Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Calcium signaling pathway 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [10] 51, 66, 84, 85, 86, 88, 210, 211, 218, 222 💬
2 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
3 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
4 cAMP signaling pathway 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [10] 51, 66, 84, 85, 86, 88, 210, 211, 218, 222 💬
5 cAMP signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
6 cAMP signaling pathway 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
7 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [10] 51, 66, 84, 85, 86, 88, 210, 211, 218, 222 💬
8 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
9 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
10 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 Sildenafil citrate 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
11 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 Sildenafil 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
12 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Oxandrolone 💬 Oxandrolone [2] 211, 285 💬
13 Melanogenesis 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
14 Melanogenesis 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
15 Neuroactive ligand-receptor interaction 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [10] 51, 66, 84, 85, 86, 88, 210, 211, 218, 222 💬
16 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
17 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
18 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 Methylprednisolone 💬 Methylprednisolone [51]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 111, 127, 145, 162, 164, 211, 222, 223, 224, 271, 283, 284, 285, 296, 300 💬
19 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 Methylprednisolone acetate 💬 Methylprednisolone [51]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 111, 127, 145, 162, 164, 211, 222, 223, 224, 271, 283, 284, 285, 296, 300 💬
20 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 Methylprednisolone sodium succinate 💬 Methylprednisolone hemisuccinate [8] 13, 46, 49, 50, 51, 85, 211, 222 💬
21 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 Methylprednisolone hemisuccinate 💬 Methylprednisolone hemisuccinate [8] 13, 46, 49, 50, 51, 85, 211, 222 💬
22 Oocyte meiosis 💬
 [1] AR 💬 Oxandrolone 💬 Oxandrolone [2] 211, 285 💬
23 Pathways in cancer 💬
 [1] AR 💬 Oxandrolone 💬 Oxandrolone [2] 211, 285 💬
24 Pathways in cancer 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [10] 51, 66, 84, 85, 86, 88, 210, 211, 218, 222 💬
25 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
26 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
27 Prostate cancer 💬
 [1] AR 💬 Oxandrolone 💬 Oxandrolone [2] 211, 285 💬
28 Purine metabolism 💬
 [1] PDE5A 💬 Sildenafil citrate 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
29 Purine metabolism 💬
 [1] PDE5A 💬 Sildenafil 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
30 Relaxin signaling pathway 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
31 Relaxin signaling pathway 💬
 [1] EDNRB 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
32 Renin secretion 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [10] 51, 66, 84, 85, 86, 88, 210, 211, 218, 222 💬
33 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
34 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
35 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [10] 51, 66, 84, 85, 86, 88, 210, 211, 218, 222 💬
36 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
37 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [12] 13, 40, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

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