51. Scleroderma Clinical trials / Disease details

Clinical trials : 525 / Drugs : 565 - (DrugBank : 148) / Drug target genes : 114 - Drug target pathways : 217

13 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04927390 (ClinicalTrials.gov)	December 8, 2021	19/5/2021	Mycophenolate in Limited Cutaneous Systemic Sclerosis (MINIMISE-Pilot)	A Randomised Prospective Open Label Pilot Trial Comparing Mycophenolate Mofetil(MMF) With no Immunos ...	Systemic Sclerosis;Limited Cutaneous Systemic Sclerosis	Drug: Mycophenolate Mofetil 500mg	University College, London	Versus Arthritis	Recruiting	18 Years	N/A	All	120	Phase 2	United Kingdom
2	EUCTR2019-004718-32-NL (EUCTR)	09/10/2020	09/10/2020	Stem cell transplantation in diffuse cutaneous systemic sclerosis: upfront therapy or rescue therapy ...	Upfront autologous hematopoietic stem cell transplantation versus immunosuppressive medication in ea ...	Diffuse cutaneous systemic sclerosis according to the ACR/EULAR criteria;Therapeutic area: Diseases ...	Trade Name: Mycophenolate mofetil	UMC Utrecht	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	120	Phase 4	Netherlands
3	NCT04244916 (ClinicalTrials.gov)	May 25, 2020	6/1/2020	MPA AUC Monitoring in Patients Receiving MMF for Diffuse Cutaneous or Pulmonary Involvement in Syste ...	Prospective Study to Investigate the Relevance of Monitoring Area Under the Curve of Mycophenolic Ac ...	Systemic Sclerosis	Biological: AUC of MPA measure	Assistance Publique - Hôpitaux de Paris	NULL	Recruiting	18 Years	N/A	All	50		France
4	NCT03678987 (ClinicalTrials.gov)	September 13, 2018	13/9/2018	Mycophenolate Mofetil Pharmacokinetics in Systemic Sclerosis	Mycophenolate Mofetilin Systemic Sclerosis: A Phase 1 Pharmacokinetic Study of Orally Ingested Mycop ...	Systemic Sclerosis;Gastrointestinal Complication	Diagnostic Test: P-MPA concentration;Drug: mycophenolic acid	Region Skane	NULL	Completed	18 Years	N/A	All	35	Phase 1	Sweden
5	NCT03221257 (ClinicalTrials.gov)	November 28, 2017	12/7/2017	Scleroderma Lung Study III - Combining Pirfenidone With Mycophenolate	Scleroderma Lung Study III (SLS III): Combining the Anti-fibrotic Effects of Pirfenidone (PFD) With ...	Scleroderma, Systemic;Interstitial Lung Disease	Drug: Pirfenidone (PFD);Drug: Placebo (Plac);Drug: Mycophenolate Mofetil (MMF)	Michael Roth	University of Michigan;Genentech, Inc.;University of California, Los Angeles	Completed	18 Years	N/A	All	51	Phase 2	United States
6	NCT02896205 (ClinicalTrials.gov)	October 2016	27/8/2016	Study to Compare the Efficacy of Mycophenolate Mofetilin Systemic Sclerosis Related Early Interstiti ...	A Randomized Controlled Trial to Compare the Efficacy of Oral Mycophenolate MofetilWith Placebo in P ...	Systemic Sclerosis;Scleroderma;Interstitial Lung Disease	Drug: Mycophenolate mofetil;Drug: Placebo	Postgraduate Institute of Medical Education and Research	NULL	Completed	18 Years	N/A	All	41	Phase 3	India
7	NCT02370693 (ClinicalTrials.gov)	March 2016	11/2/2015	Comparing and Combining Bortezomib and Mycophenolate in SSc Pulmonary Fibrosis	Comparing and Combining Bortezomib and Mycophenolate in SSc Pulmonary Fibrosis Grant Number: R34HL12 ...	Interstitial Lung Disease;ILD;Systemic Sclerosis;Scleroderma	Drug: Bortezomib;Drug: Placebo;Drug: Mycophenolate mofetil	Northwestern University	National Heart, Lung, and Blood Institute (NHLBI)	Recruiting	18 Years	N/A	All	30	Phase 2	United States
8	NCT01670565 (ClinicalTrials.gov)	August 2012	15/8/2012	Belimumab for the Treatment of Diffuse Cutaneous Systemic Sclerosis	Belimumab for the Treatment of Diffuse Cutaneous Systemic Sclerosis: A Phase 2a, Single-centered, Ra ...	Systemic Sclerosis	Drug: Belimumab;Drug: Mycophenolate Mofetil;Other: Placebo Infusion	Hospital for Special Surgery, New York	Human Genome Sciences Inc.	Completed	18 Years	N/A	All	20	Phase 2	United States
9	NCT02339441 (ClinicalTrials.gov)	June 2010	22/12/2014	Treatment Outcome in Early Diffuse Cutaneous Systemic Sclerosis	Treatment Outcome in Early Diffuse Cutaneous Systemic Sclerosis	Early Diffuse Cutaneous Systemic Sclerosis	Drug: Methotrexate;Drug: Mycophenolate mofetil;Drug: Cyclophosphamide	University of Manchester	NULL	Completed	18 Years	N/A	Both	320	N/A	NULL
10	NCT01047072 (ClinicalTrials.gov)	January 2010	11/1/2010	Low-Dose Conditioning Followed by Donor Stem Cell Transplant in Treating Patients With Severe System ...	Phase II Clinical Trial of Allogeneic Hematopoietic Cell Transplantation After Nonmyeloablative Cond ...	Systemic Scleroderma	Drug: fludarabine phosphate;Radiation: total-body irradiation;Drug: tacrolimus;Drug: mycophenolate mof ...	Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium	National Cancer Institute (NCI)	Withdrawn	18 Years	65 Years	Both	0	Phase 2	United States

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