Target Gene/Pathway Pathway / Gene

---

Search results

---

No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[2] MAP2K1, MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Acute myeloid leukemia × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 1. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
2	Acute myeloid leukemia 💬	[2] MAP2K1, MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Acute myeloid leukemia × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 1. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
3	Alcoholism 💬	[1] MAP2K1 💬 Alcoholism × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Alcoholism × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 3. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
4	Alcoholism 💬	[1] MAP2K1 💬 Alcoholism × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Alcoholism × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 3. Alcoholism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
5	Alzheimer disease 💬	[2] MAP2K1, MAP2K2 💬 Alzheimer disease × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Alzheimer disease × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 5. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
6	Alzheimer disease 💬	[2] MAP2K1, MAP2K2 💬 Alzheimer disease × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Alzheimer disease × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 5. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
7	AMPK signaling pathway 💬	[1] HMGCR 💬 AMPK signaling pathway × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1	Lovastatin 💬 AMPK signaling pathway × Name Other Names Lovastatin Mevacor	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 7. AMPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolemia;Familial hypercholesterolaemia; 156 Rett syndrome; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Austin syndrome;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 195 Noonan syndrome; 206 Fragile X syndrome; 263 Cerebrotendinous xanthomatosis;CTX;27-hydroxylase deficiency;CYP27 deficiency; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Chromosome 1q21.1 duplication syndrome;Trisomy 1q;9q34 deletion syndrome;Chromosome 9q34.3 deletion syndrome;Chromosome 9q deletion syndrome;9q subtelomeric deletion syndrome;9q- syndrome;9q34.3 deletion/microdeletion syndrome;Kleefstra syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
8	AMPK signaling pathway 💬	[1] HMGCR 💬 AMPK signaling pathway × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1	Simvastatin 💬 AMPK signaling pathway × Name Other Names Simvastatin MK-733 Zocor	Simvastatin	[22]  6 , 13, 15, 34, 46, 49, 51, 57, 66, 79, 86, 89, 94, 158, 160, 162, 195, 223, 265, 298, 299, 310 💬 8. AMPK signaling pathway × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 15 Inclusion body myositis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;Glomerulonephritis; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolemia;Familial hypercholesterolaemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Austin syndrome;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 162 Pemphigoid;Bullous pemphigoid;BP;Epidermolysis bullosa acquisita;Acquired epidermolysis bullosa; 195 Noonan syndrome; 223 Primary membranoproliferative glomerulonephritis;Primary MPGN;Primary membranoproliferative glomerulonephritis type I;Primary MPGN I;Primary membranoproliferative glomerulonephritis type III;Primary MPGN III;Membranoproliferative glomerulonephritis;Glomerulonephritis;C3 glomerulonephritis;C3 glomerulopathy;IC-MPGN;MPGN; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;CF; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Chromosome 1q21.1 duplication syndrome;Trisomy 1q;9q34 deletion syndrome;Chromosome 9q34.3 deletion syndrome;Chromosome 9q deletion syndrome;9q subtelomeric deletion syndrome;9q- syndrome;9q34.3 deletion/microdeletion syndrome;Kleefstra syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
9	Apelin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Apelin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Apelin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 9. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
10	Apelin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Apelin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Apelin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 9. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
11	Apoptosis 💬	[2] MAP2K1, MAP2K2 💬 Apoptosis × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Apoptosis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 11. Apoptosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
12	Apoptosis 💬	[2] MAP2K1, MAP2K2 💬 Apoptosis × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Apoptosis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 11. Apoptosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
13	Autophagy - animal 💬	[2] MAP2K1, MAP2K2 💬 Autophagy - animal × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Autophagy - animal × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 13. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
14	Autophagy - animal 💬	[2] MAP2K1, MAP2K2 💬 Autophagy - animal × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Autophagy - animal × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 13. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
15	B cell receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 B cell receptor signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 B cell receptor signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 15. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
16	B cell receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 B cell receptor signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 B cell receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 15. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
17	Bile secretion 💬	[1] HMGCR 💬 Bile secretion × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1	Lovastatin 💬 Bile secretion × Name Other Names Lovastatin Mevacor	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 17. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolemia;Familial hypercholesterolaemia; 156 Rett syndrome; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Austin syndrome;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 195 Noonan syndrome; 206 Fragile X syndrome; 263 Cerebrotendinous xanthomatosis;CTX;27-hydroxylase deficiency;CYP27 deficiency; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Chromosome 1q21.1 duplication syndrome;Trisomy 1q;9q34 deletion syndrome;Chromosome 9q34.3 deletion syndrome;Chromosome 9q deletion syndrome;9q subtelomeric deletion syndrome;9q- syndrome;9q34.3 deletion/microdeletion syndrome;Kleefstra syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
18	Bile secretion 💬	[1] HMGCR 💬 Bile secretion × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1	Simvastatin 💬 Bile secretion × Name Other Names Simvastatin MK-733 Zocor	Simvastatin	[22]  6 , 13, 15, 34, 46, 49, 51, 57, 66, 79, 86, 89, 94, 158, 160, 162, 195, 223, 265, 298, 299, 310 💬 18. Bile secretion × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 15 Inclusion body myositis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;Glomerulonephritis; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolemia;Familial hypercholesterolaemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Austin syndrome;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 162 Pemphigoid;Bullous pemphigoid;BP;Epidermolysis bullosa acquisita;Acquired epidermolysis bullosa; 195 Noonan syndrome; 223 Primary membranoproliferative glomerulonephritis;Primary MPGN;Primary membranoproliferative glomerulonephritis type I;Primary MPGN I;Primary membranoproliferative glomerulonephritis type III;Primary MPGN III;Membranoproliferative glomerulonephritis;Glomerulonephritis;C3 glomerulonephritis;C3 glomerulopathy;IC-MPGN;MPGN; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;CF; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Chromosome 1q21.1 duplication syndrome;Trisomy 1q;9q34 deletion syndrome;Chromosome 9q34.3 deletion syndrome;Chromosome 9q deletion syndrome;9q subtelomeric deletion syndrome;9q- syndrome;9q34.3 deletion/microdeletion syndrome;Kleefstra syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
19	Bladder cancer 💬	[2] MAP2K1, MAP2K2 💬 Bladder cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Bladder cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 19. Bladder cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
20	Bladder cancer 💬	[2] MAP2K1, MAP2K2 💬 Bladder cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Bladder cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 19. Bladder cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
21	Breast cancer 💬	[2] MAP2K1, MAP2K2 💬 Breast cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Breast cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 21. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
22	Breast cancer 💬	[2] MAP2K1, MAP2K2 💬 Breast cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Breast cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 21. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
23	Cadherin signaling 💬	[2] MAP2K1, MAP2K2 💬 Cadherin signaling × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Cadherin signaling × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 23. Cadherin signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
24	Cadherin signaling 💬	[2] MAP2K1, MAP2K2 💬 Cadherin signaling × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Cadherin signaling × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 23. Cadherin signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
25	cAMP signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 cAMP signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 cAMP signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 25. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
26	cAMP signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 cAMP signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 cAMP signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 25. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
27	Cellular senescence 💬	[2] MAP2K1, MAP2K2 💬 Cellular senescence × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Cellular senescence × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 27. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
28	Cellular senescence 💬	[2] MAP2K1, MAP2K2 💬 Cellular senescence × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Cellular senescence × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 27. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
29	Central carbon metabolism in cancer 💬	[2] MAP2K1, MAP2K2 💬 Central carbon metabolism in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Central carbon metabolism in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 29. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
30	Central carbon metabolism in cancer 💬	[2] MAP2K1, MAP2K2 💬 Central carbon metabolism in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Central carbon metabolism in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 29. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
31	cGMP-PKG signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 cGMP-PKG signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 cGMP-PKG signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 31. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
32	cGMP-PKG signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 cGMP-PKG signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 cGMP-PKG signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 31. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
33	cGMP-PKG signaling pathway 💬	[1] NPR2 💬 cGMP-PKG signaling pathway × Name Full Name NPR2 atrial natriuretic peptide receptor 2 isoform 1 precursor	Vosoritide 💬 cGMP-PKG signaling pathway × Name Other Names Vosoritide Voxzogo	Vosoritide	[3] 19, 195, 276 💬 33. cGMP-PKG signaling pathway × Disease ID Name 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 195 Noonan syndrome; 276 Achondroplasia;
34	Chemical carcinogenesis - reactive oxygen species 💬	[2] MAP2K1, MAP2K2 💬 Chemical carcinogenesis - reactive oxygen species × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 34. Chemical carcinogenesis - reactive oxygen species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
35	Chemical carcinogenesis - reactive oxygen species 💬	[2] MAP2K1, MAP2K2 💬 Chemical carcinogenesis - reactive oxygen species × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 34. Chemical carcinogenesis - reactive oxygen species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
36	Chemical carcinogenesis - receptor activation 💬	[2] MAP2K1, MAP2K2 💬 Chemical carcinogenesis - receptor activation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 36. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
37	Chemical carcinogenesis - receptor activation 💬	[2] MAP2K1, MAP2K2 💬 Chemical carcinogenesis - receptor activation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Chemical carcinogenesis - receptor activation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 36. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
38	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Chemokine signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Chemokine signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 38. Chemokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
39	Chemokine signaling pathway 💬	[1] MAP2K1 💬 Chemokine signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Chemokine signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 38. Chemokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
40	Choline metabolism in cancer 💬	[2] MAP2K1, MAP2K2 💬 Choline metabolism in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Choline metabolism in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 40. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
41	Choline metabolism in cancer 💬	[2] MAP2K1, MAP2K2 💬 Choline metabolism in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Choline metabolism in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 40. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
42	Cholinergic synapse 💬	[1] MAP2K1 💬 Cholinergic synapse × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Cholinergic synapse × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 42. Cholinergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
43	Cholinergic synapse 💬	[1] MAP2K1 💬 Cholinergic synapse × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Cholinergic synapse × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 42. Cholinergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
44	Chronic myeloid leukemia 💬	[2] MAP2K1, MAP2K2 💬 Chronic myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Chronic myeloid leukemia × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 44. Chronic myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
45	Chronic myeloid leukemia 💬	[2] MAP2K1, MAP2K2 💬 Chronic myeloid leukemia × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Chronic myeloid leukemia × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 44. Chronic myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
46	Colorectal cancer 💬	[2] MAP2K1, MAP2K2 💬 Colorectal cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Colorectal cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 46. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
47	Colorectal cancer 💬	[2] MAP2K1, MAP2K2 💬 Colorectal cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Colorectal cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 46. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
48	Cushing syndrome 💬	[2] MAP2K1, MAP2K2 💬 Cushing syndrome × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Cushing syndrome × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 48. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
49	Cushing syndrome 💬	[2] MAP2K1, MAP2K2 💬 Cushing syndrome × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Cushing syndrome × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 48. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
50	Cytokine-cytokine receptor interaction 💬	[1] GHR 💬 Cytokine-cytokine receptor interaction × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somapacitan 💬 Cytokine-cytokine receptor interaction × Name Other Names Somapacitan Somapacitan-beco Sogroya	Somapacitan	[1] 195 💬 50. Cytokine-cytokine receptor interaction × Disease ID Name 195 Noonan syndrome;
51	Efferocytosis 💬	[2] MAP2K1, MAP2K2 💬 Efferocytosis × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Efferocytosis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 51. Efferocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
52	Efferocytosis 💬	[2] MAP2K1, MAP2K2 💬 Efferocytosis × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Efferocytosis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 51. Efferocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
53	Endometrial cancer 💬	[2] MAP2K1, MAP2K2 💬 Endometrial cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Endometrial cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 53. Endometrial cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
54	Endometrial cancer 💬	[2] MAP2K1, MAP2K2 💬 Endometrial cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Endometrial cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 53. Endometrial cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
55	ErbB signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 ErbB signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 ErbB signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 55. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
56	ErbB signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 ErbB signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 ErbB signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 55. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
57	Estrogen signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Estrogen signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Estrogen signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 57. Estrogen signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
58	Estrogen signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Estrogen signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Estrogen signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 57. Estrogen signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
59	Fc epsilon RI signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Fc epsilon RI signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Fc epsilon RI signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 59. Fc epsilon RI signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
60	Fc epsilon RI signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Fc epsilon RI signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Fc epsilon RI signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 59. Fc epsilon RI signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
61	Fc gamma R-mediated phagosome formation 💬	[1] MAP2K1 💬 Fc gamma R-mediated phagosome formation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Fc gamma R-mediated phagosome formation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 61. Fc gamma R-mediated phagosome formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
62	Fc gamma R-mediated phagosome formation 💬	[1] MAP2K1 💬 Fc gamma R-mediated phagosome formation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Fc gamma R-mediated phagosome formation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 61. Fc gamma R-mediated phagosome formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
63	Focal adhesion 💬	[1] MAP2K1 💬 Focal adhesion × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Focal adhesion × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 63. Focal adhesion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
64	Focal adhesion 💬	[1] MAP2K1 💬 Focal adhesion × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Focal adhesion × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 63. Focal adhesion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
65	FoxO signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 FoxO signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 FoxO signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 65. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
66	FoxO signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 FoxO signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 FoxO signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 65. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
67	Gap junction 💬	[2] MAP2K1, MAP2K2 💬 Gap junction × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Gap junction × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 67. Gap junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
68	Gap junction 💬	[2] MAP2K1, MAP2K2 💬 Gap junction × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Gap junction × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 67. Gap junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
69	Gastric cancer 💬	[2] MAP2K1, MAP2K2 💬 Gastric cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Gastric cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 69. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
70	Gastric cancer 💬	[2] MAP2K1, MAP2K2 💬 Gastric cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Gastric cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 69. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
71	Glioma 💬	[2] MAP2K1, MAP2K2 💬 Glioma × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Glioma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 71. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
72	Glioma 💬	[2] MAP2K1, MAP2K2 💬 Glioma × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Glioma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 71. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
73	GnRH secretion 💬	[2] MAP2K1, MAP2K2 💬 GnRH secretion × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 GnRH secretion × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 73. GnRH secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
74	GnRH secretion 💬	[2] MAP2K1, MAP2K2 💬 GnRH secretion × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 GnRH secretion × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 73. GnRH secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
75	GnRH signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 GnRH signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 GnRH signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 75. GnRH signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
76	GnRH signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 GnRH signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 GnRH signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 75. GnRH signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
77	Growth hormone synthesis, secretion and action 💬	[1] GHR 💬 Growth hormone synthesis, secretion and action × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somapacitan 💬 Growth hormone synthesis, secretion and action × Name Other Names Somapacitan Somapacitan-beco Sogroya	Somapacitan	[1] 195 💬 77. Growth hormone synthesis, secretion and action × Disease ID Name 195 Noonan syndrome;
78	Growth hormone synthesis, secretion and action 💬	[2] MAP2K1, MAP2K2 💬 Growth hormone synthesis, secretion and action × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 78. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
79	Growth hormone synthesis, secretion and action 💬	[2] MAP2K1, MAP2K2 💬 Growth hormone synthesis, secretion and action × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Growth hormone synthesis, secretion and action × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 78. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
80	Hepatitis B 💬	[2] MAP2K1, MAP2K2 💬 Hepatitis B × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Hepatitis B × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 80. Hepatitis B × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
81	Hepatitis B 💬	[2] MAP2K1, MAP2K2 💬 Hepatitis B × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Hepatitis B × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 80. Hepatitis B × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
82	Hepatitis C 💬	[2] MAP2K1, MAP2K2 💬 Hepatitis C × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Hepatitis C × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 82. Hepatitis C × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
83	Hepatitis C 💬	[2] MAP2K1, MAP2K2 💬 Hepatitis C × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Hepatitis C × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 82. Hepatitis C × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
84	Hepatocellular carcinoma 💬	[2] MAP2K1, MAP2K2 💬 Hepatocellular carcinoma × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Hepatocellular carcinoma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 84. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
85	Hepatocellular carcinoma 💬	[2] MAP2K1, MAP2K2 💬 Hepatocellular carcinoma × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Hepatocellular carcinoma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 84. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
86	HIF-1 signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 HIF-1 signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 HIF-1 signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 86. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
87	HIF-1 signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 HIF-1 signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 HIF-1 signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 86. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
88	Hormone signaling 💬	[1] GHR 💬 Hormone signaling × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somapacitan 💬 Hormone signaling × Name Other Names Somapacitan Somapacitan-beco Sogroya	Somapacitan	[1] 195 💬 88. Hormone signaling × Disease ID Name 195 Noonan syndrome;
89	Hormone signaling 💬	[1] NPR2 💬 Hormone signaling × Name Full Name NPR2 atrial natriuretic peptide receptor 2 isoform 1 precursor	Vosoritide 💬 Hormone signaling × Name Other Names Vosoritide Voxzogo	Vosoritide	[3] 19, 195, 276 💬 89. Hormone signaling × Disease ID Name 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 195 Noonan syndrome; 276 Achondroplasia;
90	Human cytomegalovirus infection 💬	[2] MAP2K1, MAP2K2 💬 Human cytomegalovirus infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Human cytomegalovirus infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 90. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
91	Human cytomegalovirus infection 💬	[2] MAP2K1, MAP2K2 💬 Human cytomegalovirus infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Human cytomegalovirus infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 90. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
92	Human immunodeficiency virus 1 infection 💬	[2] MAP2K1, MAP2K2 💬 Human immunodeficiency virus 1 infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 92. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
93	Human immunodeficiency virus 1 infection 💬	[2] MAP2K1, MAP2K2 💬 Human immunodeficiency virus 1 infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Human immunodeficiency virus 1 infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 92. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
94	Human papillomavirus infection 💬	[2] MAP2K1, MAP2K2 💬 Human papillomavirus infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Human papillomavirus infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 94. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
95	Human papillomavirus infection 💬	[2] MAP2K1, MAP2K2 💬 Human papillomavirus infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Human papillomavirus infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 94. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
96	Human T-cell leukemia virus 1 infection 💬	[2] MAP2K1, MAP2K2 💬 Human T-cell leukemia virus 1 infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 96. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
97	Human T-cell leukemia virus 1 infection 💬	[2] MAP2K1, MAP2K2 💬 Human T-cell leukemia virus 1 infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Human T-cell leukemia virus 1 infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 96. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
98	IgSF CAM signaling 💬	[2] MAP2K1, MAP2K2 💬 IgSF CAM signaling × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 IgSF CAM signaling × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 98. IgSF CAM signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
99	IgSF CAM signaling 💬	[2] MAP2K1, MAP2K2 💬 IgSF CAM signaling × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 IgSF CAM signaling × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 98. IgSF CAM signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
100	Influenza A 💬	[2] MAP2K1, MAP2K2 💬 Influenza A × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Influenza A × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 100. Influenza A × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
101	Influenza A 💬	[2] MAP2K1, MAP2K2 💬 Influenza A × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Influenza A × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 100. Influenza A × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
102	Insulin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Insulin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Insulin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 102. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
103	Insulin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Insulin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Insulin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 102. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
104	JAK-STAT signaling pathway 💬	[1] GHR 💬 JAK-STAT signaling pathway × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somapacitan 💬 JAK-STAT signaling pathway × Name Other Names Somapacitan Somapacitan-beco Sogroya	Somapacitan	[1] 195 💬 104. JAK-STAT signaling pathway × Disease ID Name 195 Noonan syndrome;
105	Kaposi sarcoma-associated herpesvirus infection 💬	[2] MAP2K1, MAP2K2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 105. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
106	Kaposi sarcoma-associated herpesvirus infection 💬	[2] MAP2K1, MAP2K2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 105. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
107	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬 Long-term depression × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Long-term depression × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 107. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
108	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬 Long-term depression × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Long-term depression × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 107. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
109	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬 Long-term potentiation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Long-term potentiation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 109. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
110	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬 Long-term potentiation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Long-term potentiation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 109. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
111	MAPK signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 MAPK signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 MAPK signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 111. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
112	MAPK signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 MAPK signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 MAPK signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 111. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
113	Melanogenesis 💬	[2] MAP2K1, MAP2K2 💬 Melanogenesis × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Melanogenesis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 113. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
114	Melanogenesis 💬	[2] MAP2K1, MAP2K2 💬 Melanogenesis × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Melanogenesis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 113. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
115	Melanoma 💬	[2] MAP2K1, MAP2K2 💬 Melanoma × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Melanoma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 115. Melanoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
116	Melanoma 💬	[2] MAP2K1, MAP2K2 💬 Melanoma × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Melanoma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 115. Melanoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
117	MicroRNAs in cancer 💬	[2] MAP2K1, MAP2K2 💬 MicroRNAs in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 MicroRNAs in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 117. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
118	MicroRNAs in cancer 💬	[2] MAP2K1, MAP2K2 💬 MicroRNAs in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 MicroRNAs in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 117. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
119	mTOR signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 mTOR signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 mTOR signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 119. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
120	mTOR signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 mTOR signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 mTOR signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 119. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
121	Natural killer cell mediated cytotoxicity 💬	[2] MAP2K1, MAP2K2 💬 Natural killer cell mediated cytotoxicity × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 121. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
122	Natural killer cell mediated cytotoxicity 💬	[2] MAP2K1, MAP2K2 💬 Natural killer cell mediated cytotoxicity × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Natural killer cell mediated cytotoxicity × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 121. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
123	Neuroactive ligand-receptor interaction 💬	[1] GHR 💬 Neuroactive ligand-receptor interaction × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somapacitan 💬 Neuroactive ligand-receptor interaction × Name Other Names Somapacitan Somapacitan-beco Sogroya	Somapacitan	[1] 195 💬 123. Neuroactive ligand-receptor interaction × Disease ID Name 195 Noonan syndrome;
124	Neurotrophin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Neurotrophin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Neurotrophin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 124. Neurotrophin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
125	Neurotrophin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Neurotrophin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Neurotrophin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 124. Neurotrophin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
126	Neutrophil extracellular trap formation 💬	[2] MAP2K1, MAP2K2 💬 Neutrophil extracellular trap formation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Neutrophil extracellular trap formation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 126. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
127	Neutrophil extracellular trap formation 💬	[2] MAP2K1, MAP2K2 💬 Neutrophil extracellular trap formation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Neutrophil extracellular trap formation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 126. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
128	Non-small cell lung cancer 💬	[2] MAP2K1, MAP2K2 💬 Non-small cell lung cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Non-small cell lung cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 128. Non-small cell lung cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
129	Non-small cell lung cancer 💬	[2] MAP2K1, MAP2K2 💬 Non-small cell lung cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Non-small cell lung cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 128. Non-small cell lung cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
130	Oocyte meiosis 💬	[1] MAP2K1 💬 Oocyte meiosis × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Oocyte meiosis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 130. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
131	Oocyte meiosis 💬	[1] MAP2K1 💬 Oocyte meiosis × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Oocyte meiosis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 130. Oocyte meiosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
132	Osteoclast differentiation 💬	[1] MAP2K1 💬 Osteoclast differentiation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Osteoclast differentiation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 132. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
133	Osteoclast differentiation 💬	[1] MAP2K1 💬 Osteoclast differentiation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Osteoclast differentiation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 132. Osteoclast differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
134	Oxytocin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Oxytocin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Oxytocin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 134. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
135	Oxytocin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Oxytocin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Oxytocin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 134. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
136	Oxytocin signaling pathway 💬	[1] NPR2 💬 Oxytocin signaling pathway × Name Full Name NPR2 atrial natriuretic peptide receptor 2 isoform 1 precursor	Vosoritide 💬 Oxytocin signaling pathway × Name Other Names Vosoritide Voxzogo	Vosoritide	[3] 19, 195, 276 💬 136. Oxytocin signaling pathway × Disease ID Name 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 195 Noonan syndrome; 276 Achondroplasia;
137	Pancreatic cancer 💬	[1] MAP2K1 💬 Pancreatic cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Pancreatic cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 137. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
138	Pancreatic cancer 💬	[1] MAP2K1 💬 Pancreatic cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Pancreatic cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 137. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
139	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Parathyroid hormone synthesis, secretion and action × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 139. Parathyroid hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
140	Parathyroid hormone synthesis, secretion and action 💬	[1] MAP2K1 💬 Parathyroid hormone synthesis, secretion and action × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Parathyroid hormone synthesis, secretion and action × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 139. Parathyroid hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
141	Pathways in cancer 💬	[2] MAP2K1, MAP2K2 💬 Pathways in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Pathways in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 141. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
142	Pathways in cancer 💬	[2] MAP2K1, MAP2K2 💬 Pathways in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Pathways in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 141. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
143	Pathways of neurodegeneration - multiple diseases 💬	[2] MAP2K1, MAP2K2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 143. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
144	Pathways of neurodegeneration - multiple diseases 💬	[2] MAP2K1, MAP2K2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 143. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
145	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[2] MAP2K1, MAP2K2 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 145. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
146	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[2] MAP2K1, MAP2K2 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 145. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
147	Phospholipase D signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Phospholipase D signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Phospholipase D signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 147. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
148	Phospholipase D signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Phospholipase D signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Phospholipase D signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 147. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
149	PI3K-Akt signaling pathway 💬	[1] GHR 💬 PI3K-Akt signaling pathway × Name Full Name GHR growth hormone receptor isoform 1 precursor	Somapacitan 💬 PI3K-Akt signaling pathway × Name Other Names Somapacitan Somapacitan-beco Sogroya	Somapacitan	[1] 195 💬 149. PI3K-Akt signaling pathway × Disease ID Name 195 Noonan syndrome;
150	PI3K-Akt signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 PI3K-Akt signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 PI3K-Akt signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 150. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
151	PI3K-Akt signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 PI3K-Akt signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 PI3K-Akt signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 150. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
152	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Progesterone-mediated oocyte maturation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Progesterone-mediated oocyte maturation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 152. Progesterone-mediated oocyte maturation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
153	Progesterone-mediated oocyte maturation 💬	[1] MAP2K1 💬 Progesterone-mediated oocyte maturation × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Progesterone-mediated oocyte maturation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 152. Progesterone-mediated oocyte maturation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
154	Prolactin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Prolactin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Prolactin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 154. Prolactin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
155	Prolactin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Prolactin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Prolactin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 154. Prolactin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
156	Prostate cancer 💬	[2] MAP2K1, MAP2K2 💬 Prostate cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Prostate cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 156. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
157	Prostate cancer 💬	[2] MAP2K1, MAP2K2 💬 Prostate cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Prostate cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 156. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
158	Proteoglycans in cancer 💬	[2] MAP2K1, MAP2K2 💬 Proteoglycans in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Proteoglycans in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 158. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
159	Proteoglycans in cancer 💬	[2] MAP2K1, MAP2K2 💬 Proteoglycans in cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Proteoglycans in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 158. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
160	Purine metabolism 💬	[1] NPR2 💬 Purine metabolism × Name Full Name NPR2 atrial natriuretic peptide receptor 2 isoform 1 precursor	Vosoritide 💬 Purine metabolism × Name Other Names Vosoritide Voxzogo	Vosoritide	[3] 19, 195, 276 💬 160. Purine metabolism × Disease ID Name 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 195 Noonan syndrome; 276 Achondroplasia;
161	Rap1 signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Rap1 signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Rap1 signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 161. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
162	Rap1 signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Rap1 signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Rap1 signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 161. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
163	Ras signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Ras signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Ras signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 163. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
164	Ras signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Ras signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Ras signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 163. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
165	Regulation of actin cytoskeleton 💬	[2] MAP2K1, MAP2K2 💬 Regulation of actin cytoskeleton × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Regulation of actin cytoskeleton × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 165. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
166	Regulation of actin cytoskeleton 💬	[2] MAP2K1, MAP2K2 💬 Regulation of actin cytoskeleton × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Regulation of actin cytoskeleton × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 165. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
167	Relaxin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Relaxin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Relaxin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 167. Relaxin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
168	Relaxin signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Relaxin signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Relaxin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 167. Relaxin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
169	Renal cell carcinoma 💬	[2] MAP2K1, MAP2K2 💬 Renal cell carcinoma × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Renal cell carcinoma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 169. Renal cell carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
170	Renal cell carcinoma 💬	[2] MAP2K1, MAP2K2 💬 Renal cell carcinoma × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Renal cell carcinoma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 169. Renal cell carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
171	Salmonella infection 💬	[2] MAP2K1, MAP2K2 💬 Salmonella infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Salmonella infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 171. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
172	Salmonella infection 💬	[2] MAP2K1, MAP2K2 💬 Salmonella infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Salmonella infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 171. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
173	Serotonergic synapse 💬	[1] MAP2K1 💬 Serotonergic synapse × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 Serotonergic synapse × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 173. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
174	Serotonergic synapse 💬	[1] MAP2K1 💬 Serotonergic synapse × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 Serotonergic synapse × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 173. Serotonergic synapse × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
175	Signaling pathways regulating pluripotency of stem cells 💬	[2] MAP2K1, MAP2K2 💬 Signaling pathways regulating pluripotency of stem cells × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 175. Signaling pathways regulating pluripotency of stem cells × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
176	Signaling pathways regulating pluripotency of stem cells 💬	[2] MAP2K1, MAP2K2 💬 Signaling pathways regulating pluripotency of stem cells × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 175. Signaling pathways regulating pluripotency of stem cells × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
177	Sphingolipid signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Sphingolipid signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Sphingolipid signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 177. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
178	Sphingolipid signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Sphingolipid signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Sphingolipid signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 177. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
179	T cell receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 T cell receptor signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 T cell receptor signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 179. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
180	T cell receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 T cell receptor signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 T cell receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 179. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
181	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬 Terpenoid backbone biosynthesis × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1	Lovastatin 💬 Terpenoid backbone biosynthesis × Name Other Names Lovastatin Mevacor	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 181. Terpenoid backbone biosynthesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolemia;Familial hypercholesterolaemia; 156 Rett syndrome; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Austin syndrome;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 195 Noonan syndrome; 206 Fragile X syndrome; 263 Cerebrotendinous xanthomatosis;CTX;27-hydroxylase deficiency;CYP27 deficiency; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Chromosome 1q21.1 duplication syndrome;Trisomy 1q;9q34 deletion syndrome;Chromosome 9q34.3 deletion syndrome;Chromosome 9q deletion syndrome;9q subtelomeric deletion syndrome;9q- syndrome;9q34.3 deletion/microdeletion syndrome;Kleefstra syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
182	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬 Terpenoid backbone biosynthesis × Name Full Name HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1	Simvastatin 💬 Terpenoid backbone biosynthesis × Name Other Names Simvastatin MK-733 Zocor	Simvastatin	[22]  6 , 13, 15, 34, 46, 49, 51, 57, 66, 79, 86, 89, 94, 158, 160, 162, 195, 223, 265, 298, 299, 310 💬 182. Terpenoid backbone biosynthesis × Disease ID Name  6  Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome; 13 Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis; 15 Inclusion body myositis; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc; 57 Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;Glomerulonephritis; 79 Homozygous familial hypercholesterolemia;Familial hypercholesterolemia;Familial hypercholesterolaemia; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 94 Primary sclerosing cholangitis;PSC; 158 Tuberous sclerosis;Tuberous sclerosis complex;TSC; 160 Congenital ichthyosis;Keratinopathic ichthyosis;Epidermolytic ichthyosis;Superficial epidermolytic ichthyosis;Harlequin ichthyosis;Autosomal recessive congenital ichthyosis;Congenital Ichthyosiform Erythroderma;Foliate ichthyosis;Ichthyosis syndrome;Netherton syndrome;Sjogren-Larsson syndrome;Sjögren-Larsson syndrome;Keratitis-ichtyosis-deafness syndrome;KID syndrome;Dorfman-Chanarin syndrome;Neutral lipid storage disease;NLSD;Multiple sulfatase deficiency;Austin disease;Austin syndrome;Recessive X-linked ichthyosis;RXLI;X-linked recessive ichthyosis;Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature;IBID;Trichothiodystrophy;Follicular ichthyosis;Congenital hemidysplasia, ichthyosiform erythroderma or nevus, and limb defects syndrome;CHILD syndrome;Conradi-Hunermann-Happle syndrome;Conradi-Hünermann-Happle syndrome;CHHS; 162 Pemphigoid;Bullous pemphigoid;BP;Epidermolysis bullosa acquisita;Acquired epidermolysis bullosa; 195 Noonan syndrome; 223 Primary membranoproliferative glomerulonephritis;Primary MPGN;Primary membranoproliferative glomerulonephritis type I;Primary MPGN I;Primary membranoproliferative glomerulonephritis type III;Primary MPGN III;Membranoproliferative glomerulonephritis;Glomerulonephritis;C3 glomerulonephritis;C3 glomerulopathy;IC-MPGN;MPGN; 265 Lipodystrophy; 298 Hereditary pancreatitis;Chronic pancreatitis; 299 Cystic fibrosis;CF; 310 Congenital anomalies syndrome;Partial trisomy 1q syndrome;Chromosome 1q21.1 duplication syndrome;Trisomy 1q;9q34 deletion syndrome;Chromosome 9q34.3 deletion syndrome;Chromosome 9q deletion syndrome;9q subtelomeric deletion syndrome;9q- syndrome;9q34.3 deletion/microdeletion syndrome;Kleefstra syndrome;Cornelia de Lange syndrome;CdLS;Smith-Lemli-Opitz syndrome;SLO syndrome;
183	Thyroid cancer 💬	[2] MAP2K1, MAP2K2 💬 Thyroid cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Thyroid cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 183. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
184	Thyroid cancer 💬	[2] MAP2K1, MAP2K2 💬 Thyroid cancer × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Thyroid cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 183. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
185	Thyroid hormone signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Thyroid hormone signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Thyroid hormone signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 185. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
186	Thyroid hormone signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Thyroid hormone signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Thyroid hormone signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 185. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
187	TNF signaling pathway 💬	[1] MAP2K1 💬 TNF signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib 💬 TNF signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 187. TNF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
188	TNF signaling pathway 💬	[1] MAP2K1 💬 TNF signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1	Trametinib dimethyl sulfoxide 💬 TNF signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 187. TNF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
189	Toll-like receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Toll-like receptor signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Toll-like receptor signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 189. Toll-like receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
190	Toll-like receptor signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 Toll-like receptor signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Toll-like receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 189. Toll-like receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
191	Vascular smooth muscle contraction 💬	[2] MAP2K1, MAP2K2 💬 Vascular smooth muscle contraction × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Vascular smooth muscle contraction × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 191. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
192	Vascular smooth muscle contraction 💬	[2] MAP2K1, MAP2K2 💬 Vascular smooth muscle contraction × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Vascular smooth muscle contraction × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 191. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
193	Vascular smooth muscle contraction 💬	[1] NPR2 💬 Vascular smooth muscle contraction × Name Full Name NPR2 atrial natriuretic peptide receptor 2 isoform 1 precursor	Vosoritide 💬 Vascular smooth muscle contraction × Name Other Names Vosoritide Voxzogo	Vosoritide	[3] 19, 195, 276 💬 193. Vascular smooth muscle contraction × Disease ID Name 19 Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis; 195 Noonan syndrome; 276 Achondroplasia;
194	VEGF signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 VEGF signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 VEGF signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 194. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
195	VEGF signaling pathway 💬	[2] MAP2K1, MAP2K2 💬 VEGF signaling pathway × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 VEGF signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 194. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
196	Yersinia infection 💬	[2] MAP2K1, MAP2K2 💬 Yersinia infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Yersinia infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 196. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
197	Yersinia infection 💬	[2] MAP2K1, MAP2K2 💬 Yersinia infection × Name Full Name MAP2K1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1 MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Yersinia infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 196. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;

Back to top