Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 KCNA4 💬 [2] Cortisol synthesis and secretion, Cushing syndrome Dalfampridine 💬 Dalfampridine [5] 3, 4, 6, 13, 14 💬
2 KCNA4 💬 [2] Cortisol synthesis and secretion, Cushing syndrome Amifampridine 💬 Amifampridine [3] 3, 11, 12 💬
3 KCNC3 💬 [1] Spinocerebellar ataxia Dalfampridine 💬 Dalfampridine [5] 3, 4, 6, 13, 14 💬
4 KCNC3 💬 [1] Spinocerebellar ataxia Amifampridine 💬 Amifampridine [3] 3, 11, 12 💬
5 KCND2 💬 [1] Serotonergic synapse Dalfampridine 💬 Dalfampridine [5] 3, 4, 6, 13, 14 💬
6 KCND2 💬 [1] Serotonergic synapse Amifampridine 💬 Amifampridine [3] 3, 11, 12 💬
7 KCND3 💬 [1] Spinocerebellar ataxia Amiodarone 💬 Amiodarone [2] 28, 127 💬
8 KCND3 💬 [1] Spinocerebellar ataxia Dalfampridine 💬 Dalfampridine [5] 3, 4, 6, 13, 14 💬
9 KCND3 💬 [1] Spinocerebellar ataxia Amifampridine 💬 Amifampridine [3] 3, 11, 12 💬
10 KCNJ3 💬 [10] Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, GnRH secretion, Morphine addiction Amiodarone 💬 Amiodarone [2] 28, 127 💬
11 KCNJ5 💬 [9] Circadian entrainment, Retrograde endocannabinoid signaling, Serotonergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, Aldosterone synthesis and secretion, GnRH secretion, Morphine addiction Amiodarone 💬 Amiodarone [2] 28, 127 💬
12 KCNJ8 💬 [1] cGMP-PKG signaling pathway Amiodarone 💬 Amiodarone [2] 28, 127 💬
13 KCNJ11 💬 [3] Insulin secretion, GnRH secretion, Type II diabetes mellitus Diazoxide 💬 Diazoxide [2] 13, 193 💬
14 KCNJ11 💬 [3] Insulin secretion, GnRH secretion, Type II diabetes mellitus Minoxidil 💬 Minoxidil [1] 179 💬
15 KCNJ11 💬 [3] Insulin secretion, GnRH secretion, Type II diabetes mellitus Repaglinide 💬 Repaglinide [4] 6, 21, 46, 299 💬
16 KCNJ11 💬 [3] Insulin secretion, GnRH secretion, Type II diabetes mellitus Amiodarone 💬 Amiodarone [2] 28, 127 💬
17 KCNJ12 💬 [2] Cholinergic synapse, Oxytocin signaling pathway Amiodarone 💬 Amiodarone [2] 28, 127 💬
18 KCNQ1 💬 [6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection Amiodarone 💬 Amiodarone [2] 28, 127 💬
19 KCNQ1 💬 [6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection Ezogabine 💬 Ezogabine [2] 2, 144 💬
20 KCNQ2 💬 [1] Cholinergic synapse Ezogabine 💬 Ezogabine [2] 2, 144 💬
21 KCNQ3 💬 [1] Cholinergic synapse Ezogabine 💬 Ezogabine [2] 2, 144 💬
22 KDR 💬 [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Axitinib 💬 Axitinib [1] 34 💬
23 KDR 💬 [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Sorafenib 💬 Sorafenib [2] 34, 86 💬
24 KDR 💬 [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Sunitinib 💬 Sunitinib [2] 28, 34 💬
25 KDR 💬 [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Cediranib 💬 Cediranib [1] 34 💬
26 KDR 💬 [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Cabozantinib 💬 Cabozantinib [1] 34 💬
27 KDR 💬 [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Nintedanib 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
28 KDR 💬 [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis Tesevatinib 💬 Tesevatinib [1] 67 💬
29 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Dasatinib 💬 Dasatinib [2] 51, 85 💬
30 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Dasatinib 💬 Dasatinib [2] 51, 85 💬
31 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
32 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Sorafenib 💬 Sorafenib [2] 34, 86 💬
33 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Sunitinib 💬 Sunitinib [2] 28, 34 💬
34 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Nilotinib 💬 Nilotinib [5] 6, 8, 34, 51, 86 💬
35 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Masitinib 💬 Masitinib [6] 2, 5, 6, 13, 46, 96 💬
36 KIT 💬 [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer Pexidartinib 💬 Pexidartinib [1] 34 💬
37 KLKB1 💬 [1] Complement and coagulation cascades Conestat alfa 💬 Conestat alfa [1] 61 💬
38 KCNQ5 💬 [1] Cholinergic synapse Ezogabine 💬 Ezogabine [2] 2, 144 💬
39 KCNQ4 💬 [1] Cholinergic synapse Ezogabine 💬 Ezogabine [2] 2, 144 💬
40 KEAP1 💬 [6] Ubiquitin mediated proteolysis, Parkinson disease, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Dimethyl fumarate 💬 Dimethyl fumarate [5] 13, 49, 51, 86, 296 💬