DR info

Clinical trials : 89 / Drugs : 107 - (DrugBank : 40) / Drug target genes : 65 - Drug target pathways : 108

Progressive supranuclear palsy and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)

ID	Diseases (Sorted by score)	Score
5	Progressive supranuclear palsy	-
6	Parkinson disease	60.082
13	Multiple sclerosis/Neuromyelitis optica	53.116
2	Amyotrophic lateral sclerosis	52.309
17	Multiple system atrophy	41.368
3	Spinal muscular atrophy	37.572
206	Fragile X syndrome	36.011
8	Huntington disease	30.643
156	Rett syndrome	28.720
22	Moyamoya disease	26.436
70	Spinal stenosis	26.138
18	Spinocerebellar degeneration	24.615
46	Malignant rheumatoid arthritis	23.064
97	Ulcerative colitis	22.800
96	Crohn disease	21.066
21	Mitochondrial disease	20.283
140	Dorabe syndrome	20.094
193	Prader-Willi syndrome	19.572
205	Fragile X syndrome related disease	18.726
34	Neurofibromatosis	18.292
296	Biliary atresia	18.162
144	Lennox-Gastaut syndrome	17.465
158	Tuberous sclerosis	16.594
152	PCDH19 related syndrome	16.000
201	Angelman syndrome	15.634
98	Eosinophilic gastrointestinal disease	14.066
203	22q11.2 deletion syndrome	14.000
231	Alpha-1-antitrypsin deficiency	12.853
145	West syndrome	12.350
127	Frontotemporal lobar degeneration	11.941
215	Tetralogy of Fallot	11.559
272	Fibrodysplasia ossificans progressiva	11.361
155	Acquired aphasia with convulsive disorder	10.593
298	Hereditary pancreatitis	9.405
169	Menkes disease	9.000
170	Occipital horn syndrome	9.000
36	Epidermolysis bullosa	8.802
113	Muscular dystrophy	8.063
75	Cushing disease	7.888
85	Idiopathic interstitial pneumonia	7.351
102	Rubinstein-Taybi syndrome	7.000
86	Pulmonary arterial hypertension	6.580
84	Sarcoidosis	6.292
118	Myelomeningocele	6.219
4	Primary lateral sclerosis	5.992
26	HTLV-1-associated myelopathy	5.305
256	Muscle glycogenosis	5.104
254	Porphyria	4.919
11	Myasthenia gravis	4.825
233	Wolfram syndrome	4.729
226	Interstitial cystitis with Hunners ulcer	4.713
89	Lymphangioleiomyomatosis	4.672
90	Retinitis pigmentosa	4.612
7	Corticobasal degeneration	4.185
78	Hypopituitarism	4.146
65	Primary immunodeficiency	4.102
299	Cystic fibrosis	3.438
58	Hypertrophic cardiomyopathy	3.301
323	Aromatic L-amino acid decarboxylase deficiency	3.000
57	Idiopathic dilated cardiomyopathy	2.949
280	Huge arteriovenous malformation with cervicofacial or limb lesion	2.888
222	Primary nephrotic syndrome	2.390
288	Autoimmune acquired coagulation factor deficiency	2.369
331	Idiopathic multicentric castleman disease	2.164
210	Single Ventricle	2.120
337	Homocystinuria	2.000
49	Systemic lupus erythematosus	1.858
278	Huge lymphatic malformation with cervicofacial lesion	1.855
212	Tricuspid atresia	1.212
107	Juvenile idiopathic arthritis	1.182
53	Sjogren syndrome	1.148
51	Scleroderma	1.141
149	Hemiconvulsion hemiplegia epilepsy syndrome	1.129
28	Systemic amyloidosis	1.049
251	Urea cycle disorder	1.031
19	Lysosomal storage disease	1.027
111	Congenital myopathy	1.000