Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Benazepril 💬 Benazepril [4] 49, 57, 218, 224 💬
2 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Captopril 💬 Captopril [8]  6 , 17, 46, 86, 96, 97, 107, 271 💬
3 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Cilazapril 💬 Cilazapril [1] 66 💬
4 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Cilazapril 💬 Cilazapril [1] 66 💬
5 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Enalapril 💬 Enalapril [6] 19, 46, 66, 113, 210, 222 💬
6 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Imidapril 💬 Imidapril [1] 67 💬
7 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Lisinopril 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬
8 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Lisinopril 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬
9 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Moexipril 💬 Moexipril [1] 93 💬
10 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Perindopril 💬 Perindopril [4] 58, 113, 167, 222 💬
11 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Quinapril 💬 Quinapril [1] 19 💬
12 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Ramipril 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬
13 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
14 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
15 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Candesartan 💬 Candesartan [2] 58, 67 💬
16 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Candesartan cilexetil 💬 Candesartan cilexetil [1] 67 💬
17 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
18 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
19 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
20 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Telmisartan 💬 Telmisartan [2] 66, 67 💬
21 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
22 Diabetic cardiomyopathy 💬
 [2] CPT1B, CPT2 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
23 Diabetic cardiomyopathy 💬
 [1] INSR 💬 Insulin detemir 💬 Insulin detemir [1] 299 💬
24 Diabetic cardiomyopathy 💬
 [1] INSR 💬 Insulin glargine 💬 Insulin glargine [1] 299 💬
25 Diabetic cardiomyopathy 💬
 [1] INSR 💬 Insulin human 💬 Insulin human [2] 96, 156 💬
26 Diabetic cardiomyopathy 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
27 Diabetic cardiomyopathy 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
28 Diabetic cardiomyopathy 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
29 Diabetic cardiomyopathy 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
30 Diabetic cardiomyopathy 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
31 Diabetic cardiomyopathy 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
32 Diabetic cardiomyopathy 💬
 [1] PARP1 💬 Olaparib 💬 Olaparib [2] 86, 285 💬
33 Diabetic cardiomyopathy 💬
 [3] PDK2, PDK3, PDK4 💬 Sodium dichloroacetate 💬 Sodium dichloroacetate [1] 86 💬
34 Diabetic cardiomyopathy 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
35 Diabetic cardiomyopathy 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
36 Diabetic cardiomyopathy 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
37 Diabetic cardiomyopathy 💬
 [1] PPARA 💬 Bezafibrate 💬 Bezafibrate [7] 20, 93, 94, 160, 296, 316, 324 💬
38 Diabetic cardiomyopathy 💬
 [1] PPARA 💬 Elafibranor 💬 Elafibranor [2] 93, 94 💬
39 Diabetic cardiomyopathy 💬
 [1] PPARA 💬 Fenofibrate 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
40 Diabetic cardiomyopathy 💬
 [1] PPARA 💬 Pemafibrate 💬 Pemafibrate [1] 93 💬
41 Diabetic cardiomyopathy 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
42 Diabetic cardiomyopathy 💬
 [1] PRKCD 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬
43 Diabetic cardiomyopathy 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
44 Diabetic cardiomyopathy 💬
 [1] REN 💬 Aliskiren 💬 Aliskiren [3] 66, 167, 222 💬
45 Diabetic cardiomyopathy 💬
 [3] TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab [3] 51, 85, 222 💬
46 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
47 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
48 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Bisoprolol 💬 Bisoprolol [4] 58, 67, 86, 113 💬
49 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Carvedilol 💬 Carvedilol [4] 57, 86, 113, 210 💬
50 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Celiprolol 💬 Celiprolol [1] 168 💬
51 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Dipivefrin 💬 Dipivefrin [1]  6  💬
52 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Dobutamine 💬 Dobutamine [4] 57, 58, 86, 215 💬
53 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Droxidopa 💬 Droxidopa [5]  5 ,  6 , 17, 169, 170 💬
54 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Ephedrine 💬 Ephedrine [1] 11 💬
55 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Epinephrine 💬 Epinephrine [3] 46, 70, 96 💬
56 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Esmolol 💬 Esmolol [1] 58 💬
57 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Metoprolol 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
58 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Nadolol 💬 Nadolol [1]  6  💬
59 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
60 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Noradrenaline 💬 Norepinephrine [2] 22, 296 💬
61 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
62 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Pseudoephedrine 💬 Pseudoephedrine [1] 17 💬
63 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Timolol 💬 Timolol [2] 157, 227 💬
64 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Timolol 💬 Timolol [2] 157, 227 💬
65 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
66 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
67 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
68 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
69 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
70 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
71 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
72 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
73 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
74 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
75 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
76 Dilated cardiomyopathy 💬
 [2] CACNA2D1, CACNA2D2 💬 Mirogabalin 💬 Mirogabalin [1] 70 💬
77 Dilated cardiomyopathy 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Gabapentin 💬 Gabapentin [5]  6 , 13, 19, 70, 298 💬
78 Dilated cardiomyopathy 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Pregabalin 💬 Pregabalin [5] 13, 36, 46, 70, 298 💬
79 Dilated cardiomyopathy 💬
 [1] DMD 💬 Casimersen 💬 Casimersen [1] 113 💬
80 Dilated cardiomyopathy 💬
 [1] DMD 💬 Drisapersen 💬 Drisapersen [1] 113 💬
81 Dilated cardiomyopathy 💬
 [1] DMD 💬 Eteplirsen 💬 Eteplirsen [1] 113 💬
82 Dilated cardiomyopathy 💬
 [1] DMD 💬 Golodirsen 💬 Golodirsen [1] 113 💬
83 Dilated cardiomyopathy 💬
 [1] DMD 💬 Viltolarsen 💬 Viltolarsen [1] 113 💬
84 Dilated cardiomyopathy 💬
 [1] ITGA4 💬 Firategrast 💬 Firategrast [1] 13 💬
85 Dilated cardiomyopathy 💬
 [1] ITGA4 💬 Natalizumab 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
86 Dilated cardiomyopathy 💬
 [2] ITGA4, ITGB7 💬 Abrilumab 💬 Abrilumab [2] 96, 97 💬
87 Dilated cardiomyopathy 💬
 [2] ITGA4, ITGB7 💬 Vedolizumab 💬 Vedolizumab [3] 94, 96, 97 💬
88 Dilated cardiomyopathy 💬
 [1] ITGB7 💬 Etrolizumab 💬 Etrolizumab [2] 96, 97 💬
89 Dilated cardiomyopathy 💬
 [1] MYH7 💬 Mavacamten 💬 Mavacamten [1] 58 💬
90 Dilated cardiomyopathy 💬
 [3] TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab [3] 51, 85, 222 💬
91 Dilated cardiomyopathy 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
92 Dilated cardiomyopathy 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
93 Dilated cardiomyopathy 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
94 Dilated cardiomyopathy 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
95 Dilated cardiomyopathy 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
96 Dilated cardiomyopathy 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
97 Dilated cardiomyopathy 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
98 Dilated cardiomyopathy 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
99 Dilated cardiomyopathy 💬
 [1] TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
100 Dilated cardiomyopathy 💬
 [1] TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
101 Dilated cardiomyopathy 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
102 DNA replication 💬
 [2] POLA1, POLA2 💬 Clofarabine 💬 Clofarabine [5] 19, 20, 60, 234, 326 💬
103 Dopaminergic synapse 💬
 [3] CACNA1B, CACNA1C, CACNA1D 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
104 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
105 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
106 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Isradipine 💬 Isradipine [1]  6  💬
107 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
108 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
109 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
110 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
111 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Propiverine 💬 Propiverine [1] 226 💬
112 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
113 Dopaminergic synapse 💬
 [7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
114 Dopaminergic synapse 💬
 [1] COMT 💬 Entacapone 💬 Entacapone [2]  6 , 17 💬
115 Dopaminergic synapse 💬
 [1] COMT 💬 Opicapone 💬 Opicapone [1]  6  💬
116 Dopaminergic synapse 💬
 [1] COMT 💬 Tolcapone 💬 Tolcapone [3]  6 , 28, 127 💬
117 Dopaminergic synapse 💬
 [1] DDC 💬 Benserazide 💬 Benserazide [1]  6  💬
118 Dopaminergic synapse 💬
 [1] DDC 💬 Carbidopa 💬 Carbidopa [7]  6 , 13, 17, 90, 140, 164, 201 💬
119 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 Apomorphine 💬 Apomorphine [3]  5 ,  6 ,  7  💬
120 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 Flupentixol 💬 Flupentixol [1] 97 💬
121 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 Pergolide 💬 Pergolide [1]  6  💬
122 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dexpramipexole 💬 Dexpramipexole [1]  2  💬
123 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopamine 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
124 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Foslevodopa 💬 Foslevodopa [1]  6  💬
125 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Levodopa 💬 Levodopa [6]  6 , 17, 90, 140, 164, 201 💬
126 Dopaminergic synapse 💬
 [2] DRD1, DRD5 💬 Tavapadon 💬 Tavapadon [1]  6  💬
127 Dopaminergic synapse 💬
 [1] DRD2 💬 Bromocriptine 💬 Bromocriptine [2]  6 , 74 💬
128 Dopaminergic synapse 💬
 [1] DRD2 💬 Buspirone 💬 Buspirone [2]  6 , 51 💬
129 Dopaminergic synapse 💬
 [1] DRD2 💬 Cabergoline 💬 Cabergoline [3]  6 , 74, 75 💬
130 Dopaminergic synapse 💬
 [1] DRD2 💬 Cariprazine 💬 Cariprazine [1] 21 💬
131 Dopaminergic synapse 💬
 [1] DRD2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
132 Dopaminergic synapse 💬
 [1] DRD2 💬 Domperidone 💬 Domperidone [5]  6 , 13, 17, 51, 230 💬
133 Dopaminergic synapse 💬
 [1] DRD2 💬 Domperidone maleate 💬 Domperidone [5]  6 , 13, 17, 51, 230 💬
134 Dopaminergic synapse 💬
 [1] DRD2 💬 Haloperidol 💬 Haloperidol [1]  8  💬
135 Dopaminergic synapse 💬
 [1] DRD2 💬 Iloperidone 💬 Iloperidone [1]  6  💬
136 Dopaminergic synapse 💬
 [1] DRD2 💬 Melperone 💬 Melperone [1]  6  💬
137 Dopaminergic synapse 💬
 [1] DRD2 💬 Metoclopramide 💬 Metoclopramide [2] 46, 51 💬
138 Dopaminergic synapse 💬
 [1] DRD2 💬 Pimozide 💬 Pimozide [1]  2  💬
139 Dopaminergic synapse 💬
 [1] DRD2 💬 Pridopidine 💬 Pridopidine [3]  2 ,  6 ,  8  💬
140 Dopaminergic synapse 💬
 [1] DRD2 💬 Quetiapine 💬 Quetiapine [2]  6 , 13 💬
141 Dopaminergic synapse 💬
 [1] DRD2 💬 Risperidone 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
142 Dopaminergic synapse 💬
 [1] DRD2 💬 Rotigotine 💬 Rotigotine [1]  6  💬
143 Dopaminergic synapse 💬
 [1] DRD2 💬 Sulpiride 💬 Sulpiride [2]  6 , 70 💬
144 Dopaminergic synapse 💬
 [1] DRD2 💬 Terguride 💬 Terguride [2] 51, 86 💬
145 Dopaminergic synapse 💬
 [1] DRD2 💬 Tiapride 💬 Tiapride [1]  8  💬
146 Dopaminergic synapse 💬
 [1] DRD2 💬 Trifluoperazine maleate 💬 Trifluoperazine [2] 283, 284 💬
147 Dopaminergic synapse 💬
 [1] DRD2 💬 Trifluoperazine 💬 Trifluoperazine [2] 283, 284 💬
148 Dopaminergic synapse 💬
 [2] DRD2, DRD3 💬 Aripiprazole 💬 Aripiprazole [2]  6 , 206 💬
149 Dopaminergic synapse 💬
 [2] DRD2, DRD3 💬 Pardoprunox 💬 Pardoprunox [1]  6  💬
150 Dopaminergic synapse 💬
 [2] DRD2, DRD3 💬 Piribedil 💬 Piribedil [1]  6  💬
151 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 Lisuride 💬 Lisuride [2]  6 , 86 💬
152 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 Olanzapine 💬 Olanzapine [2]  2 ,  8  💬
153 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 Pramipexole 💬 Pramipexole [3]  2 ,  6 , 20 💬
154 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 Ropinirole 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
155 Dopaminergic synapse 💬
 [1] DRD4 💬 Clozapine 💬 Clozapine [1]  6  💬
156 Dopaminergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
157 Dopaminergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
158 Dopaminergic synapse 💬
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
159 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Acamprosate 💬 Acamprosate [2]  6 , 206 💬
160 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Amantadine 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
161 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
162 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Esketamine 💬 Esketamine [3]  2 ,  4 , 70 💬
163 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Ketamine 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
164 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Latrepirdine 💬 Latrepirdine [1]  8  💬
165 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Memantine 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
166 Dopaminergic synapse 💬
 [3] KCNJ3, KCNJ5, SCN1A 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
167 Dopaminergic synapse 💬
 [1] MAOA 💬 Moclobemide 💬 Moclobemide [1]  6  💬
168 Dopaminergic synapse 💬
 [2] MAOA, MAOB 💬 Iproniazid 💬 Iproniazid [1]  6  💬
169 Dopaminergic synapse 💬
 [2] MAOA, MAOB 💬 Phenelzine 💬 Phenelzine [1]  6  💬
170 Dopaminergic synapse 💬
 [3] MAOA, MAOB, SLC6A3 💬 Phentermine 💬 Phentermine [1] 97 💬
171 Dopaminergic synapse 💬
 [1] MAOB 💬 Rasagiline 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
172 Dopaminergic synapse 💬
 [1] MAOB 💬 Rasagiline tartrate 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
173 Dopaminergic synapse 💬
 [1] MAOB 💬 Safinamide 💬 Safinamide [2]  6 , 17 💬
174 Dopaminergic synapse 💬
 [1] MAOB 💬 Selegiline 💬 Selegiline [1]  6  💬
175 Dopaminergic synapse 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
176 Dopaminergic synapse 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
177 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 Cyclosporine 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
178 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬
179 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
180 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
181 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬
182 Dopaminergic synapse 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
183 Dopaminergic synapse 💬
 [1] SCN1A 💬 Bupivacaine 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
184 Dopaminergic synapse 💬
 [1] SCN1A 💬 Carbamazepine 💬 Carbamazepine [3]  6 , 13, 231 💬
185 Dopaminergic synapse 💬
 [1] SCN1A 💬 Cifenline 💬 Cibenzoline [1] 58 💬
186 Dopaminergic synapse 💬
 [1] SCN1A 💬 Eleclazine 💬 Eleclazine [1] 58 💬
187 Dopaminergic synapse 💬
 [1] SCN1A 💬 Flecainide 💬 Flecainide [1]  6  💬
188 Dopaminergic synapse 💬
 [1] SCN1A 💬 Lamotrigine 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
189 Dopaminergic synapse 💬
 [1] SCN1A 💬 Levobupivacaine 💬 Levobupivacaine [1] 46 💬
190 Dopaminergic synapse 💬
 [1] SCN1A 💬 Lidocaine 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
191 Dopaminergic synapse 💬
 [1] SCN1A 💬 Lidocaine hydrochloride monohydrate 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
192 Dopaminergic synapse 💬
 [1] SCN1A 💬 Mexiletine 💬 Mexiletine [5]  1 ,  2 , 10, 113, 114 💬
193 Dopaminergic synapse 💬
 [1] SCN1A 💬 Oxcarbazepine 💬 Oxcarbazepine [1] 13 💬
194 Dopaminergic synapse 💬
 [1] SCN1A 💬 Oxybuprocaine 💬 Oxybuprocaine [1]  6  💬
195 Dopaminergic synapse 💬
 [1] SCN1A 💬 Phenytoin 💬 Phenytoin [1] 13 💬
196 Dopaminergic synapse 💬
 [1] SCN1A 💬 Quinidine 💬 Quinidine [3]  2 ,  8 , 13 💬
197 Dopaminergic synapse 💬
 [1] SCN1A 💬 Ropivacaine 💬 Ropivacaine [4] 22, 36, 46, 70 💬
198 Dopaminergic synapse 💬
 [1] SCN1A 💬 Rufinamide 💬 Rufinamide [1] 144 💬
199 Dopaminergic synapse 💬
 [1] SCN1A 💬 Zonisamide 💬 Zonisamide [1]  6  💬
200 Dopaminergic synapse 💬
 [1] SLC18A2 💬 Deutetrabenazine 💬 Deutetrabenazine [1]  8  💬
201 Dopaminergic synapse 💬
 [1] SLC18A2 💬 Tetrabenazine 💬 Tetrabenazine [1]  8  💬
202 Dopaminergic synapse 💬
 [1] SLC18A2 💬 Valbenazine 💬 Valbenazine [1]  8  💬
203 Dopaminergic synapse 💬
 [1] SLC6A3 💬 Armodafinil 💬 Armodafinil [3]  6 , 13, 84 💬
204 Dopaminergic synapse 💬
 [1] SLC6A3 💬 Bupropion 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
205 Dopaminergic synapse 💬
 [1] SLC6A3 💬 Lisdexamfetamine 💬 Lisdexamfetamine [1] 13 💬
206 Dopaminergic synapse 💬
 [1] SLC6A3 💬 Methylphenidate 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
207 Drug metabolism - cytochrome P450 💬
 [3] ADH1A, ADH1B, ADH1C 💬 Fomepizole 💬 Fomepizole [1] 301 💬
208 Drug metabolism - cytochrome P450 💬
 [1] MAOA 💬 Moclobemide 💬 Moclobemide [1]  6  💬
209 Drug metabolism - cytochrome P450 💬
 [2] MAOA, MAOB 💬 Iproniazid 💬 Iproniazid [1]  6  💬
210 Drug metabolism - cytochrome P450 💬
 [2] MAOA, MAOB 💬 Phenelzine 💬 Phenelzine [1]  6  💬
211 Drug metabolism - cytochrome P450 💬
 [2] MAOA, MAOB 💬 Phentermine 💬 Phentermine [1] 97 💬
212 Drug metabolism - cytochrome P450 💬
 [1] MAOB 💬 Rasagiline 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
213 Drug metabolism - cytochrome P450 💬
 [1] MAOB 💬 Rasagiline tartrate 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
214 Drug metabolism - cytochrome P450 💬
 [1] MAOB 💬 Safinamide 💬 Safinamide [2]  6 , 17 💬
215 Drug metabolism - cytochrome P450 💬
 [1] MAOB 💬 Selegiline 💬 Selegiline [1]  6  💬
216 Drug metabolism - other enzymes 💬
 [1] GUSB 💬 Vestronidase alfa 💬 Vestronidase alfa [1] 19 💬
217 Drug metabolism - other enzymes 💬
 [1] HPRT1 💬 Mercaptopurine 💬 Mercaptopurine [4] 65, 96, 97, 164 💬
218 Drug metabolism - other enzymes 💬
 [1] HPRT1 💬 Mercaptopurine 💬 Mercaptopurine [4] 65, 96, 97, 164 💬
219 Drug metabolism - other enzymes 💬
 [1] HPRT1 💬 Tioguanine 💬 Tioguanine [2] 13, 37 💬
220 Drug metabolism - other enzymes 💬
 [2] IMPDH1, IMPDH2 💬 Mizoribine 💬 Mizoribine [8] 46, 49, 51, 53, 66, 94, 222, 224 💬
221 Drug metabolism - other enzymes 💬
 [2] IMPDH1, IMPDH2 💬 Mycophenolate mofetil 💬 Mycophenolate mofetil [34]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
222 Drug metabolism - other enzymes 💬
 [2] IMPDH1, IMPDH2 💬 Mycophenolic acid 💬 Mycophenolic acid [36]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
223 Drug metabolism - other enzymes 💬
 [1] MPO 💬 Verdiperstat 💬 Verdiperstat [3]  2 , 17, 127 💬
224 Drug metabolism - other enzymes 💬
 [1] RRM1 💬 Cladribine 💬 Cladribine [3] 11, 13, 94 💬
225 Drug metabolism - other enzymes 💬
 [1] RRM1 💬 Clofarabine 💬 Clofarabine [5] 19, 20, 60, 234, 326 💬
226 Drug metabolism - other enzymes 💬
 [1] RRM1 💬 Fludarabine 💬 Fludarabine [20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬
227 Drug metabolism - other enzymes 💬
 [1] RRM2 💬 Hydroxyurea 💬 Hydroxyurea [8]  3 , 13, 19, 20, 65, 85, 86, 284 💬
228 Drug metabolism - other enzymes 💬
 [1] XDH 💬 Allopurinol 💬 Allopurinol [7]  6 , 46, 57, 60, 66, 96, 97 💬
229 Drug metabolism - other enzymes 💬
 [1] XDH 💬 Febuxostat 💬 Febuxostat [3]  2 ,  6 , 13 💬

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