| 1 | 
                
                    ODC1
                
             💬
 | [3]  Arginine and proline metabolism Arginine and proline metabolism, Glutathione metabolism, Metabolic pathways | Eflornithine 
                
                    Eflornithine
                
             💬
 | 
                
                    Eflornithine
                
             | [1]  65 65 💬
 | 
| 2 | 
                
                    OPRD1
                
             💬
 | [3]  cGMP-PKG signaling pathway cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction | Nalmefene 
                
                    Nalmefene
                
             💬
 | 
                
                    Nalmefene
                
             | [1]  6 6 💬
 | 
| 3 | 
                
                    OPRD1
                
             💬
 | [3]  cGMP-PKG signaling pathway cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction | Naltrexone 
                
                    Naltrexone
                
             💬
 | 
                
                    Naltrexone
                
             | [13]  6 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
 | 
| 4 | 
                
                    OPRD1
                
             💬
 | [3]  cGMP-PKG signaling pathway cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction | Oxycodone 
                
                    Oxycodone
                
             💬
 | 
                
                    Oxycodone
                
             | [5]  6 6, 13, 70, 226, 298 💬
 | 
| 5 | 
                
                    OPRD1
                
             💬
 | [3]  cGMP-PKG signaling pathway cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction | Loperamide 
                
                    Loperamide
                
             💬
 | 
                
                    Loperamide
                
             | [2]  13 13, 97 💬
 | 
| 6 | 
                
                    OPRD1
                
             💬
 | [3]  cGMP-PKG signaling pathway cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction | Nalbuphine 
                
                    Nalbuphine
                
             💬
 | 
                
                    Nalbuphine
                
             | [1]  85 85 💬
 | 
| 7 | 
                
                    OPRD1
                
             💬
 | [3]  cGMP-PKG signaling pathway cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction | Naloxone 
                
                    Naloxone
                
             💬
 | 
                
                    Naloxone
                
             | [2]  6 6, 226 💬
 | 
| 8 | 
                
                    OPRK1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Dezocine 
                
                    Dezocine
                
             💬
 | 
                
                    Dezocine
                
             | [1]  46 46 💬
 | 
| 9 | 
                
                    OPRK1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Nalmefene 
                
                    Nalmefene
                
             💬
 | 
                
                    Nalmefene
                
             | [1]  6 6 💬
 | 
| 10 | 
                
                    OPRK1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Naltrexone 
                
                    Naltrexone
                
             💬
 | 
                
                    Naltrexone
                
             | [13]  6 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
 | 
| 11 | 
                
                    OPRK1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Oxycodone 
                
                    Oxycodone
                
             💬
 | 
                
                    Oxycodone
                
             | [5]  6 6, 13, 70, 226, 298 💬
 | 
| 12 | 
                
                    OPRK1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Buprenorphine 
                
                    Buprenorphine
                
             💬
 | 
                
                    Buprenorphine
                
             | [2]  46 46, 70 💬
 | 
| 13 | 
                
                    OPRK1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Loperamide 
                
                    Loperamide
                
             💬
 | 
                
                    Loperamide
                
             | [2]  13 13, 97 💬
 | 
| 14 | 
                
                    OPRK1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Nalbuphine 
                
                    Nalbuphine
                
             💬
 | 
                
                    Nalbuphine
                
             | [1]  85 85 💬
 | 
| 15 | 
                
                    OPRK1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Naloxone 
                
                    Naloxone
                
             💬
 | 
                
                    Naloxone
                
             | [2]  6 6, 226 💬
 | 
| 16 | 
                
                    OPRK1
                
             💬
 | [1]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction | Trimebutine 
                
                    Trimebutine
                
             💬
 | 
                
                    Trimebutine
                
             | [1]  51 51 💬
 | 
| 17 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Fentanyl 
                
                    Fentanyl
                
             💬
 | 
                
                    Fentanyl
                
             | [3]  46 46, 70, 215 💬
 | 
| 18 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Dezocine 
                
                    Dezocine
                
             💬
 | 
                
                    Dezocine
                
             | [1]  46 46 💬
 | 
| 19 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Nalmefene 
                
                    Nalmefene
                
             💬
 | 
                
                    Nalmefene
                
             | [1]  6 6 💬
 | 
| 20 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Naltrexone 
                
                    Naltrexone
                
             💬
 | 
                
                    Naltrexone
                
             | [13]  6 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
 | 
| 21 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Oxycodone 
                
                    Oxycodone
                
             💬
 | 
                
                    Oxycodone
                
             | [5]  6 6, 13, 70, 226, 298 💬
 | 
| 22 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Sufentanil 
                
                    Sufentanil
                
             💬
 | 
                
                    Sufentanil
                
             | [2]  70 70, 280 💬
 | 
| 23 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Buprenorphine 
                
                    Buprenorphine
                
             💬
 | 
                
                    Buprenorphine
                
             | [2]  46 46, 70 💬
 | 
| 24 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Dihydrocodeine 
                
                    Dihydrocodeine
                
             💬
 | 
                
                    Dihydrocodeine
                
             | [1]  310 310 💬
 | 
| 25 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Hydromorphone 
                
                    Hydromorphone
                
             💬
 | 
                
                    Hydromorphone
                
             | [1]  70 70 💬
 | 
| 26 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Loperamide 
                
                    Loperamide
                
             💬
 | 
                
                    Loperamide
                
             | [2]  13 13, 97 💬
 | 
| 27 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Morphine 
                
                    Morphine
                
             💬
 | 
                
                    Morphine
                
             | [5]  36 36, 46, 70, 85, 86 💬
 | 
| 28 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Nalbuphine 
                
                    Nalbuphine
                
             💬
 | 
                
                    Nalbuphine
                
             | [1]  85 85 💬
 | 
| 29 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Naloxone 
                
                    Naloxone
                
             💬
 | 
                
                    Naloxone
                
             | [2]  6 6, 226 💬
 | 
| 30 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Oxymorphone 
                
                    Oxymorphone
                
             💬
 | 
                
                    Oxymorphone
                
             | [1]  70 70 💬
 | 
| 31 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Remifentanil 
                
                    Remifentanil
                
             💬
 | 
                
                    Remifentanil
                
             | [2]  6 6, 70 💬
 | 
| 32 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Tramadol 
                
                    Tramadol
                
             💬
 | 
                
                    Tramadol
                
             | [5]  46 46, 70, 78, 226, 271 💬
 | 
| 33 | 
                
                    OPRM1
                
             💬
 | [3]  Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction | Trimebutine 
                
                    Trimebutine
                
             💬
 | 
                
                    Trimebutine
                
             | [1]  51 51 💬
 | 
| 34 | 
                
                    OXTR
                
             💬
 | [4]  Calcium signaling pathway Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway | Oxytocin 
                
                    Oxytocin
                
             💬
 | 
                
                    Oxytocin
                
             | [7]  6 6, 72, 127, 168, 193, 206, 226 💬
 | 
| 35 | 
                
                    OXTR
                
             💬
 | [4]  Calcium signaling pathway Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway | Atosiban 
                
                    Atosiban
                
             💬
 | 
                
                    Atosiban
                
             | [1]  118 118 💬
 |