Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[77] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...

Selumetinib 💬

[1] 34 💬

2

[77] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...

Trametinib 💬

[4] 2, 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
34	Neurofibromatosis
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion
280	Huge arteriovenous malformation with cervicofacial or limb lesion

3

[77] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...

Cobimetinib 💬

[1] 280 💬

4

[77] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...

Binimetinib 💬

[1] 34 💬

5

[77] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...

Mirdametinib 💬

[1] 34 💬

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