Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adherens junction 💬	[1] INSR 💬 Adherens junction × Name Full Name INSR insulin receptor	Insulin human 💬 Adherens junction × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 1. Adherens junction × Disease ID Name 156 Rett syndrome;
2	Adrenergic signaling in cardiomyocytes 💬	[5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬 Adrenergic signaling in cardiomyocytes × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S SCN5A sodium voltage-gated channel alpha subunit 5	Topiramate 💬 Adrenergic signaling in cardiomyocytes × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 2. Adrenergic signaling in cardiomyocytes × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
3	Alcoholism 💬	[1] DRD2 💬 Alcoholism × Name Full Name DRD2 dopamine receptor D2	Risperidone 💬 Alcoholism × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 3. Alcoholism × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
4	Alcoholism 💬	[1] DRD2 💬 Alcoholism × Name Full Name DRD2 dopamine receptor D2	Sarizotan hydrochloride 💬 Alcoholism × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 4. Alcoholism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
5	Alcoholism 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alcoholism × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Alcoholism × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 5. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
6	Alcoholism 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alcoholism × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Alcoholism × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 5. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
7	Alcoholism 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alcoholism × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Alcoholism × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 7. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
8	Alcoholism 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alcoholism × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Alcoholism × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 7. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
9	Alcoholism 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alcoholism × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Alcoholism × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 9. Alcoholism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
10	Alcoholism 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alcoholism × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Alcoholism × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 9. Alcoholism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
11	Aldosterone synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Aldosterone synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Aldosterone synthesis and secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 11. Aldosterone synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
12	Aldosterone-regulated sodium reabsorption 💬	[1] INSR 💬 Aldosterone-regulated sodium reabsorption × Name Full Name INSR insulin receptor	Insulin human 💬 Aldosterone-regulated sodium reabsorption × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 12. Aldosterone-regulated sodium reabsorption × Disease ID Name 156 Rett syndrome;
13	Allograft rejection 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Allograft rejection × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Allograft rejection × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 13. Allograft rejection × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
14	Alzheimer disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Alzheimer disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Alzheimer disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 14. Alzheimer disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
15	Alzheimer disease 💬	[3] CHRM1, CHRM3, CHRM5 💬 Alzheimer disease × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM3 cholinergic receptor muscarinic 3 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine 💬 Alzheimer disease × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 15. Alzheimer disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
16	Alzheimer disease 💬	[3] CHRM1, CHRM3, CHRM5 💬 Alzheimer disease × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM3 cholinergic receptor muscarinic 3 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine hydrochloride 💬 Alzheimer disease × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 15. Alzheimer disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
17	Alzheimer disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alzheimer disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Alzheimer disease × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 17. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
18	Alzheimer disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alzheimer disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Alzheimer disease × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 17. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
19	Alzheimer disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alzheimer disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Alzheimer disease × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 19. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
20	Alzheimer disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alzheimer disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Alzheimer disease × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 19. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
21	Alzheimer disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alzheimer disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Alzheimer disease × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 21. Alzheimer disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
22	Alzheimer disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Alzheimer disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Alzheimer disease × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 21. Alzheimer disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
23	Alzheimer disease 💬	[1] INSR 💬 Alzheimer disease × Name Full Name INSR insulin receptor	Insulin human 💬 Alzheimer disease × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 23. Alzheimer disease × Disease ID Name 156 Rett syndrome;
24	Amphetamine addiction 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Amphetamine addiction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Amphetamine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 24. Amphetamine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
25	Amphetamine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amphetamine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Amphetamine addiction × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 25. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
26	Amphetamine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amphetamine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Amphetamine addiction × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 25. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
27	Amphetamine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amphetamine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Amphetamine addiction × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 27. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
28	Amphetamine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amphetamine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Amphetamine addiction × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 27. Amphetamine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
29	Amphetamine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amphetamine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Amphetamine addiction × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 29. Amphetamine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
30	Amphetamine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amphetamine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Amphetamine addiction × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 29. Amphetamine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
31	AMPK signaling pathway 💬	[1] HMGCR 💬 AMPK signaling pathway × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Lovastatin 💬 AMPK signaling pathway × Name Other Names Lovastatin Lovastatin (USP/INN) MK-803 ML-530B Mevacor (TN) ALTOPREV LOVASTATIN	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 31. AMPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolaemia; 156 Rett syndrome; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 195 Noonan syndrome; 206 Fragile X syndrome; 263 Cerebrotendinous xanthomatosis;CTX;27-hydroxylase deficiency;CYP27 deficiency; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Trisomy 1q;9q34 deletion syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
32	AMPK signaling pathway 💬	[1] INSR 💬 AMPK signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 AMPK signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 32. AMPK signaling pathway × Disease ID Name 156 Rett syndrome;
33	Amyotrophic lateral sclerosis 💬	[2] GRIA1, GRIA2 💬 Amyotrophic lateral sclerosis × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Amyotrophic lateral sclerosis × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 33. Amyotrophic lateral sclerosis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
34	Amyotrophic lateral sclerosis 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amyotrophic lateral sclerosis × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Amyotrophic lateral sclerosis × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 34. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
35	Amyotrophic lateral sclerosis 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amyotrophic lateral sclerosis × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Amyotrophic lateral sclerosis × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 34. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
36	Amyotrophic lateral sclerosis 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amyotrophic lateral sclerosis × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Amyotrophic lateral sclerosis × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 36. Amyotrophic lateral sclerosis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
37	Amyotrophic lateral sclerosis 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amyotrophic lateral sclerosis × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Amyotrophic lateral sclerosis × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 36. Amyotrophic lateral sclerosis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
38	Amyotrophic lateral sclerosis 💬	[6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 Amyotrophic lateral sclerosis × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D SIGMAR1 sigma non-opioid intracellular receptor 1	Dextromethorphan hydrobromide 💬 Amyotrophic lateral sclerosis × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 38. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
39	Amyotrophic lateral sclerosis 💬	[6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 Amyotrophic lateral sclerosis × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D SIGMAR1 sigma non-opioid intracellular receptor 1	Dextromethorphan 💬 Amyotrophic lateral sclerosis × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 38. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
40	Amyotrophic lateral sclerosis 💬	[1] SIGMAR1 💬 Amyotrophic lateral sclerosis × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1	Blarcamesine 💬 Amyotrophic lateral sclerosis × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 40. Amyotrophic lateral sclerosis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
41	Amyotrophic lateral sclerosis 💬	[1] SIGMAR1 💬 Amyotrophic lateral sclerosis × Name Full Name SIGMAR1 sigma non-opioid intracellular receptor 1	Blarcamesine hydrochloride 💬 Amyotrophic lateral sclerosis × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 40. Amyotrophic lateral sclerosis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
42	Antigen processing and presentation 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Antigen processing and presentation × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Antigen processing and presentation × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 42. Antigen processing and presentation × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
43	Arrhythmogenic right ventricular cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Arrhythmogenic right ventricular cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 43. Arrhythmogenic right ventricular cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
44	Asthma 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Asthma × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Asthma × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 44. Asthma × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
45	Autoimmune thyroid disease 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Autoimmune thyroid disease × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Autoimmune thyroid disease × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 45. Autoimmune thyroid disease × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
46	Bile secretion 💬	[1] CA2 💬 Bile secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Bile secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 46. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
47	Bile secretion 💬	[1] HMGCR 💬 Bile secretion × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Lovastatin 💬 Bile secretion × Name Other Names Lovastatin Lovastatin (USP/INN) MK-803 ML-530B Mevacor (TN) ALTOPREV LOVASTATIN	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 47. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolaemia; 156 Rett syndrome; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 195 Noonan syndrome; 206 Fragile X syndrome; 263 Cerebrotendinous xanthomatosis;CTX;27-hydroxylase deficiency;CYP27 deficiency; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Trisomy 1q;9q34 deletion syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
48	Calcium signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Calcium signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Calcium signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 48. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
49	Calcium signaling pathway 💬	[4] CHRM1, CHRM2, CHRM3, CHRM5 💬 Calcium signaling pathway × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2 CHRM3 cholinergic receptor muscarinic 3 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine 💬 Calcium signaling pathway × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 49. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
50	Calcium signaling pathway 💬	[4] CHRM1, CHRM2, CHRM3, CHRM5 💬 Calcium signaling pathway × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2 CHRM3 cholinergic receptor muscarinic 3 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine hydrochloride 💬 Calcium signaling pathway × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 49. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
51	Calcium signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Calcium signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Calcium signaling pathway × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 51. Calcium signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
52	Calcium signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Calcium signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Calcium signaling pathway × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 51. Calcium signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
53	Calcium signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Calcium signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Calcium signaling pathway × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 53. Calcium signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
54	Calcium signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Calcium signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Calcium signaling pathway × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 53. Calcium signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
55	Calcium signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Calcium signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Calcium signaling pathway × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 55. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
56	Calcium signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Calcium signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Calcium signaling pathway × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 55. Calcium signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
57	Calcium signaling pathway 💬	[1] HTR2 💬 Calcium signaling pathway × Name Full Name HTR2	Risperidone 💬 Calcium signaling pathway × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 57. Calcium signaling pathway × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
58	cAMP signaling pathway 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 cAMP signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 cAMP signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 58. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
59	cAMP signaling pathway 💬	[2] CHRM1, CHRM2 💬 cAMP signaling pathway × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2	Blarcamesine 💬 cAMP signaling pathway × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 59. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
60	cAMP signaling pathway 💬	[2] CHRM1, CHRM2 💬 cAMP signaling pathway × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2	Blarcamesine hydrochloride 💬 cAMP signaling pathway × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 59. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
61	cAMP signaling pathway 💬	[1] DRD2 💬 cAMP signaling pathway × Name Full Name DRD2 dopamine receptor D2	Risperidone 💬 cAMP signaling pathway × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 61. cAMP signaling pathway × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
62	cAMP signaling pathway 💬	[2] DRD2, HTR1 💬 cAMP signaling pathway × Name Full Name DRD2 dopamine receptor D2 HTR1	Sarizotan hydrochloride 💬 cAMP signaling pathway × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 62. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
63	cAMP signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 cAMP signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 cAMP signaling pathway × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 63. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
64	cAMP signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 cAMP signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 cAMP signaling pathway × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 63. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
65	cAMP signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 cAMP signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 cAMP signaling pathway × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 65. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
66	cAMP signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 cAMP signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 cAMP signaling pathway × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 65. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
67	cAMP signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 cAMP signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 cAMP signaling pathway × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 67. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
68	cAMP signaling pathway 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 cAMP signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 cAMP signaling pathway × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 67. cAMP signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
69	Carbohydrate digestion and absorption 💬	[1] CACNA1D 💬 Carbohydrate digestion and absorption × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Carbohydrate digestion and absorption × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 69. Carbohydrate digestion and absorption × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
70	Cardiac muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cardiac muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cardiac muscle contraction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 70. Cardiac muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
71	Cell adhesion molecules 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Cell adhesion molecules × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Cell adhesion molecules × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 71. Cell adhesion molecules × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
72	Cellular senescence 💬	[1] CACNA1D 💬 Cellular senescence × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Cellular senescence × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 72. Cellular senescence × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
73	Cellular senescence 💬	[6] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1 💬 Cellular senescence × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1	Glatiramer acetate 💬 Cellular senescence × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 73. Cellular senescence × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
74	cGMP-PKG signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 cGMP-PKG signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 cGMP-PKG signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 74. cGMP-PKG signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
75	cGMP-PKG signaling pathway 💬	[1] INSR 💬 cGMP-PKG signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 cGMP-PKG signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 75. cGMP-PKG signaling pathway × Disease ID Name 156 Rett syndrome;
76	Chemical carcinogenesis - receptor activation 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Chemical carcinogenesis - receptor activation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 76. Chemical carcinogenesis - receptor activation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
77	Cholinergic synapse 💬	[1] ACHE 💬 Cholinergic synapse × Name Full Name ACHE acetylcholinesterase (Yt blood group)	Donepezil hydrochloride 💬 Cholinergic synapse × Name Other Names Donepezil hydrochloride Donepezil hydrochloride (JP18/USP) Aricept (TN) ADLARITY ARICEPT DONEPEZIL DONEPEZIL HYDROCHLORIDE	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 77. Cholinergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
78	Cholinergic synapse 💬	[1] ACHE 💬 Cholinergic synapse × Name Full Name ACHE acetylcholinesterase (Yt blood group)	Donepezil 💬 Cholinergic synapse × Name Other Names Donepezil Donepezil (JAN/INN) Donaz (TN) Allydone (TN)	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 77. Cholinergic synapse × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
79	Cholinergic synapse 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cholinergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cholinergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 79. Cholinergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
80	Cholinergic synapse 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Cholinergic synapse × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2 CHRM3 cholinergic receptor muscarinic 3 CHRM4 cholinergic receptor muscarinic 4 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine 💬 Cholinergic synapse × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 80. Cholinergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
81	Cholinergic synapse 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Cholinergic synapse × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2 CHRM3 cholinergic receptor muscarinic 3 CHRM4 cholinergic receptor muscarinic 4 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine hydrochloride 💬 Cholinergic synapse × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 80. Cholinergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
82	Circadian entrainment 💬	[6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Circadian entrainment × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Circadian entrainment × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 82. Circadian entrainment × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
83	Circadian entrainment 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Circadian entrainment × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Circadian entrainment × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 83. Circadian entrainment × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
84	Circadian entrainment 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Circadian entrainment × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Circadian entrainment × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 83. Circadian entrainment × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
85	Circadian entrainment 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Circadian entrainment × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Circadian entrainment × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 85. Circadian entrainment × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
86	Circadian entrainment 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Circadian entrainment × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Circadian entrainment × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 85. Circadian entrainment × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
87	Circadian entrainment 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Circadian entrainment × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Circadian entrainment × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 87. Circadian entrainment × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
88	Circadian entrainment 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Circadian entrainment × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Circadian entrainment × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 87. Circadian entrainment × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
89	Cocaine addiction 💬	[1] DRD2 💬 Cocaine addiction × Name Full Name DRD2 dopamine receptor D2	Risperidone 💬 Cocaine addiction × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 89. Cocaine addiction × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
90	Cocaine addiction 💬	[1] DRD2 💬 Cocaine addiction × Name Full Name DRD2 dopamine receptor D2	Sarizotan hydrochloride 💬 Cocaine addiction × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 90. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
91	Cocaine addiction 💬	[1] GRIA2 💬 Cocaine addiction × Name Full Name GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Cocaine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 91. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
92	Cocaine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Cocaine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Cocaine addiction × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 92. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
93	Cocaine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Cocaine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Cocaine addiction × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 92. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
94	Cocaine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Cocaine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Cocaine addiction × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 94. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
95	Cocaine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Cocaine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Cocaine addiction × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 94. Cocaine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
96	Cocaine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Cocaine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Cocaine addiction × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 96. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
97	Cocaine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Cocaine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Cocaine addiction × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 96. Cocaine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
98	Collecting duct acid secretion 💬	[1] CA2 💬 Collecting duct acid secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Collecting duct acid secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 98. Collecting duct acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
99	Cortisol synthesis and secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cortisol synthesis and secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cortisol synthesis and secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 99. Cortisol synthesis and secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
100	Cushing syndrome 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cushing syndrome × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Cushing syndrome × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 100. Cushing syndrome × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
101	Cytokine-cytokine receptor interaction 💬	[1] GHR 💬 Cytokine-cytokine receptor interaction × Name Full Name GHR growth hormone receptor	Somatropin 💬 Cytokine-cytokine receptor interaction × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 101. Cytokine-cytokine receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
102	Diabetic cardiomyopathy 💬	[1] INSR 💬 Diabetic cardiomyopathy × Name Full Name INSR insulin receptor	Insulin human 💬 Diabetic cardiomyopathy × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 102. Diabetic cardiomyopathy × Disease ID Name 156 Rett syndrome;
103	Dilated cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Dilated cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Dilated cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 103. Dilated cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
104	Dopaminergic synapse 💬	[7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 Dopaminergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 SCN1A sodium voltage-gated channel alpha subunit 1	Topiramate 💬 Dopaminergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 104. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
105	Dopaminergic synapse 💬	[1] DRD2 💬 Dopaminergic synapse × Name Full Name DRD2 dopamine receptor D2	Risperidone 💬 Dopaminergic synapse × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 105. Dopaminergic synapse × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
106	Dopaminergic synapse 💬	[1] DRD2 💬 Dopaminergic synapse × Name Full Name DRD2 dopamine receptor D2	Sarizotan hydrochloride 💬 Dopaminergic synapse × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 106. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
107	Dopaminergic synapse 💬	[2] GRIN2A, GRIN2B 💬 Dopaminergic synapse × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Dextromethorphan hydrobromide 💬 Dopaminergic synapse × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 107. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
108	Dopaminergic synapse 💬	[2] GRIN2A, GRIN2B 💬 Dopaminergic synapse × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Dextromethorphan 💬 Dopaminergic synapse × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 107. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
109	Dopaminergic synapse 💬	[2] GRIN2A, GRIN2B 💬 Dopaminergic synapse × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Esketamine 💬 Dopaminergic synapse × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 109. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
110	Dopaminergic synapse 💬	[2] GRIN2A, GRIN2B 💬 Dopaminergic synapse × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Esketamine hydrochloride 💬 Dopaminergic synapse × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 109. Dopaminergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
111	Dopaminergic synapse 💬	[2] GRIN2A, GRIN2B 💬 Dopaminergic synapse × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Ketamine hydrochloride 💬 Dopaminergic synapse × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 111. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
112	Dopaminergic synapse 💬	[2] GRIN2A, GRIN2B 💬 Dopaminergic synapse × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Ketamine 💬 Dopaminergic synapse × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 111. Dopaminergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
113	Efferocytosis 💬	[1] S1PR1 💬 Efferocytosis × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod hydrochloride 💬 Efferocytosis × Name Other Names Fingolimod hydrochloride Fingolimod hydrochloride (JAN/USAN) Gilenya (TN) GILENYA FINGOLIMOD FINGOLIMOD HYDROCHLORIDE	Fingolimod	[3] 13, 14, 156 💬 113. Efferocytosis × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
114	Efferocytosis 💬	[1] S1PR1 💬 Efferocytosis × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod 💬 Efferocytosis × Name Other Names Fingolimod Fingolimod (INN) Gilenya (TN)	Fingolimod	[3] 13, 14, 156 💬 113. Efferocytosis × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
115	Efferocytosis 💬	[1] S1PR1 💬 Efferocytosis × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod lauryl sulfate 💬 Efferocytosis × Name Other Names Fingolimod lauryl sulfate Fingolimod lauryl sulfate Tascenso (TN) TASCENSO ODT	Fingolimod	[3] 13, 14, 156 💬 113. Efferocytosis × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
116	Endocytosis 💬	[6] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1 💬 Endocytosis × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1	Glatiramer acetate 💬 Endocytosis × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 116. Endocytosis × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
117	Epstein-Barr virus infection 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Epstein-Barr virus infection × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Epstein-Barr virus infection × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 117. Epstein-Barr virus infection × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
118	FoxO signaling pathway 💬	[1] INSR 💬 FoxO signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 FoxO signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 118. FoxO signaling pathway × Disease ID Name 156 Rett syndrome;
119	FoxO signaling pathway 💬	[1] S1PR1 💬 FoxO signaling pathway × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod hydrochloride 💬 FoxO signaling pathway × Name Other Names Fingolimod hydrochloride Fingolimod hydrochloride (JAN/USAN) Gilenya (TN) GILENYA FINGOLIMOD FINGOLIMOD HYDROCHLORIDE	Fingolimod	[3] 13, 14, 156 💬 119. FoxO signaling pathway × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
120	FoxO signaling pathway 💬	[1] S1PR1 💬 FoxO signaling pathway × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod 💬 FoxO signaling pathway × Name Other Names Fingolimod Fingolimod (INN) Gilenya (TN)	Fingolimod	[3] 13, 14, 156 💬 119. FoxO signaling pathway × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
121	FoxO signaling pathway 💬	[1] S1PR1 💬 FoxO signaling pathway × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod lauryl sulfate 💬 FoxO signaling pathway × Name Other Names Fingolimod lauryl sulfate Fingolimod lauryl sulfate Tascenso (TN) TASCENSO ODT	Fingolimod	[3] 13, 14, 156 💬 119. FoxO signaling pathway × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
122	GABAergic synapse 💬	[20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 GABAergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Topiramate 💬 GABAergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 122. GABAergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
123	Gap junction 💬	[1] DRD2 💬 Gap junction × Name Full Name DRD2 dopamine receptor D2	Sarizotan hydrochloride 💬 Gap junction × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 123. Gap junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
124	Gap junction 💬	[2] DRD2, HTR2 💬 Gap junction × Name Full Name DRD2 dopamine receptor D2 HTR2	Risperidone 💬 Gap junction × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 124. Gap junction × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
125	Gastric acid secretion 💬	[1] CA2 💬 Gastric acid secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Gastric acid secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 125. Gastric acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
126	Gastric acid secretion 💬	[1] CHRM3 💬 Gastric acid secretion × Name Full Name CHRM3 cholinergic receptor muscarinic 3	Blarcamesine 💬 Gastric acid secretion × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 126. Gastric acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
127	Gastric acid secretion 💬	[1] CHRM3 💬 Gastric acid secretion × Name Full Name CHRM3 cholinergic receptor muscarinic 3	Blarcamesine hydrochloride 💬 Gastric acid secretion × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 126. Gastric acid secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
128	Glutamatergic synapse 💬	[11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Glutamatergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Glutamatergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 128. Glutamatergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
129	Glutamatergic synapse 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Glutamatergic synapse × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Glutamatergic synapse × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 129. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
130	Glutamatergic synapse 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Glutamatergic synapse × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Glutamatergic synapse × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 129. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
131	Glutamatergic synapse 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Glutamatergic synapse × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Glutamatergic synapse × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 131. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
132	Glutamatergic synapse 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Glutamatergic synapse × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Glutamatergic synapse × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 131. Glutamatergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
133	Glutamatergic synapse 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Glutamatergic synapse × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Glutamatergic synapse × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 133. Glutamatergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
134	Glutamatergic synapse 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Glutamatergic synapse × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Glutamatergic synapse × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 133. Glutamatergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
135	Glycerophospholipid metabolism 💬	[1] ACHE 💬 Glycerophospholipid metabolism × Name Full Name ACHE acetylcholinesterase (Yt blood group)	Donepezil hydrochloride 💬 Glycerophospholipid metabolism × Name Other Names Donepezil hydrochloride Donepezil hydrochloride (JP18/USP) Aricept (TN) ADLARITY ARICEPT DONEPEZIL DONEPEZIL HYDROCHLORIDE	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 135. Glycerophospholipid metabolism × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
136	Glycerophospholipid metabolism 💬	[1] ACHE 💬 Glycerophospholipid metabolism × Name Full Name ACHE acetylcholinesterase (Yt blood group)	Donepezil 💬 Glycerophospholipid metabolism × Name Other Names Donepezil Donepezil (JAN/INN) Donaz (TN) Allydone (TN)	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 135. Glycerophospholipid metabolism × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
137	GnRH secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 GnRH secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 137. GnRH secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
138	GnRH signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 GnRH signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 GnRH signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 138. GnRH signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
139	Graft-versus-host disease 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Graft-versus-host disease × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Graft-versus-host disease × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 139. Graft-versus-host disease × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
140	Growth hormone synthesis, secretion and action 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Growth hormone synthesis, secretion and action × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Growth hormone synthesis, secretion and action × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 140. Growth hormone synthesis, secretion and action × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
141	Growth hormone synthesis, secretion and action 💬	[1] GHR 💬 Growth hormone synthesis, secretion and action × Name Full Name GHR growth hormone receptor	Somatropin 💬 Growth hormone synthesis, secretion and action × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 141. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
142	Hematopoietic cell lineage 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Hematopoietic cell lineage × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Hematopoietic cell lineage × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 142. Hematopoietic cell lineage × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
143	Herpes simplex virus 1 infection 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Herpes simplex virus 1 infection × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Herpes simplex virus 1 infection × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 143. Herpes simplex virus 1 infection × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
144	HIF-1 signaling pathway 💬	[1] INSR 💬 HIF-1 signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 HIF-1 signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 144. HIF-1 signaling pathway × Disease ID Name 156 Rett syndrome;
145	Hormone signaling 💬	[1] DRD2 💬 Hormone signaling × Name Full Name DRD2 dopamine receptor D2	Risperidone 💬 Hormone signaling × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 145. Hormone signaling × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
146	Hormone signaling 💬	[1] DRD2 💬 Hormone signaling × Name Full Name DRD2 dopamine receptor D2	Sarizotan hydrochloride 💬 Hormone signaling × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 146. Hormone signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
147	Hormone signaling 💬	[1] GHR 💬 Hormone signaling × Name Full Name GHR growth hormone receptor	Somatropin 💬 Hormone signaling × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 147. Hormone signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
148	Hormone signaling 💬	[1] INSR 💬 Hormone signaling × Name Full Name INSR insulin receptor	Insulin human 💬 Hormone signaling × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 148. Hormone signaling × Disease ID Name 156 Rett syndrome;
149	Human cytomegalovirus infection 💬	[6] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1 💬 Human cytomegalovirus infection × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1	Glatiramer acetate 💬 Human cytomegalovirus infection × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 149. Human cytomegalovirus infection × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
150	Human immunodeficiency virus 1 infection 💬	[6] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1 💬 Human immunodeficiency virus 1 infection × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1	Glatiramer acetate 💬 Human immunodeficiency virus 1 infection × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 150. Human immunodeficiency virus 1 infection × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
151	Human papillomavirus infection 💬	[6] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1 💬 Human papillomavirus infection × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1	Glatiramer acetate 💬 Human papillomavirus infection × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 151. Human papillomavirus infection × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
152	Human T-cell leukemia virus 1 infection 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Human T-cell leukemia virus 1 infection × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Human T-cell leukemia virus 1 infection × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 152. Human T-cell leukemia virus 1 infection × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
153	Huntington disease 💬	[4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Huntington disease × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Huntington disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 153. Huntington disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
154	Huntington disease 💬	[2] GRIN1, GRIN2B 💬 Huntington disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Dextromethorphan hydrobromide 💬 Huntington disease × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 154. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
155	Huntington disease 💬	[2] GRIN1, GRIN2B 💬 Huntington disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Dextromethorphan 💬 Huntington disease × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 154. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
156	Huntington disease 💬	[2] GRIN1, GRIN2B 💬 Huntington disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Esketamine 💬 Huntington disease × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 156. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
157	Huntington disease 💬	[2] GRIN1, GRIN2B 💬 Huntington disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Esketamine hydrochloride 💬 Huntington disease × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 156. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
158	Huntington disease 💬	[2] GRIN1, GRIN2B 💬 Huntington disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Ketamine hydrochloride 💬 Huntington disease × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 158. Huntington disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
159	Huntington disease 💬	[2] GRIN1, GRIN2B 💬 Huntington disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Ketamine 💬 Huntington disease × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 158. Huntington disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
160	Hypertrophic cardiomyopathy 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Hypertrophic cardiomyopathy × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Hypertrophic cardiomyopathy × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 160. Hypertrophic cardiomyopathy × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
161	Inflammatory bowel disease 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Inflammatory bowel disease × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Inflammatory bowel disease × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 161. Inflammatory bowel disease × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
162	Inflammatory mediator regulation of TRP channels 💬	[1] HTR2 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HTR2	Risperidone 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 162. Inflammatory mediator regulation of TRP channels × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
163	Influenza A 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Influenza A × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Influenza A × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 163. Influenza A × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
164	Insulin resistance 💬	[1] INSR 💬 Insulin resistance × Name Full Name INSR insulin receptor	Insulin human 💬 Insulin resistance × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 164. Insulin resistance × Disease ID Name 156 Rett syndrome;
165	Insulin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Insulin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Insulin secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 165. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
166	Insulin secretion 💬	[1] CHRM3 💬 Insulin secretion × Name Full Name CHRM3 cholinergic receptor muscarinic 3	Blarcamesine 💬 Insulin secretion × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 166. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
167	Insulin secretion 💬	[1] CHRM3 💬 Insulin secretion × Name Full Name CHRM3 cholinergic receptor muscarinic 3	Blarcamesine hydrochloride 💬 Insulin secretion × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 166. Insulin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
168	Insulin signaling pathway 💬	[1] INSR 💬 Insulin signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 Insulin signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 168. Insulin signaling pathway × Disease ID Name 156 Rett syndrome;
169	Intestinal immune network for IgA production 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Intestinal immune network for IgA production × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Intestinal immune network for IgA production × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 169. Intestinal immune network for IgA production × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
170	JAK-STAT signaling pathway 💬	[1] GHR 💬 JAK-STAT signaling pathway × Name Full Name GHR growth hormone receptor	Somatropin 💬 JAK-STAT signaling pathway × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 170. JAK-STAT signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
171	Kaposi sarcoma-associated herpesvirus infection 💬	[6] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1	Glatiramer acetate 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 171. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
172	Leishmaniasis 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Leishmaniasis × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Leishmaniasis × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 172. Leishmaniasis × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
173	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬 Long-term depression × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Long-term depression × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 173. Long-term depression × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
174	Long-term potentiation 💬	[3] CACNA1C, GRIA1, GRIA2 💬 Long-term potentiation × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2	Topiramate 💬 Long-term potentiation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 174. Long-term potentiation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
175	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Long-term potentiation × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Long-term potentiation × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 175. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
176	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Long-term potentiation × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Long-term potentiation × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 175. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
177	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Long-term potentiation × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Long-term potentiation × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 177. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
178	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Long-term potentiation × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Long-term potentiation × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 177. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
179	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Long-term potentiation × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Long-term potentiation × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 179. Long-term potentiation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
180	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Long-term potentiation × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Long-term potentiation × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 179. Long-term potentiation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
181	Longevity regulating pathway 💬	[1] INSR 💬 Longevity regulating pathway × Name Full Name INSR insulin receptor	Insulin human 💬 Longevity regulating pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 181. Longevity regulating pathway × Disease ID Name 156 Rett syndrome;
182	Longevity regulating pathway - multiple species 💬	[1] INSR 💬 Longevity regulating pathway - multiple species × Name Full Name INSR insulin receptor	Insulin human 💬 Longevity regulating pathway - multiple species × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 182. Longevity regulating pathway - multiple species × Disease ID Name 156 Rett syndrome;
183	MAPK signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 MAPK signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 MAPK signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 183. MAPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
184	MAPK signaling pathway 💬	[1] INSR 💬 MAPK signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 MAPK signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 184. MAPK signaling pathway × Disease ID Name 156 Rett syndrome;
185	Morphine addiction 💬	[16] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ 💬 Morphine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta	Topiramate 💬 Morphine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 185. Morphine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
186	mTOR signaling pathway 💬	[1] INSR 💬 mTOR signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 mTOR signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 186. mTOR signaling pathway × Disease ID Name 156 Rett syndrome;
187	Natural killer cell mediated cytotoxicity 💬	[5] MHC1, MHC1, MHC1, MHC1, MHC1 💬 Natural killer cell mediated cytotoxicity × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1	Glatiramer acetate 💬 Natural killer cell mediated cytotoxicity × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 187. Natural killer cell mediated cytotoxicity × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
188	Neuroactive ligand signaling 💬	[1] ACHE 💬 Neuroactive ligand signaling × Name Full Name ACHE acetylcholinesterase (Yt blood group)	Donepezil hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Donepezil hydrochloride Donepezil hydrochloride (JP18/USP) Aricept (TN) ADLARITY ARICEPT DONEPEZIL DONEPEZIL HYDROCHLORIDE	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 188. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
189	Neuroactive ligand signaling 💬	[1] ACHE 💬 Neuroactive ligand signaling × Name Full Name ACHE acetylcholinesterase (Yt blood group)	Donepezil 💬 Neuroactive ligand signaling × Name Other Names Donepezil Donepezil (JAN/INN) Donaz (TN) Allydone (TN)	Donepezil	[8]  5 ,  6 , 13, 46, 124, 127, 156, 206 💬 188. Neuroactive ligand signaling × Disease ID Name  5  Progressive supranuclear palsy;PSP;  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 124 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease; 127 Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia; 156 Rett syndrome; 206 Fragile X syndrome;
190	Neuroactive ligand signaling 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Neuroactive ligand signaling × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2 CHRM3 cholinergic receptor muscarinic 3 CHRM4 cholinergic receptor muscarinic 4 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine 💬 Neuroactive ligand signaling × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 190. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
191	Neuroactive ligand signaling 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Neuroactive ligand signaling × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2 CHRM3 cholinergic receptor muscarinic 3 CHRM4 cholinergic receptor muscarinic 4 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 190. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
192	Neuroactive ligand signaling 💬	[2] DRD2, HTR1 💬 Neuroactive ligand signaling × Name Full Name DRD2 dopamine receptor D2 HTR1	Sarizotan hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 192. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
193	Neuroactive ligand signaling 💬	[2] DRD2, HTR2 💬 Neuroactive ligand signaling × Name Full Name DRD2 dopamine receptor D2 HTR2	Risperidone 💬 Neuroactive ligand signaling × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 193. Neuroactive ligand signaling × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
194	Neuroactive ligand signaling 💬	[25] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand signaling × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Neuroactive ligand signaling × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 194. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
195	Neuroactive ligand signaling 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand signaling × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Neuroactive ligand signaling × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 195. Neuroactive ligand signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
196	Neuroactive ligand signaling 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand signaling × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Neuroactive ligand signaling × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 195. Neuroactive ligand signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
197	Neuroactive ligand signaling 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand signaling × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Neuroactive ligand signaling × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 197. Neuroactive ligand signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
198	Neuroactive ligand signaling 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand signaling × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 197. Neuroactive ligand signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
199	Neuroactive ligand signaling 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand signaling × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Neuroactive ligand signaling × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 199. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
200	Neuroactive ligand signaling 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand signaling × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Neuroactive ligand signaling × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 199. Neuroactive ligand signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
201	Neuroactive ligand-receptor interaction 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Neuroactive ligand-receptor interaction × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2 CHRM3 cholinergic receptor muscarinic 3 CHRM4 cholinergic receptor muscarinic 4 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine 💬 Neuroactive ligand-receptor interaction × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 201. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
202	Neuroactive ligand-receptor interaction 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Neuroactive ligand-receptor interaction × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2 CHRM3 cholinergic receptor muscarinic 3 CHRM4 cholinergic receptor muscarinic 4 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 201. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
203	Neuroactive ligand-receptor interaction 💬	[2] CNR1, CNR2 💬 Neuroactive ligand-receptor interaction × Name Full Name CNR1 cannabinoid receptor 1 CNR2 cannabinoid receptor 2	Cannabidiol 💬 Neuroactive ligand-receptor interaction × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 203. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
204	Neuroactive ligand-receptor interaction 💬	[2] DRD2, HTR1 💬 Neuroactive ligand-receptor interaction × Name Full Name DRD2 dopamine receptor D2 HTR1	Sarizotan hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 204. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
205	Neuroactive ligand-receptor interaction 💬	[2] DRD2, HTR2 💬 Neuroactive ligand-receptor interaction × Name Full Name DRD2 dopamine receptor D2 HTR2	Risperidone 💬 Neuroactive ligand-receptor interaction × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 205. Neuroactive ligand-receptor interaction × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
206	Neuroactive ligand-receptor interaction 💬	[25] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Neuroactive ligand-receptor interaction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4 GRIK1 glutamate ionotropic receptor kainate type subunit 1 GRIK2 glutamate ionotropic receptor kainate type subunit 2 GRIK3 glutamate ionotropic receptor kainate type subunit 3 GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK5 glutamate ionotropic receptor kainate type subunit 5	Topiramate 💬 Neuroactive ligand-receptor interaction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 206. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
207	Neuroactive ligand-receptor interaction 💬	[1] GHR 💬 Neuroactive ligand-receptor interaction × Name Full Name GHR growth hormone receptor	Somatropin 💬 Neuroactive ligand-receptor interaction × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 207. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
208	Neuroactive ligand-receptor interaction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Neuroactive ligand-receptor interaction × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 208. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
209	Neuroactive ligand-receptor interaction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Neuroactive ligand-receptor interaction × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 208. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
210	Neuroactive ligand-receptor interaction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Neuroactive ligand-receptor interaction × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 210. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
211	Neuroactive ligand-receptor interaction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 210. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
212	Neuroactive ligand-receptor interaction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 212. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
213	Neuroactive ligand-receptor interaction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Neuroactive ligand-receptor interaction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Neuroactive ligand-receptor interaction × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 212. Neuroactive ligand-receptor interaction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
214	Neuroactive ligand-receptor interaction 💬	[1] S1PR1 💬 Neuroactive ligand-receptor interaction × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod hydrochloride 💬 Neuroactive ligand-receptor interaction × Name Other Names Fingolimod hydrochloride Fingolimod hydrochloride (JAN/USAN) Gilenya (TN) GILENYA FINGOLIMOD FINGOLIMOD HYDROCHLORIDE	Fingolimod	[3] 13, 14, 156 💬 214. Neuroactive ligand-receptor interaction × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
215	Neuroactive ligand-receptor interaction 💬	[1] S1PR1 💬 Neuroactive ligand-receptor interaction × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod 💬 Neuroactive ligand-receptor interaction × Name Other Names Fingolimod Fingolimod (INN) Gilenya (TN)	Fingolimod	[3] 13, 14, 156 💬 214. Neuroactive ligand-receptor interaction × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
216	Neuroactive ligand-receptor interaction 💬	[1] S1PR1 💬 Neuroactive ligand-receptor interaction × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod lauryl sulfate 💬 Neuroactive ligand-receptor interaction × Name Other Names Fingolimod lauryl sulfate Fingolimod lauryl sulfate Tascenso (TN) TASCENSO ODT	Fingolimod	[3] 13, 14, 156 💬 214. Neuroactive ligand-receptor interaction × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
217	Nicotine addiction 💬	[20] GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Nicotine addiction × Name Full Name GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Nicotine addiction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 217. Nicotine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
218	Nicotine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Nicotine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Nicotine addiction × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 218. Nicotine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
219	Nicotine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Nicotine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Nicotine addiction × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 218. Nicotine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
220	Nicotine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Nicotine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Nicotine addiction × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 220. Nicotine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
221	Nicotine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Nicotine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Nicotine addiction × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 220. Nicotine addiction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
222	Nicotine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Nicotine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Nicotine addiction × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 222. Nicotine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
223	Nicotine addiction 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Nicotine addiction × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Nicotine addiction × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 222. Nicotine addiction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
224	Nitrogen metabolism 💬	[2] CA2, CA4 💬 Nitrogen metabolism × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Topiramate 💬 Nitrogen metabolism × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 224. Nitrogen metabolism × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
225	Non-alcoholic fatty liver disease 💬	[1] INSR 💬 Non-alcoholic fatty liver disease × Name Full Name INSR insulin receptor	Insulin human 💬 Non-alcoholic fatty liver disease × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 225. Non-alcoholic fatty liver disease × Disease ID Name 156 Rett syndrome;
226	Ovarian steroidogenesis 💬	[1] INSR 💬 Ovarian steroidogenesis × Name Full Name INSR insulin receptor	Insulin human 💬 Ovarian steroidogenesis × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 226. Ovarian steroidogenesis × Disease ID Name 156 Rett syndrome;
227	Oxytocin signaling pathway 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Oxytocin signaling pathway × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Oxytocin signaling pathway × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 227. Oxytocin signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
228	Pancreatic secretion 💬	[1] CA2 💬 Pancreatic secretion × Name Full Name CA2 carbonic anhydrase 2	Topiramate 💬 Pancreatic secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 228. Pancreatic secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
229	Pancreatic secretion 💬	[1] CHRM3 💬 Pancreatic secretion × Name Full Name CHRM3 cholinergic receptor muscarinic 3	Blarcamesine 💬 Pancreatic secretion × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 229. Pancreatic secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
230	Pancreatic secretion 💬	[1] CHRM3 💬 Pancreatic secretion × Name Full Name CHRM3 cholinergic receptor muscarinic 3	Blarcamesine hydrochloride 💬 Pancreatic secretion × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 229. Pancreatic secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
231	Parkinson disease 💬	[1] DRD2 💬 Parkinson disease × Name Full Name DRD2 dopamine receptor D2	Risperidone 💬 Parkinson disease × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 231. Parkinson disease × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
232	Parkinson disease 💬	[1] DRD2 💬 Parkinson disease × Name Full Name DRD2 dopamine receptor D2	Sarizotan hydrochloride 💬 Parkinson disease × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 232. Parkinson disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
233	Pathways of neurodegeneration - multiple diseases 💬	[8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 233. Pathways of neurodegeneration - multiple diseases × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
234	Pathways of neurodegeneration - multiple diseases 💬	[4] CHRM1, CHRM3, CHRM5, SIGMAR1 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM3 cholinergic receptor muscarinic 3 CHRM5 cholinergic receptor muscarinic 5 SIGMAR1 sigma non-opioid intracellular receptor 1	Blarcamesine 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 234. Pathways of neurodegeneration - multiple diseases × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
235	Pathways of neurodegeneration - multiple diseases 💬	[4] CHRM1, CHRM3, CHRM5, SIGMAR1 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM3 cholinergic receptor muscarinic 3 CHRM5 cholinergic receptor muscarinic 5 SIGMAR1 sigma non-opioid intracellular receptor 1	Blarcamesine hydrochloride 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 234. Pathways of neurodegeneration - multiple diseases × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
236	Pathways of neurodegeneration - multiple diseases 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 236. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
237	Pathways of neurodegeneration - multiple diseases 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 236. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
238	Pathways of neurodegeneration - multiple diseases 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 238. Pathways of neurodegeneration - multiple diseases × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
239	Pathways of neurodegeneration - multiple diseases 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 238. Pathways of neurodegeneration - multiple diseases × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
240	Pathways of neurodegeneration - multiple diseases 💬	[6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D SIGMAR1 sigma non-opioid intracellular receptor 1	Dextromethorphan hydrobromide 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 240. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
241	Pathways of neurodegeneration - multiple diseases 💬	[6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D SIGMAR1 sigma non-opioid intracellular receptor 1	Dextromethorphan 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 240. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
242	Phagosome 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Phagosome × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Phagosome × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 242. Phagosome × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
243	Phospholipase D signaling pathway 💬	[1] INSR 💬 Phospholipase D signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 Phospholipase D signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 243. Phospholipase D signaling pathway × Disease ID Name 156 Rett syndrome;
244	PI3K-Akt signaling pathway 💬	[2] CHRM1, CHRM2 💬 PI3K-Akt signaling pathway × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2	Blarcamesine 💬 PI3K-Akt signaling pathway × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 244. PI3K-Akt signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
245	PI3K-Akt signaling pathway 💬	[2] CHRM1, CHRM2 💬 PI3K-Akt signaling pathway × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2	Blarcamesine hydrochloride 💬 PI3K-Akt signaling pathway × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 244. PI3K-Akt signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
246	PI3K-Akt signaling pathway 💬	[1] GHR 💬 PI3K-Akt signaling pathway × Name Full Name GHR growth hormone receptor	Somatropin 💬 PI3K-Akt signaling pathway × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 246. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
247	PI3K-Akt signaling pathway 💬	[1] INSR 💬 PI3K-Akt signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 PI3K-Akt signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 247. PI3K-Akt signaling pathway × Disease ID Name 156 Rett syndrome;
248	Prion disease 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Prion disease × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Prion disease × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 248. Prion disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
249	Prion disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Prion disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Prion disease × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 249. Prion disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
250	Prion disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Prion disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Prion disease × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 249. Prion disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
251	Prion disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Prion disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Prion disease × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 251. Prion disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
252	Prion disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Prion disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Prion disease × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 251. Prion disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
253	Prion disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Prion disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Prion disease × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 253. Prion disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
254	Prion disease 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Prion disease × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Prion disease × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 253. Prion disease × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
255	Proximal tubule bicarbonate reclamation 💬	[2] CA2, CA4 💬 Proximal tubule bicarbonate reclamation × Name Full Name CA2 carbonic anhydrase 2 CA4 carbonic anhydrase 4	Topiramate 💬 Proximal tubule bicarbonate reclamation × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 255. Proximal tubule bicarbonate reclamation × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
256	Rap1 signaling pathway 💬	[1] CNR1 💬 Rap1 signaling pathway × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Rap1 signaling pathway × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 256. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
257	Rap1 signaling pathway 💬	[1] DRD2 💬 Rap1 signaling pathway × Name Full Name DRD2 dopamine receptor D2	Risperidone 💬 Rap1 signaling pathway × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 257. Rap1 signaling pathway × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
258	Rap1 signaling pathway 💬	[1] DRD2 💬 Rap1 signaling pathway × Name Full Name DRD2 dopamine receptor D2	Sarizotan hydrochloride 💬 Rap1 signaling pathway × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 258. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
259	Rap1 signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Rap1 signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Dextromethorphan hydrobromide 💬 Rap1 signaling pathway × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 259. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
260	Rap1 signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Rap1 signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Dextromethorphan 💬 Rap1 signaling pathway × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 259. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
261	Rap1 signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Rap1 signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Esketamine 💬 Rap1 signaling pathway × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 261. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
262	Rap1 signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Rap1 signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Esketamine hydrochloride 💬 Rap1 signaling pathway × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 261. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
263	Rap1 signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Rap1 signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Ketamine hydrochloride 💬 Rap1 signaling pathway × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 263. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
264	Rap1 signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Rap1 signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Ketamine 💬 Rap1 signaling pathway × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 263. Rap1 signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
265	Rap1 signaling pathway 💬	[1] INSR 💬 Rap1 signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 Rap1 signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 265. Rap1 signaling pathway × Disease ID Name 156 Rett syndrome;
266	Ras signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Ras signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Dextromethorphan hydrobromide 💬 Ras signaling pathway × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 266. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
267	Ras signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Ras signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Dextromethorphan 💬 Ras signaling pathway × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 266. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
268	Ras signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Ras signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Esketamine 💬 Ras signaling pathway × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 268. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
269	Ras signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Ras signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Esketamine hydrochloride 💬 Ras signaling pathway × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 268. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
270	Ras signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Ras signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Ketamine hydrochloride 💬 Ras signaling pathway × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 270. Ras signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
271	Ras signaling pathway 💬	[3] GRIN1, GRIN2A, GRIN2B 💬 Ras signaling pathway × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Ketamine 💬 Ras signaling pathway × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 270. Ras signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
272	Ras signaling pathway 💬	[1] INSR 💬 Ras signaling pathway × Name Full Name INSR insulin receptor	Insulin human 💬 Ras signaling pathway × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 272. Ras signaling pathway × Disease ID Name 156 Rett syndrome;
273	Regulation of actin cytoskeleton 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Regulation of actin cytoskeleton × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2 CHRM3 cholinergic receptor muscarinic 3 CHRM4 cholinergic receptor muscarinic 4 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine 💬 Regulation of actin cytoskeleton × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 273. Regulation of actin cytoskeleton × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
274	Regulation of actin cytoskeleton 💬	[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Regulation of actin cytoskeleton × Name Full Name CHRM1 cholinergic receptor muscarinic 1 CHRM2 cholinergic receptor muscarinic 2 CHRM3 cholinergic receptor muscarinic 3 CHRM4 cholinergic receptor muscarinic 4 CHRM5 cholinergic receptor muscarinic 5	Blarcamesine hydrochloride 💬 Regulation of actin cytoskeleton × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 273. Regulation of actin cytoskeleton × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
275	Regulation of lipolysis in adipocytes 💬	[1] INSR 💬 Regulation of lipolysis in adipocytes × Name Full Name INSR insulin receptor	Insulin human 💬 Regulation of lipolysis in adipocytes × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 275. Regulation of lipolysis in adipocytes × Disease ID Name 156 Rett syndrome;
276	Renin secretion 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Renin secretion × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Renin secretion × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 276. Renin secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
277	Retrograde endocannabinoid signaling 💬	[24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, GABRB, GABRB, GABRB, GABRD, GABRE, GABRG, GABRG, GABRG, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Retrograde endocannabinoid signaling × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRA GABRA GABRA GABRA GABRA GABRA GABRB GABRB GABRB GABRD gamma-aminobutyric acid type A receptor subunit delta GABRE gamma-aminobutyric acid type A receptor subunit epsilon GABRG GABRG GABRG GABRP gamma-aminobutyric acid type A receptor subunit pi GABRQ gamma-aminobutyric acid type A receptor subunit theta GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GRIA4 glutamate ionotropic receptor AMPA type subunit 4	Topiramate 💬 Retrograde endocannabinoid signaling × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 277. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
278	Retrograde endocannabinoid signaling 💬	[1] CNR1 💬 Retrograde endocannabinoid signaling × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Retrograde endocannabinoid signaling × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 278. Retrograde endocannabinoid signaling × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
279	Rheumatoid arthritis 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Rheumatoid arthritis × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Rheumatoid arthritis × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 279. Rheumatoid arthritis × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
280	Salivary secretion 💬	[1] CHRM3 💬 Salivary secretion × Name Full Name CHRM3 cholinergic receptor muscarinic 3	Blarcamesine 💬 Salivary secretion × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 280. Salivary secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
281	Salivary secretion 💬	[1] CHRM3 💬 Salivary secretion × Name Full Name CHRM3 cholinergic receptor muscarinic 3	Blarcamesine hydrochloride 💬 Salivary secretion × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 280. Salivary secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
282	Serotonergic synapse 💬	[7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB, GABRB, GABRB 💬 Serotonergic synapse × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S GABRB GABRB GABRB	Topiramate 💬 Serotonergic synapse × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 282. Serotonergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
283	Serotonergic synapse 💬	[1] HTR1 💬 Serotonergic synapse × Name Full Name HTR1	Sarizotan hydrochloride 💬 Serotonergic synapse × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 283. Serotonergic synapse × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
284	Serotonergic synapse 💬	[1] HTR2 💬 Serotonergic synapse × Name Full Name HTR2	Risperidone 💬 Serotonergic synapse × Name Other Names Risperidone Risperidone (JP18/USP/INN) Risperdal (TN) PERSERIS RISPERDAL CONSTA RISPERIDONE RYKINDO UZEDY	Risperidone	[3]  8 , 156, 187 💬 284. Serotonergic synapse × Disease ID Name  8  Huntington disease;Huntington chorea; 156 Rett syndrome; 187 Kabuki syndrome;
285	Sphingolipid signaling pathway 💬	[1] S1PR1 💬 Sphingolipid signaling pathway × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod hydrochloride 💬 Sphingolipid signaling pathway × Name Other Names Fingolimod hydrochloride Fingolimod hydrochloride (JAN/USAN) Gilenya (TN) GILENYA FINGOLIMOD FINGOLIMOD HYDROCHLORIDE	Fingolimod	[3] 13, 14, 156 💬 285. Sphingolipid signaling pathway × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
286	Sphingolipid signaling pathway 💬	[1] S1PR1 💬 Sphingolipid signaling pathway × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod 💬 Sphingolipid signaling pathway × Name Other Names Fingolimod Fingolimod (INN) Gilenya (TN)	Fingolimod	[3] 13, 14, 156 💬 285. Sphingolipid signaling pathway × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
287	Sphingolipid signaling pathway 💬	[1] S1PR1 💬 Sphingolipid signaling pathway × Name Full Name S1PR1 sphingosine-1-phosphate receptor 1	Fingolimod lauryl sulfate 💬 Sphingolipid signaling pathway × Name Other Names Fingolimod lauryl sulfate Fingolimod lauryl sulfate Tascenso (TN) TASCENSO ODT	Fingolimod	[3] 13, 14, 156 💬 285. Sphingolipid signaling pathway × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 156 Rett syndrome;
288	Spinocerebellar ataxia 💬	[3] GRIA1, GRIA2, GRIA3 💬 Spinocerebellar ataxia × Name Full Name GRIA1 glutamate ionotropic receptor AMPA type subunit 1 GRIA2 glutamate ionotropic receptor AMPA type subunit 2 GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Spinocerebellar ataxia × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 288. Spinocerebellar ataxia × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
289	Spinocerebellar ataxia 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Spinocerebellar ataxia × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan hydrobromide 💬 Spinocerebellar ataxia × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 289. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
290	Spinocerebellar ataxia 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Spinocerebellar ataxia × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Dextromethorphan 💬 Spinocerebellar ataxia × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 289. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
291	Spinocerebellar ataxia 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Spinocerebellar ataxia × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine 💬 Spinocerebellar ataxia × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 291. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
292	Spinocerebellar ataxia 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Spinocerebellar ataxia × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Esketamine hydrochloride 💬 Spinocerebellar ataxia × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 291. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
293	Spinocerebellar ataxia 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Spinocerebellar ataxia × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine hydrochloride 💬 Spinocerebellar ataxia × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 293. Spinocerebellar ataxia × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
294	Spinocerebellar ataxia 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Spinocerebellar ataxia × Name Full Name GRIN1 glutamate ionotropic receptor NMDA type subunit 1 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B GRIN2C glutamate ionotropic receptor NMDA type subunit 2C GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Ketamine 💬 Spinocerebellar ataxia × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 293. Spinocerebellar ataxia × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
295	Staphylococcus aureus infection 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Staphylococcus aureus infection × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Staphylococcus aureus infection × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 295. Staphylococcus aureus infection × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
296	Systemic lupus erythematosus 💬	[2] GRIN2A, GRIN2B 💬 Systemic lupus erythematosus × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Dextromethorphan hydrobromide 💬 Systemic lupus erythematosus × Name Other Names Dextromethorphan hydrobromide Dextromethorphan hydrobromide (USP) Dextromethorphan hydrobromide hydrate (JP18) Benylin DM (TN)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 296. Systemic lupus erythematosus × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
297	Systemic lupus erythematosus 💬	[2] GRIN2A, GRIN2B 💬 Systemic lupus erythematosus × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Dextromethorphan 💬 Systemic lupus erythematosus × Name Other Names Dextromethorphan Dextromethorphan (USP)	Dextromethorphan	[10]  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬 296. Systemic lupus erythematosus × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 21 Mitochondrial disease;Choronic progressive external ophthalmolegia;CPEO;Leigh syndrome;Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episode;MELAS;Myoclonus epilepsy associated with ragged-red fibers;MERRF;Mitochondrial respiratory chain disorders;Pearson syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 85 Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
298	Systemic lupus erythematosus 💬	[2] GRIN2A, GRIN2B 💬 Systemic lupus erythematosus × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Esketamine 💬 Systemic lupus erythematosus × Name Other Names Esketamine Esketamine (USAN/INN)	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 298. Systemic lupus erythematosus × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
299	Systemic lupus erythematosus 💬	[2] GRIN2A, GRIN2B 💬 Systemic lupus erythematosus × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Esketamine hydrochloride 💬 Systemic lupus erythematosus × Name Other Names Esketamine hydrochloride Esketamine hydrochloride (JAN/USAN) Spravato (TN) SPRAVATO	Esketamine	[7]  2 ,  4 ,  6 , 70, 96, 97, 156 💬 298. Systemic lupus erythematosus × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  4  Primary lateral sclerosis;PLS;  6  Parkinson disease;Disease Parkinson's; 70 Spinal stenosis;Extensive spinal canal stenosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 156 Rett syndrome;
300	Systemic lupus erythematosus 💬	[2] GRIN2A, GRIN2B 💬 Systemic lupus erythematosus × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Ketamine hydrochloride 💬 Systemic lupus erythematosus × Name Other Names Ketamine hydrochloride Ketamine hydrochloride (JP18/USP) Ketalar (TN) KETALAR KETAMINE HYDROCHLORIDE	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 300. Systemic lupus erythematosus × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
301	Systemic lupus erythematosus 💬	[2] GRIN2A, GRIN2B 💬 Systemic lupus erythematosus × Name Full Name GRIN2A glutamate ionotropic receptor NMDA type subunit 2A GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Ketamine 💬 Systemic lupus erythematosus × Name Other Names Ketamine Ketamine (INN) Tekam (TN)	Ketamine	[6]  6 , 13, 70, 113, 156, 215 💬 300. Systemic lupus erythematosus × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 70 Spinal stenosis;Extensive spinal canal stenosis; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 215 Tetralogy of Fallot;Fallot tetralogy;
302	Systemic lupus erythematosus 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Systemic lupus erythematosus × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Systemic lupus erythematosus × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 302. Systemic lupus erythematosus × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
303	Taste transduction 💬	[10] CACNA1C, GABRA, GABRA, GABRA, GABRA, GABRA, GABRA, SCN2A, SCN3A, SCN9A 💬 Taste transduction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C GABRA GABRA GABRA GABRA GABRA GABRA SCN2A sodium voltage-gated channel alpha subunit 2 SCN3A sodium voltage-gated channel alpha subunit 3 SCN9A sodium voltage-gated channel alpha subunit 9	Topiramate 💬 Taste transduction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 303. Taste transduction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
304	Taste transduction 💬	[1] CHRM3 💬 Taste transduction × Name Full Name CHRM3 cholinergic receptor muscarinic 3	Blarcamesine 💬 Taste transduction × Name Other Names Blarcamesine Blarcamesine (USAN)	Blarcamesine	[2]  6 , 156 💬 304. Taste transduction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
305	Taste transduction 💬	[1] CHRM3 💬 Taste transduction × Name Full Name CHRM3 cholinergic receptor muscarinic 3	Blarcamesine hydrochloride 💬 Taste transduction × Name Other Names Blarcamesine hydrochloride Blarcamesine hydrochloride (USAN)	Blarcamesine	[2]  6 , 156 💬 304. Taste transduction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
306	Taste transduction 💬	[1] HTR1 💬 Taste transduction × Name Full Name HTR1	Sarizotan hydrochloride 💬 Taste transduction × Name Other Names Sarizotan hydrochloride Sarizotan hydrochloride (USAN) EMD 128130	Sarizotan	[2]  6 , 156 💬 306. Taste transduction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 156 Rett syndrome;
307	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬 Terpenoid backbone biosynthesis × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Lovastatin 💬 Terpenoid backbone biosynthesis × Name Other Names Lovastatin Lovastatin (USP/INN) MK-803 ML-530B Mevacor (TN) ALTOPREV LOVASTATIN	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 307. Terpenoid backbone biosynthesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolaemia; 156 Rett syndrome; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 195 Noonan syndrome; 206 Fragile X syndrome; 263 Cerebrotendinous xanthomatosis;CTX;27-hydroxylase deficiency;CYP27 deficiency; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Trisomy 1q;9q34 deletion syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
308	Th1 and Th2 cell differentiation 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Th1 and Th2 cell differentiation × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Th1 and Th2 cell differentiation × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 308. Th1 and Th2 cell differentiation × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
309	Th17 cell differentiation 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Th17 cell differentiation × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Th17 cell differentiation × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 309. Th17 cell differentiation × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
310	Thermogenesis 💬	[1] CNR1 💬 Thermogenesis × Name Full Name CNR1 cannabinoid receptor 1	Cannabidiol 💬 Thermogenesis × Name Other Names Cannabidiol Cannabidiol (JAN/USAN/INN) CBD Epidiolex (TN) EPIDIOLEX	Cannabidiol	[20]  6 ,  8 , 13, 19, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 310. Thermogenesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's;  8  Huntington disease;Huntington chorea; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 95 Autoimmune hepatitis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 145 West syndrome;Infantile spasm;Infantile spasms;Infantile spasms syndrome;Infantile epileptic spasms;Infantile epileptic spasms syndrome; 156 Rett syndrome; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 193 Prader-Willi syndrome; 206 Fragile X syndrome; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
311	Tight junction 💬	[1] CACNA1D 💬 Tight junction × Name Full Name CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Tight junction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 311. Tight junction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
312	Toxoplasmosis 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Toxoplasmosis × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Toxoplasmosis × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 312. Toxoplasmosis × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
313	Transcriptional misregulation in cancer 💬	[1] GRIA3 💬 Transcriptional misregulation in cancer × Name Full Name GRIA3 glutamate ionotropic receptor AMPA type subunit 3	Topiramate 💬 Transcriptional misregulation in cancer × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 313. Transcriptional misregulation in cancer × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
314	Tuberculosis 💬	[14] MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Tuberculosis × Name Full Name MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Tuberculosis × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 314. Tuberculosis × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
315	Type I diabetes mellitus 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Type I diabetes mellitus × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Type I diabetes mellitus × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 315. Type I diabetes mellitus × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
316	Type II diabetes mellitus 💬	[2] CACNA1C, CACNA1D 💬 Type II diabetes mellitus × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D	Topiramate 💬 Type II diabetes mellitus × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 316. Type II diabetes mellitus × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
317	Type II diabetes mellitus 💬	[1] INSR 💬 Type II diabetes mellitus × Name Full Name INSR insulin receptor	Insulin human 💬 Type II diabetes mellitus × Name Other Names Insulin human Insulin human (USP/INN) Insulin human (genetical recombination) (JP18) Insulin human (biosynthesis) (JAN) Insulin human (synthesis) (JAN) Humulin (TN) AFREZZA HUMULIN MYXREDLIN	Insulin human	[1] 156 💬 317. Type II diabetes mellitus × Disease ID Name 156 Rett syndrome;
318	Vascular smooth muscle contraction 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Vascular smooth muscle contraction × Name Full Name CACNA1C calcium voltage-gated channel subunit alpha1 C CACNA1D calcium voltage-gated channel subunit alpha1 D CACNA1F calcium voltage-gated channel subunit alpha1 F CACNA1S calcium voltage-gated channel subunit alpha1 S	Topiramate 💬 Vascular smooth muscle contraction × Name Other Names Topiramate Topiramate (JAN/USP/INN) Topamax (TN) Trokendi xr (TN) EPRONTIA QUDEXY TOPAMAX TROKENDI XR TOPIRAMATE	Topiramate	[5]  6 , 140, 144, 156, 193 💬 318. Vascular smooth muscle contraction × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 140 Dorabe syndrome;Dravet syndrome; 144 Lennox-Gastaut syndrome; 156 Rett syndrome; 193 Prader-Willi syndrome;
319	Viral carcinogenesis 💬	[6] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1 💬 Viral carcinogenesis × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1	Glatiramer acetate 💬 Viral carcinogenesis × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 319. Viral carcinogenesis × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;
320	Viral myocarditis 💬	[20] MHC1, MHC1, MHC1, MHC1, MHC1, MHC1, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Viral myocarditis × Name Full Name MHC1 MHC1 MHC1 MHC1 MHC1 MHC1 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2 MHC2	Glatiramer acetate 💬 Viral myocarditis × Name Other Names Glatiramer acetate Glatiramer acetate (JAN/USAN) Copaxone (TN) COPAXONE GLATIRAMER ACETATE GLATOPA	Glatiramer	[3] 13, 96, 156 💬 320. Viral myocarditis × Disease ID Name 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 156 Rett syndrome;

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