Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)
(Synonym: Otrexup (TN))		[2] Abatacept,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D03203 		[4] CD80,
CD86,
DHFR,
DHFR2 💬		[17] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬[1] 46
2Abatacept + Methotrexate
(Synonym: Otrexup (TN))		[2] Abatacept,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D03203 		[4] CD80,
CD86,
DHFR,
DHFR2 💬		[17] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬[1] 46
3Adalimumab 40 mg sc every other week[1] Adalimumab[1] D02597 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 271
4Adalimumab 40 mg subcutaneous (SC) every other week (EOW)[1] Adalimumab[1] D02597 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
5Adalimumab with methotrexate
(Synonym: Otrexup (TN))		[2] Adalimumab,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D02597 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
6Any other approved Antiepileptic Drug----[1] 144
7Apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side[1] Sinecatechins[1] D08997 --[1] 160
8Apremilast
(Synonym: Otezla (TN))		[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[7] 46, 50, 56, 97, 107, 162, 271
9Apremilast (CC-10004)
(Synonym: Otezla (TN))		[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[1] 56
10Apremilast 10 mg
(Synonym: Otezla (TN))		[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[2] 56, 107
11Apremilast 20 mg
(Synonym: Otezla (TN))		[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[3] 46, 56, 107
12Apremilast 30 mg
(Synonym: Otezla (TN))		[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[3] 46, 56, 107
13Apremilast 30mg
(Synonym: Otezla (TN))		[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[1] 50
14Apremilast tablet 20 mg
(Synonym: Otezla (TN))		[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[1] 271
15Apremilast tablet 30 mg BID
(Synonym: Otezla (TN))		[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[1] 271
16AZATHIOPRINE or METHOTREXATE
(Synonym: Otrexup (TN))		[2] Azathioprine,
Methotrexate (Synonym: Otrexup)		[4] D00142 (Name: Otrexup (TN)),
D00238 ,
D02115 ,
D03033 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96
17Behavioral: Other Academic sham tutoring----[1] 34
18BMN 110 - Every Other Week----[1] 19
19BMN 110 Every Other Week----[1] 19
20BMS Drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin)
(Synonym: Prilosec OTC (TN))		[5] Digoxin,
Flurbiprofen,
Midazolam,
Montelukast,
Omeprazole (Synonym: Prilosec OTC)		[13] D00298 ,
D00330 ,
D00455 ,
D00529 ,
D00550 ,
D00696 ,
D01207 ,
D01475 ,
D02290 ,
D05028 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 ,
D08229 		[25] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4,
ATP4A,
ATP4B,
CYSLTR1,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
PTGS1,
PTGS2 💬		[49] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Arachidonic acid metabolism, Bile secretion, C-type lectin receptor signaling pathway, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Chemical carcinogenesis - DNA adducts, Collecting duct acid secretion, Endocrine and other factor-regulated calcium reabsorption, GABAergic synapse, Gastric acid secretion, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Insulin secretion, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, Mineral absorption, Morphine addiction, NF-kappa B signaling pathway, Neuroactive ligand-receptor interaction, Nicotine addiction, Ovarian steroidogenesis, Oxidative phosphorylation, Oxytocin signaling pathway, Pancreatic secretion, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, Taste transduction, Thyroid hormone signaling pathway, Thyroid hormone synthesis, VEGF signaling pathway, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 46
21BMS-582949 and Methotrexate
(Synonym: Otrexup (TN))		[2] BMS-582949,
Methotrexate (Synonym: Otrexup)		[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
22Bromocriptine and other dopamine agonists[2] Bromocriptine,
Dopamine		[4] D00633 ,
D00780 ,
D03165 ,
D07870 		[6] DRD1,
DRD2,
DRD3,
DRD4,
DRD5,
PRL 💬		[15] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 6
23Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF
(Synonym: Otrexup (TN))		[6] Busulfan,
Filgrastim,
Fludarabine,
Methotrexate (Synonym: Otrexup),
Phosphate ion,
Tacrolimus		[8] D00107 ,
D00142 (Name: Otrexup (TN)),
D00248 ,
D01907 ,
D02115 ,
D03235 ,
D07966 ,
D08556 		[9] CSF3R,
DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2,
RRM1 💬		[47] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 60
24Certolizumab Pegol + Methotrexate (MTX)
(Synonym: Otrexup (TN))		[2] Certolizumab pegol,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D03441 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
25Cipro (Ciprofloxacin, BAYQ3939)
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
26Ciprofloxacin
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[5] 2, 60, 96, 97, 299
27Ciprofloxacin (BAYQ3939) dry powder for inhalation
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
28Ciprofloxacin (Cipro Inhale, BAYQ3939)
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
29Ciprofloxacin (Cipro, BAYQ3939)
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
30Ciprofloxacin (ciproxin)
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
31Ciprofloxacin dispersion for inhalation
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
32Ciprofloxacin DPI
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
33Ciprofloxacin DPI (BAYQ3939)
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
34Ciprofloxacin for Inhalation
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
35Ciprofloxacin hydrochloride
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[2] 96, 299
36CIPROFLOXACIN HYDROCHLORIDE MONOHYDRATE
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
37Ciprofloxacin Inhale
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
38Clartihromycin, amoxicillin, and omeprazole
(Synonym: Prilosec OTC (TN))		[2] Amoxicillin,
Omeprazole (Synonym: Prilosec OTC)		[7] D00229 ,
D00455 ,
D01207 ,
D02925 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 ,
D07452 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 6
39Clobetasol propionate + Methotrexate
(Synonym: Otrexup (TN))		[3] Clobetasol,
Clobetasol propionate,
Methotrexate (Synonym: Otrexup)		[4] D00142 (Name: Otrexup (TN)),
D01272 ,
D02115 ,
D07715 		[3] DHFR,
DHFR2,
NR3C1 💬		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 162
40Combination Product: Exercise, and methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
41Combination Product: Laser, exercise, and methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
42Combination Product: Methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
43CP-690,550 + methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
44Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids
(Synonym: Otrexup (TN))		[3] Azathioprine,
Cyclophosphamide,
Methotrexate (Synonym: Otrexup)		[6] D00142 (Name: Otrexup (TN)),
D00238 ,
D00287 ,
D02115 ,
D03033 ,
D07760 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44
45Cyclosporin, Methotrexate (GVHD prophylaxis)
(Synonym: Otrexup (TN))		[2] Cyclosporine,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D00184 ,
D02115 		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[38] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 326
46Diagnostic Test: Other exploratory blood biomarkers----[1] 298
47Diclofenac + Omeprazole
(Synonym: Prilosec OTC (TN))		[2] Diclofenac,
Omeprazole (Synonym: Prilosec OTC)		[7] D00455 ,
D00903 ,
D00904 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 ,
D07816 		[4] ATP4A,
ATP4B,
PTGS1,
PTGS2 💬		[26] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Collecting duct acid secretion, Gastric acid secretion, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxidative phosphorylation, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 46
48Dimebon + Omeprazole
(Synonym: Prilosec OTC (TN))		[2] Latrepirdine,
Omeprazole (Synonym: Prilosec OTC)		[5] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 ,
D09917 		[8] ACHE,
ATP4A,
ATP4B,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[26] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Dopaminergic synapse, Gastric acid secretion, Glutamatergic synapse, Glycerophospholipid metabolism, Huntington disease, Long-term potentiation, Metabolic pathways, Neuroactive ligand-receptor interaction, Nicotine addiction, Oxidative phosphorylation, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[1] 8
49DMARDs (methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
50Doxorubicin, methotrexate, cyclophosphamide, L-asparaginase
(Synonym: Otrexup (TN))		[4] Asparaginase Escherichia coli,
Cyclophosphamide,
Doxorubicin,
Methotrexate (Synonym: Otrexup)		[6] D00142 (Name: Otrexup (TN)),
D00287 ,
D02115 ,
D02997 ,
D03899 ,
D07760 		[4] DHFR,
DHFR2,
TOP2A,
TOP2B 💬		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Platinum drug resistance 💬[1] 65
51Early immunosuppressants (azathioprine, methotrexate)
(Synonym: Otrexup (TN))		[2] Azathioprine,
Methotrexate (Synonym: Otrexup)		[4] D00142 (Name: Otrexup (TN)),
D00238 ,
D02115 ,
D03033 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96
52Enalapril and other angiotensin converting enzyme inhibitors[2] Angiotensin II,
Enalapril		[4] D00150 ,
D00621 ,
D02014 ,
D07892 		[3] ACE,
AGTR1,
AGTR2 💬		[18] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 19
53Etanercept + Methotrexate
(Synonym: Otrexup (TN))		[2] Etanercept,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D00742 ,
D02115 		[4] DHFR,
DHFR2,
LTA,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
54Etanercept , Methotrexate
(Synonym: Otrexup (TN))		[2] Etanercept,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D00742 ,
D02115 		[4] DHFR,
DHFR2,
LTA,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
55Etanercept, methotrexate and depomedrone
(Synonym: Otrexup (TN))		[2] Etanercept,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D00742 ,
D02115 		[4] DHFR,
DHFR2,
LTA,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
56Etanercept, Methotrexate, Prednisolone
(Synonym: Otrexup (TN))		[3] Etanercept,
Methotrexate (Synonym: Otrexup),
Prednisolone		[11] D00142 (Name: Otrexup (TN)),
D00472 ,
D00742 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02115 ,
D02156 ,
D03301 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 56
57Etanercept, other Biologics, Disease-modifying antirheumatic drugs (DMARDs), etc[1] Etanercept[1] D00742 [2] LTA,
TNF 💬		[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
58Ethylmethylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester (**See other 2 names below)----[1] 6
59Ezetimibe + other lipid-lowering medication(s)[1] Ezetimibe[1] D01966 [1] NPC1L1 💬[1] Fat digestion and absorption 💬[1] 260
60Fixed dose combination Ciprofloxacin/Celecoxib
(Synonym: CIPROFLOXACIN OTIC)		[2] Celecoxib,
Ciprofloxacin (Synonym: Otovel)		[3] D00186 (Name: Otiprio (TN)),
D00567 ,
D02216 (Name: CIPROFLOXACIN OTIC)		[1] PTGS2 💬[22] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 2
61Fluocinolone Acetonide
(Synonym: FLAC OTIC OIL)		[2] Fluocinolone,
Fluocinolone acetonide (Synonym: Synalar Bi-otic Solution)		[1] D01825 (Name: FLAC OTIC OIL)[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 90
62Genetic: Infusion of autologous cryopreserved EFS-ADA LV CD34+ cells (OTL-101)----[1] 65
63Genetic: Infusion of autologous EFS-ADA LV CD34+ (OTL-101)----[1] 65
64GSK3196165 (Otilimab)[1] Otilimab[1] D11343 (Name: Otilimab)[1] CSF2 💬[16] Acute myeloid leukemia, Amoebiasis, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, IL-17 signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Natural killer cell mediated cytotoxicity, Rheumatoid arthritis, Shigellosis, T cell receptor signaling pathway, TNF signaling pathway, Transcriptional misregulation in cancer 💬[2] 46, 256
65Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)
(Synonym: Otrexup (TN))		[4] Azathioprine,
Methotrexate (Synonym: Otrexup),
Mycophenolate mofetil,
Mycophenolic acid		[8] D00142 (Name: Otrexup (TN)),
D00238 ,
D00752 ,
D02115 ,
D03033 ,
D05094 ,
D05095 ,
D05096 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬		[7] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism 💬[1] 49
66Immunosuppressors (Thiopurines or Methotrexate)
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96
67Infliximab + methotrexate (MTX)
(Synonym: Otrexup (TN))		[2] Infliximab,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D02598 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
68Infliximab plus methotrexate
(Synonym: Otrexup (TN))		[2] Infliximab,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D02598 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 107
69Infliximab, methylprednisolone, methotrexate
(Synonym: Otrexup (TN))		[3] Infliximab,
Methotrexate (Synonym: Otrexup),
Methylprednisolone		[9] D00142 (Name: Otrexup (TN)),
D00407 ,
D00751 ,
D00979 ,
D02115 ,
D02598 ,
D05000 ,
D05001 ,
D05002 		[4] DHFR,
DHFR2,
NR3C1,
TNF 💬		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
70Intrathecal methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 13
71L01X - Other antineoplastic agents----[1] 85
72Losartan and other angiotensin receptor blockers[2] Angiotensin II,
Losartan		[4] D00150 ,
D00357 ,
D02014 ,
D08146 		[2] AGTR1,
AGTR2 💬		[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 19
73M2951 (Other Name: Evobrutinib)[1] Evobrutinib---[1] 49
74Methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
75Methotrexate 'Lederle' 2,5mg tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
76Methotrexate 'Lederle' 2.5mg Tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
77Methotrexate 'Lederle' Tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
78Methotrexate (Metoject® prefilled pen)
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
79Methotrexate (MTX)
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
80Methotrexate (stable dose)
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
81Methotrexate (tapering dose)
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
82Methotrexate + biologic administration
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
83Methotrexate + Infliximab
(Synonym: Otrexup (TN))		[2] Infliximab,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D02598 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
84Methotrexate + Methylprednisolone
(Synonym: Otrexup (TN))		[2] Methotrexate (Synonym: Otrexup),
Methylprednisolone		[8] D00142 (Name: Otrexup (TN)),
D00407 ,
D00751 ,
D00979 ,
D02115 ,
D05000 ,
D05001 ,
D05002 		[3] DHFR,
DHFR2,
NR3C1 💬		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 46
85Methotrexate + salazopyrine + hydroxychloroquine administration
(Synonym: Otrexup (TN))		[2] Hydroxychloroquine,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D08050 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
86METHOTREXATE - 20 MG/0.8 ML SOLUZIONE INIETTABILE 4 SIRINGHE PRERIEMPITE MONOUSO DA 1.25 ML
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96
87Methotrexate - Amneal
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
88Methotrexate - DAVA
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
89Methotrexate - Delay
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
90Methotrexate - etanercept - prednisolone arm
(Synonym: Otrexup (TN))		[3] Etanercept,
Methotrexate (Synonym: Otrexup),
Prednisolone		[11] D00142 (Name: Otrexup (TN)),
D00472 ,
D00742 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02115 ,
D02156 ,
D03301 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[2] 46, 107
91Methotrexate - Immediate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
92Methotrexate 10 mg
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
93Methotrexate 10 mg tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
94Methotrexate 2.5 mg
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44
95METHOTREXATE 2.5 mg tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
96Methotrexate 2.5mg Tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
97Methotrexate 2.5mg Tablets BP
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
98Methotrexate 25 mg
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44
99Methotrexate 50mg/ml solution for injection, pre-filled syringe
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
100Methotrexate ``Lederle`` 2.5mg tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
101Methotrexate alone
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 107
102Methotrexate and folic acid
(Synonym: Otrexup (TN))		[2] Folic acid,
Methotrexate (Synonym: Otrexup)		[3] D00070 ,
D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 49
103Methotrexate as methotrexate disodium
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
104Methotrexate bellon
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 97
105Methotrexate bellon 25mg/ml
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 97
106Methotrexate capsules
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
107METHOTREXATE DISODIUM
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[5] 46, 96, 97, 107, 271
108Methotrexate Ebewe
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
109METHOTREXATE HOSPIRA 2,5 mg tablety
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
110METHOTREXATE HOSPIRA 2.5 mg tablety
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
111Methotrexate injection
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 96, 97
112Methotrexate Lachema 5inj. sol
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50
113Methotrexate Lederle 2.5 mg Tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
114Methotrexate Pfizer 2,5 mg tabletter
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
115Methotrexate Placebo
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
116Methotrexate plus ENBREL or ENBREL alone
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
117Methotrexate plus ERB-041 for 12 weeks
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
118Methotrexate plus sulfasalazine
(Synonym: Otrexup (TN))		[2] Methotrexate (Synonym: Otrexup),
Sulfasalazine		[3] D00142 (Name: Otrexup (TN)),
D00448 ,
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
119Methotrexate pre-filled pen
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
120Methotrexate prefilled pen
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 107
121Methotrexate prefilled syringe
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
122METHOTREXATE SODIUM
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 256
123Methotrexate Sodium 2.5mg Tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
124Methotrexate Sodium Tablets 2.5 mg
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
125Methotrexate Sodium Tablets 2.5mg
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
126Methotrexate Tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 40
127Methotrexate tablets 2.5 mg
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
128Methotrexate treatment
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 41, 46
129Methotrexate Wyeth 2,5mg
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50
130Methotrexate Wyeth 2,5mg tbl.
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50
131Methotrexate ® 2.5mg Tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
132Methotrexate(MTX)
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
133Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
134Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
135Methotrexate(necessary)
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
136METHOTREXATE*100CPR 2,5MG
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
137METHOTREXATE*10MG/1,33ML 4S
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
138METHOTREXATE*15MG/2ML 4SIR
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
139METHOTREXATE*2,5MG 25CPR
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
140METHOTREXATE*20MG/2,66ML 4S
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
141METHOTREXATE*25CPR 2,5MG
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 107
142METHOTREXATE*7,5MG/ML 4SIR.
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
143Methotrexate, Leucovorin and BMS-986142
(Synonym: Otrexup (TN))		[3] BMS-986142,
Leucovorin,
Methotrexate (Synonym: Otrexup)		[5] D00142 (Name: Otrexup (TN)),
D01211 ,
D02115 ,
D07986 ,
D07987 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
144Methotrexate,Adalimumab
(Synonym: Otrexup (TN))		[2] Adalimumab,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D02597 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
145Methotrexate-Lachema
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
146Methotrexate-Sulfasalazine-Hydroxychloroquine
(Synonym: Otrexup (TN))		[3] Hydroxychloroquine,
Methotrexate (Synonym: Otrexup),
Sulfasalazine		[4] D00142 (Name: Otrexup (TN)),
D00448 ,
D02115 ,
D08050 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
147Methotrexate® 2.5 mg tablets
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
148Methylprednisolone (or other glucocorticoid)[1] Methylprednisolone[6] D00407 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 43
149MP-435(dose1) + Methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
150MSDMDs other than Betaseron (Interferon beta-1b, BAY86-5046)[2] Human interferon beta,
Interferon beta-1b		[1] D00746 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[1] 13
151Mycophenolate mofetil,methotrexate
(Synonym: Otrexup (TN))		[3] Methotrexate (Synonym: Otrexup),
Mycophenolate mofetil,
Mycophenolic acid		[6] D00142 (Name: Otrexup (TN)),
D00752 ,
D02115 ,
D05094 ,
D05095 ,
D05096 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬		[7] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism 💬[3] 42, 43, 45
152Naproxen 500 mg tablets (PN 200 minus omeprazole)
(Synonym: Prilosec OTC (TN))		[2] Naproxen,
Omeprazole (Synonym: Prilosec OTC)		[5] D00118 ,
D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[4] ATP4A,
ATP4B,
PTGS1,
PTGS2 💬		[26] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Collecting duct acid secretion, Gastric acid secretion, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxidative phosphorylation, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[2] 46, 271
153Omeprazole
(Synonym: Prilosec OTC (TN))		[1] Omeprazole (Synonym: Prilosec OTC)[4] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
154Omeprazole (UK licensed generic product)
(Synonym: Prilosec OTC (TN))		[1] Omeprazole (Synonym: Prilosec OTC)[4] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 85
155Omeprazole 20 mg
(Synonym: Prilosec OTC (TN))		[1] Omeprazole (Synonym: Prilosec OTC)[4] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[2] 96, 97
156Omeprazole 20 MG Oral Tablet
(Synonym: Prilosec OTC (TN))		[1] Omeprazole (Synonym: Prilosec OTC)[4] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 98
157Omeprazole 20mg
(Synonym: Prilosec OTC (TN))		[1] Omeprazole (Synonym: Prilosec OTC)[4] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 51
158Omeprazole 20mg BID
(Synonym: Prilosec OTC (TN))		[1] Omeprazole (Synonym: Prilosec OTC)[4] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 98
159Omeprazole 40 mg
(Synonym: Prilosec OTC (TN))		[1] Omeprazole (Synonym: Prilosec OTC)[4] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 96
160Omeprazole 40mg Capsule
(Synonym: Prilosec OTC (TN))		[1] Omeprazole (Synonym: Prilosec OTC)[4] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 299
161OMEPRAZOLE MAGNESIUM
(Synonym: Prilosec OTC (TN))		[2] Magnesium,
Omeprazole (Synonym: Prilosec OTC)		[4] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 225
162Omeprazole rectally 1mg/kg
(Synonym: Prilosec OTC (TN))		[1] Omeprazole (Synonym: Prilosec OTC)[4] D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 294
163Oral ciprofloxacin
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
164Oral ciprofloxacin plus inhaled colistin
(Synonym: CIPROFLOXACIN OTIC)		[2] Ciprofloxacin (Synonym: Otovel),
Colistin		[4] D00186 (Name: Otiprio (TN)),
D02138 ,
D02216 (Name: CIPROFLOXACIN OTIC),
D07746 		--[1] 299
165Oral methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
166OT----[1] 193
167Otelixizumab[1] Otelixizumab[1] D08959 (Name: Otelixizumab)[3] CD3D,
CD3E,
CD3G 💬		[11] Chagas disease, Epstein-Barr virus infection, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human immunodeficiency virus 1 infection, Measles, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation 💬[1] 46
168Otezla[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[3] 56, 107, 162
169OTEZLA - 10 MG + 20 MG + 30 MG COMPRESSA RIVESTITA CON FILM USO ORALE - BLISTER (PVC/ALU) IN UN ASTUCCIO - 4 COMPRESSE DA 10 MG + 4 COMPRESSE DA 20 MG +19 COMPRESSE DA 30 MG[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[2] 56, 107
170OTEZLA - 30 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/ALU) - 56 COMPRESSE[1] Apremilast (Synonym: Otezla)[1] D08860 (Name: Otezla (TN))[4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[1] 107
171Other analgesics and antipyretics----[1] 13
172Other antiepileptics----[1] 140
173Other Biologic Therapies----[2] 96, 97
174Other biological agent----[2] 46, 96
175Other Biologics----[1] 46
176Other COX-2 inhibitor----[1] 271
177Other Cox-2 inhibitors----[1] 271
178Other Crystalloid----[1] 296
179Other disease-modifying therapy----[1] 13
180Other DMARDs----[1] 46
181Other H1 antagonist----[1] 13
182Other hematological Agents----[1] 65
183Other intervention(s)----[1] 70
184OTHER NERVOUS SYSTEM DRUGS----[2] 6, 13
185Other Non Steroidal Anti-Inflammatory Drugs (NSAIDs) except etodolac[1] Etodolac[1] D00315 [1] PTGS2 💬[22] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 46
186Other Non-selective NSAIDs----[1] 271
187Other non-sponsor pancreatic enzyme replacement therapy----[1] 299
188Other Parkinson's Disease treatments----[1] 6
189Other respiratory system products----[1] 299
190OTHER SOURCES----[1] 228
191Other vasodilator----[1] 51
192Other:----[2] 2, 65
193Other: 0 mg----[1] 97
194Other: 0.02% Fm, SH, tBCL----[1] 53
195Other: 0.9% sodium chloride[2] Chloride ion,
Sodium chloride		[1] D02056 --[1] 65
196Other: 0.9ml sodium chloride[2] Chloride ion,
Sodium chloride		[1] D02056 --[1] 271
197Other: 1 Food Elimination Diet----[1] 98
198Other: 1 Food Elimination Diet Therapy----[1] 98
199Other: 100% pomegranate juice[1] Pomegranate---[2] 96, 97
200Other: 13C6 Leucine[1] Leucine[1] D00030 --[3] 5, 7, 127
201Other: 18F-FDG[1] Fludeoxyglucose (18F)---[2] 46, 84
202Other: 18F-FDG PET/CT[1] Fludeoxyglucose (18F)---[1] 41
203Other: 18F-Fluorodeoxyglucose (18F-FDG) PET/CT[1] Fludeoxyglucose (18F)---[1] 84
204Other: 18F-GE-180[1] Flutriciclamide F-18---[1] 46
205Other: 2h standardized aerobic exercise----[1] 78
206Other: 3-days water-fasting[1] Water[1] D00001 --[1] 67
207Other: 31-Phosphorus RMN Spectroscopy[1] Phosphorus---[1] 8
208Other: 4 Food Elimination Diet----[1] 98
209Other: 4 Food Elimination Diet (post 1FED failure)----[1] 98
210Other: 5-ASA Withdrawal[1] Mesalazine[1] D00377 --[1] 96
211Other: 6 Food Elimination Diet (after 1FED failure)----[1] 98
212Other: 6 Food Elimination Diet Therapy----[1] 98
213Other: 60% Oxygen[1] Oxygen[1] D00003 --[1] 85
214Other: [11C]-Methionine PET/MRI[1] Methionine[2] D00019 ,
D04983 		--[1] 75
215Other: [11C]donepezil PET[1] Donepezil[2] D00670 ,
D07869 		[1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[1] 6
216Other: A-STEP----[1] 299
217Other: A-STEP (New Protocol)----[1] 299
218Other: Abdominal compression----[1] 17
219Other: Absorptive clearance scan----[1] 299
220Other: Acute response to high-impact exercise----[1] 96
221Other: Ad libitum water intake[1] Water[1] D00001 --[1] 67
222Other: Adalimumab[1] Adalimumab[1] D02597 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
223Other: Adalimumab treatment[1] Adalimumab[1] D02597 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 151
224Other: Additional Therapies----[1] 97
225Other: Air - oxygen[1] Oxygen[1] D00003 --[1] 299
226Other: Aminoacid, alanine-infusion[1] Alanine[1] D00012 --[1] 251
227Other: Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised----[1] 2
228Other: Antigen (wheat base soy sauce) spray[1] Wheat[1] D06902 --[1] 98
229Other: anxiety----[1] 13
230Other: Assessment of medication compliance----[1] 98
231Other: At-home natalizumab treated MS patient[1] Natalizumab[1] D06886 [1] ITGA4 💬[14] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬[1] 13
232Other: Autogenic drainage----[1] 299
233Other: Autologous Platelet rich plasma----[1] 35
234Other: autologous serum and rebamipide 2%[1] Rebamipide[1] D01121 --[1] 53
235Other: Avise PG - Diagnostic test----[1] 46
236Other: Balance[1] Isoxaflutole---[3] 6, 13, 299
237Other: Balance exercise[1] Isoxaflutole---[1] 6
238Other: Balance exercise program using exoskeleton device[1] Isoxaflutole---[1] 13
239Other: Balance exercises[1] Isoxaflutole---[1] 13
240Other: Balance Trainer Balance Exercises[1] Isoxaflutole---[1] 13
241Other: Balance Training[1] Isoxaflutole---[2] 6, 13
242Other: Baseline serum vitamin D level at or above 50 nmol/l[1] Vitamin D---[1] 46
243Other: Baseline serum vitamin D level below 50 nmol/l[1] Vitamin D---[1] 46
244Other: beetroot juice extract----[1] 113
245Other: Berg Balance Scale[1] Isoxaflutole---[2] 6, 13
246Other: Best Medical Treatment----[1] 6
247Other: Best Practice----[1] 60
248Other: Biological samples----[1] 206
249Other: Biopsy----[1] 51
250Other: Blood analysis for frataxin's level measurement----[1] 18
251Other: Blood collection for measurement of eculizumab peak concentrations[1] Eculizumab[1] D03940 [1] C5 💬[10] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[1] 62
252Other: Blood drawing only Group C----[1] 49
253Other: Blood draws----[3] 49, 51, 85
254Other: Blood glucose results[1] Dextrose, unspecified form---[1] 299
255Other: blood sample----[1] 299
256Other: Blood sample and cotton skin swabs[1] Cotton---[1] 162
257Other: Blood samples----[1] 93
258Other: Blood sampling for Laboratory Developed Test (LDT) analysis----[1] 65
259Other: Blood test----[2] 83, 96
260Other: Blood-flow restricted training----[1] 15
261Other: BMI greater than or equal to 30kg/m2 scheduled for PSG. Undergo blood draw (arterial blood gas and metabolic panel) and data collection from PSG study.----[1] 230
262Other: BMI greater than or equal to 30kg/m2 scheduled for PSG. Undergo blood draw (venous blood gas and metabolic panel) and data collection from PSG study.----[1] 230
263Other: Bone Marrow aspiration----[1] 2
264Other: Bone Marrow Cell Transplantation----[1] 274
265Other: Brain MRI (magnetic resonance imaging)----[1] 17
266Other: Brief Pain Inventory questionnaire----[1] 19
267Other: Bronchoalveolar samples----[1] 51
268Other: BSC----[1] 85
269Other: Caffeine[1] Caffeine[2] D00528 ,
D01453 		[11] ADORA1,
ADORA2A,
PDE1B,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE5A 💬		[22] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 13
270Other: Calcium stable isotope[1] Calcium---[1] 186
271Other: Carbon monoxide-bubbled mediums[2] Activated charcoal,
Carbon monoxide		[1] D09706 --[1] 298
272Other: carboxy methyl cellulose[2] Methylcellulose,
Microcrystalline cellulose		[2] D00093 ,
D04996 		--[1] 53
273Other: Cardiopulmonary evaluation----[1] 13
274Other: Cawthorne Cooksey exercises----[1] 13
275Other: CD LFD----[1] 96
276Other: CD-TREAT diet----[1] 96
277Other: Challenge agent: capsaicin[1] Capsaicin (Synonym: Pallerix OTC BIOfrequency Chip)[1] D00250 [1] TRPV1 💬[2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 19
278Other: Classic, progressive endurance training----[1] 13
279Other: Clinical data collection----[3] 49, 51, 85
280Other: clinical observation----[1] 205
281Other: CoA-Z----[1] 120
282Other: Coaching Sessions----[1] 49
283Other: CoDuSe balance training and step square exercises[1] Isoxaflutole---[1] 13
284Other: Coffee[1] Arabica coffee bean---[1] 96
285Other: Cognitive training----[1] 206
286Other: Colchicine Cessation[1] Colchicine[1] D00570 [9] TUBB,
TUBB1,
TUBB2A,
TUBB2B,
TUBB3,
TUBB4A,
TUBB4B,
TUBB6,
TUBB8 💬		[10] Alzheimer disease, Amyotrophic lateral sclerosis, Gap junction, Huntington disease, Parkinson disease, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Phagosome, Prion disease, Salmonella infection 💬[1] 266
287Other: collection of CSF, blood, urine, saliva----[1] 6
288Other: Communicative Effectiveness Survey----[1] 2
289Other: Comparator: CPET cycle ergometer (Gold Standard)[1] Gold---[1] 299
290Other: Computer game based balance and walking rehabilitation for individuals with Parkinson's Disease[1] Isoxaflutole---[1] 6
291Other: Concomitant Medication----[1] 49
292Other: Continuation of dornase alfa (dnase)[1] Dornase alfa[1] D03896 --[1] 299
293Other: Continuation of hypertonic saline (HS)----[1] 299
294Other: continue their usual therapy----[1] 66
295Other: Control----[9] 6, 19, 67, 70, 75, 85, 97, 162, 193
296Other: Control Diet----[1] 96
297Other: Control group----[1] 2
298Other: Control group(Normal saline)----[1] 97
299Other: Control wound treatment----[1] 36
300Other: Controlled environment tests (series of tasks of everyday life)----[1] 6
301Other: Controls Primary Cervical Dystonia (Trihexyphenidyl)[1] Trihexyphenidyl[2] D00787 ,
D08638 		[5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[1] 6
302Other: conventional balance training[1] Isoxaflutole---[1] 13
303Other: Conventional drugs----[1] 97
304Other: Conventional PCA mode----[1] 70
305Other: Conventional physiotherapy----[1] 6
306Other: Core stability----[1] 13
307Other: corn starch[1] Starch, corn[1] D05297 --[1] 49
308Other: corticotropin releasing hormone (CRH)[1] Corticotropin[1] D00146 [1] MC2R 💬[5] Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[1] 78
309Other: Cough monitor[1] Methamidophos---[1] 85
310Other: Covid-19 vaccine----[1] 13
311Other: Crohn's disease exclusion diet (CDED)----[1] 96
312Other: Crohn's Disease TReatment-with-EATing diet (CD-TREAT diet)----[1] 96
313Other: Crohns Disease Exclusion Diet----[1] 96
314Other: Cultured Thymus Tissue Implantation and Parental Parathyroid Transplantation----[1] 65
315Other: Cultured Thymus Tissue Implantation with Parathyroid Transplantation----[1] 65
316Other: current treatment----[1] 46
317Other: cyclosporin A[1] Cyclosporine[1] D00184 [5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 60
318Other: Cysteamine bitartrate[1] Cysteamine[2] D03634 ,
D03635 		--[1] 19
319Other: D-xylose[1] Xylose[1] D06346 --[1] 98
320Other: D5W----[1] 222
321Other: Data Capture[1] Bifenthrin---[1] 6
322Other: De-implementation of Inhaled Nitric Oxide (iNO) use[1] Nitric Oxide[1] D00074 --[1] 294
323Other: Dead Sea Solar and Water Treatment[1] Water[1] D00001 --[1] 46
324Other: Determination of calcium intake by a dietician interview[1] Calcium---[2] 13, 46
325Other: dextrose water 5%[2] Dextrose, unspecified form,
Water		[1] D00001 --[1] 56
326Other: diagnostic laboratory biomarker analysis----[1] 74
327Other: Diagnostics for glucose tolerance with 3 different methods.[1] Dextrose, unspecified form---[1] 299
328Other: Diary completion----[1] 6
329Other: Diet----[1] 240
330Other: Diet treatment----[1] 240
331Other: Diet-CD----[1] 96
332Other: dietary intervention with no-carrageenan diet----[1] 97
333Other: Dietary recommendations----[1] 51
334Other: Digestible Maltodextrin[1] Maltodextrin[1] D02329 --[1] 96
335Other: Discontinuation of dornase alfa (dnase)[1] Dornase alfa[1] D03896 --[1] 299
336Other: Discontinuation of hypertonic saline (HS)----[1] 299
337Other: DMT withdrawal----[1] 13
338Other: dobutamine[1] Dobutamine[4] D00632 ,
D03879 ,
D03880 ,
D03881 		[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 215
339Other: Donor derived G-CSF mobilized PBC[1] Filgrastim[1] D03235 [1] CSF3R 💬[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬[1] 60
340Other: Donor Lymphocyte Infusion----[1] 65
341Other: Dosage of Delta-aminolevulinic acid and Porphobilinogen[2] Aminolevulinic acid,
Porphobilinogen		[2] D02908 ,
D07567 		--[1] 254
342Other: Dose reduction to 2mg/L----[1] 46
343Other: Dose reduction to 5mg/L----[1] 46
344Other: Dried blood spot test for MPS----[1] 19
345Other: Drug free----[1] 49
346Other: Dual Task Performance----[1] 13
347Other: Dummy Tripterygium wilfordii Hook F (TwHF)[1] Tripterygium wilfordii whole---[1] 46
348Other: Dynamic Balance Training[1] Isoxaflutole---[1] 13
349Other: Dynamic balance walking training[1] Isoxaflutole---[1] 13
350Other: Dystrophin levels----[1] 113
351Other: DYT 1 Dystonia----[1] 6
352Other: DYT 1 Dystonia (Healthy Control)----[1] 6
353Other: e-Monitoring----[1] 97
354Other: Eating Assessment Tool 10----[1] 2
355Other: Eating Assessment Tool-10----[1] 2
356Other: Echocardiogram----[1] 113
357Other: Eculizumab[1] Eculizumab[1] D03940 [1] C5 💬[10] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[1] 109
358Other: EEnG Questionnaire----[1] 291
359Other: EIT----[1] 228
360Other: Electroencephalogram (EEG) awake andextended overnight----[1] 19
361Other: Elektro-Entero-Graphy procedure----[1] 291
362Other: Elimination diet----[1] 98
363Other: Empiric use of Calcium Carbonate and Calcitriol[3] Calcitriol,
Calcium,
Carbonate ion		[1] D00129 [1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[1] 235
364Other: Endurance----[1] 6
365Other: enteral nutrition----[1] 96
366Other: Epiduroscopy----[1] 70
367Other: Epistaxis charts----[1] 227
368Other: EUS procedure----[1] 298
369Other: Evaluation by Investigator----[1] 6
370Other: Evaluation of degree chronic fatigue.----[1] 13
371Other: Event-related evoked potential using electroencephalography (EEG).----[1] 6
372Other: Exclusion Diet----[1] 96
373Other: Exclusive enteral nutrition----[1] 96
374Other: Exclusive Enteral Nutrition (EEN)----[1] 96
375Other: Exercise capacity----[1] 299
376Other: Exercise echocardiography----[1] 58
377Other: Exercise followed cold water immersion[1] Water[1] D00001 --[1] 46
378Other: Exercise intervention----[2] 13, 18
379Other: Exposure to methylprednisolone during pregnancy[1] Methylprednisolone[6] D00407 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 13
380Other: Extracorporeal Photopheresis (ECP) with Methoxsalen[1] Methoxsalen[1] D00139 --[1] 51
381Other: Faecal bacterial transplantation----[1] 97
382Other: Fast Mimicking Diet----[1] 97
383Other: fatigue----[1] 13
384Other: Fear of falling----[1] 13
385Other: fingolimod[1] Fingolimod[1] D10001 [1] S1PR1 💬[3] FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[1] 13
386Other: Fitbit Activity Monitor[1] Methamidophos---[1] 49
387Other: flow cytometry----[3] 28, 51, 60
388Other: Fluid Restriction----[1] 72
389Other: Fluorescein angiography[1] Fluorescein[2] D01261 ,
D02024 		--[1] 19
390Other: fog----[1] 6
391Other: Follow-up study of the untreated cohort----[1] 193
392Other: Food Diary----[1] 65
393Other: Four Square Step Test----[2] 6, 13
394Other: Fractional Exhaled NO (FENO)----[1] 96
395Other: Fresh Frozen Plasma----[1] 14
396Other: Fruit juice----[1] 299
397Other: Functional involvement of identified epigenetic alterations----[1] 102
398Other: Functional mobility----[2] 6, 13
399Other: Functional Oral Intake Scale----[1] 2
400Other: Functional Reach Test----[2] 6, 13
401Other: Gadobutrol[1] Gadobutrol[1] D07420 --[1] 46
402Other: Gait and balance group training[1] Isoxaflutole---[1] 6
403Other: General and Neurological examination----[1] 19
404Other: general population----[2] 46, 271
405Other: Generation of Induced Pluripotent Stem Cells (iPSC) from fibroblasts obtained by skin biopsy----[1] 102
406Other: Genetic data/DNA/RNA----[3] 49, 51, 85
407Other: GH pause----[1] 78
408Other: GHRH plus arginine test[2] Arginine,
Somatorelin		[2] D02982 ,
D08523 		[1] GHRHR 💬[2] Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction 💬[1] 78
409Other: GHRH+Arg, GHRH+Arg, ITT[1] Somatorelin[1] D08523 [1] GHRHR 💬[2] Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction 💬[1] 78
410Other: Glucose[1] Dextrose, unspecified form---[1] 254
411Other: Glucose -potentiated arginine (GPA) stimulation tests[2] Arginine,
Dextrose, unspecified form		[1] D02982 --[1] 299
412Other: Glucose profile for 2 weeks[1] Dextrose, unspecified form---[1] 299
413Other: glucose solution at a dose of 1.75 g/kg (up to a maximum of 75 g) for the OGTT and glucose solution at a dose of 0.5 g/kg (up to a maximum of 35 g) was injected in 2.5-3 min for the IGTT[1] Dextrose, unspecified form---[1] 299
414Other: Glycerine gel[1] Glycerin[1] D00028 --[1] 265
415Other: Gold Standard Questionnaire[1] Gold---[1] 291
416Other: Green tea (Camellia sinensis)[1] Green tea leaf[1] D06903 --[1] 96
417Other: Groningen Anti-Inflammatory Diet (GrAID)----[1] 96
418Other: Group 2 (DMARDS treated group)----[1] 46
419Other: Group B SLE one blood donation----[1] 49
420Other: Group balance training[1] Isoxaflutole---[1] 13
421Other: Group Exercise: community setting----[1] 70
422Other: Growth hormone[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[1] 78
423Other: GSK2586184 single dose taken with food----[1] 49
424Other: GSK2586184 single dose taken without food----[1] 49
425Other: Haematopoietic Stem Cell Transplantation (HSCT)----[1] 65
426Other: Hand training----[1] 46
427Other: Harkány medicinal water[1] Water[1] D00001 --[1] 46
428Other: healthy controls----[1] 63
429Other: Healthy volunteers----[1] 46
430Other: hemicellulose crystalline----[1] 6
431Other: Hepatic elastography----[1] 299
432Other: High energy / protein diet.----[1] 96
433Other: High Glycemic Index Meal----[1] 299
434Other: High intensity exercise and balance training[1] Isoxaflutole---[1] 6
435Other: high performance liquid chromatography----[1] 96
436Other: High resolution peripheral quantitative computed tomography (HRpQCT)----[1] 172
437Other: High Water Intake[1] Water[1] D00001 --[1] 67
438Other: High-impact exercise intervention----[1] 96
439Other: High-intensity training in shallow and deep water[1] Water[1] D00001 --[1] 6
440Other: Histamine[1] Histamine[1] D08040 [4] HRH1,
HRH2,
HRH3,
HRH4 💬		[4] Calcium signaling pathway, Gastric acid secretion, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 13
441Other: Histone acetylation profiles of cells of SRT patients with CREBBP mutations----[1] 102
442Other: Historical control----[1] 2
443Other: Hoehn and Yahr Scale----[1] 6
444Other: Home functional balance physiotherapy[1] Isoxaflutole---[1] 6
445Other: Honey[1] Honey[1] D06776 --[1] 98
446Other: Human Milk Derived Fortifier[1] Cow milk---[1] 210
447Other: Human umbilical cord-derived MSCs and cyclosporin A[1] Cyclosporine[1] D00184 [5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 60
448Other: Human/Bovine Milk[1] Cow milk---[1] 210
449Other: Hydrocortisone[1] Hydrocortisone (Synonym: Oto End 10)[1] D00088 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 75
450Other: Hydrogen peroxide[2] Hydrogen,
Hydrogen peroxide		[1] D00008 --[1] 13
451Other: Hydroxychloroquine/Chloroquine[2] Chloroquine,
Hydroxychloroquine		[4] D02125 ,
D02366 ,
D03469 ,
D08050 		--[1] 46
452Other: Hyperbaric oxygen[1] Oxygen[1] D00003 --[1] 96
453Other: Hyperbaric Oxygen Therapy[1] Oxygen[1] D00003 --[2] 97, 226
454Other: Hyperpolarized Xenon MRI[1] Xenon[2] D01901 ,
D06339 		--[1] 299
455Other: Hypoglycemic Clamp----[1] 299
456Other: Hypothyroidism QOL questionnaire----[1] 80
457Other: Ibuprofen and Isosorbide Dinitrate combination[2] Ibuprofen (Synonym: Otis Clapp Ultraprin),
Isosorbide dinitrate		[5] D00126 ,
D00516 ,
D01122 ,
D04490 ,
D06606 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 113
458Other: Iloprost (Ventavis inhaled, BAYQ6256)[1] Iloprost[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86
459Other: Imaging----[1] 13
460Other: Imitation Surgical Procedure (ISP)----[1] 6
461Other: immunologic technique----[1] 49
462Other: Impact of biotherapy on postoperative morbidity in ulcerative colitis----[1] 97
463Other: Impact Peptide 1.5----[1] 299
464Other: inactive drug----[1] 226
465Other: Incontinence Severity----[1] 13
466Other: Individualized exercises: clinical setting----[1] 70
467Other: Induced hypotonic hyponatremia - SIAD model----[1] 72
468Other: infliximab (IFX) infusion[1] Infliximab[1] D02598 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 96
469Other: Inhalable Hypertonic saline 7%----[1] 299
470Other: Inhalable Hypertonic saline 7% + Hyaluronan 0.1%[1] Hyaluronic acid[1] D08043 --[1] 299
471Other: Inhaled Hyperpolarized Xenon-129[1] Xenon[2] D01901 ,
D06339 		--[1] 228
472Other: Intensify treatment with the existing drug----[2] 96, 97
473Other: intensive supportive care----[1] 66
474Other: Intrathecal saline injection----[1] 13
475Other: ISA 51----[1] 50
476Other: ISA 51 VG----[1] 49
477Other: ITT, ITT, GHRH+Arg.[1] Somatorelin[1] D08523 [1] GHRHR 💬[2] Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction 💬[1] 78
478Other: IV saline infusion----[1] 96
479Other: IV steroids combination alone----[1] 41
480Other: IVIg[1] Human immunoglobulin G---[1] 35
481Other: Joint Mobilizations (spine, sacroiliac, hip)----[1] 70
482Other: Kesimpta[1] Ofatumumab[1] D09314 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 13
483Other: Ketogenic Diet----[2] 19, 67
484Other: Lab Work----[1] 46
485Other: Laboratory Biomarker Analysis----[21] 11, 13, 14, 26, 28, 34, 49, 51, 60, 62, 65, 89, 96, 97, 205, 232, 283, 284, 285, 298, 331
486Other: Language Intervention----[1] 206
487Other: Lengthening adalimumab dosing interval[1] Adalimumab[1] D02597 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 96
488Other: Leukapheresis- Collection of stem cells----[1] 96
489Other: levothyroxine[1] Levothyroxine[2] D01010 ,
D08125 		[2] THRA,
THRB 💬		[2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬[1] 78
490Other: Liberation therapy----[1] 13
491Other: Liquid Meal Test (Carbohydrate-rich)----[1] 299
492Other: Liquid Meal Test (Fat-rich)----[1] 299
493Other: Liquid Meal Test (Mixed)----[1] 299
494Other: Liver Evaluation----[1] 240
495Other: Liver questionnaire----[1] 231
496Other: Losartan[1] Losartan[2] D00357 ,
D08146 		[1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 46
497Other: Low Blood Pressure Control----[1] 67
498Other: Low dose (1 mcg) ACTH stimulation test[1] Corticotropin[1] D00146 [1] MC2R 💬[5] Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[1] 193
499Other: Low Glycemic Index Meal----[1] 299
500Other: Low n-6 PUFA Diet----[1] 96
501Other: Low-intensity exercise therapy----[1] 298
502Other: Lower Limb Strength----[1] 6
503Other: Magnetic Resonance Imaging (MRI)----[1] 113
504Other: Mangafodipir trisodium[1] Mangafodipir[1] D08262 --[1] 58
505Other: Meal Challenge----[1] 240
506Other: measure of endothelial function----[1] 299
507Other: Measurement of drug (Adalimumab/Infliximab)[2] Adalimumab,
Infliximab		[2] D02597 ,
D02598 		[1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[2] 96, 97
508Other: Medical air[2] Medical air,
Oxygen		[1] D00003 --[1] 85
509Other: medical chart review----[1] 60
510Other: Medical History Questionnaires----[1] 65
511Other: Medication Compliance Phone Call----[1] 98
512Other: Mesalazine[1] Mesalazine[1] D00377 --[1] 97
513Other: Metabolic Exercise Testing using stationary bicycle----[1] 113
514Other: Metformin[1] Metformin[2] D00944 ,
D04966 		[2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[1] 46
515Other: Methacholine Challenge Test[1] Methacholine---[1] 96
516Other: Methotrexate therapy[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
517Other: MIBG label with I123 or I124----[1] 6
518Other: Microindentation----[1] 172
519Other: mitoxantrone - immunomodulator[1] Mitoxantrone[2] D02166 ,
D08224 		[2] TOP2A,
TOP2B 💬		[1] Platinum drug resistance 💬[1] 13
520Other: Mixed meal test evaluation test arm----[1] 299
521Other: Mixed Meal Tolerance Test----[1] 299
522Other: Mobile platform exercise----[1] 6
523Other: Mock injection----[1] 90
524Other: modified Atkins diet----[1] 145
525Other: Modified Mixed Meal Tolerance Test----[1] 65
526Other: Modified Oral Glucose Tolerance Test[1] Dextrose, unspecified form---[1] 65
527Other: Modified paleolithic diet----[1] 13
528Other: Monthly assessments of functional motor abilities by a trained therapist----[1] 3
529Other: Motor Assessments before taking regular PD treatment----[1] 6
530Other: Motor Assessments on regular PD treatment----[1] 6
531Other: MP+DDCI----[1] 6
532Other: MP-Equivalent----[1] 6
533Other: MP-Low----[1] 6
534Other: MPS I----[1] 19
535Other: MRI----[3] 6, 127, 206
536Other: MSCs----[1] 13
537Other: Multidisciplinary intensive rehabilitation treatment----[1] 6
538Other: Muscle oxygenation----[1] 299
539Other: Music----[1] 6
540Other: myBETAapp----[1] 13
541Other: N-thymidine[1] Thymidine---[1] 215
542Other: Natalizumab[1] Natalizumab[1] D06886 [1] ITGA4 💬[14] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬[1] 13
543Other: Natalizumab discontinuation[1] Natalizumab[1] D06886 [1] ITGA4 💬[14] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬[1] 13
544Other: natural herbs of coconut, aloe vera, and pepperint[2] Aloe vera leaf (Synonym: C Ottways Lax Tab),
Coconut		---[1] 53
545Other: NBT-NM108 (0 g/day)----[1] 13
546Other: Neupro 4 mg / 24 Hr. Transdermal Patch[1] Rotigotine[1] D05768 [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 6
547Other: Neurology exam----[1] 19
548Other: Neuromuscular evaluation----[1] 13
549Other: Nil per os----[1] 291
550Other: Nintendo Wii Fit Balance exercises[1] Isoxaflutole---[1] 13
551Other: No active treatment----[1] 274
552Other: No anti-inflammatory treatment----[1] 271
553Other: No device----[1] 13
554Other: No doxycycline[1] Doxycycline[5] D00307 ,
D02129 ,
D03903 ,
D03904 ,
D07876 		--[1] 299
555Other: No enzyme therapy----[1] 298
556Other: NO intervention----[4] 13, 70, 96, 97
557Other: No Intervention: Standard of Care----[1] 85
558Other: No IT treatment----[1] 19
559Other: No MSDMDs therapy (control)----[1] 13
560Other: No pancreatic enzyme replacement therapy----[1] 299
561Other: No Plasma Exchange----[2] 43, 44
562Other: No treatment----[2] 53, 274
563Other: No Treatment Arm----[1] 13
564Other: No treatment given----[1] 78
565Other: Non Impact Aerobics----[1] 13
566Other: Non-hormonal period----[1] 299
567Other: Non-Motor Symptoms----[1] 6
568Other: Noninvasive actigraphy monitor[1] Methamidophos---[1] 86
569Other: Nordic walking (only osteoporosis group)----[1] 6
570Other: Normal (control) diet----[1] 240
571Other: normal diet----[1] 96
572Other: normal saline----[4] 13, 222, 226, 280
573Other: Normal Saline for injection----[1] 84
574Other: NS----[1] 96
575Other: Numerical rating scale----[1] 46
576Other: Nutrition counseling----[1] 298
577Other: Obese----[1] 75
578Other: Observation----[1] 265
579Other: Observation of Ocrelizumab as Treatment in RRMS Patients[1] Ocrelizumab[1] D05218 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 13
580Other: Observation Only----[1] 331
581Other: Observational----[1] 90
582Other: Observational cohort----[1] 6
583Other: Observational Control----[1] 13
584Other: Ocrelizumab[1] Ocrelizumab[1] D05218 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 13
585Other: Ofatumumab[1] Ofatumumab[1] D09314 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 13
586Other: OGTT----[1] 299
587Other: On-demand treatment----[1] 299
588Other: One-leg Stance Test----[1] 13
589Other: Ophthalmologic examinations----[1] 299
590Other: Optimized Supportive Care----[1] 66
591Other: Optimizing basal infusion (B.I)----[1] 70
592Other: Optional Blood-Oxygen-level Dependent functionalMRI[1] Oxygen[1] D00003 --[1] 6
593Other: Oral Glucose tolerance test[1] Dextrose, unspecified form---[3] 160, 195, 299
594Other: Oral Glucose Tolerance Test (OGTT) assessment arm[1] Dextrose, unspecified form---[1] 299
595Other: Oral Nitric Oxide testing[1] Nitric Oxide[1] D00074 --[1] 98
596Other: Other Biologic Agents----[2] 96, 97
597Other: Other biological samples to biobank (skin, lung and muscle biopsies----[3] 49, 51, 85
598Other: Other intervention(s)----[1] 70
599Other: Other: Disease modifying therapies (DMT)----[1] 13
600Other: Other: Symptomatic treatment of ALS----[1] 2
601Other: Outpatient rheumatology department----[1] 46
602Other: Overnight metyrapone test[1] Metyrapone[2] D00410 ,
D05019 		[1] CYP11B1 💬[4] Cortisol synthesis and secretion, Cushing syndrome, Metabolic pathways, Steroid hormone biosynthesis 💬[1] 193
603Other: Oxygen[1] Oxygen[1] D00003 --[1] 85
604Other: Oxygen (2Liter/min)[1] Oxygen[1] D00003 --[1] 85
605Other: Oxygen (4Liter/min)[1] Oxygen[1] D00003 --[1] 85
606Other: Oxygen - Air[1] Oxygen[1] D00003 --[1] 299
607Other: Oxygen Supplementation[1] Oxygen[1] D00003 --[1] 86
608Other: ozone therapy[1] Ozone---[1] 51
609Other: Packing----[1] 227
610Other: pain----[1] 13
611Other: Palliative Care----[5] 19, 65, 120, 160, 326
612Other: Parkinson mPower mobile application----[1] 6
613Other: Parts A/B: Sham Control----[1] 19
614Other: Passive : lecture series----[1] 13
615Other: PBO----[1] 162
616Other: PCDAI----[1] 96
617Other: PD exercise intervention----[1] 6
618Other: PD vitamin + exercise----[1] 6
619Other: PEAK----[1] 13
620Other: Peanut Butter[1] Peanut---[1] 13
621Other: Pentadecanoic acid (PA) and Triheptadecanoin (THA)----[1] 299
622Other: PENTASA (mesalamine/ 5-Aminosalicylic acid (5-ASA)[2] Aminosalicylic acid,
Mesalazine		[2] D00162 ,
D00377 		--[1] 97
623Other: Periodized exercise training----[1] 13
624Other: Peripheral Blood Stem Cells----[2] 60, 62
625Other: Pharmacogenomic Study----[1] 26
626Other: Pharmacokinetic analysis----[1] 49
627Other: Pharmacological Study----[7] 28, 34, 62, 74, 89, 232, 331
628Other: Phenylalanine (Phe)-restricted diet[1] Phenylalanine[1] D00021 --[1] 240
629Other: Physalis angulata ethanol extract[1] Ethanol (Synonym: hand sanitizer OTC)[4] D00068 ,
D02798 ,
D04855 ,
D06542 		--[1] 51
630Other: Physical Function Performance Test----[1] 6
631Other: Physical Therapy----[2] 6, 70
632Other: Pittsburgh Compound B [11C]-PIB[1] Pittsburgh Compound B---[1] 6
633Other: Plant-based diet----[1] 46
634Other: plasticity-based computerized cognitive remediation program----[1] 13
635Other: PNF----[1] 13
636Other: Position Sense----[1] 13
637Other: Postoperative nausea and vomiting at 24 hour----[1] 235
638Other: Postoperative nausea and vomiting at 6 hour----[1] 235
639Other: Postoperative pain at 24 hour----[1] 235
640Other: Postoperative pain at 6 hour----[1] 235
641Other: Postoperative sore throat and hoarseness at 24 hour----[1] 235
642Other: Postoperative sore throat and hoarseness at 6 hour----[1] 235
643Other: Potable water[1] Water[1] D00001 --[1] 19
644Other: prednisone[1] Prednisone[1] D00473 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 46
645Other: pretreatment antibiotics----[1] 97
646Other: Progressive exercise----[1] 13
647Other: propensity score----[1] 13
648Other: Prospective observational registry----[1] 3
649Other: PSP----[1] 13
650Other: PTH based Calcium Carbonate and Calcitriol repletion[4] Calcitriol,
Calcium,
Calcium carbonate (Synonym: Relief OTC antacid),
Carbonate ion		[3] D00129 ,
D00932 ,
D10802 		[1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[1] 235
651Other: Pulmonary Function Testing (PFT)----[1] 113
652Other: Pulmonary rehabilitation program----[1] 85
653Other: QALCIMUM questionnaire----[2] 13, 46
654Other: Quality of life assessment----[1] 122
655Other: Quality of Life questionnaire----[1] 19
656Other: Quality-of-Life Assessment----[9] 34, 36, 51, 62, 65, 96, 283, 286, 298
657Other: quercetin[1] Quercetin---[1] 299
658Other: Questionnaire Administration----[4] 16, 34, 51, 298
659Other: Questionnaires----[5] 6, 13, 41, 93, 96
660Other: Reaction Time and Postural Control----[1] 299
661Other: Real-time data capture app[1] Bifenthrin---[1] 46
662Other: Recommendation with regard to nutrition----[1] 6
663Other: Reduction group 1----[1] 46
664Other: Reduction group 2----[1] 46
665Other: Refered to general practice----[1] 46
666Other: Resistance Exercise Program----[1] 46
667Other: Review of past medical history, clinical exam, and electroencephalogram, polysomnography and urine samples of melatonin and pupillometry.[1] Melatonin[1] D08170 [2] MTNR1A,
MTNR1B 💬		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[1] 149
668Other: Rheumatoid Arthritis Impact of Disease questionnaire----[1] 46
669Other: Rhythmic Auditory Stimulation (RAS)----[2] 6, 13
670Other: Rhythmic Balance-Movement Training (rBMT)[1] Isoxaflutole---[1] 6
671Other: RMST----[1] 256
672Other: Rosemary essential oil[1] Rosemary---[1] 51
673Other: Rotigotine[1] Rotigotine[1] D05768 [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 6
674Other: Routine----[1] 240
675Other: routine management----[1] 291
676Other: routine therapy----[1] 299
677Other: RP% Measurement by FCM as a Diagnostic Test for ITP----[1] 63
678Other: Salbutamol nebulisation and with CPAP[1] Salbutamol[1] D02147 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 228
679Other: Saline----[8] 2, 6, 46, 97, 98, 256, 274, 301
680Other: Saline as a nasal spray----[1] 226
681Other: Saline solution----[1] 67
682Other: Saline solution.----[1] 67
683Other: Screening to prevent falls----[1] 6
684Other: secukinumab[1] Secukinumab[1] D09967 [1] IL17A 💬[6] Alcoholic liver disease, Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation 💬[1] 271
685Other: Serum calcium concentrations results[1] Calcium---[1] 235
686Other: serum levels of angiogenin, bFGF, VEGF[1] Basic Fibroblast Growth Factor---[1] 56
687Other: Sham----[1] 301
688Other: Sham (no implant)----[1] 90
689Other: Sham abdominal compression----[1] 17
690Other: Sham Comparator----[1] 299
691Other: Sham group----[1] 6
692Other: Sham procedure----[1] 90
693Other: Sham Surgery----[1] 6
694Other: Sham-procedure----[2] 90, 303
695Other: Sham-procedure (dose cohort 1&2 only)----[2] 90, 303
696Other: Simvastatin[1] Simvastatin[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[1] 46
697Other: Siponimod[1] Siponimod[1] D11460 [2] S1PR1,
S1PR5 💬		[3] FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[1] 13
698Other: SLE treatment----[1] 49
699Other: Smartphone Application----[1] 49
700Other: Smartphone-based balance exercises[1] Isoxaflutole---[1] 6
701Other: sodium chloride[2] Chloride ion,
Sodium chloride		[1] D02056 --[1] 51
702Other: Specific SL-therapy----[1] 6
703Other: specifically design 6 month resistance training program----[1] 13
704Other: Specimen Collection----[1] 215
705Other: Spinning grp----[1] 13
706Other: Sputum Sample----[1] 299
707Other: Squat-to-stand maneuver----[1] 58
708Other: Standard----[1] 67
709Other: Standard Blood Pressure Control----[1] 67
710Other: Standard care----[1] 227
711Other: standard immune suppression, oral----[1] 228
712Other: Standard nutrition----[1] 96
713Other: standard of care----[7] 13, 49, 64, 85, 96, 245, 246
714Other: Standard of care (SOC)----[1] 62
715Other: Standard of Care Sildenafil[1] Sildenafil[2] D02229 ,
D08514 		[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 90, 301
716Other: Standard steroid treatment----[1] 113
717Other: Standard therapy----[1] 49
718Other: Standard Treatment----[1] 227
719Other: Standard treatment according to the Clinical protocols----[3] 49, 51, 235
720Other: Standard-of-care----[1] 86
721Other: Standardized meals----[1] 86
722Other: Standardized scales: MDS-UPDRS (Part II to IV) and RDRS----[1] 6
723Other: Static Balance Test[1] Isoxaflutole---[1] 13
724Other: Stem Cell Transplant----[1] 96
725Other: Sterile Normal Saline (0.9% NaCl)----[1] 231
726Other: sterile saline----[1] 46
727Other: Stool Sample----[2] 6, 299
728Other: Strength training----[1] 13
729Other: Strength training in shallow water and dry land[1] Water[1] D00001 --[1] 6
730Other: Subacute hypoxic exposures----[1] 86
731Other: Subconjunctival injection of saline----[1] 90
732Other: Subcortical Stimulation----[1] 6
733Other: Sugar pill----[1] 90
734Other: Sulfur Pool & Medicinal Mud----[1] 46
735Other: Supervised physical therapy----[1] 13
736Other: Surgery----[2] 74, 96
737Other: Swallowing Quality of Life Questionnaire----[1] 2
738Other: Swallowing Related Quality of Life Questionnaire----[1] 2
739Other: Symptom Survey----[1] 98
740Other: Symptomatic hypocalcaemia at 24 hour----[1] 235
741Other: Symptomatic hypocalcaemia at 6 hour----[1] 235
742Other: Symptomatic therapy----[1] 160
743Other: t-DCS group----[1] 6
744Other: Tampa Kinesiophobia Scale, Berg-Balance Test, International Physical Activity Questionnaire-Short Form, Falls Efficacy Scale[1] Isoxaflutole---[1] 6
745Other: Technetium [Tc-99m] sulfur colloid and Indium [In-111] DTPA[2] Indium,
Pentetic acid		[1] D05422 --[1] 299
746Other: Telerehabilitation Based Functional Balance and Mobility Exercise[1] Isoxaflutole---[1] 6
747Other: Telerehabilitation Based LSVT BIG Exercise Protocol----[1] 6
748Other: Test Soda----[1] 299
749Other: The Center for Neurologic Studies Bulbar Function Scale----[1] 2
750Other: The Center for Neurologic Study Bulbar Function Scale----[1] 2
751Other: The patients' parents have to complete the VINELAND II adaptive behavior scales scoring, The Sleep Disturbance Scale for Children (SDSC) and Horne & Ostberg Circadian Typology Questionnaire----[1] 149
752Other: the timed 360° turn test----[1] 6
753Other: Therapy Education----[1] 97
754Other: Threonine[1] Threonine[1] D00041 --[2] 96, 97
755Other: Timed Up an Go Test----[1] 13
756Other: Timed Up and Go Test----[1] 6
757Other: Tobacco questionnaire[1] Tobacco leaf---[1] 299
758Other: Tobramycin time of administration[1] Tobramycin[2] D00063 ,
D02542 		--[1] 299
759Other: Training groupe----[1] 13
760Other: Transthoracic echocardiography at rest, during PLR, HG and CPX (including blood gas analysis in both groups). Additionally Fallot patients will undergo routine blood testings.----[1] 215
761Other: triangular test----[1] 96
762Other: Trunk impairment----[1] 13
763Other: Trunk Impairment Scale----[1] 6
764Other: Trunk position sense----[1] 13
765Other: tyramine[1] Tyramine---[1] 6
766Other: UC-MSCs by peripheral intravenous infusion[1] Human Umbilical Cord Mesenchymal Stem Cells---[1] 96
767Other: Ulcerative Colitis Diet----[1] 97
768Other: Ultrasonography assessment----[1] 49
769Other: Unified Parkinson's Disease Rating Scale----[1] 6
770Other: Untreated Cohort----[1] 85
771Other: Untreated contemporaneous cohort----[1] 118
772Other: Urine Collection----[1] 215
773Other: Use of a postpartum diary and additional blood draws----[1] 288
774Other: Use of a postpartum diary and additional blood draws.----[1] 288
775Other: USPIO MRI - Gadolinium MRI[1] Gadolinium---[1] 13
776Other: Usual care----[3] 46, 107, 299
777Other: Usual care arm exercise----[1] 6
778Other: Usual drug treatment of Parkinson's disease----[1] 6
779Other: Valsalva----[1] 58
780Other: Vegan Diet----[1] 46
781Other: Vegetable Oil----[1] 257
782Other: Vehicle----[1] 160
783Other: Vehicle (D5W or saline)----[1] 66
784Other: Vestibular habituation exercises----[1] 13
785Other: Vestibular rehabilitation: balance and eye movement exercises[1] Isoxaflutole---[1] 13
786Other: Virtual reality group----[1] 13
787Other: Visual Acuity (VA)----[2] 90, 301
788Other: Vital signs----[1] 19
789Other: Vitamin K[1] Phylloquinone[1] D00148 --[1] 13
790Other: Vitamin K Cream[1] Phylloquinone[1] D00148 --[1] 13
791Other: Voluntary cough test----[1] 6
792Other: Walk distance test----[1] 58
793Other: Water[1] Water[1] D00001 --[1] 67
794Other: Water prescription[1] Water[1] D00001 --[1] 67
795Other: Wheat flour[1] Wheat[1] D06902 --[1] 266
796Other: Withdrawal from alpha1 antitrypsin replacement therapy----[1] 231
797Other: Withdrawal of dalfampridine-ER 10mg[1] Dalfampridine[1] D04127 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[1] 13
798Other: Xanthan Gum[1] Xanthan gum[1] D06333 --[1] 98
799OTILIMAB[1] Otilimab[1] D11343 (Name: Otilimab)[1] CSF2 💬[16] Acute myeloid leukemia, Amoebiasis, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, IL-17 signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Natural killer cell mediated cytotoxicity, Rheumatoid arthritis, Shigellosis, T cell receptor signaling pathway, TNF signaling pathway, Transcriptional misregulation in cancer 💬[2] 46, 256
800Otilimab (GSK3196165)[1] Otilimab[1] D11343 (Name: Otilimab)[1] CSF2 💬[16] Acute myeloid leukemia, Amoebiasis, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, IL-17 signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Natural killer cell mediated cytotoxicity, Rheumatoid arthritis, Shigellosis, T cell receptor signaling pathway, TNF signaling pathway, Transcriptional misregulation in cancer 💬[1] 46
801OTL-101----[1] 65
802OTL-103----[1] 65
803OTL-103 Dispersion for Infusion----[1] 65
804OTL-200----[1] 19
805OTL-200 Dispersion for Infusion----[1] 19
806OTL38----[1] 46
807Phase 1: Methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
808PN 200 tablets (500 mg naproxen and 20 mg omeprazole)
(Synonym: Prilosec OTC (TN))		[2] Naproxen,
Omeprazole (Synonym: Prilosec OTC)		[5] D00118 ,
D00455 ,
D01207 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[4] ATP4A,
ATP4B,
PTGS1,
PTGS2 💬		[26] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Collecting duct acid secretion, Gastric acid secretion, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxidative phosphorylation, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[2] 46, 271
809PO ciprofloxacin
(Synonym: CIPROFLOXACIN OTIC)		[1] Ciprofloxacin (Synonym: Otovel)[2] D00186 (Name: Otiprio (TN)),
D02216 (Name: CIPROFLOXACIN OTIC)		--[1] 299
810Response to anakinra associated with methotrexate
(Synonym: Otrexup (TN))		[2] Anakinra,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D02934 		[4] DHFR,
DHFR2,
IL1R1,
IL1R2 💬		[20] Amoebiasis, Antifolate resistance, Biosynthesis of cofactors, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Metabolic pathways, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[1] 46
811Response to infliximab associated with methotrexate
(Synonym: Otrexup (TN))		[2] Infliximab,
Methotrexate (Synonym: Otrexup)		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D02598 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
812Rifaximin+omeprazole+miralax
(Synonym: Prilosec OTC (TN))		[2] Omeprazole (Synonym: Prilosec OTC),
Rifaximin		[5] D00455 ,
D01207 ,
D02554 ,
D05259 (Name: Prilosec OTC (TN)),
D05261 		[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 96
813Sedatives/Hypnotics,Other----[1] 107
814See D.3.9.3 'Other descriptive name' below----[1] 46
815Stable weekly dose of methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
816Tacrolimus with Methotrexate
(Synonym: Otrexup (TN))		[2] Methotrexate (Synonym: Otrexup),
Tacrolimus		[4] D00107 ,
D00142 (Name: Otrexup (TN)),
D02115 ,
D08556 		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[38] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 46
817TAK-715 and methotrexate
(Synonym: Otrexup (TN))		[2] Methotrexate (Synonym: Otrexup),
TAK-715		[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
818TAK-783 and methotrexate
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
819Tasocitinib plus Methotrexate
(Synonym: Otrexup (TN))		[2] Methotrexate (Synonym: Otrexup),
Tofacitinib		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D09970 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46
820TNF-alpha antagonist and other biotherapy----[1] 46
821Tocilizumab + methotrexate(MTX)
(Synonym: Otrexup (TN))		[2] Methotrexate (Synonym: Otrexup),
Tocilizumab		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D02596 		[3] DHFR,
DHFR2,
IL6R 💬		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46
822Tocilizumab plus methotrexate
(Synonym: Otrexup (TN))		[2] Methotrexate (Synonym: Otrexup),
Tocilizumab		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D02596 		[3] DHFR,
DHFR2,
IL6R 💬		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46
823Tocilizumab+Methotrexate(MTX)
(Synonym: Otrexup (TN))		[2] Methotrexate (Synonym: Otrexup),
Tocilizumab		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D02596 		[3] DHFR,
DHFR2,
IL6R 💬		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46
824Tofacitinib with methotrexate
(Synonym: Otrexup (TN))		[2] Methotrexate (Synonym: Otrexup),
Tofacitinib		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D09970 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46
825Tofacitinib without methotrexate
(Synonym: Otrexup (TN))		[2] Methotrexate (Synonym: Otrexup),
Tofacitinib		[3] D00142 (Name: Otrexup (TN)),
D02115 ,
D09970 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46
826Treatment with systemic therapy (methotrexate)
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 162
827Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level
(Synonym: Otrexup (TN))		[1] Methotrexate (Synonym: Otrexup)[2] D00142 (Name: Otrexup (TN)),
D02115 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46