DR info

Clinical trials : 108 / Drugs : 91 - (DrugBank : 36) / Drug target genes : 52 - Drug target pathways : 77

Fragile X syndrome and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
206	Fragile X syndrome	-
6	Parkinson disease	50.607
13	Multiple sclerosis/Neuromyelitis optica	45.299
8	Huntington disease	44.316
2	Amyotrophic lateral sclerosis	42.572
17	Multiple system atrophy	36.430
5	Progressive supranuclear palsy	36.011
97	Ulcerative colitis	33.960
18	Spinocerebellar degeneration	33.600
156	Rett syndrome	32.297
46	Malignant rheumatoid arthritis	29.053
3	Spinal muscular atrophy	28.157
21	Mitochondrial disease	26.505
140	Dorabe syndrome	26.324
96	Crohn disease	23.956
144	Lennox-Gastaut syndrome	23.520
193	Prader-Willi syndrome	23.208
70	Spinal stenosis	22.727
22	Moyamoya disease	22.095
205	Fragile X syndrome related disease	18.947
158	Tuberous sclerosis	18.473
145	West syndrome	16.735
152	PCDH19 related syndrome	16.000
201	Angelman syndrome	15.818
34	Neurofibromatosis	14.345
203	22q11.2 deletion syndrome	14.000
298	Hereditary pancreatitis	13.252
231	Alpha-1-antitrypsin deficiency	12.171
272	Fibrodysplasia ossificans progressiva	11.670
155	Acquired aphasia with convulsive disorder	10.953
75	Cushing disease	10.459
36	Epidermolysis bullosa	10.408
98	Eosinophilic gastrointestinal disease	10.182
296	Biliary atresia	9.752
84	Sarcoidosis	9.539
113	Muscular dystrophy	8.708
127	Frontotemporal lobar degeneration	7.259
118	Myelomeningocele	6.238
4	Primary lateral sclerosis	6.140
78	Hypopituitarism	6.046
169	Menkes disease	4.222
170	Occipital horn syndrome	4.222
179	Williams syndrome	4.222
215	Tetralogy of Fallot	4.214
280	Huge arteriovenous malformation with cervicofacial or limb lesion	3.954
49	Systemic lupus erythematosus	3.649
288	Autoimmune acquired coagulation factor deficiency	3.277
299	Cystic fibrosis	3.244
86	Pulmonary arterial hypertension	3.204
226	Interstitial cystitis with Hunners ulcer	3.125
11	Myasthenia gravis	3.000
171	Wilson disease	3.000
323	Aromatic L-amino acid decarboxylase deficiency	3.000
65	Primary immunodeficiency	2.250
85	Idiopathic interstitial pneumonia	2.182
337	Homocystinuria	2.000
120	Hereditary dystonia	2.000
77	Growth hormone secreting pituitary adenoma	2.000
254	Porphyria	1.657
67	Polycystic kidney disease	1.509
271	Ankylosing spondylitis	1.447
187	Kabuki syndrome	1.358
58	Hypertrophic cardiomyopathy	1.333
212	Tricuspid atresia	1.229
225	Congenital nephrogenic diabetes insipidus	1.219
210	Single Ventricle	1.172
149	Hemiconvulsion hemiplegia epilepsy syndrome	1.168
57	Idiopathic dilated cardiomyopathy	1.111
251	Urea cycle disorder	1.037
309	Progressive myoclonus epilepsy	1.037