Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
111C-acetate1件: Acetic acid C-11---3件: 13, 86, 88 💬
26-minute walk distance (6MWD) test----2件: 86, 88 💬
36-minute walk distance (6MWD) test ON ambient AIR----2件: 86, 88 💬
46-minute walk distance test with supplemental oxygen----2件: 86, 88 💬
5ACT-064992----5件: 51, 85, 86, 88, 210 💬
6ACT-293987----3件: 51, 86, 88 💬
7Adempas1件: Riociguat1件: Riociguat 💬 3件: GUCY1A,
GUCY1A,
GUCY1B 💬 		10件: Circadian entrainment, Gap junction, Long-term depression, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬5件: 51, 86, 88, 225, 299 💬
8Ambrisentan1件: Ambrisentan1件: Ambrisentan 💬 1件: EDNRA 💬 7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬8件: 51, 66, 84, 85, 86, 88, 210, 211 💬
9Ambrisentan 5 MG1件: Ambrisentan1件: Ambrisentan 💬 1件: EDNRA 💬 7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 88 💬
10Ammonia1件: Ammonia1件: Ammonia solution, strong 💬 --3件: 88, 251, 296 💬
11Atorvastatin1件: Atorvastatin2件: Atorvastatin calcium ,
Atorvastatin 💬 		1件: HMGCR 💬 3件: AMPK signaling pathway, Bile secretion, Terpenoid backbone biosynthesis 💬17件: 13, 22, 46, 49, 51, 58, 79, 84, 88, 93, 96, 97, 160, 225, 271, 297, 299 💬
12Ballon pulmonary angioplasty----1件: 88 💬
13Balloon pulmonary angioplasty----1件: 88 💬
14Barnascan----1件: 88 💬
15BAY 63-2521----2件: 86, 88 💬
16BAY 63-2521 coated tablets 0.5 MG----2件: 86, 88 💬
17BAY 63-2521 coated tablets 1 MG----2件: 86, 88 💬
18BAY 63-2521 coated tablets 1.5 MG----2件: 86, 88 💬
19BAY 63-2521 coated tablets 2 MG----2件: 86, 88 💬
20BAY 63-2521 coated tablets 2.5 MG----2件: 86, 88 💬
21BAY 63-2521 IR coated tablet 1.0 MG----1件: 88 💬
22BAY 63-2521 IR coated tablet 1.5 MG----1件: 88 💬
23BAY 63-2521 IR coated tablet 2.0 MG----1件: 88 💬
24BAY 63-2521 IR coated tablet 2.5 MG----1件: 88 💬
25BAY 63-2521 IR tablet 0.5 MG----1件: 88 💬
26BAY 63-2521 IR tablet 1.0 MG----1件: 88 💬
27BAY 63-2521 IR tablet 1.5 MG----1件: 88 💬
28BAY 63-2521 IR tablet 2.0 MG----1件: 88 💬
29BAY 63-2521 IR tablet 2.5 MG----1件: 88 💬
30BAY 63-2521 tablets 0.5 MG----2件: 86, 88 💬
31BAY 63-2521 tablets 1 MG----2件: 86, 88 💬
32BAY 63-2521 tablets 1.5 MG----2件: 86, 88 💬
33BAY 63-2521 tablets 2 MG----2件: 86, 88 💬
34BAY 63-2521 tablets 2.5 MG----2件: 86, 88 💬
35BAY1237592----2件: 86, 88 💬
36BAY63-2521----4件: 51, 86, 88, 299 💬
37Blood sample----28件: 2, 3, 8, 13, 34, 46, 49, 51, 53, 61, 65, 66, 67, 84, 88, 96, 97, 107, 113, 127, 195, 206, 235, 274, 280, 288, 294, 299 💬
38Bosentan1件: Bosentan2件: Bosentan ,
Bosentan 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬11件: 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
39Bosentan monohydrate1件: Bosentan2件: Bosentan ,
Bosentan 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 51, 84, 86, 88 💬
40BPA----1件: 88 💬
41Catheter directed therapy----1件: 88 💬
42Computed tomography lung subtraction iodine mapping----1件: 88 💬
43D-glucose1件: D-glucose---2件: 86, 88 💬
44Dapagliflozin1件: Dapagliflozin1件: Dapagliflozin 💬 --10件: 6, 28, 49, 66, 67, 86, 88, 215, 218, 222 💬
45Diltiazem1件: Diltiazem3件: Diltiazem hydrochloride ,
Diltiazem malate ,
Diltiazem 💬 		4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 51, 58, 88 💬
46Edoxaban1件: Edoxaban3件: Edoxaban tosilate hydrate ,
Edoxaban ,
Edoxaban tosylate 💬 		1件: F10 💬 1件: Complement and coagulation cascades 💬2件: 46, 88 💬
47Endogenous thrombin potential----2件: 86, 88 💬
48Fludeoxyglucose1件: Fludeoxyglucose---1件: 88 💬
49Forxiga1件: Dapagliflozin1件: Dapagliflozin 💬 --2件: 86, 88 💬
50GSK1325760----2件: 86, 88 💬
51Hyperpolarized XE129----5件: 51, 85, 86, 88, 299 💬
52Imatinib mesilate1件: Imatinib2件: Imatinib mesylate ,
Imatinib 💬 		3件: ABL1,
KIT,
PDGFRA 💬 		31件: Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬3件: 13, 86, 88 💬
53JNJ-67896062 / ACT-064992----2件: 86, 88 💬
54Light transmission aggregometry----2件: 86, 88 💬
55Long term oxygen therapy----1件: 88 💬
56Macitentan1件: Macitentan1件: Macitentan 💬 2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬5件: 51, 85, 86, 88, 210 💬
57Macitentan 10 MG1件: Macitentan1件: Macitentan 💬 2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 51, 86, 88 💬
58Macitentan 10MG1件: Macitentan1件: Macitentan 💬 2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 51, 88 💬
59Macitentan compresse1件: Macitentan1件: Macitentan 💬 2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 86, 88 💬
60Macitentan tablets1件: Macitentan1件: Macitentan 💬 2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 86, 88 💬
61Macitentan tablets 1件: Macitentan1件: Macitentan 💬 2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 86, 88 💬
62Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-B]pyridine-3-YL]-5-pyrimidinyl(methyl)carb----2件: 86, 88 💬
63Methyl [4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-B]pyridin-3-YL]-5-pyrimidinyl]meth----2件: 86, 88 💬
64MK-4836----2件: 86, 88 💬
65Multihance----2件: 86, 88 💬
66N-acetyl cysteine----6件: 13, 34, 85, 88, 296, 310 💬
67Nitric oxide1件: Nitric Oxide1件: Nitric oxide 💬 --8件: 51, 85, 86, 88, 97, 210, 294, 299 💬
68Opsumit1件: Macitentan1件: Macitentan 💬 2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 86, 88 💬
69Opsumit®1件: Macitentan1件: Macitentan 💬 2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 86, 88 💬
70Oxygen1件: Oxygen1件: Oxygen 💬 --13件: 22, 49, 70, 85, 86, 88, 149, 168, 235, 271, 298, 299, 330 💬
71Oxygen administration1件: Oxygen1件: Oxygen 💬 --1件: 88 💬
72Oxygen, liquid1件: Oxygen1件: Oxygen 💬 --2件: 86, 88 💬
73Platelet function analyzer-100----2件: 86, 88 💬
74Pulmonary endarterectomy----1件: 88 💬
75Pulmonary endarteriectomy----1件: 88 💬
76Pulmonary hypertension (PH)-specific medication----1件: 88 💬
77Remodulin 10MG/ML 20ML1件: Treprostinil3件: Treprostinil ,
Treprostinil monosodium salt ,
Treprostinil diolamine 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 88 💬
78Remodulin 1MG/ML 20ML1件: Treprostinil3件: Treprostinil ,
Treprostinil monosodium salt ,
Treprostinil diolamine 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 88 💬
79Remodulin 2.5MG/ML 20ML1件: Treprostinil3件: Treprostinil ,
Treprostinil monosodium salt ,
Treprostinil diolamine 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 88 💬
80Remodulin 5MG/ML 20ML1件: Treprostinil3件: Treprostinil ,
Treprostinil monosodium salt ,
Treprostinil diolamine 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 88 💬
81Respiratory and exercise therapy with supplemental oxygen----1件: 88 💬
82Riociguat1件: Riociguat1件: Riociguat 💬 3件: GUCY1A,
GUCY1A,
GUCY1B 💬 		10件: Circadian entrainment, Gap junction, Long-term depression, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬6件: 51, 84, 86, 88, 225, 299 💬
83Riociguat oral tablet1件: Riociguat1件: Riociguat 💬 3件: GUCY1A,
GUCY1A,
GUCY1B 💬 		10件: Circadian entrainment, Gap junction, Long-term depression, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬3件: 51, 86, 88 💬
84RO 47-0203----4件: 51, 85, 86, 88 💬
85Rotational thromboelastometry----2件: 86, 88 💬
86Routine treatment----1件: 88 💬
87Sauerstoff----2件: 86, 88 💬
88Selexipag1件: Selexipag1件: Selexipag 💬 1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬6件: 47, 51, 70, 84, 86, 88 💬
89Sham oxygen therapy----2件: 86, 88 💬
90Supplemental oxygen therapy----2件: 86, 88 💬
91Supplemental oxygen VIA A mask----1件: 88 💬
92Systemic anticoagulation----1件: 88 💬
93Tracleer1件: Bosentan2件: Bosentan ,
Bosentan 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬8件: 13, 51, 84, 85, 86, 88, 210, 211 💬
94Tracleer*56CPR RIV 125MG1件: Bosentan2件: Bosentan ,
Bosentan 💬 		2件: EDNRA,
EDNRB 💬 		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 51, 86, 88 💬
95Treprostinil sodium1件: Treprostinil3件: Treprostinil ,
Treprostinil monosodium salt ,
Treprostinil diolamine 💬 		1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬3件: 51, 86, 88 💬
96Uptravi1件: Selexipag1件: Selexipag 💬 1件: PTGIR 💬 3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬3件: 84, 86, 88 💬
97Volibris1件: Ambrisentan1件: Ambrisentan 💬 1件: EDNRA 💬 7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 51, 85, 86, 88 💬
98Warfarin1件: Warfarin3件: Warfarin sodium ,
Warfarin potassium ,
Warfarin 💬 		2件: NQO1,
VKORC1 💬 		5件: Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬10件: 6, 8, 19, 46, 49, 66, 85, 86, 88, 91 💬
99Warfarin potassium1件: Warfarin3件: Warfarin sodium ,
Warfarin potassium ,
Warfarin 💬 		2件: NQO1,
VKORC1 💬 		5件: Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬1件: 88 💬