Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

ECM-receptor interaction 💬

[1] ITGA4 💬

Firategrast 💬

Firategrast

[1] 13 💬

ECM-receptor interaction 💬

[1] ITGA4 💬

Natalizumab 💬

Natalizumab

[6] 13, 15, 25, 46, 63, 96 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
96	Crohn disease;Terminal ileitis;

ECM-receptor interaction 💬

[2] ITGA4, ITGB7 💬

Abrilumab 💬

Abrilumab

[2] 96, 97 💬

ECM-receptor interaction 💬

[2] ITGA4, ITGB7 💬

Vedolizumab 💬

Vedolizumab

[3] 94, 96, 97 💬

ECM-receptor interaction 💬

[1] ITGB7 💬

Etrolizumab 💬

Etrolizumab

[2] 96, 97 💬

ECM-receptor interaction 💬

[1] SV2A 💬

Brivaracetam 💬

Brivaracetam

[2] 149, 309 💬

ECM-receptor interaction 💬

[1] SV2A 💬

Levetiracetam 💬

Levetiracetam

[5] 2 , 4 , 6 , 13, 307 💬

ECM-receptor interaction 💬

[3] SV2A, SV2B, SV2C 💬

Padsevonil 💬

Padsevonil

[1] 149 💬

ECM-receptor interaction 💬

[1] VWF 💬

Caplacizumab 💬

Caplacizumab

[1] 64 💬

EGFR tyrosine kinase inhibitor resistance 💬

[3] AXL, KDR, MET 💬

Cabozantinib 💬

Cabozantinib

[1] 34 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] BCL2 💬

Venetoclax 💬

Venetoclax

[1] 28 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] BRAF 💬

Dabrafenib 💬

Dabrafenib

[1] 34 💬

EGFR tyrosine kinase inhibitor resistance 💬

[4] BRAF, KDR, PDGFRB, RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] EGFR, ERBB2 💬

Neratinib 💬

Neratinib

[1] 34 💬

EGFR tyrosine kinase inhibitor resistance 💬

[3] EGFR, ERBB2, KDR 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] FGFR2 💬

Palifermin 💬

Palifermin

[5] 13, 36, 38, 39, 65 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
65	Primary immunodeficiency;

EGFR tyrosine kinase inhibitor resistance 💬

[2] FGFR2, FGFR3 💬

Infigratinib 💬

Infigratinib

[1] 276 💬

EGFR tyrosine kinase inhibitor resistance 💬

[5] FGFR2, FGFR3, KDR, PDGFRA, PDGFRB 💬

Name	Full Name
FGFR2	fibroblast growth factor receptor 2
FGFR3	fibroblast growth factor receptor 3
KDR	kinase insert domain receptor
PDGFRA	platelet derived growth factor receptor alpha
PDGFRB	platelet derived growth factor receptor beta

Nintedanib 💬

Nintedanib

[5] 51, 85, 89, 227, 228 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

EGFR tyrosine kinase inhibitor resistance 💬

[1] IGF1R 💬

Linsitinib 💬

Linsitinib

[1] 232 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] IGF1R 💬

Mecasermin 💬

Mecasermin

[6] 65, 78, 96, 168, 265, 299 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] IGF1R 💬

Teprotumumab 💬

Teprotumumab

[1] 51 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] IL6 💬

Olokizumab 💬

Olokizumab

[2] 46, 96 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] IL6 💬

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

EGFR tyrosine kinase inhibitor resistance 💬

[1] IL6 💬

Pomalidomide 💬

Pomalidomide

[5] 28, 51, 85, 227, 331 💬

Disease ID	Name
28	Systemic amyloidosis;AL amyloidosis;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

EGFR tyrosine kinase inhibitor resistance 💬

[1] IL6 💬

Siltuximab 💬

Siltuximab

[2] 28, 331 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] IL6 💬

Sirukumab 💬

Sirukumab

[2] 41, 46 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] IL6R 💬

Sarilumab 💬

Sarilumab

[5] 41, 46, 84, 107, 271 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
84	Sarcoidosis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

EGFR tyrosine kinase inhibitor resistance 💬

[1] IL6R 💬

Satralizumab 💬

Satralizumab

[3] 11, 13, 86 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] IL6R 💬

Tocilizumab 💬

Tocilizumab

[21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
54	Adult still disease;Adult-onset Stills disease;
55	Relapsing polychondritis;
56	Behcet disease;Behçet disease;BD;
86	Pulmonary arterial hypertension;PAH;
107	Juvenile idiopathic arthritis;JIA;
266	Familial mediterranean fever;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

EGFR tyrosine kinase inhibitor resistance 💬

[1] JAK1 💬

Abrocitinib 💬

Abrocitinib

[1] 84 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] JAK1 💬

Filgotinib 💬

Filgotinib

[6] 46, 53, 96, 97, 222, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
222	Primary nephrotic syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

EGFR tyrosine kinase inhibitor resistance 💬

[1] JAK1 💬

Itacitinib 💬

Itacitinib

[4] 46, 51, 97, 228 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
97	Ulcerative colitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

EGFR tyrosine kinase inhibitor resistance 💬

[1] JAK1 💬

Upadacitinib 💬

Upadacitinib

[8] 40, 41, 46, 49, 96, 97, 107, 271 💬

Disease ID	Name
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

EGFR tyrosine kinase inhibitor resistance 💬

[2] JAK1, JAK2 💬

Baricitinib 💬

Baricitinib

[13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
265	Lipodystrophy;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
325	Hereditary autoinflammatory syndrome;

EGFR tyrosine kinase inhibitor resistance 💬

[2] JAK1, JAK2 💬

Peficitinib 💬

Peficitinib

[1] 46 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] JAK1, JAK2 💬

Ruxolitinib 💬

Ruxolitinib

[3] 60, 65, 228 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] JAK1, JAK2 💬

Tofacitinib 💬

Tofacitinib

[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬

Disease ID	Name
11	Myasthenia gravis;MG;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
65	Primary immunodeficiency;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

EGFR tyrosine kinase inhibitor resistance 💬

[1] KDR 💬

Axitinib 💬

Axitinib

[1] 34 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] KDR 💬

Cediranib 💬

Cediranib

[1] 34 💬

EGFR tyrosine kinase inhibitor resistance 💬

[3] KDR, PDGFRA, PDGFRB 💬

Sunitinib 💬

Sunitinib

[2] 28, 34 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

EGFR tyrosine kinase inhibitor resistance 💬

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

EGFR tyrosine kinase inhibitor resistance 💬

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

EGFR tyrosine kinase inhibitor resistance 💬

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] PDGFRA 💬

Imatinib 💬

Imatinib

[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
89	Lymphangioleiomyomatosis;LAM;
162	Pemphigoid;

EGFR tyrosine kinase inhibitor resistance 💬

[2] PDGFRA, PDGFRB 💬

Nilotinib 💬

Nilotinib

[5] 6 , 8 , 34, 51, 86 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] PDGFRB, SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

EGFR tyrosine kinase inhibitor resistance 💬

[2] PDGFRB, SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

EGFR tyrosine kinase inhibitor resistance 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] SRC 💬

Bosutinib 💬

Bosutinib

[2] 2 , 67 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] SRC 💬

Saracatinib 💬

Saracatinib

[3] 6 , 89, 272 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] VEGFA 💬

Aflibercept 💬

Aflibercept

[2] 90, 166 💬

EGFR tyrosine kinase inhibitor resistance 💬

[1] VEGFA 💬

Bevacizumab 💬

Name

Other Names

Bevacizumab

Bevacizumab (USAN)
Bevacizumab (genetical recombination) (JAN)
Bevacizumab (genetical recombination) [Bevacizumab biosimilar 1] (JAN)
Bevacizumab (genetical recombination) [Bevacizumab biosimilar 2] (JAN)
Bevacizumab (genetical recombination) [Bevacizumab biosimilar 3] (JAN)
Bevacizumab (genetical recombination) [Bevacizumab biosimilar 4] (JAN)
Bevacizumab-awwb
Bevacizumab-bvzr
Avastin (TN)
Mvasi (TN)
ALYMSYS
ZIRABEV

Bevacizumab

[6] 13, 34, 85, 87, 227, 280 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
85	Idiopathic interstitial pneumonia;IIPs;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

EGFR tyrosine kinase inhibitor resistance 💬

[1] VEGFA 💬

Ranibizumab 💬

Name	Other Names
Ranibizumab	Ranibizumab (USAN/INN) Ranibizumab (genetical recombination) (JAN) Ranibizumab (genetical recombination) [Ranibizumab biosimilar 1] (JAN) Ranibizumab-nuna Lucentis (TN) Byooviz (TN) Susvimo (TN) Ximluci (TN) CIMERLI

Ranibizumab

[4] 34, 166, 227, 301 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digitoxin 💬

Digitoxin

[1] 299 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digoxin 💬

Digoxin

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Clomifene 💬

Clomifene

[1] 74 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Danazol 💬

Danazol

[5] 60, 63, 64, 65, 285 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Desogestrel 💬

Desogestrel

[1] 230 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estetrol 💬

Estetrol

[1] 53 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estetrol 💬

Estetrol

[1] 53 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estradiol 💬

Name	Other Names
Estradiol	Estradiol (JAN/USP/INN) Climara (TN) Divigel (TN) Estrace (TN) Estraderm (TN) Estrasorb (TN) Estring (TN) Estrogel (TN) Innofem (TN) Vagifem (TN) Vivelle (TN) IMVEXXY MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM

Estradiol

[7] 13, 46, 49, 65, 76, 226, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
76	Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
299	Cystic fibrosis;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estradiol valerate 💬

Estradiol valerate

[1] 65 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estriol 💬

Estriol

[2] 13, 227 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Estriol tripropionate 💬

Estriol

[2] 13, 227 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Ethinyl estradiol 💬

Ethinylestradiol

[4] 13, 46, 49, 299 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Fulvestrant 💬

Fulvestrant

[2] 49, 86 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Mestranol 💬

Mestranol

[2] 46, 49 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Prasterone 💬

Prasterone

[6] 49, 53, 83, 86, 96, 113 💬

Disease ID	Name
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
83	Addison disease;Primary chronic adrenocortical insufficiency;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Raloxifene 💬

Raloxifene

[1] 46 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] ESR1 💬

Tamoxifen 💬

Tamoxifen

[3] 2 , 113, 227 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] PTH1R 💬

Parathyroid hormone 💬

Parathyroid hormone

[4] 65, 70, 235, 326 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] PTH1R 💬

Teriparatide 💬

Teriparatide

[7] 46, 65, 68, 70, 71, 235, 274 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
68	Ossification of the ligamentum flavum;Ossification of ligamentum flavum;OLF;
70	Spinal stenosis;Extensive spinal canal stenosis;
71	Idiopathic osteonecrosis of the femoral head;Idiopathic femoral head necrosis;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
274	Osteogenesis Imperfecta;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Alfacalcidol 💬

Alfacalcidol

[8] 41, 46, 49, 50, 96, 107, 235, 238 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
96	Crohn disease;Terminal ileitis;
107	Juvenile idiopathic arthritis;JIA;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
238	Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Calcifediol 💬

Calcifediol

[2] 113, 299 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Calcipotriene 💬

Calcipotriol

[2] 36, 51 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Calcitriol 💬

Calcitriol

[9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬

Disease ID	Name
18	Spinocerebellar degeneration;SCD;
37	Generalised pustular psoriasis;Pustular psoriasis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
158	Tuberous sclerosis;Tuberous sclerosis complex;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
326	Osteopetrosis;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Cholecalciferol 💬

Cholecalciferol

[24] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
65	Primary immunodeficiency;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
162	Pemphigoid;
202	Smith-Magenis syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Dihydrotachysterol 💬

Dihydrotachysterol

[2] 6 , 85 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Eldecalcitol 💬

Eldecalcitol

[1] 46 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Ergocalciferol 💬

Ergocalciferol

[6] 46, 49, 84, 96, 97, 299 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
299	Cystic fibrosis;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Paricalcitol 💬

Paricalcitol

[5] 19, 66, 218, 238, 298 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
218	Alport syndrome;
238	Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;
298	Hereditary pancreatitis;Chronic pancreatitis;

Endocrine resistance 💬

[1] BCL2 💬

Venetoclax 💬

Venetoclax

[1] 28 💬

Endocrine resistance 💬

[1] BRAF 💬

Dabrafenib 💬

Dabrafenib

[1] 34 💬

Endocrine resistance 💬

[2] BRAF, RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

Endocrine resistance 💬

[1] CDK4 💬

Abemaciclib 💬

Abemaciclib

[1] 34 💬

100

Endocrine resistance 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

101

Endocrine resistance 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

102

Endocrine resistance 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

103

Endocrine resistance 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

104

Endocrine resistance 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

105

Endocrine resistance 💬

[2] EGFR, ERBB2 💬

Neratinib 💬

Neratinib

[1] 34 💬

106

Endocrine resistance 💬

[2] EGFR, ERBB2 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

107

Endocrine resistance 💬

[1] ESR1 💬

Danazol 💬

Danazol

[5] 60, 63, 64, 65, 285 💬

108

Endocrine resistance 💬

[1] ESR1 💬

Desogestrel 💬

Desogestrel

[1] 230 💬

109

Endocrine resistance 💬

[1] ESR1 💬

Ethinyl estradiol 💬

Ethinylestradiol

[4] 13, 46, 49, 299 💬

110

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Clomifene 💬

Clomifene

[1] 74 💬

111

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Estetrol 💬

Estetrol

[1] 53 💬

112

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Estetrol 💬

Estetrol

[1] 53 💬

113

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Estradiol 💬

Name	Other Names
Estradiol	Estradiol (JAN/USP/INN) Climara (TN) Divigel (TN) Estrace (TN) Estraderm (TN) Estrasorb (TN) Estring (TN) Estrogel (TN) Innofem (TN) Vagifem (TN) Vivelle (TN) IMVEXXY MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM

Estradiol

[7] 13, 46, 49, 65, 76, 226, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
76	Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
299	Cystic fibrosis;

114

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Estradiol valerate 💬

Estradiol valerate

[1] 65 💬

115

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Estriol 💬

Estriol

[2] 13, 227 💬

116

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Estriol tripropionate 💬

Estriol

[2] 13, 227 💬

117

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Fulvestrant 💬

Fulvestrant

[2] 49, 86 💬

118

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Mestranol 💬

Mestranol

[2] 46, 49 💬

119

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Prasterone 💬

Prasterone

[6] 49, 53, 83, 86, 96, 113 💬

Disease ID	Name
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
83	Addison disease;Primary chronic adrenocortical insufficiency;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;

120

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Raloxifene 💬

Raloxifene

[1] 46 💬

121

Endocrine resistance 💬

[2] ESR1, ESR2 💬

Tamoxifen 💬

Tamoxifen

[3] 2 , 113, 227 💬

122

Endocrine resistance 💬

[1] IGF1R 💬

Linsitinib 💬

Linsitinib

[1] 232 💬

123

Endocrine resistance 💬

[1] IGF1R 💬

Mecasermin 💬

Mecasermin

[6] 65, 78, 96, 168, 265, 299 💬

124

Endocrine resistance 💬

[1] IGF1R 💬

Teprotumumab 💬

Teprotumumab

[1] 51 💬

125

Endocrine resistance 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

126

Endocrine resistance 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

127

Endocrine resistance 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

128

Endocrine resistance 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

129

Endocrine resistance 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

130

Endocrine resistance 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Losmapimod 💬

Losmapimod

[2] 113, 222 💬

131

Endocrine resistance 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Neflamapimod 💬

Neflamapimod

[1] 8 💬

132

Endocrine resistance 💬

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

133

Endocrine resistance 💬

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

134

Endocrine resistance 💬

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

135

Endocrine resistance 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

136

Endocrine resistance 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

137

Endocrine resistance 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

138

Endocrine resistance 💬

[1] SRC 💬

Bosutinib 💬

Bosutinib

[2] 2 , 67 💬

139

Endocrine resistance 💬

[1] SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

140

Endocrine resistance 💬

[1] SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

141

Endocrine resistance 💬

[1] SRC 💬

Saracatinib 💬

Saracatinib

[3] 6 , 89, 272 💬

142

Endocytosis 💬

[1] CCR5 💬

Cenicriviroc 💬

Cenicriviroc

[1] 94 💬

143

Endocytosis 💬

[1] CCR5 💬

Maraviroc 💬

Maraviroc

[2] 46, 84 💬

144

Endocytosis 💬

[2] CXCR1, CXCR2 💬

Reparixin 💬

Reparixin

[2] 298, 299 💬

145

Endocytosis 💬

[1] CXCR4 💬

Plerixafor 💬

Plerixafor

[5] 19, 20, 65, 285, 299 💬

146

Endocytosis 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

147

Endocytosis 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

148

Endocytosis 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

149

Endocytosis 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

150

Endocytosis 💬

[1] EGFR 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

151

Endocytosis 💬

[1] EGFR 💬

Neratinib 💬

Neratinib

[1] 34 💬

152

Endocytosis 💬

[1] EGFR 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

153

Endocytosis 💬

[1] FGFR2 💬

Palifermin 💬

Palifermin

[5] 13, 36, 38, 39, 65 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
36	Epidermolysis bullosa;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
65	Primary immunodeficiency;

154

Endocytosis 💬

[2] FGFR2, FGFR3 💬

Infigratinib 💬

Infigratinib

[1] 276 💬

155

Endocytosis 💬

[3] FGFR2, FGFR3, PDGFRA 💬

Nintedanib 💬

Nintedanib

[5] 51, 85, 89, 227, 228 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

156

Endocytosis 💬

[1] IGF1R 💬

Linsitinib 💬

Linsitinib

[1] 232 💬

157

Endocytosis 💬

[1] IGF1R 💬

Mecasermin 💬

Mecasermin

[6] 65, 78, 96, 168, 265, 299 💬

158

Endocytosis 💬

[1] IGF1R 💬

Teprotumumab 💬

Teprotumumab

[1] 51 💬

159

Endocytosis 💬

[1] IL2RA 💬

Basiliximab 💬

Basiliximab

[6] 2 , 50, 66, 97, 222, 228 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
50	Dermatomyositis;Polymyositis;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
97	Ulcerative colitis;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

160

Endocytosis 💬

[1] IL2RA 💬

Daclizumab 💬

Daclizumab

[8] 13, 56, 60, 65, 97, 107, 283, 284 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
65	Primary immunodeficiency;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;

161

Endocytosis 💬

[3] IL2RA, IL2RB, IL2RG 💬

Aldesleukin 💬

Aldesleukin

[6] 2 , 35, 49, 65, 96, 97 💬

162

Endocytosis 💬

[1] PDGFRA 💬

Imatinib 💬

Imatinib

[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
89	Lymphangioleiomyomatosis;LAM;
162	Pemphigoid;

163

Endocytosis 💬

[1] PDGFRA 💬

Nilotinib 💬

Nilotinib

[5] 6 , 8 , 34, 51, 86 💬

164

Endocytosis 💬

[1] PDGFRA 💬

Sunitinib 💬

Sunitinib

[2] 28, 34 💬

165

Endocytosis 💬

[1] PML 💬

Tretinoin 💬

Tretinoin

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;

166

Endocytosis 💬

[1] SRC 💬

Bosutinib 💬

Bosutinib

[2] 2 , 67 💬

167

Endocytosis 💬

[1] SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

168

Endocytosis 💬

[1] SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

169

Endocytosis 💬

[1] SRC 💬

Saracatinib 💬

Saracatinib

[3] 6 , 89, 272 💬

170

Endocytosis 💬

[1] TFRC 💬

Pabinafusp alfa 💬

Pabinafusp alfa

[1] 19 💬

171

Endometrial cancer 💬

[1] BRAF 💬

Dabrafenib 💬

Dabrafenib

[1] 34 💬

172

Endometrial cancer 💬

[2] BRAF, RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

173

Endometrial cancer 💬

[1] CASP9 💬

Rimiducid 💬

Rimiducid

[6] 19, 60, 65, 284, 285, 326 💬

174

Endometrial cancer 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

175

Endometrial cancer 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

176

Endometrial cancer 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

177

Endometrial cancer 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

178

Endometrial cancer 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

179

Endometrial cancer 💬

[2] EGFR, ERBB2 💬

Neratinib 💬

Neratinib

[1] 34 💬

180

Endometrial cancer 💬

[2] EGFR, ERBB2 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

181

Endometrial cancer 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

182

Endometrial cancer 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

183

Endometrial cancer 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

184

Endometrial cancer 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

185

Endometrial cancer 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

186

Endometrial cancer 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

187

Endometrial cancer 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

188

Endometrial cancer 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

189

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] ADAM17 💬

Apratastat 💬

Apratastat

[1] 46 💬

190

Epithelial cell signaling in Helicobacter pylori infection 💬

[2] CXCR1, CXCR2 💬

Reparixin 💬

Reparixin

[2] 298, 299 💬

191

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

192

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

193

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

194

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

195

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] EGFR 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

196

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] EGFR 💬

Neratinib 💬

Neratinib

[1] 34 💬

197

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] EGFR 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

198

Epithelial cell signaling in Helicobacter pylori infection 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Losmapimod 💬

Losmapimod

[2] 113, 222 💬

199

Epithelial cell signaling in Helicobacter pylori infection 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Neflamapimod 💬

Neflamapimod

[1] 8 💬

200

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] MET 💬

Cabozantinib 💬

Cabozantinib

[1] 34 💬

201

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] NFKB1 💬

Iguratimod 💬

Iguratimod

[5] 46, 51, 53, 271, 300 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

202

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] RELA 💬

Edasalonexent 💬

Edasalonexent

[1] 113 💬

203

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] SRC 💬

Bosutinib 💬

Bosutinib

[2] 2 , 67 💬

204

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

205

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

206

Epithelial cell signaling in Helicobacter pylori infection 💬

[1] SRC 💬

Saracatinib 💬

Saracatinib

[3] 6 , 89, 272 💬

207

Epstein-Barr virus infection 💬

[1] BCL2 💬

Venetoclax 💬

Venetoclax

[1] 28 💬

208

Epstein-Barr virus infection 💬

[1] BTK 💬

Acalabrutinib 💬

Acalabrutinib

[2] 46, 61 💬

209

Epstein-Barr virus infection 💬

[1] BTK 💬

Branebrutinib 💬

Branebrutinib

[3] 46, 49, 53 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;

210

Epstein-Barr virus infection 💬

[1] BTK 💬

Evobrutinib 💬

Evobrutinib

[3] 13, 46, 49 💬

211

Epstein-Barr virus infection 💬

[1] BTK 💬

Fenebrutinib 💬

Fenebrutinib

[1] 13 💬

212

Epstein-Barr virus infection 💬

[1] BTK 💬

Ibrutinib 💬

Ibrutinib

[3] 28, 60, 61 💬

213

Epstein-Barr virus infection 💬

[1] BTK 💬

Orelabrutinib 💬

Orelabrutinib

[4] 13, 49, 61, 63 💬

214

Epstein-Barr virus infection 💬

[1] BTK 💬

Remibrutinib 💬

Remibrutinib

[2] 13, 53 💬

215

Epstein-Barr virus infection 💬

[1] BTK 💬

Zanubrutinib 💬

Zanubrutinib

[5] 13, 63, 222, 300, 331 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
222	Primary nephrotic syndrome;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

216

Epstein-Barr virus infection 💬

[1] CASP9 💬

Rimiducid 💬

Rimiducid

[6] 19, 60, 65, 284, 285, 326 💬

217

Epstein-Barr virus infection 💬

[1] CD19 💬

Inebilizumab 💬

Inebilizumab

[4] 11, 13, 51, 300 💬

218

Epstein-Barr virus infection 💬

[1] CD19 💬

Obexelimab 💬

Obexelimab

[1] 300 💬

219

Epstein-Barr virus infection 💬

[3] CD3D, CD3E, CD3G 💬

Otelixizumab 💬

Otelixizumab

[1] 46 💬

220

Epstein-Barr virus infection 💬

[3] CD3D, CD3E, CD3G 💬

Visilizumab 💬

Visilizumab

[2] 96, 97 💬

221

Epstein-Barr virus infection 💬

[1] CD3E 💬

Mosunetuzumab 💬

Mosunetuzumab

[1] 49 💬

222

Epstein-Barr virus infection 💬

[1] CD40 💬

Bleselumab 💬

Bleselumab

[1] 222 💬

223

Epstein-Barr virus infection 💬

[1] CD40 💬

Iscalimab 💬

Iscalimab

[2] 49, 53 💬

224

Epstein-Barr virus infection 💬

[1] CD40 💬

Ravagalimab 💬

Ravagalimab

[2] 53, 97 💬

225

Epstein-Barr virus infection 💬

[1] CD58 💬

Alefacept 💬

Alefacept

[6] 37, 60, 65, 164, 284, 285 💬

226

Epstein-Barr virus infection 💬

[2] CDK4, CDK6 💬

Abemaciclib 💬

Abemaciclib

[1] 34 💬

227

Epstein-Barr virus infection 💬

[2] HDAC1, HDAC2 💬

Vorinostat 💬

Vorinostat

[2] 75, 96 💬

228

Epstein-Barr virus infection 💬

[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬

Name	Full Name
IFNA1	interferon alpha 1
IFNA10	interferon alpha 10
IFNA13	interferon alpha 13
IFNA14	interferon alpha 14
IFNA16	interferon alpha 16
IFNA17	interferon alpha 17
IFNA2	interferon alpha 2
IFNA21	interferon alpha 21
IFNA4	interferon alpha 4
IFNA5	interferon alpha 5
IFNA6	interferon alpha 6
IFNA7	interferon alpha 7
IFNA8	interferon alpha 8

Rontalizumab 💬

Rontalizumab

[1] 49 💬

229

Epstein-Barr virus infection 💬

[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬

Name	Full Name
IFNA1	interferon alpha 1
IFNA10	interferon alpha 10
IFNA13	interferon alpha 13
IFNA14	interferon alpha 14
IFNA16	interferon alpha 16
IFNA17	interferon alpha 17
IFNA2	interferon alpha 2
IFNA21	interferon alpha 21
IFNA4	interferon alpha 4
IFNA5	interferon alpha 5
IFNA6	interferon alpha 6
IFNA7	interferon alpha 7
IFNA8	interferon alpha 8

Sifalimumab 💬

Sifalimumab

[1] 49 💬

230

Epstein-Barr virus infection 💬

[2] IFNAR1, IFNAR2 💬

Anifrolumab 💬

Anifrolumab

[3] 46, 49, 53 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;

231

Epstein-Barr virus infection 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa 💬

Interferon alfa

[6] 13, 25, 26, 28, 56, 96 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
56	Behcet disease;Behçet disease;BD;
96	Crohn disease;Terminal ileitis;

232

Epstein-Barr virus infection 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa-2a 💬

Interferon alfa-2a

[1] 56 💬

233

Epstein-Barr virus infection 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa-2b 💬

Interferon alfa-2b

[2] 25, 34 💬

234

Epstein-Barr virus infection 💬

[2] IFNAR1, IFNAR2 💬

Interferon beta-1a 💬

Interferon beta-1a

[4] 13, 26, 96, 97 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

235

Epstein-Barr virus infection 💬

[2] IFNAR1, IFNAR2 💬

Interferon beta-1b 💬

Interferon beta-1b

[1] 13 💬

236

Epstein-Barr virus infection 💬

[2] IFNAR1, IFNAR2 💬

Peginterferon beta-1a 💬

Peginterferon beta-1a

[1] 13 💬

237

Epstein-Barr virus infection 💬

[1] IL6 💬

Olokizumab 💬

Olokizumab

[2] 46, 96 💬

238

Epstein-Barr virus infection 💬

[1] IL6 💬

Siltuximab 💬

Siltuximab

[2] 28, 331 💬

239

Epstein-Barr virus infection 💬

[1] IL6 💬

Sirukumab 💬

Sirukumab

[2] 41, 46 💬

240

Epstein-Barr virus infection 💬

[2] IL6, TNF 💬

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

241

Epstein-Barr virus infection 💬

[2] IL6, TNF 💬

Pomalidomide 💬

Pomalidomide

[5] 28, 51, 85, 227, 331 💬

Disease ID	Name
28	Systemic amyloidosis;AL amyloidosis;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

242

Epstein-Barr virus infection 💬

[1] ITGAL 💬

Efalizumab 💬

Efalizumab

[9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
37	Generalised pustular psoriasis;Pustular psoriasis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
61	Autoimmune hemolytic anemia;AIHA;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;

243

Epstein-Barr virus infection 💬

[1] JAK1 💬

Abrocitinib 💬

Abrocitinib

[1] 84 💬

244

Epstein-Barr virus infection 💬

[1] JAK1 💬

Baricitinib 💬

Baricitinib

[13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
265	Lipodystrophy;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
325	Hereditary autoinflammatory syndrome;

245

Epstein-Barr virus infection 💬

[1] JAK1 💬

Filgotinib 💬

Filgotinib

[6] 46, 53, 96, 97, 222, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
222	Primary nephrotic syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

246

Epstein-Barr virus infection 💬

[1] JAK1 💬

Itacitinib 💬

Itacitinib

[4] 46, 51, 97, 228 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
97	Ulcerative colitis;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

247

Epstein-Barr virus infection 💬

[1] JAK1 💬

Ruxolitinib 💬

Ruxolitinib

[3] 60, 65, 228 💬

248

Epstein-Barr virus infection 💬

[1] JAK1 💬

Upadacitinib 💬

Upadacitinib

[8] 40, 41, 46, 49, 96, 97, 107, 271 💬

Disease ID	Name
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

249

Epstein-Barr virus infection 💬

[2] JAK1, JAK3 💬

Peficitinib 💬

Peficitinib

[1] 46 💬

250

Epstein-Barr virus infection 💬

[3] JAK1, JAK3, TYK2 💬

Tofacitinib 💬

Tofacitinib

[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬

Disease ID	Name
11	Myasthenia gravis;MG;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
65	Primary immunodeficiency;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

251

Epstein-Barr virus infection 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Losmapimod 💬

Losmapimod

[2] 113, 222 💬

252

Epstein-Barr virus infection 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Neflamapimod 💬

Neflamapimod

[1] 8 💬

253

Epstein-Barr virus infection 💬

[1] NFKB1 💬

Iguratimod 💬

Iguratimod

[5] 46, 51, 53, 271, 300 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

254

Epstein-Barr virus infection 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

255

Epstein-Barr virus infection 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

256

Epstein-Barr virus infection 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

257

Epstein-Barr virus infection 💬

[1] RELA 💬

Edasalonexent 💬

Edasalonexent

[1] 113 💬

258

Epstein-Barr virus infection 💬

[1] SYK 💬

Fostamatinib 💬

Fostamatinib

[4] 46, 49, 61, 66 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
61	Autoimmune hemolytic anemia;AIHA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

259

Epstein-Barr virus infection 💬

[1] TNF 💬

Adalimumab 💬

Name

Other Names

Adalimumab

Adalimumab (USAN/INN)
Adalimumab (genetical recombination) (JAN)
Adalimumab (genetical recombination) [Adalimumab biosimilar 1] (JAN)
Adalimumab (genetical recombination) [Adalimumab biosimilar 2] (JAN)
Adalimumab (genetical recombination) [Adalimumab biosimilar 3] (JAN)
Adalimumab-adaz
Adalimumab-adbm
Adalimumab-afzb
Adalimumab-atto
Adalimumab-bwwd
Adalimumab-fkjp
Humira (TN)
Abrilada (TN)
Amjevita (TN)
Cyltezo (TN)
Hadlima (TN)
Hyrimoz (TN)

Adalimumab

[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
37	Generalised pustular psoriasis;Pustular psoriasis;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
56	Behcet disease;Behçet disease;BD;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
160	Congenital ichthyosis;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

260

Epstein-Barr virus infection 💬

[1] TNF 💬

Certolizumab pegol 💬

Certolizumab pegol

[8] 37, 46, 49, 96, 97, 107, 226, 271 💬

Disease ID	Name
37	Generalised pustular psoriasis;Pustular psoriasis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

261

Epstein-Barr virus infection 💬

[1] TNF 💬

Etanercept 💬

Name	Other Names
Etanercept	Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)

Etanercept

[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬

Disease ID	Name
15	Inclusion body myositis;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
85	Idiopathic interstitial pneumonia;IIPs;
107	Juvenile idiopathic arthritis;JIA;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
285	Fanconi anemia;

262

Epstein-Barr virus infection 💬

[1] TNF 💬

Golimumab 💬

Golimumab

[8] 46, 56, 84, 96, 97, 107, 270, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
56	Behcet disease;Behçet disease;BD;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

263

Epstein-Barr virus infection 💬

[1] TNF 💬

Infliximab 💬

Name	Other Names
Infliximab	Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)

Infliximab

[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬

Disease ID	Name
35	Pemphigus;
37	Generalised pustular psoriasis;Pustular psoriasis;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
55	Relapsing polychondritis;
56	Behcet disease;Behçet disease;BD;
65	Primary immunodeficiency;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
164	Oculocutaneous albinism;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

264

Epstein-Barr virus infection 💬

[1] TNF 💬

Lenalidomide 💬

Lenalidomide

[8] 16, 26, 28, 34, 49, 284, 300, 331 💬

Disease ID	Name
16	Crow-Fukase syndrome;POEMS syndrome;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
49	Systemic lupus erythematosus;SLE;
284	Diamond-Blackfan anemia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

265

Epstein-Barr virus infection 💬

[1] TNF 💬

Ozoralizumab 💬

Ozoralizumab

[1] 46 💬

266

Epstein-Barr virus infection 💬

[1] TNF 💬

Pegsunercept 💬

Pegsunercept

[1] 46 💬

267

Epstein-Barr virus infection 💬

[1] TNF 💬

Thalidomide 💬

Thalidomide

[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
16	Crow-Fukase syndrome;POEMS syndrome;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;
65	Primary immunodeficiency;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
94	Primary sclerosing cholangitis;PSC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
298	Hereditary pancreatitis;Chronic pancreatitis;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

268

Epstein-Barr virus infection 💬

[1] TYK2 💬

Deucravacitinib 💬

Deucravacitinib

[3] 49, 96, 97 💬

269

ErbB signaling pathway 💬

[1] ABL1 💬

Imatinib 💬

Imatinib

[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
89	Lymphangioleiomyomatosis;LAM;
162	Pemphigoid;

270

ErbB signaling pathway 💬

[1] ABL1 💬

Nilotinib 💬

Nilotinib

[5] 6 , 8 , 34, 51, 86 💬

271

ErbB signaling pathway 💬

[2] ABL1, SRC 💬

Bosutinib 💬

Bosutinib

[2] 2 , 67 💬

272

ErbB signaling pathway 💬

[2] ABL1, SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

273

ErbB signaling pathway 💬

[2] ABL1, SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

274

ErbB signaling pathway 💬

[2] ABL1, SRC 💬

Saracatinib 💬

Saracatinib

[3] 6 , 89, 272 💬

275

ErbB signaling pathway 💬

[1] BRAF 💬

Dabrafenib 💬

Dabrafenib

[1] 34 💬

276

ErbB signaling pathway 💬

[2] BRAF, RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

277

ErbB signaling pathway 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

278

ErbB signaling pathway 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

279

ErbB signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

280

ErbB signaling pathway 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

281

ErbB signaling pathway 💬

[2] EGFR, ERBB2 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

282

ErbB signaling pathway 💬

[2] EGFR, ERBB2 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

283

ErbB signaling pathway 💬

[3] EGFR, ERBB2, ERBB4 💬

Neratinib 💬

Neratinib

[1] 34 💬

284

ErbB signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

285

ErbB signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

286

ErbB signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

287

ErbB signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

288

ErbB signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

289

ErbB signaling pathway 💬

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

290

ErbB signaling pathway 💬

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

291

ErbB signaling pathway 💬

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

292

ErbB signaling pathway 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

293

ErbB signaling pathway 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

294

ErbB signaling pathway 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

295

ErbB signaling pathway 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

296

Estrogen signaling pathway 💬

[1] BCL2 💬

Venetoclax 💬

Venetoclax

[1] 28 💬

297

Estrogen signaling pathway 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

298

Estrogen signaling pathway 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

299

Estrogen signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

300

Estrogen signaling pathway 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

301

Estrogen signaling pathway 💬

[1] EGFR 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

302

Estrogen signaling pathway 💬

[1] EGFR 💬

Neratinib 💬

Neratinib

[1] 34 💬

303

Estrogen signaling pathway 💬

[1] EGFR 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

304

Estrogen signaling pathway 💬

[1] ESR1 💬

Ethinyl estradiol 💬

Ethinylestradiol

[4] 13, 46, 49, 299 💬

305

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Clomifene 💬

Clomifene

[1] 74 💬

306

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Estetrol 💬

Estetrol

[1] 53 💬

307

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Estetrol 💬

Estetrol

[1] 53 💬

308

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Estradiol 💬

Name	Other Names
Estradiol	Estradiol (JAN/USP/INN) Climara (TN) Divigel (TN) Estrace (TN) Estraderm (TN) Estrasorb (TN) Estring (TN) Estrogel (TN) Innofem (TN) Vagifem (TN) Vivelle (TN) IMVEXXY MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM

Estradiol

[7] 13, 46, 49, 65, 76, 226, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
76	Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
299	Cystic fibrosis;

309

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Estradiol valerate 💬

Estradiol valerate

[1] 65 💬

310

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Estriol 💬

Estriol

[2] 13, 227 💬

311

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Estriol tripropionate 💬

Estriol

[2] 13, 227 💬

312

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Fulvestrant 💬

Fulvestrant

[2] 49, 86 💬

313

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Mestranol 💬

Mestranol

[2] 46, 49 💬

314

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Prasterone 💬

Prasterone

[6] 49, 53, 83, 86, 96, 113 💬

Disease ID	Name
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
83	Addison disease;Primary chronic adrenocortical insufficiency;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
113	Muscular dystrophy;

315

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Raloxifene 💬

Raloxifene

[1] 46 💬

316

Estrogen signaling pathway 💬

[2] ESR1, ESR2 💬

Tamoxifen 💬

Tamoxifen

[3] 2 , 113, 227 💬

317

Estrogen signaling pathway 💬

[2] ESR1, PGR 💬

Danazol 💬

Danazol

[5] 60, 63, 64, 65, 285 💬

318

Estrogen signaling pathway 💬

[2] ESR1, PGR 💬

Desogestrel 💬

Desogestrel

[1] 230 💬

319

Estrogen signaling pathway 💬

[2] GABBR1, GABBR2 💬

Arbaclofen 💬

Arbaclofen

[2] 13, 206 💬

320

Estrogen signaling pathway 💬

[2] GABBR1, GABBR2 💬

Arbaclofen placarbil 💬

Arbaclofen Placarbil

[1] 13 💬

321

Estrogen signaling pathway 💬

[2] GABBR1, GABBR2 💬

Baclofen 💬

Baclofen

[8] 2 , 10, 13, 18, 65, 70, 149, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
10	Charcot-Marie-Tooth disease;CMT;
13	Multiple sclerosis/Neuromyelitis optica;
18	Spinocerebellar degeneration;SCD;
65	Primary immunodeficiency;
70	Spinal stenosis;Extensive spinal canal stenosis;
149	Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
206	Fragile X syndrome;

322

Estrogen signaling pathway 💬

[2] GABBR1, GABBR2 💬

Valiloxybate 💬

Valiloxybate

[1] 6 💬

323

Estrogen signaling pathway 💬

[2] KCNJ3, KCNJ5 💬

Amiodarone 💬

Amiodarone

[2] 28, 127 💬

324

Estrogen signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

325

Estrogen signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

326

Estrogen signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

327

Estrogen signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

328

Estrogen signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

329

Estrogen signaling pathway 💬

[1] OPRM1 💬

Buprenorphine 💬

Buprenorphine

[2] 46, 70 💬

330

Estrogen signaling pathway 💬

[1] OPRM1 💬

Dezocine 💬

Dezocine

[1] 46 💬

331

Estrogen signaling pathway 💬

[1] OPRM1 💬

Dihydrocodeine 💬

Dihydrocodeine

[1] 310 💬

332

Estrogen signaling pathway 💬

[1] OPRM1 💬

Fentanyl 💬

Fentanyl

[3] 46, 70, 215 💬

333

Estrogen signaling pathway 💬

[1] OPRM1 💬

Hydromorphone 💬

Hydromorphone

[1] 70 💬

334

Estrogen signaling pathway 💬

[1] OPRM1 💬

Loperamide 💬

Loperamide

[2] 13, 97 💬

335

Estrogen signaling pathway 💬

[1] OPRM1 💬

Morphine 💬

Morphine

[5] 36, 46, 70, 85, 86 💬

Disease ID	Name
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;

336

Estrogen signaling pathway 💬

[1] OPRM1 💬

Nalbuphine 💬

Nalbuphine

[1] 85 💬

337

Estrogen signaling pathway 💬

[1] OPRM1 💬

Nalmefene 💬

Nalmefene

[1] 6 💬

338

Estrogen signaling pathway 💬

[1] OPRM1 💬

Naloxone 💬

Naloxone

[2] 6 , 226 💬

339

Estrogen signaling pathway 💬

[1] OPRM1 💬

Naltrexone 💬

Naltrexone

[13] 6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
10	Charcot-Marie-Tooth disease;CMT;
13	Multiple sclerosis/Neuromyelitis optica;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;

340

Estrogen signaling pathway 💬

[1] OPRM1 💬

Oxycodone 💬

Oxycodone

[5] 6 , 13, 70, 226, 298 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
70	Spinal stenosis;Extensive spinal canal stenosis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
298	Hereditary pancreatitis;Chronic pancreatitis;

341

Estrogen signaling pathway 💬

[1] OPRM1 💬

Oxymorphone 💬

Oxymorphone

[1] 70 💬

342

Estrogen signaling pathway 💬

[1] OPRM1 💬

Remifentanil 💬

Remifentanil

[2] 6 , 70 💬

343

Estrogen signaling pathway 💬

[1] OPRM1 💬

Sufentanil 💬

Sufentanil

[2] 70, 280 💬

344

Estrogen signaling pathway 💬

[1] OPRM1 💬

Tramadol 💬

Tramadol

[5] 46, 70, 78, 226, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

345

Estrogen signaling pathway 💬

[1] OPRM1 💬

Trimebutine 💬

Trimebutine

[1] 51 💬

346

Estrogen signaling pathway 💬

[1] PGR 💬

Dydrogesterone 💬

Dydrogesterone

[1] 13 💬

347

Estrogen signaling pathway 💬

[1] PGR 💬

Levonorgestrel 💬

Levonorgestrel

[1] 13 💬

348

Estrogen signaling pathway 💬

[1] PGR 💬

Medroxyprogesterone acetate 💬

Medroxyprogesterone acetate

[8] 13, 35, 46, 49, 50, 51, 60, 107 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
60	Aplastic anemia;
107	Juvenile idiopathic arthritis;JIA;

349

Estrogen signaling pathway 💬

[1] PGR 💬

Megestrol acetate 💬

Megestrol acetate

[1] 76 💬

350

Estrogen signaling pathway 💬

[1] PGR 💬

Mifepristone 💬

Mifepristone

[1] 75 💬

351

Estrogen signaling pathway 💬

[1] PGR 💬

Nomegestrol 💬

Nomegestrol

[1] 13 💬

352

Estrogen signaling pathway 💬

[1] PGR 💬

Nomegestrol acetate 💬

Nomegestrol acetate

[1] 13 💬

353

Estrogen signaling pathway 💬

[1] PGR 💬

Norethindrone 💬

Norethisterone

[4] 13, 46, 49, 299 💬

354

Estrogen signaling pathway 💬

[1] PGR 💬

Norgestimate 💬

Norgestimate

[1] 299 💬

355

Estrogen signaling pathway 💬

[1] PGR 💬

Progesterone 💬

Progesterone

[2] 76, 299 💬

356

Estrogen signaling pathway 💬

[1] PGR 💬

Ulipristal 💬

Ulipristal

[1] 10 💬

357

Estrogen signaling pathway 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

358

Estrogen signaling pathway 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

359

Estrogen signaling pathway 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

360

Estrogen signaling pathway 💬

[1] PRKCD 💬

Sotrastaurin 💬

Sotrastaurin

[1] 97 💬

361

Estrogen signaling pathway 💬

[1] RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

362

Estrogen signaling pathway 💬

[1] RARA 💬

Acitretin 💬

Acitretin

[1] 37 💬

363

Estrogen signaling pathway 💬

[1] RARA 💬

Alitretinoin 💬

Alitretinoin

[1] 49 💬

364

Estrogen signaling pathway 💬

[1] RARA 💬

Fenretinide 💬

Fenretinide

[1] 299 💬

365

Estrogen signaling pathway 💬

[1] RARA 💬

Isotretinoin 💬

Isotretinoin

[4] 36, 39, 159, 160 💬

366

Estrogen signaling pathway 💬

[1] RARA 💬

Tamibarotene 💬

Tamibarotene

[2] 26, 96 💬

367

Estrogen signaling pathway 💬

[1] RARA 💬

Tretinoin 💬

Tretinoin

[6] 2 , 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
75	Cushing disease;Cushing;
94	Primary sclerosing cholangitis;PSC;
231	Alpha-1-antitrypsin deficiency;AATD;