, 95, 96, 274, 299 💬