Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[2] MAP2K1, MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Acute myeloid leukemia × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 1. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
2	Acute myeloid leukemia 💬	[2] MAP2K1, MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Acute myeloid leukemia × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 1. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
3	Alcoholism 💬	[1] MAP2K1 💬 Alcoholism × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Alcoholism × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 3. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
4	Alcoholism 💬	[1] MAP2K1 💬 Alcoholism × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Alcoholism × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 3. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
5	Alzheimer disease 💬	[2] MAP2K1, MAP2K2 💬 Alzheimer disease × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Alzheimer disease × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 5. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
6	Alzheimer disease 💬	[2] MAP2K1, MAP2K2 💬 Alzheimer disease × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Alzheimer disease × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 5. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
7	AMPK signaling pathway 💬	[1] HMGCR 💬 AMPK signaling pathway × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Lovastatin 💬 AMPK signaling pathway × Name Other Names Lovastatin Lovastatin (USP/INN) MK-803 ML-530B Mevacor (TN) ALTOPREV LOVASTATIN	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 7. AMPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolaemia; 156 Rett syndrome; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 195 Noonan syndrome; 206 Fragile X syndrome; 263 Cerebrotendinous xanthomatosis;CTX;27-hydroxylase deficiency;CYP27 deficiency; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Trisomy 1q;9q34 deletion syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
8	AMPK signaling pathway 💬	[1] HMGCR 💬 AMPK signaling pathway × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 AMPK signaling pathway × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID ZOCOR SIMVASTATIN	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 8. AMPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 15 Inclusion body myositis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolaemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;Factor XIII deficiency;Factor VIII deficiency;Acquired hemophilia A;VWF deficiency;von Willebrand Disease;VWD;Factor V deficiency;Factor X deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;CF; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Trisomy 1q;9q34 deletion syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
9	Apelin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Apelin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Apelin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 9. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
10	Apelin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Apelin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Apelin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 9. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
11	Apoptosis 💬	[2] MAP2K1, MAP2K2 💬 Apoptosis × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Apoptosis × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 11. Apoptosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
12	Apoptosis 💬	[2] MAP2K1, MAP2K2 💬 Apoptosis × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Apoptosis × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 11. Apoptosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
13	Autophagy - animal 💬	[2] MAP2K1, MAP2K2 💬 Autophagy - animal × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Autophagy - animal × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 13. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
14	Autophagy - animal 💬	[2] MAP2K1, MAP2K2 💬 Autophagy - animal × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Autophagy - animal × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 13. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
15	B cell receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 B cell receptor signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 B cell receptor signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 15. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
16	B cell receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 B cell receptor signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 B cell receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 15. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
17	Bile secretion 💬	[1] HMGCR 💬 Bile secretion × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Lovastatin 💬 Bile secretion × Name Other Names Lovastatin Lovastatin (USP/INN) MK-803 ML-530B Mevacor (TN) ALTOPREV LOVASTATIN	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 17. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolaemia; 156 Rett syndrome; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 195 Noonan syndrome; 206 Fragile X syndrome; 263 Cerebrotendinous xanthomatosis;CTX;27-hydroxylase deficiency;CYP27 deficiency; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Trisomy 1q;9q34 deletion syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
18	Bile secretion 💬	[1] HMGCR 💬 Bile secretion × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 Bile secretion × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID ZOCOR SIMVASTATIN	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 18. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 15 Inclusion body myositis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolaemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;Factor XIII deficiency;Factor VIII deficiency;Acquired hemophilia A;VWF deficiency;von Willebrand Disease;VWD;Factor V deficiency;Factor X deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;CF; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Trisomy 1q;9q34 deletion syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
19	Bladder cancer 💬	[2] MAP2K1, MAP2K2 💬 Bladder cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Bladder cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 19. Bladder cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
20	Bladder cancer 💬	[2] MAP2K1, MAP2K2 💬 Bladder cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Bladder cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 19. Bladder cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
21	Breast cancer 💬	[2] MAP2K1, MAP2K2 💬 Breast cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Breast cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 21. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
22	Breast cancer 💬	[2] MAP2K1, MAP2K2 💬 Breast cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Breast cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 21. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
23	cAMP signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 cAMP signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 cAMP signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 23. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
24	cAMP signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 cAMP signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 cAMP signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 23. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
25	Cellular senescence 💬	[2] MAP2K1, MAP2K2 💬 Cellular senescence × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Cellular senescence × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 25. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
26	Cellular senescence 💬	[2] MAP2K1, MAP2K2 💬 Cellular senescence × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Cellular senescence × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 25. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
27	Central carbon metabolism in cancer 💬	[2] MAP2K1, MAP2K2 💬 Central carbon metabolism in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Central carbon metabolism in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 27. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
28	Central carbon metabolism in cancer 💬	[2] MAP2K1, MAP2K2 💬 Central carbon metabolism in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Central carbon metabolism in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 27. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
29	cGMP-PKG signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 cGMP-PKG signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 cGMP-PKG signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 29. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
30	cGMP-PKG signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 cGMP-PKG signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 cGMP-PKG signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 29. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
31	cGMP-PKG signaling pathway 💬	[1] NPR2 💬 cGMP-PKG signaling pathway × Name Full Name NPR2 natriuretic peptide receptor 2	Vosoritide 💬 cGMP-PKG signaling pathway × Name Other Names Vosoritide Vosoritide (USAN/INN) Vosoritide (genetical recombination) (JAN) Voxzogo (TN) VOSORITIDE	Vosoritide	[3] 19, 195, 276 💬 31. cGMP-PKG signaling pathway × Disease ID Name 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 195 Noonan syndrome; 276 Achondroplasia;
32	Chemical carcinogenesis - reactive oxygen species 💬	[2] MAP2K1, MAP2K2 💬 Chemical carcinogenesis - reactive oxygen species × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 32. Chemical carcinogenesis - reactive oxygen species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
33	Chemical carcinogenesis - reactive oxygen species 💬	[2] MAP2K1, MAP2K2 💬 Chemical carcinogenesis - reactive oxygen species × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 32. Chemical carcinogenesis - reactive oxygen species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
34	Chemical carcinogenesis - receptor activation 💬	[2] MAP2K1, MAP2K2 💬 Chemical carcinogenesis - receptor activation × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 34. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
35	Chemical carcinogenesis - receptor activation 💬	[2] MAP2K1, MAP2K2 💬 Chemical carcinogenesis - receptor activation × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Chemical carcinogenesis - receptor activation × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 34. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
36	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Chemokine signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Chemokine signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 36. Chemokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
37	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Chemokine signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Chemokine signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 36. Chemokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
38	Choline metabolism in cancer 💬	[2] MAP2K1, MAP2K2 💬 Choline metabolism in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Choline metabolism in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 38. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
39	Choline metabolism in cancer 💬	[2] MAP2K1, MAP2K2 💬 Choline metabolism in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Choline metabolism in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 38. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
40	Cholinergic synapse 💬	[1] MAP2K1 💬 Cholinergic synapse × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Cholinergic synapse × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 40. Cholinergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
41	Cholinergic synapse 💬	[1] MAP2K1 💬 Cholinergic synapse × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Cholinergic synapse × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 40. Cholinergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
42	Chronic myeloid leukemia 💬	[2] MAP2K1, MAP2K2 💬 Chronic myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Chronic myeloid leukemia × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 42. Chronic myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
43	Chronic myeloid leukemia 💬	[2] MAP2K1, MAP2K2 💬 Chronic myeloid leukemia × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Chronic myeloid leukemia × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 42. Chronic myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
44	Colorectal cancer 💬	[2] MAP2K1, MAP2K2 💬 Colorectal cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Colorectal cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 44. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
45	Colorectal cancer 💬	[2] MAP2K1, MAP2K2 💬 Colorectal cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Colorectal cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 44. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
46	Cushing syndrome 💬	[2] MAP2K1, MAP2K2 💬 Cushing syndrome × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Cushing syndrome × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 46. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
47	Cushing syndrome 💬	[2] MAP2K1, MAP2K2 💬 Cushing syndrome × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Cushing syndrome × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 46. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
48	Cytokine-cytokine receptor interaction 💬	[1] GHR 💬 Cytokine-cytokine receptor interaction × Name Full Name GHR growth hormone receptor	Somapacitan 💬 Cytokine-cytokine receptor interaction × Name Other Names Somapacitan Somapacitan (USAN/INN) Somapacitan (genetical recombination) (JAN) Somapacitan-beco Sogroya (TN) SOGROYA	Somapacitan	[1] 195 💬 48. Cytokine-cytokine receptor interaction × Disease ID Name 195 Noonan syndrome;
49	Cytokine-cytokine receptor interaction 💬	[1] GHR 💬 Cytokine-cytokine receptor interaction × Name Full Name GHR growth hormone receptor	Somatropin 💬 Cytokine-cytokine receptor interaction × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 49. Cytokine-cytokine receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
50	Efferocytosis 💬	[2] MAP2K1, MAP2K2 💬 Efferocytosis × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Efferocytosis × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 50. Efferocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
51	Efferocytosis 💬	[2] MAP2K1, MAP2K2 💬 Efferocytosis × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Efferocytosis × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 50. Efferocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
52	Endometrial cancer 💬	[2] MAP2K1, MAP2K2 💬 Endometrial cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Endometrial cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 52. Endometrial cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
53	Endometrial cancer 💬	[2] MAP2K1, MAP2K2 💬 Endometrial cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Endometrial cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 52. Endometrial cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
54	ErbB signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 ErbB signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 ErbB signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 54. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
55	ErbB signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 ErbB signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 ErbB signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 54. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
56	Estrogen signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Estrogen signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Estrogen signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 56. Estrogen signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
57	Estrogen signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Estrogen signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Estrogen signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 56. Estrogen signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
58	Fc epsilon RI signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Fc epsilon RI signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Fc epsilon RI signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 58. Fc epsilon RI signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
59	Fc epsilon RI signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Fc epsilon RI signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Fc epsilon RI signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 58. Fc epsilon RI signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
60	Fc gamma R-mediated phagocytosis 💬	[1] MAP2K1 💬 Fc gamma R-mediated phagocytosis × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Fc gamma R-mediated phagocytosis × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 60. Fc gamma R-mediated phagocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
61	Fc gamma R-mediated phagocytosis 💬	[1] MAP2K1 💬 Fc gamma R-mediated phagocytosis × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Fc gamma R-mediated phagocytosis × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 60. Fc gamma R-mediated phagocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
62	Focal adhesion 💬	[1] MAP2K1 💬 Focal adhesion × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Focal adhesion × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 62. Focal adhesion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
63	Focal adhesion 💬	[1] MAP2K1 💬 Focal adhesion × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Focal adhesion × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 62. Focal adhesion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
64	FoxO signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 FoxO signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 FoxO signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 64. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
65	FoxO signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 FoxO signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 FoxO signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 64. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
66	Gap junction 💬	[2] MAP2K1, MAP2K2 💬 Gap junction × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Gap junction × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 66. Gap junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
67	Gap junction 💬	[2] MAP2K1, MAP2K2 💬 Gap junction × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Gap junction × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 66. Gap junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
68	Gastric cancer 💬	[2] MAP2K1, MAP2K2 💬 Gastric cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Gastric cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 68. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
69	Gastric cancer 💬	[2] MAP2K1, MAP2K2 💬 Gastric cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Gastric cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 68. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
70	Glioma 💬	[2] MAP2K1, MAP2K2 💬 Glioma × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Glioma × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 70. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
71	Glioma 💬	[2] MAP2K1, MAP2K2 💬 Glioma × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Glioma × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 70. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
72	GnRH secretion 💬	[2] MAP2K1, MAP2K2 💬 GnRH secretion × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 GnRH secretion × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 72. GnRH secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
73	GnRH secretion 💬	[2] MAP2K1, MAP2K2 💬 GnRH secretion × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 GnRH secretion × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 72. GnRH secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
74	GnRH signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 GnRH signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 GnRH signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 74. GnRH signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
75	GnRH signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 GnRH signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 GnRH signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 74. GnRH signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
76	Growth hormone synthesis, secretion and action 💬	[1] GHR 💬 Growth hormone synthesis, secretion and action × Name Full Name GHR growth hormone receptor	Somapacitan 💬 Growth hormone synthesis, secretion and action × Name Other Names Somapacitan Somapacitan (USAN/INN) Somapacitan (genetical recombination) (JAN) Somapacitan-beco Sogroya (TN) SOGROYA	Somapacitan	[1] 195 💬 76. Growth hormone synthesis, secretion and action × Disease ID Name 195 Noonan syndrome;
77	Growth hormone synthesis, secretion and action 💬	[1] GHR 💬 Growth hormone synthesis, secretion and action × Name Full Name GHR growth hormone receptor	Somatropin 💬 Growth hormone synthesis, secretion and action × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 77. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
78	Growth hormone synthesis, secretion and action 💬	[2] MAP2K1, MAP2K2 💬 Growth hormone synthesis, secretion and action × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 78. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
79	Growth hormone synthesis, secretion and action 💬	[2] MAP2K1, MAP2K2 💬 Growth hormone synthesis, secretion and action × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Growth hormone synthesis, secretion and action × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 78. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
80	Hepatitis B 💬	[2] MAP2K1, MAP2K2 💬 Hepatitis B × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Hepatitis B × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 80. Hepatitis B × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
81	Hepatitis B 💬	[2] MAP2K1, MAP2K2 💬 Hepatitis B × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Hepatitis B × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 80. Hepatitis B × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
82	Hepatitis C 💬	[2] MAP2K1, MAP2K2 💬 Hepatitis C × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Hepatitis C × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 82. Hepatitis C × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
83	Hepatitis C 💬	[2] MAP2K1, MAP2K2 💬 Hepatitis C × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Hepatitis C × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 82. Hepatitis C × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
84	Hepatocellular carcinoma 💬	[2] MAP2K1, MAP2K2 💬 Hepatocellular carcinoma × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Hepatocellular carcinoma × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 84. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
85	Hepatocellular carcinoma 💬	[2] MAP2K1, MAP2K2 💬 Hepatocellular carcinoma × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Hepatocellular carcinoma × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 84. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
86	HIF-1 signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 HIF-1 signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 HIF-1 signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 86. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
87	HIF-1 signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 HIF-1 signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 HIF-1 signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 86. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
88	Hormone signaling 💬	[1] GHR 💬 Hormone signaling × Name Full Name GHR growth hormone receptor	Somapacitan 💬 Hormone signaling × Name Other Names Somapacitan Somapacitan (USAN/INN) Somapacitan (genetical recombination) (JAN) Somapacitan-beco Sogroya (TN) SOGROYA	Somapacitan	[1] 195 💬 88. Hormone signaling × Disease ID Name 195 Noonan syndrome;
89	Hormone signaling 💬	[1] GHR 💬 Hormone signaling × Name Full Name GHR growth hormone receptor	Somatropin 💬 Hormone signaling × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 89. Hormone signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
90	Hormone signaling 💬	[1] NPR2 💬 Hormone signaling × Name Full Name NPR2 natriuretic peptide receptor 2	Vosoritide 💬 Hormone signaling × Name Other Names Vosoritide Vosoritide (USAN/INN) Vosoritide (genetical recombination) (JAN) Voxzogo (TN) VOSORITIDE	Vosoritide	[3] 19, 195, 276 💬 90. Hormone signaling × Disease ID Name 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 195 Noonan syndrome; 276 Achondroplasia;
91	Human cytomegalovirus infection 💬	[2] MAP2K1, MAP2K2 💬 Human cytomegalovirus infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Human cytomegalovirus infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 91. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
92	Human cytomegalovirus infection 💬	[2] MAP2K1, MAP2K2 💬 Human cytomegalovirus infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Human cytomegalovirus infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 91. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
93	Human immunodeficiency virus 1 infection 💬	[2] MAP2K1, MAP2K2 💬 Human immunodeficiency virus 1 infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 93. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
94	Human immunodeficiency virus 1 infection 💬	[2] MAP2K1, MAP2K2 💬 Human immunodeficiency virus 1 infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Human immunodeficiency virus 1 infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 93. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
95	Human papillomavirus infection 💬	[2] MAP2K1, MAP2K2 💬 Human papillomavirus infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Human papillomavirus infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 95. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
96	Human papillomavirus infection 💬	[2] MAP2K1, MAP2K2 💬 Human papillomavirus infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Human papillomavirus infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 95. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
97	Human T-cell leukemia virus 1 infection 💬	[2] MAP2K1, MAP2K2 💬 Human T-cell leukemia virus 1 infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 97. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
98	Human T-cell leukemia virus 1 infection 💬	[2] MAP2K1, MAP2K2 💬 Human T-cell leukemia virus 1 infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Human T-cell leukemia virus 1 infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 97. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
99	Influenza A 💬	[2] MAP2K1, MAP2K2 💬 Influenza A × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Influenza A × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 99. Influenza A × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
100	Influenza A 💬	[2] MAP2K1, MAP2K2 💬 Influenza A × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Influenza A × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 99. Influenza A × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
101	Insulin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Insulin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Insulin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 101. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
102	Insulin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Insulin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Insulin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 101. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
103	JAK-STAT signaling pathway 💬	[1] GHR 💬 JAK-STAT signaling pathway × Name Full Name GHR growth hormone receptor	Somapacitan 💬 JAK-STAT signaling pathway × Name Other Names Somapacitan Somapacitan (USAN/INN) Somapacitan (genetical recombination) (JAN) Somapacitan-beco Sogroya (TN) SOGROYA	Somapacitan	[1] 195 💬 103. JAK-STAT signaling pathway × Disease ID Name 195 Noonan syndrome;
104	JAK-STAT signaling pathway 💬	[1] GHR 💬 JAK-STAT signaling pathway × Name Full Name GHR growth hormone receptor	Somatropin 💬 JAK-STAT signaling pathway × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 104. JAK-STAT signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
105	Kaposi sarcoma-associated herpesvirus infection 💬	[2] MAP2K1, MAP2K2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 105. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
106	Kaposi sarcoma-associated herpesvirus infection 💬	[2] MAP2K1, MAP2K2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 105. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
107	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬 Long-term depression × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Long-term depression × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 107. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
108	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬 Long-term depression × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Long-term depression × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 107. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
109	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬 Long-term potentiation × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Long-term potentiation × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 109. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
110	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬 Long-term potentiation × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Long-term potentiation × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 109. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
111	MAPK signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 MAPK signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 MAPK signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 111. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
112	MAPK signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 MAPK signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 MAPK signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 111. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
113	Melanogenesis 💬	[2] MAP2K1, MAP2K2 💬 Melanogenesis × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Melanogenesis × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 113. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
114	Melanogenesis 💬	[2] MAP2K1, MAP2K2 💬 Melanogenesis × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Melanogenesis × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 113. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
115	Melanoma 💬	[2] MAP2K1, MAP2K2 💬 Melanoma × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Melanoma × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 115. Melanoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
116	Melanoma 💬	[2] MAP2K1, MAP2K2 💬 Melanoma × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Melanoma × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 115. Melanoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
117	MicroRNAs in cancer 💬	[2] MAP2K1, MAP2K2 💬 MicroRNAs in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 MicroRNAs in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 117. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
118	MicroRNAs in cancer 💬	[2] MAP2K1, MAP2K2 💬 MicroRNAs in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 MicroRNAs in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 117. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
119	mTOR signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 mTOR signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 mTOR signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 119. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
120	mTOR signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 mTOR signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 mTOR signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 119. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
121	Natural killer cell mediated cytotoxicity 💬	[2] MAP2K1, MAP2K2 💬 Natural killer cell mediated cytotoxicity × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 121. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
122	Natural killer cell mediated cytotoxicity 💬	[2] MAP2K1, MAP2K2 💬 Natural killer cell mediated cytotoxicity × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Natural killer cell mediated cytotoxicity × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 121. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
123	Neuroactive ligand-receptor interaction 💬	[1] GHR 💬 Neuroactive ligand-receptor interaction × Name Full Name GHR growth hormone receptor	Somapacitan 💬 Neuroactive ligand-receptor interaction × Name Other Names Somapacitan Somapacitan (USAN/INN) Somapacitan (genetical recombination) (JAN) Somapacitan-beco Sogroya (TN) SOGROYA	Somapacitan	[1] 195 💬 123. Neuroactive ligand-receptor interaction × Disease ID Name 195 Noonan syndrome;
124	Neuroactive ligand-receptor interaction 💬	[1] GHR 💬 Neuroactive ligand-receptor interaction × Name Full Name GHR growth hormone receptor	Somatropin 💬 Neuroactive ligand-receptor interaction × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 124. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
125	Neurotrophin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Neurotrophin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Neurotrophin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 125. Neurotrophin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
126	Neurotrophin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Neurotrophin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Neurotrophin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 125. Neurotrophin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
127	Neutrophil extracellular trap formation 💬	[2] MAP2K1, MAP2K2 💬 Neutrophil extracellular trap formation × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Neutrophil extracellular trap formation × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 127. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
128	Neutrophil extracellular trap formation 💬	[2] MAP2K1, MAP2K2 💬 Neutrophil extracellular trap formation × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Neutrophil extracellular trap formation × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 127. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
129	Non-small cell lung cancer 💬	[2] MAP2K1, MAP2K2 💬 Non-small cell lung cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Non-small cell lung cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 129. Non-small cell lung cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
130	Non-small cell lung cancer 💬	[2] MAP2K1, MAP2K2 💬 Non-small cell lung cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Non-small cell lung cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 129. Non-small cell lung cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
131	Oocyte meiosis 💬	[1] MAP2K1 💬 Oocyte meiosis × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Oocyte meiosis × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 131. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
132	Oocyte meiosis 💬	[1] MAP2K1 💬 Oocyte meiosis × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Oocyte meiosis × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 131. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
133	Osteoclast differentiation 💬	[1] MAP2K1 💬 Osteoclast differentiation × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Osteoclast differentiation × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 133. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
134	Osteoclast differentiation 💬	[1] MAP2K1 💬 Osteoclast differentiation × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Osteoclast differentiation × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 133. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
135	Oxytocin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Oxytocin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Oxytocin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 135. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
136	Oxytocin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Oxytocin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Oxytocin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 135. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
137	Oxytocin signaling pathway 💬	[1] NPR2 💬 Oxytocin signaling pathway × Name Full Name NPR2 natriuretic peptide receptor 2	Vosoritide 💬 Oxytocin signaling pathway × Name Other Names Vosoritide Vosoritide (USAN/INN) Vosoritide (genetical recombination) (JAN) Voxzogo (TN) VOSORITIDE	Vosoritide	[3] 19, 195, 276 💬 137. Oxytocin signaling pathway × Disease ID Name 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 195 Noonan syndrome; 276 Achondroplasia;
138	Pancreatic cancer 💬	[1] MAP2K1 💬 Pancreatic cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Pancreatic cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 138. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
139	Pancreatic cancer 💬	[1] MAP2K1 💬 Pancreatic cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Pancreatic cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 138. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
140	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Parathyroid hormone synthesis, secretion and action × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 140. Parathyroid hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
141	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Parathyroid hormone synthesis, secretion and action × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 140. Parathyroid hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
142	Pathways in cancer 💬	[2] MAP2K1, MAP2K2 💬 Pathways in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Pathways in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 142. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
143	Pathways in cancer 💬	[2] MAP2K1, MAP2K2 💬 Pathways in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Pathways in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 142. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
144	Pathways of neurodegeneration - multiple diseases 💬	[2] MAP2K1, MAP2K2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 144. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
145	Pathways of neurodegeneration - multiple diseases 💬	[2] MAP2K1, MAP2K2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 144. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
146	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[2] MAP2K1, MAP2K2 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 146. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
147	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[2] MAP2K1, MAP2K2 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 146. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
148	Phospholipase D signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Phospholipase D signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Phospholipase D signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 148. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
149	Phospholipase D signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Phospholipase D signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Phospholipase D signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 148. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
150	PI3K-Akt signaling pathway 💬	[1] GHR 💬 PI3K-Akt signaling pathway × Name Full Name GHR growth hormone receptor	Somapacitan 💬 PI3K-Akt signaling pathway × Name Other Names Somapacitan Somapacitan (USAN/INN) Somapacitan (genetical recombination) (JAN) Somapacitan-beco Sogroya (TN) SOGROYA	Somapacitan	[1] 195 💬 150. PI3K-Akt signaling pathway × Disease ID Name 195 Noonan syndrome;
151	PI3K-Akt signaling pathway 💬	[1] GHR 💬 PI3K-Akt signaling pathway × Name Full Name GHR growth hormone receptor	Somatropin 💬 PI3K-Akt signaling pathway × Name Other Names Somatropin Somatropin (USP/INN) Somatropin (genetical recombination) (JAN) Human growth hormone (JAN) Asellacrin (TN) Humatrope (TN) Nutropin (TN) Omnitrope (TN) GENOTROPIN HUMATROPE NORDITROPIN OMNITROPE SEROSTIM SOMATROPIN ZOMACTON	Somatotropin	[28]  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬 151. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  3  Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 36 Epidermolysis bullosa;Kindler syndrome; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 65 Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;APS;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3; 74 Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma; 75 Cushing disease;Cushing syndrome; 76 Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;Central precocious puberty;Gonadotropin producing pituitary adenoma; 77 Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;Acromegaly; 78 Hypopituitarism;Anterior pituitary hypothyroidism; 96 Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD; 97 Ulcerative colitis;UC;Inflammatory bowel disease;IBD; 107 Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA; 113 Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;Muscle-eye-brain disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy; 156 Rett syndrome; 187 Kabuki syndrome; 191 Werner syndrome; 193 Prader-Willi syndrome; 195 Noonan syndrome; 238 Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;Vitamin D-resistant rickets;VDRR;Hypophosphatemic rickets;Vitamin D-resistant osteomalacia;VDRO;Hypophosphatemic osteomalacia;Acquired vitamin D-resistant osteomalacia;Acquired VDRO;Tumor-induced osteomalacia;TIO; 246 Methylmalonic acidemia;MMA; 265 Lipodystrophy; 274 Osteogenesis Imperfecta; 276 Achondroplasia; 299 Cystic fibrosis;CF; 337 Homocystinuria;Homocystinuria type I;Cystathionine beta-synthase deficiency;CBS deficiency;Homocystinuria type II;Homocystinuria cblC type;Cobalamin C deficiency;cblC deficiency;Homocystinuria type III;Methylenetetrahydrofolate reductase deficiency;MTHFR deficiency;
152	PI3K-Akt signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 PI3K-Akt signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 PI3K-Akt signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 152. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
153	PI3K-Akt signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 PI3K-Akt signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 PI3K-Akt signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 152. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
154	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Progesterone-mediated oocyte maturation × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 154. Progesterone-mediated oocyte maturation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
155	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Progesterone-mediated oocyte maturation × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Progesterone-mediated oocyte maturation × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 154. Progesterone-mediated oocyte maturation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
156	Prolactin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Prolactin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Prolactin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 156. Prolactin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
157	Prolactin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Prolactin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Prolactin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 156. Prolactin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
158	Prostate cancer 💬	[2] MAP2K1, MAP2K2 💬 Prostate cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Prostate cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 158. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
159	Prostate cancer 💬	[2] MAP2K1, MAP2K2 💬 Prostate cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Prostate cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 158. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
160	Proteoglycans in cancer 💬	[2] MAP2K1, MAP2K2 💬 Proteoglycans in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Proteoglycans in cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 160. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
161	Proteoglycans in cancer 💬	[2] MAP2K1, MAP2K2 💬 Proteoglycans in cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Proteoglycans in cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 160. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
162	Purine metabolism 💬	[1] NPR2 💬 Purine metabolism × Name Full Name NPR2 natriuretic peptide receptor 2	Vosoritide 💬 Purine metabolism × Name Other Names Vosoritide Vosoritide (USAN/INN) Vosoritide (genetical recombination) (JAN) Voxzogo (TN) VOSORITIDE	Vosoritide	[3] 19, 195, 276 💬 162. Purine metabolism × Disease ID Name 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 195 Noonan syndrome; 276 Achondroplasia;
163	Rap1 signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Rap1 signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Rap1 signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 163. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
164	Rap1 signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Rap1 signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Rap1 signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 163. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
165	Ras signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Ras signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Ras signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 165. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
166	Ras signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Ras signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Ras signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 165. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
167	Regulation of actin cytoskeleton 💬	[2] MAP2K1, MAP2K2 💬 Regulation of actin cytoskeleton × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Regulation of actin cytoskeleton × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 167. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
168	Regulation of actin cytoskeleton 💬	[2] MAP2K1, MAP2K2 💬 Regulation of actin cytoskeleton × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Regulation of actin cytoskeleton × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 167. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
169	Relaxin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Relaxin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Relaxin signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 169. Relaxin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
170	Relaxin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Relaxin signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Relaxin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 169. Relaxin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
171	Renal cell carcinoma 💬	[2] MAP2K1, MAP2K2 💬 Renal cell carcinoma × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Renal cell carcinoma × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 171. Renal cell carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
172	Renal cell carcinoma 💬	[2] MAP2K1, MAP2K2 💬 Renal cell carcinoma × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Renal cell carcinoma × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 171. Renal cell carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
173	Salmonella infection 💬	[2] MAP2K1, MAP2K2 💬 Salmonella infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Salmonella infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 173. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
174	Salmonella infection 💬	[2] MAP2K1, MAP2K2 💬 Salmonella infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Salmonella infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 173. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
175	Serotonergic synapse 💬	[1] MAP2K1 💬 Serotonergic synapse × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 Serotonergic synapse × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 175. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
176	Serotonergic synapse 💬	[1] MAP2K1 💬 Serotonergic synapse × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 Serotonergic synapse × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 175. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
177	Signaling pathways regulating pluripotency of stem cells 💬	[2] MAP2K1, MAP2K2 💬 Signaling pathways regulating pluripotency of stem cells × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 177. Signaling pathways regulating pluripotency of stem cells × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
178	Signaling pathways regulating pluripotency of stem cells 💬	[2] MAP2K1, MAP2K2 💬 Signaling pathways regulating pluripotency of stem cells × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 177. Signaling pathways regulating pluripotency of stem cells × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
179	Sphingolipid signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Sphingolipid signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Sphingolipid signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 179. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
180	Sphingolipid signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Sphingolipid signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Sphingolipid signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 179. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
181	T cell receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 T cell receptor signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 T cell receptor signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 181. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
182	T cell receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 T cell receptor signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 T cell receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 181. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
183	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬 Terpenoid backbone biosynthesis × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Lovastatin 💬 Terpenoid backbone biosynthesis × Name Other Names Lovastatin Lovastatin (USP/INN) MK-803 ML-530B Mevacor (TN) ALTOPREV LOVASTATIN	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 183. Terpenoid backbone biosynthesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolaemia; 156 Rett syndrome; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 195 Noonan syndrome; 206 Fragile X syndrome; 263 Cerebrotendinous xanthomatosis;CTX;27-hydroxylase deficiency;CYP27 deficiency; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Trisomy 1q;9q34 deletion syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
184	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬 Terpenoid backbone biosynthesis × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase	Simvastatin 💬 Terpenoid backbone biosynthesis × Name Other Names Simvastatin Simvastatin (JP18/USP/INN) MK-733 Zocor (TN) FLOLIPID ZOCOR SIMVASTATIN	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 184. Terpenoid backbone biosynthesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's; 13 Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 15 Inclusion body myositis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolaemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 162 Pemphigoid; 195 Noonan syndrome; 265 Lipodystrophy; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;Factor XIII deficiency;Factor VIII deficiency;Acquired hemophilia A;VWF deficiency;von Willebrand Disease;VWD;Factor V deficiency;Factor X deficiency; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;CF; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Trisomy 1q;9q34 deletion syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
185	Thyroid cancer 💬	[2] MAP2K1, MAP2K2 💬 Thyroid cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Thyroid cancer × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 185. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
186	Thyroid cancer 💬	[2] MAP2K1, MAP2K2 💬 Thyroid cancer × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Thyroid cancer × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 185. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
187	Thyroid hormone signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Thyroid hormone signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Thyroid hormone signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 187. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
188	Thyroid hormone signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Thyroid hormone signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Thyroid hormone signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 187. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
189	TNF signaling pathway 💬	[1] MAP2K1 💬 TNF signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib 💬 TNF signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 189. TNF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
190	TNF signaling pathway 💬	[1] MAP2K1 💬 TNF signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1	Trametinib dimethyl sulfoxide 💬 TNF signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 189. TNF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
191	Toll-like receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Toll-like receptor signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Toll-like receptor signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 191. Toll-like receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
192	Toll-like receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Toll-like receptor signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Toll-like receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 191. Toll-like receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
193	Vascular smooth muscle contraction 💬	[2] MAP2K1, MAP2K2 💬 Vascular smooth muscle contraction × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Vascular smooth muscle contraction × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 193. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
194	Vascular smooth muscle contraction 💬	[2] MAP2K1, MAP2K2 💬 Vascular smooth muscle contraction × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Vascular smooth muscle contraction × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 193. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
195	Vascular smooth muscle contraction 💬	[1] NPR2 💬 Vascular smooth muscle contraction × Name Full Name NPR2 natriuretic peptide receptor 2	Vosoritide 💬 Vascular smooth muscle contraction × Name Other Names Vosoritide Vosoritide (USAN/INN) Vosoritide (genetical recombination) (JAN) Voxzogo (TN) VOSORITIDE	Vosoritide	[3] 19, 195, 276 💬 195. Vascular smooth muscle contraction × Disease ID Name 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Kanzaki disease;Pompe disease;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 195 Noonan syndrome; 276 Achondroplasia;
196	VEGF signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 VEGF signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 VEGF signaling pathway × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 196. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
197	VEGF signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 VEGF signaling pathway × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 VEGF signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 196. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
198	Yersinia infection 💬	[2] MAP2K1, MAP2K2 💬 Yersinia infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib 💬 Yersinia infection × Name Other Names Trametinib Trametinib (USAN)	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 198. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
199	Yersinia infection 💬	[2] MAP2K1, MAP2K2 💬 Yersinia infection × Name Full Name MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2	Trametinib dimethyl sulfoxide 💬 Yersinia infection × Name Other Names Trametinib dimethyl sulfoxide Trametinib dimethyl sulfoxide (JAN/USAN) Mekinist (TN) Spexotras (TN) MEKINIST	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 198. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;

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