Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. KEGG DRUG DrugBank Drug (Description in trials) KEGG GENES KEGG PATHWAY Disease ID
1 Apomorphine 💬[1] Apomorphine[2] Apomorphine; Apomorphine hydrochloride[2] DRD1,
DRD2 💬 		[13] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 5, 6, 7 💬
2 Apomorphine hydrochloride 💬[1] Apomorphine[2] Apomorphine; Apomorphine hydrochloride[2] DRD1,
DRD2 💬 		[13] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Hormone signaling, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 5, 6, 7 💬
3 Bepranemab 💬[1] Bepranemab[1] Bepranemab[1] MAPT 💬 [4] Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬[1] 5 💬
4 Botulinum toxin type A 💬[1] Botulinum toxin type A[5] Botulinum toxin A; Botulinum toxin type A; BTX-A; Incobotulinumtoxina; Onabotulinumtoxina[1] SNAP25 💬 [2] Insulin secretion, Synaptic vesicle cycle 💬[13] 2, 5, 6, 7, 13, 15, 17, 47, 51, 113, 149, 171, 226 💬
5 Davunetide 💬[1] Davunetide[1] Davunetide--[3] 5, 7, 127 💬
6 Divalproex sodium 💬[1] Valproic acid[3] Valproate; Valproate sodium; Valproic acid[7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
E4.1.1.15,
E4.1.1.15 💬 		[16] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[9] 3, 5, 26, 34, 65, 89, 90, 222, 331 💬
7 Donepezil 💬[1] Donepezil[2] Donepezil; Donepezil hydrochloride[1] ACHE 💬 [3] Cholinergic synapse, Glycerophospholipid metabolism, Neuroactive ligand signaling 💬[8] 5, 6, 13, 46, 124, 127, 156, 206 💬
8 Donepezil hydrochloride 💬[1] Donepezil[2] Donepezil; Donepezil hydrochloride[1] ACHE 💬 [3] Cholinergic synapse, Glycerophospholipid metabolism, Neuroactive ligand signaling 💬[8] 5, 6, 13, 46, 124, 127, 156, 206 💬
9 Droxidopa 💬[1] Droxidopa[2] Droxidopa; L-dops[9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬 		[16] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Hormone signaling, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 5, 6, 17, 169, 170 💬
10 Fasudil 💬[1] Fasudil[2] Fasudil; Fasudil hydrochloride[2] ROCK1,
ROCK2 💬 		[24] Adherens junction, Axon guidance, Chemokine signaling pathway, Focal adhesion, Human cytomegalovirus infection, Leukocyte transendothelial migration, Lipid and atherosclerosis, MicroRNAs in cancer, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Proteoglycans in cancer, Regulation of actin cytoskeleton, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, TGF-beta signaling pathway, Tight junction, Vascular smooth muscle contraction, Wnt signaling pathway, Yersinia infection, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 2, 5, 6, 7, 51 💬
11 Fasudil hydrochloride 💬[1] Fasudil[2] Fasudil; Fasudil hydrochloride[2] ROCK1,
ROCK2 💬 		[24] Adherens junction, Axon guidance, Chemokine signaling pathway, Focal adhesion, Human cytomegalovirus infection, Leukocyte transendothelial migration, Lipid and atherosclerosis, MicroRNAs in cancer, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Proteoglycans in cancer, Regulation of actin cytoskeleton, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, TGF-beta signaling pathway, Tight junction, Vascular smooth muscle contraction, Wnt signaling pathway, Yersinia infection, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 2, 5, 6, 7, 51 💬
12 Flortaucipir F 18 💬[1] Flortaucipir[0] [1] MAPT 💬 [4] Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬-
13 Fludeoxyglucose F 18 💬[1] Fludeoxyglucose (18F)[2] 18F-FDG; Fludeoxyglucose F 18--[9] 5, 6, 7, 34, 46, 84, 85, 127, 300 💬
14 Flutemetamol F 18 💬[1] Flutemetamol (18F)[1] Flutemetamol--[4] 5, 6, 7, 127 💬
15 Gosuranemab 💬[1] Gosuranemab[1] BMS-986168[1] MAPT 💬 [4] Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬[1] 5 💬
16 Masitinib 💬[1] Masitinib[2] Masitinib; Masitinib mesylate[1] KIT 💬 [11] Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer, Hematopoietic cell lineage, MAPK signaling pathway, Melanogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway 💬[6] 2, 5, 6, 13, 46, 96 💬
17 Niacinamide 💬[1] Nicotinamide[2] Niacinamide; Nicotinamide--[7] 6, 13, 18, 49, 67, 107, 162 💬
18 Nitrogen 💬[1] Nitrogen[1] Nitrogen--[5] 5, 6, 17, 211, 299 💬
19 Prabotulinumtoxin A 💬[1] Botulinum toxin type A[5] Botulinum toxin A; Botulinum toxin type A; BTX-A; Incobotulinumtoxina; Onabotulinumtoxina[1] SNAP25 💬 [2] Insulin secretion, Synaptic vesicle cycle 💬[13] 2, 5, 6, 7, 13, 15, 17, 47, 51, 113, 149, 171, 226 💬
20 Rasagiline 💬[1] Rasagiline[2] Rasagiline; Rasagiline mesylate[1] MAO 💬 [13] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[4] 2, 5, 6, 17 💬
21 Rasagiline mesylate 💬[1] Rasagiline[2] Rasagiline; Rasagiline mesylate[1] MAO 💬 [13] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[4] 2, 5, 6, 17 💬
22 Rasagiline tartrate 💬[1] Rasagiline[2] Rasagiline; Rasagiline mesylate[1] MAO 💬 [13] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[4] 2, 5, 6, 17 💬
23 Riluzole 💬[1] Riluzole[1] Riluzole[14] GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬 		[24] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[8] 2, 3, 5, 8, 13, 17, 203, 206 💬
24 Rivastigmine 💬[1] Rivastigmine[1] Rivastigmine[1] ACHE 💬 [3] Cholinergic synapse, Glycerophospholipid metabolism, Neuroactive ligand signaling 💬[2] 5, 6 💬
25 Rivastigmine tartrate 💬[1] Rivastigmine[1] Rivastigmine[1] ACHE 💬 [3] Cholinergic synapse, Glycerophospholipid metabolism, Neuroactive ligand signaling 💬[2] 5, 6 💬
26 Salsalate 💬[1] Salsalate[1] Salsalate[2] PTGS1,
PTGS2 💬 		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 5 💬
27 Suvorexant 💬[1] Suvorexant[1] Suvorexant[2] HCRTR1,
HCRTR2 💬 		[2] Hormone signaling, Neuroactive ligand-receptor interaction 💬[3] 5, 6, 13 💬
28 Tolfenamic acid 💬[1] Tolfenamic acid[1] Tolfenamic acid[2] PTGS1,
PTGS2 💬 		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Efferocytosis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 5 💬
29 Trihexyphenidyl 💬[1] Trihexyphenidyl[1] Trihexyphenidyl[5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬 		[14] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 5, 6 💬
30 Trihexyphenidyl hydrochloride 💬[1] Trihexyphenidyl[1] Trihexyphenidyl[5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬 		[14] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 5, 6 💬
31 Ubidecarenone 💬[1] Ubidecarenone[2] Coenzyme Q10; COQ10--[13] 2, 5, 6, 8, 10, 46, 57, 96, 107, 113, 193, 214, 215 💬
32 Valproate sodium 💬[1] Valproic acid[3] Valproate; Valproate sodium; Valproic acid[7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
E4.1.1.15,
E4.1.1.15 💬 		[16] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[9] 3, 5, 26, 34, 65, 89, 90, 222, 331 💬
33 Valproic acid 💬[1] Valproic acid[3] Valproate; Valproate sodium; Valproic acid[7] ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
E4.1.1.15,
E4.1.1.15 💬 		[16] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬[9] 3, 5, 26, 34, 65, 89, 90, 222, 331 💬
34 Water 💬[1] Water[1] Water--[25] 2, 5, 6, 13, 17, 19, 22, 46, 51, 53, 56, 57, 63, 64, 66, 67, 85, 96, 97, 206, 226, 230, 274, 278, 299 💬
35 Zoledronate disodium 💬[1] Zoledronic acid[3] Zoledronate; Zoledronic acid; Zoledronic acid monohydrate[1] FDPS 💬 [3] Human T-cell leukemia virus 1 infection, Influenza A, Terpenoid backbone biosynthesis 💬[14] 6, 13, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
36 Zoledronate trisodium 💬[1] Zoledronic acid[3] Zoledronate; Zoledronic acid; Zoledronic acid monohydrate[1] FDPS 💬 [3] Human T-cell leukemia virus 1 infection, Influenza A, Terpenoid backbone biosynthesis 💬[14] 6, 13, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
37 Zoledronic acid 💬[1] Zoledronic acid[3] Zoledronate; Zoledronic acid; Zoledronic acid monohydrate[1] FDPS 💬 [3] Human T-cell leukemia virus 1 infection, Influenza A, Terpenoid backbone biosynthesis 💬[14] 6, 13, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
38 Zoledronic acid 💬[1] Zoledronic acid[3] Zoledronate; Zoledronic acid; Zoledronic acid monohydrate[1] FDPS 💬 [3] Human T-cell leukemia virus 1 infection, Influenza A, Terpenoid backbone biosynthesis 💬[14] 6, 13, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
39 Zoledronic acid hemipentahydrate 💬[1] Zoledronic acid[3] Zoledronate; Zoledronic acid; Zoledronic acid monohydrate[1] FDPS 💬 [3] Human T-cell leukemia virus 1 infection, Influenza A, Terpenoid backbone biosynthesis 💬[14] 6, 13, 46, 65, 75, 77, 93, 95, 96, 97, 270, 274, 299, 333 💬
40 Zolpidem 💬[1] Zolpidem[2] Zolpidem; Zolpidem tartrate[16] GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRB,
GABRB,
GABRB,
GABRD,
GABRE,
GABRG,
GABRG,
GABRG,
GABRP,
GABRQ 💬 		[8] GABAergic synapse, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 5, 6, 46 💬
41 Zolpidem tartrate 💬[1] Zolpidem[2] Zolpidem; Zolpidem tartrate[16] GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRA,
GABRB,
GABRB,
GABRB,
GABRD,
GABRE,
GABRG,
GABRG,
GABRG,
GABRP,
GABRQ 💬 		[8] GABAergic synapse, Morphine addiction, Neuroactive ligand signaling, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 5, 6, 46 💬