DR info

Clinical trials : 93 / Drugs : 77 - (DrugBank : 8) / Drug target genes : 10 - Drug target pathways : 36

Alpha-1-antitrypsin deficiency and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
231	Alpha-1-antitrypsin deficiency	-
6	Parkinson disease	29.724
97	Ulcerative colitis	28.225
13	Multiple sclerosis/Neuromyelitis optica	26.198
70	Spinal stenosis	23.353
96	Crohn disease	23.333
298	Hereditary pancreatitis	22.594
46	Malignant rheumatoid arthritis	21.729
2	Amyotrophic lateral sclerosis	20.325
36	Epidermolysis bullosa	20.152
34	Neurofibromatosis	17.199
140	Dorabe syndrome	16.275
22	Moyamoya disease	16.208
144	Lennox-Gastaut syndrome	16.200
193	Prader-Willi syndrome	16.059
152	PCDH19 related syndrome	16.000
158	Tuberous sclerosis	15.029
156	Rett syndrome	14.891
84	Sarcoidosis	14.751
8	Huntington disease	14.700
201	Angelman syndrome	13.631
3	Spinal muscular atrophy	13.428
75	Cushing disease	12.976
205	Fragile X syndrome related disease	12.873
5	Progressive supranuclear palsy	12.853
296	Biliary atresia	12.754
272	Fibrodysplasia ossificans progressiva	12.659
21	Mitochondrial disease	12.605
145	West syndrome	12.461
206	Fragile X syndrome	12.171
155	Acquired aphasia with convulsive disorder	12.106
98	Eosinophilic gastrointestinal disease	10.704
17	Multiple system atrophy	10.694
18	Spinocerebellar degeneration	10.403
10	Charcot-Marie-Tooth disease	6.317
107	Juvenile idiopathic arthritis	5.934
1	Spinal and bulbar muscular atrophy	4.011
226	Interstitial cystitis with Hunners ulcer	3.973
256	Muscle glycogenosis	3.421
168	Ehlers-Danlos syndrome	3.095
86	Pulmonary arterial hypertension	2.916
51	Scleroderma	2.847
113	Muscular dystrophy	2.665
58	Hypertrophic cardiomyopathy	2.217
38	Stevens-Johnson syndrome	2.143
53	Sjogren syndrome	2.113
337	Homocystinuria	2.000
114	Non-dystrophic myotonia syndrome	1.905
28	Systemic amyloidosis	1.481
127	Frontotemporal lobar degeneration	1.250
251	Urea cycle disorder	1.057
111	Congenital myopathy	1.000