Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] KIT 💬 Acute myeloid leukemia × Name Full Name KIT KIT proto-oncogene, receptor tyrosine kinase	Imatinib 💬 Acute myeloid leukemia × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 1. Acute myeloid leukemia × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
2	Acute myeloid leukemia 💬	[1] MTOR 💬 Acute myeloid leukemia × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Acute myeloid leukemia × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 2. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
3	Acute myeloid leukemia 💬	[1] PIK3CD 💬 Acute myeloid leukemia × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Acute myeloid leukemia × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 3. Acute myeloid leukemia × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
4	Adipocytokine signaling pathway 💬	[1] MTOR 💬 Adipocytokine signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Adipocytokine signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 4. Adipocytokine signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
5	Adipocytokine signaling pathway 💬	[1] TNF 💬 Adipocytokine signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Adipocytokine signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 5. Adipocytokine signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
6	Adipocytokine signaling pathway 💬	[1] TNF 💬 Adipocytokine signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Adipocytokine signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 6. Adipocytokine signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
7	African trypanosomiasis 💬	[1] TNF 💬 African trypanosomiasis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 African trypanosomiasis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 7. African trypanosomiasis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
8	African trypanosomiasis 💬	[1] TNF 💬 African trypanosomiasis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 African trypanosomiasis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 8. African trypanosomiasis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
9	AGE-RAGE signaling pathway in diabetic complications 💬	[1] PIK3CD 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 AGE-RAGE signaling pathway in diabetic complications × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 9. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
10	AGE-RAGE signaling pathway in diabetic complications 💬	[1] TNF 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TNF tumor necrosis factor	Etanercept 💬 AGE-RAGE signaling pathway in diabetic complications × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 10. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
11	AGE-RAGE signaling pathway in diabetic complications 💬	[1] TNF 💬 AGE-RAGE signaling pathway in diabetic complications × Name Full Name TNF tumor necrosis factor	Infliximab 💬 AGE-RAGE signaling pathway in diabetic complications × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 11. AGE-RAGE signaling pathway in diabetic complications × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
12	Alcoholic liver disease 💬	[1] TNF 💬 Alcoholic liver disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Alcoholic liver disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 12. Alcoholic liver disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
13	Alcoholic liver disease 💬	[1] TNF 💬 Alcoholic liver disease × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Alcoholic liver disease × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 13. Alcoholic liver disease × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
14	Aldosterone-regulated sodium reabsorption 💬	[1] PIK3CD 💬 Aldosterone-regulated sodium reabsorption × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Aldosterone-regulated sodium reabsorption × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 14. Aldosterone-regulated sodium reabsorption × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
15	Allograft rejection 💬	[1] TNF 💬 Allograft rejection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Allograft rejection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 15. Allograft rejection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
16	Allograft rejection 💬	[1] TNF 💬 Allograft rejection × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Allograft rejection × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 16. Allograft rejection × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
17	Alzheimer disease 💬	[1] MTOR 💬 Alzheimer disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Alzheimer disease × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 17. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
18	Alzheimer disease 💬	[1] PIK3CD 💬 Alzheimer disease × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Alzheimer disease × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 18. Alzheimer disease × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
19	Alzheimer disease 💬	[1] PTGS2 💬 Alzheimer disease × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Alzheimer disease × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 19. Alzheimer disease × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
20	Alzheimer disease 💬	[1] TNF 💬 Alzheimer disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Alzheimer disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 20. Alzheimer disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
21	Alzheimer disease 💬	[1] TNF 💬 Alzheimer disease × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Alzheimer disease × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 21. Alzheimer disease × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
22	Amoebiasis 💬	[1] PIK3CD 💬 Amoebiasis × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Amoebiasis × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 22. Amoebiasis × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
23	Amoebiasis 💬	[1] TNF 💬 Amoebiasis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Amoebiasis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 23. Amoebiasis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
24	Amoebiasis 💬	[1] TNF 💬 Amoebiasis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Amoebiasis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 24. Amoebiasis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
25	AMPK signaling pathway 💬	[1] MTOR 💬 AMPK signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 AMPK signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 25. AMPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
26	AMPK signaling pathway 💬	[1] PIK3CD 💬 AMPK signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 AMPK signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 26. AMPK signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
27	Amyotrophic lateral sclerosis 💬	[1] MTOR 💬 Amyotrophic lateral sclerosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Amyotrophic lateral sclerosis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 27. Amyotrophic lateral sclerosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
28	Amyotrophic lateral sclerosis 💬	[1] TNF 💬 Amyotrophic lateral sclerosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Amyotrophic lateral sclerosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 28. Amyotrophic lateral sclerosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
29	Amyotrophic lateral sclerosis 💬	[1] TNF 💬 Amyotrophic lateral sclerosis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Amyotrophic lateral sclerosis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 29. Amyotrophic lateral sclerosis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
30	Antifolate resistance 💬	[2] DHFR, DHFR2 💬 Antifolate resistance × Name Full Name DHFR dihydrofolate reductase DHFR2 dihydrofolate reductase 2	Methotrexate 💬 Antifolate resistance × Name Other Names Methotrexate Methotrexate (JP18/USP/INN) Otrexup (TN) Xatmep (TN) REDITREX	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 30. Antifolate resistance × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 84 Sarcoidosis; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 172 Hypophosphatasia; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
31	Antifolate resistance 💬	[1] TNF 💬 Antifolate resistance × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Antifolate resistance × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 31. Antifolate resistance × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
32	Antifolate resistance 💬	[1] TNF 💬 Antifolate resistance × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Antifolate resistance × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 32. Antifolate resistance × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
33	Antigen processing and presentation 💬	[1] TNF 💬 Antigen processing and presentation × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Antigen processing and presentation × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 33. Antigen processing and presentation × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
34	Antigen processing and presentation 💬	[1] TNF 💬 Antigen processing and presentation × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Antigen processing and presentation × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 34. Antigen processing and presentation × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
35	Apelin signaling pathway 💬	[1] MTOR 💬 Apelin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Apelin signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 35. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
36	Apoptosis 💬	[1] PIK3CD 💬 Apoptosis × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Apoptosis × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 36. Apoptosis × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
37	Apoptosis 💬	[1] TNF 💬 Apoptosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Apoptosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 37. Apoptosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
38	Apoptosis 💬	[1] TNF 💬 Apoptosis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Apoptosis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 38. Apoptosis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
39	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬 Arachidonic acid metabolism × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Arachidonic acid metabolism × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 39. Arachidonic acid metabolism × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
40	Asthma 💬	[1] TNF 💬 Asthma × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Asthma × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 40. Asthma × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
41	Asthma 💬	[1] TNF 💬 Asthma × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Asthma × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 41. Asthma × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
42	Autophagy - animal 💬	[1] MTOR 💬 Autophagy - animal × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Autophagy - animal × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 42. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
43	Autophagy - animal 💬	[1] PIK3CD 💬 Autophagy - animal × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Autophagy - animal × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 43. Autophagy - animal × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
44	Autophagy - other 💬	[1] MTOR 💬 Autophagy - other × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Autophagy - other × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 44. Autophagy - other × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
45	Axon guidance 💬	[1] ABL1 💬 Axon guidance × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase	Imatinib 💬 Axon guidance × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 45. Axon guidance × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
46	Axon guidance 💬	[1] PIK3CD 💬 Axon guidance × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Axon guidance × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 46. Axon guidance × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
47	B cell receptor signaling pathway 💬	[1] PIK3CD 💬 B cell receptor signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 B cell receptor signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 47. B cell receptor signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
48	Bacterial invasion of epithelial cells 💬	[1] PIK3CD 💬 Bacterial invasion of epithelial cells × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Bacterial invasion of epithelial cells × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 48. Bacterial invasion of epithelial cells × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
49	Biosynthesis of cofactors 💬	[2] DHFR, DHFR2 💬 Biosynthesis of cofactors × Name Full Name DHFR dihydrofolate reductase DHFR2 dihydrofolate reductase 2	Methotrexate 💬 Biosynthesis of cofactors × Name Other Names Methotrexate Methotrexate (JP18/USP/INN) Otrexup (TN) Xatmep (TN) REDITREX	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 49. Biosynthesis of cofactors × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 84 Sarcoidosis; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 172 Hypophosphatasia; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
50	Breast cancer 💬	[1] KIT 💬 Breast cancer × Name Full Name KIT KIT proto-oncogene, receptor tyrosine kinase	Imatinib 💬 Breast cancer × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 50. Breast cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
51	Breast cancer 💬	[1] MTOR 💬 Breast cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Breast cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 51. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
52	Breast cancer 💬	[1] PGR 💬 Breast cancer × Name Full Name PGR progesterone receptor	Medroxyprogesterone acetate 💬 Breast cancer × Name Other Names Medroxyprogesterone acetate Medroxyprogesterone acetate (JP18/USP) Depo-provera (TN) Depo-subq provera 104 (TN) Provera (TN) DEPO-SUBQ PROVERA MEDROXYPROGESTERONE	Medroxyprogesterone acetate	[8] 13, 35, 46, 49, 50, 51, 60, 107 💬 52. Breast cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 107 Juvenile idiopathic arthritis;JIA;
53	Breast cancer 💬	[1] PIK3CD 💬 Breast cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Breast cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 53. Breast cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
54	C-type lectin receptor signaling pathway 💬	[1] PIK3CD 💬 C-type lectin receptor signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 C-type lectin receptor signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 54. C-type lectin receptor signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
55	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬 C-type lectin receptor signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 C-type lectin receptor signaling pathway × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 55. C-type lectin receptor signaling pathway × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
56	C-type lectin receptor signaling pathway 💬	[1] TNF 💬 C-type lectin receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 C-type lectin receptor signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 56. C-type lectin receptor signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
57	C-type lectin receptor signaling pathway 💬	[1] TNF 💬 C-type lectin receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 C-type lectin receptor signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 57. C-type lectin receptor signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
58	Calcium signaling pathway 💬	[1] HRH1 💬 Calcium signaling pathway × Name Full Name HRH1 histamine receptor H1	Cetirizine 💬 Calcium signaling pathway × Name Other Names Cetirizine Cetirizine (INN) Cetiderm (TN)	Cetirizine	[4] 13, 28, 35, 300 💬 58. Calcium signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 300 IgG4-related disease;
59	Calcium signaling pathway 💬	[1] PDGFRA 💬 Calcium signaling pathway × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Calcium signaling pathway × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 59. Calcium signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
60	cAMP signaling pathway 💬	[1] PIK3CD 💬 cAMP signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 cAMP signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 60. cAMP signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
61	Carbohydrate digestion and absorption 💬	[1] PIK3CD 💬 Carbohydrate digestion and absorption × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Carbohydrate digestion and absorption × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 61. Carbohydrate digestion and absorption × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
62	Cell cycle 💬	[1] ABL1 💬 Cell cycle × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase	Imatinib 💬 Cell cycle × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 62. Cell cycle × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
63	Cellular senescence 💬	[1] MTOR 💬 Cellular senescence × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Cellular senescence × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 63. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
64	Cellular senescence 💬	[1] PIK3CD 💬 Cellular senescence × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Cellular senescence × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 64. Cellular senescence × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
65	Central carbon metabolism in cancer 💬	[2] KIT, PDGFRA 💬 Central carbon metabolism in cancer × Name Full Name KIT KIT proto-oncogene, receptor tyrosine kinase PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Central carbon metabolism in cancer × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 65. Central carbon metabolism in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
66	Central carbon metabolism in cancer 💬	[1] MTOR 💬 Central carbon metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Central carbon metabolism in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 66. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
67	Central carbon metabolism in cancer 💬	[1] PIK3CD 💬 Central carbon metabolism in cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Central carbon metabolism in cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 67. Central carbon metabolism in cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
68	Chagas disease 💬	[1] PIK3CD 💬 Chagas disease × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Chagas disease × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 68. Chagas disease × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
69	Chagas disease 💬	[1] TNF 💬 Chagas disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Chagas disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 69. Chagas disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
70	Chagas disease 💬	[1] TNF 💬 Chagas disease × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Chagas disease × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 70. Chagas disease × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
71	Chemical carcinogenesis - DNA adducts 💬	[1] PTGS2 💬 Chemical carcinogenesis - DNA adducts × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Chemical carcinogenesis - DNA adducts × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 71. Chemical carcinogenesis - DNA adducts × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
72	Chemical carcinogenesis - reactive oxygen species 💬	[1] ABL1 💬 Chemical carcinogenesis - reactive oxygen species × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase	Imatinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 72. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
73	Chemical carcinogenesis - reactive oxygen species 💬	[1] PIK3CD 💬 Chemical carcinogenesis - reactive oxygen species × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 73. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
74	Chemical carcinogenesis - receptor activation 💬	[1] MTOR 💬 Chemical carcinogenesis - receptor activation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Chemical carcinogenesis - receptor activation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 74. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
75	Chemical carcinogenesis - receptor activation 💬	[1] PGR 💬 Chemical carcinogenesis - receptor activation × Name Full Name PGR progesterone receptor	Medroxyprogesterone acetate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Medroxyprogesterone acetate Medroxyprogesterone acetate (JP18/USP) Depo-provera (TN) Depo-subq provera 104 (TN) Provera (TN) DEPO-SUBQ PROVERA MEDROXYPROGESTERONE	Medroxyprogesterone acetate	[8] 13, 35, 46, 49, 50, 51, 60, 107 💬 75. Chemical carcinogenesis - receptor activation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 107 Juvenile idiopathic arthritis;JIA;
76	Chemical carcinogenesis - receptor activation 💬	[1] PIK3CD 💬 Chemical carcinogenesis - receptor activation × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 76. Chemical carcinogenesis - receptor activation × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
77	Chemokine signaling pathway 💬	[1] PIK3CD 💬 Chemokine signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Chemokine signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 77. Chemokine signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
78	Choline metabolism in cancer 💬	[1] MTOR 💬 Choline metabolism in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Choline metabolism in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 78. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
79	Choline metabolism in cancer 💬	[1] PDGFRA 💬 Choline metabolism in cancer × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Choline metabolism in cancer × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 79. Choline metabolism in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
80	Choline metabolism in cancer 💬	[1] PIK3CD 💬 Choline metabolism in cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Choline metabolism in cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 80. Choline metabolism in cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
81	Cholinergic synapse 💬	[1] PIK3CD 💬 Cholinergic synapse × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Cholinergic synapse × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 81. Cholinergic synapse × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
82	Chronic myeloid leukemia 💬	[1] ABL1 💬 Chronic myeloid leukemia × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase	Imatinib 💬 Chronic myeloid leukemia × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 82. Chronic myeloid leukemia × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
83	Chronic myeloid leukemia 💬	[1] PIK3CD 💬 Chronic myeloid leukemia × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Chronic myeloid leukemia × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 83. Chronic myeloid leukemia × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
84	Colorectal cancer 💬	[1] MTOR 💬 Colorectal cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Colorectal cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 84. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
85	Colorectal cancer 💬	[1] PIK3CD 💬 Colorectal cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Colorectal cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 85. Colorectal cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
86	Coronavirus disease - COVID-19 💬	[1] PIK3CD 💬 Coronavirus disease - COVID-19 × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Coronavirus disease - COVID-19 × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 86. Coronavirus disease - COVID-19 × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
87	Coronavirus disease - COVID-19 💬	[1] TNF 💬 Coronavirus disease - COVID-19 × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Coronavirus disease - COVID-19 × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 87. Coronavirus disease - COVID-19 × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
88	Coronavirus disease - COVID-19 💬	[1] TNF 💬 Coronavirus disease - COVID-19 × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Coronavirus disease - COVID-19 × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 88. Coronavirus disease - COVID-19 × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
89	Cytokine-cytokine receptor interaction 💬	[1] CSF3R 💬 Cytokine-cytokine receptor interaction × Name Full Name CSF3R colony stimulating factor 3 receptor	Filgrastim 💬 Cytokine-cytokine receptor interaction × Name Other Names Filgrastim Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO	Filgrastim	[35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 89. Cytokine-cytokine receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 16 Crow-Fukase syndrome;POEMS syndrome; 22 Moyamoya disease;Occlusive disease in circle of Willis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 47 Buerger disease;Thromboangiitis obliterans; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 57 Idiopathic dilated cardiomyopathy; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 113 Muscular dystrophy; 164 Oculocutaneous albinism; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
90	Cytokine-cytokine receptor interaction 💬	[3] IL2RA, IL2RB, IL2RG 💬 Cytokine-cytokine receptor interaction × Name Full Name IL2RA interleukin 2 receptor subunit alpha IL2RB interleukin 2 receptor subunit beta IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 Cytokine-cytokine receptor interaction × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 90. Cytokine-cytokine receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
91	Cytokine-cytokine receptor interaction 💬	[2] LTA, TNF 💬 Cytokine-cytokine receptor interaction × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 Cytokine-cytokine receptor interaction × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 91. Cytokine-cytokine receptor interaction × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
92	Cytokine-cytokine receptor interaction 💬	[1] TNF 💬 Cytokine-cytokine receptor interaction × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Cytokine-cytokine receptor interaction × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 92. Cytokine-cytokine receptor interaction × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
93	Cytokine-cytokine receptor interaction 💬	[1] TNFRSF13C 💬 Cytokine-cytokine receptor interaction × Name Full Name TNFRSF13C TNF receptor superfamily member 13C	Ianalumab 💬 Cytokine-cytokine receptor interaction × Name Other Names Ianalumab Ianalumab (USAN/INN)	Ianalumab	[7] 35, 46, 49, 53, 61, 63, 95 💬 93. Cytokine-cytokine receptor interaction × Disease ID Name 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 95 Autoimmune hepatitis;
94	Diabetic cardiomyopathy 💬	[1] MTOR 💬 Diabetic cardiomyopathy × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Diabetic cardiomyopathy × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 94. Diabetic cardiomyopathy × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
95	Diabetic cardiomyopathy 💬	[1] PIK3CD 💬 Diabetic cardiomyopathy × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Diabetic cardiomyopathy × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 95. Diabetic cardiomyopathy × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
96	Dilated cardiomyopathy 💬	[1] TNF 💬 Dilated cardiomyopathy × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Dilated cardiomyopathy × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 96. Dilated cardiomyopathy × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
97	Dilated cardiomyopathy 💬	[1] TNF 💬 Dilated cardiomyopathy × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Dilated cardiomyopathy × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 97. Dilated cardiomyopathy × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
98	Drug metabolism - other enzymes 💬	[2] IMPDH1, IMPDH2 💬 Drug metabolism - other enzymes × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolate mofetil 💬 Drug metabolism - other enzymes × Name Other Names Mycophenolate mofetil Mycophenolate mofetil (JAN/USP) Cellcept (TN)	Mycophenolate mofetil	[34]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 98. Drug metabolism - other enzymes × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
99	Drug metabolism - other enzymes 💬	[2] IMPDH1, IMPDH2 💬 Drug metabolism - other enzymes × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolic acid 💬 Drug metabolism - other enzymes × Name Other Names Mycophenolic acid Mycophenolic acid (USAN/INN) Mycophenolic acid (TN)	Mycophenolic acid	[36]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 99. Drug metabolism - other enzymes × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
100	EGFR tyrosine kinase inhibitor resistance 💬	[1] MTOR 💬 EGFR tyrosine kinase inhibitor resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 100. EGFR tyrosine kinase inhibitor resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
101	EGFR tyrosine kinase inhibitor resistance 💬	[1] PDGFRA 💬 EGFR tyrosine kinase inhibitor resistance × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 101. EGFR tyrosine kinase inhibitor resistance × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
102	EGFR tyrosine kinase inhibitor resistance 💬	[1] PIK3CD 💬 EGFR tyrosine kinase inhibitor resistance × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 EGFR tyrosine kinase inhibitor resistance × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 102. EGFR tyrosine kinase inhibitor resistance × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
103	Endocrine resistance 💬	[1] MTOR 💬 Endocrine resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Endocrine resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 103. Endocrine resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
104	Endocrine resistance 💬	[1] PIK3CD 💬 Endocrine resistance × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Endocrine resistance × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 104. Endocrine resistance × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
105	Endocytosis 💬	[3] IL2RA, IL2RB, IL2RG 💬 Endocytosis × Name Full Name IL2RA interleukin 2 receptor subunit alpha IL2RB interleukin 2 receptor subunit beta IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 Endocytosis × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 105. Endocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
106	Endocytosis 💬	[1] PDGFRA 💬 Endocytosis × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Endocytosis × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 106. Endocytosis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
107	Endometrial cancer 💬	[1] PIK3CD 💬 Endometrial cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Endometrial cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 107. Endometrial cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
108	Epstein-Barr virus infection 💬	[1] PIK3CD 💬 Epstein-Barr virus infection × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Epstein-Barr virus infection × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 108. Epstein-Barr virus infection × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
109	Epstein-Barr virus infection 💬	[1] TNF 💬 Epstein-Barr virus infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Epstein-Barr virus infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 109. Epstein-Barr virus infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
110	Epstein-Barr virus infection 💬	[1] TNF 💬 Epstein-Barr virus infection × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Epstein-Barr virus infection × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 110. Epstein-Barr virus infection × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
111	ErbB signaling pathway 💬	[1] ABL1 💬 ErbB signaling pathway × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase	Imatinib 💬 ErbB signaling pathway × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 111. ErbB signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
112	ErbB signaling pathway 💬	[1] MTOR 💬 ErbB signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 ErbB signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 112. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
113	ErbB signaling pathway 💬	[1] PIK3CD 💬 ErbB signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 ErbB signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 113. ErbB signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
114	Estrogen signaling pathway 💬	[1] PGR 💬 Estrogen signaling pathway × Name Full Name PGR progesterone receptor	Medroxyprogesterone acetate 💬 Estrogen signaling pathway × Name Other Names Medroxyprogesterone acetate Medroxyprogesterone acetate (JP18/USP) Depo-provera (TN) Depo-subq provera 104 (TN) Provera (TN) DEPO-SUBQ PROVERA MEDROXYPROGESTERONE	Medroxyprogesterone acetate	[8] 13, 35, 46, 49, 50, 51, 60, 107 💬 114. Estrogen signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 107 Juvenile idiopathic arthritis;JIA;
115	Estrogen signaling pathway 💬	[1] PIK3CD 💬 Estrogen signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Estrogen signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 115. Estrogen signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
116	Fc epsilon RI signaling pathway 💬	[1] PIK3CD 💬 Fc epsilon RI signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Fc epsilon RI signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 116. Fc epsilon RI signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
117	Fc epsilon RI signaling pathway 💬	[1] TNF 💬 Fc epsilon RI signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Fc epsilon RI signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 117. Fc epsilon RI signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
118	Fc epsilon RI signaling pathway 💬	[1] TNF 💬 Fc epsilon RI signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Fc epsilon RI signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 118. Fc epsilon RI signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
119	Fc gamma R-mediated phagocytosis 💬	[1] PIK3CD 💬 Fc gamma R-mediated phagocytosis × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Fc gamma R-mediated phagocytosis × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 119. Fc gamma R-mediated phagocytosis × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
120	Fluid shear stress and atherosclerosis 💬	[1] PIK3CD 💬 Fluid shear stress and atherosclerosis × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Fluid shear stress and atherosclerosis × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 120. Fluid shear stress and atherosclerosis × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
121	Fluid shear stress and atherosclerosis 💬	[1] TNF 💬 Fluid shear stress and atherosclerosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Fluid shear stress and atherosclerosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 121. Fluid shear stress and atherosclerosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
122	Fluid shear stress and atherosclerosis 💬	[1] TNF 💬 Fluid shear stress and atherosclerosis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Fluid shear stress and atherosclerosis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 122. Fluid shear stress and atherosclerosis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
123	Focal adhesion 💬	[1] PDGFRA 💬 Focal adhesion × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Focal adhesion × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 123. Focal adhesion × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
124	Focal adhesion 💬	[1] PIK3CD 💬 Focal adhesion × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Focal adhesion × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 124. Focal adhesion × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
125	Folate biosynthesis 💬	[2] DHFR, DHFR2 💬 Folate biosynthesis × Name Full Name DHFR dihydrofolate reductase DHFR2 dihydrofolate reductase 2	Methotrexate 💬 Folate biosynthesis × Name Other Names Methotrexate Methotrexate (JP18/USP/INN) Otrexup (TN) Xatmep (TN) REDITREX	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 125. Folate biosynthesis × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 84 Sarcoidosis; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 172 Hypophosphatasia; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
126	FoxO signaling pathway 💬	[1] PIK3CD 💬 FoxO signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 FoxO signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 126. FoxO signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
127	Gap junction 💬	[1] PDGFRA 💬 Gap junction × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Gap junction × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 127. Gap junction × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
128	Gastric cancer 💬	[1] MTOR 💬 Gastric cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Gastric cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 128. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
129	Gastric cancer 💬	[1] PIK3CD 💬 Gastric cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Gastric cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 129. Gastric cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
130	Glioma 💬	[1] MTOR 💬 Glioma × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Glioma × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 130. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
131	Glioma 💬	[1] PDGFRA 💬 Glioma × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Glioma × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 131. Glioma × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
132	Glioma 💬	[1] PIK3CD 💬 Glioma × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Glioma × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 132. Glioma × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
133	GnRH secretion 💬	[1] PIK3CD 💬 GnRH secretion × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 GnRH secretion × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 133. GnRH secretion × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
134	Graft-versus-host disease 💬	[1] TNF 💬 Graft-versus-host disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Graft-versus-host disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 134. Graft-versus-host disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
135	Graft-versus-host disease 💬	[1] TNF 💬 Graft-versus-host disease × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Graft-versus-host disease × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 135. Graft-versus-host disease × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
136	Growth hormone synthesis, secretion and action 💬	[1] MTOR 💬 Growth hormone synthesis, secretion and action × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Growth hormone synthesis, secretion and action × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 136. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
137	Growth hormone synthesis, secretion and action 💬	[1] PIK3CD 💬 Growth hormone synthesis, secretion and action × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Growth hormone synthesis, secretion and action × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 137. Growth hormone synthesis, secretion and action × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
138	Hematopoietic cell lineage 💬	[1] CSF3R 💬 Hematopoietic cell lineage × Name Full Name CSF3R colony stimulating factor 3 receptor	Filgrastim 💬 Hematopoietic cell lineage × Name Other Names Filgrastim Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO	Filgrastim	[35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 138. Hematopoietic cell lineage × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 16 Crow-Fukase syndrome;POEMS syndrome; 22 Moyamoya disease;Occlusive disease in circle of Willis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 47 Buerger disease;Thromboangiitis obliterans; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 57 Idiopathic dilated cardiomyopathy; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 113 Muscular dystrophy; 164 Oculocutaneous albinism; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
139	Hematopoietic cell lineage 💬	[1] IL2RA 💬 Hematopoietic cell lineage × Name Full Name IL2RA interleukin 2 receptor subunit alpha	Aldesleukin 💬 Hematopoietic cell lineage × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 139. Hematopoietic cell lineage × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
140	Hematopoietic cell lineage 💬	[1] KIT 💬 Hematopoietic cell lineage × Name Full Name KIT KIT proto-oncogene, receptor tyrosine kinase	Imatinib 💬 Hematopoietic cell lineage × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 140. Hematopoietic cell lineage × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
141	Hematopoietic cell lineage 💬	[1] MS4A1 💬 Hematopoietic cell lineage × Name Full Name MS4A1 membrane spanning 4-domains A1	Ofatumumab 💬 Hematopoietic cell lineage × Name Other Names Ofatumumab Ofatumumab (USAN/INN) Ofatumumab (genetical recombination) (JAN) Arzerra (TN) Kesimpta (TN)	Ofatumumab	[3] 13, 35, 46 💬 141. Hematopoietic cell lineage × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
142	Hematopoietic cell lineage 💬	[1] MS4A1 💬 Hematopoietic cell lineage × Name Full Name MS4A1 membrane spanning 4-domains A1	Rituximab 💬 Hematopoietic cell lineage × Name Other Names Rituximab Rituximab (USAN/INN) Rituximab (genetical recombination) (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 1] (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 2] (JAN) Rituximab-abbs Rituximab-pvvr Rituximab-arrx Rituxan (TN) Riabni (TN) Truximab (TN) RUXIENCE TRUXIMA	Rituximab	[48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬 142. Hematopoietic cell lineage × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 19 Lysosomal storage disease;Lysosomal disease; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 36 Epidermolysis bullosa; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 52 Mixed connective tissue disease; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 83 Addison disease;Primary chronic adrenocortical insufficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 94 Primary sclerosing cholangitis;PSC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 162 Pemphigoid; 222 Primary nephrotic syndrome; 229 Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 274 Osteogenesis Imperfecta; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 296 Biliary atresia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
143	Hematopoietic cell lineage 💬	[1] TNF 💬 Hematopoietic cell lineage × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Hematopoietic cell lineage × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 143. Hematopoietic cell lineage × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
144	Hematopoietic cell lineage 💬	[1] TNF 💬 Hematopoietic cell lineage × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Hematopoietic cell lineage × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 144. Hematopoietic cell lineage × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
145	Hepatitis B 💬	[1] PIK3CD 💬 Hepatitis B × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Hepatitis B × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 145. Hepatitis B × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
146	Hepatitis B 💬	[1] TNF 💬 Hepatitis B × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Hepatitis B × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 146. Hepatitis B × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
147	Hepatitis B 💬	[1] TNF 💬 Hepatitis B × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Hepatitis B × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 147. Hepatitis B × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
148	Hepatitis C 💬	[1] PIK3CD 💬 Hepatitis C × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Hepatitis C × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 148. Hepatitis C × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
149	Hepatitis C 💬	[1] TNF 💬 Hepatitis C × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Hepatitis C × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 149. Hepatitis C × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
150	Hepatitis C 💬	[1] TNF 💬 Hepatitis C × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Hepatitis C × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 150. Hepatitis C × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
151	Hepatocellular carcinoma 💬	[1] MTOR 💬 Hepatocellular carcinoma × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Hepatocellular carcinoma × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 151. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
152	Hepatocellular carcinoma 💬	[1] PIK3CD 💬 Hepatocellular carcinoma × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Hepatocellular carcinoma × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 152. Hepatocellular carcinoma × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
153	Herpes simplex virus 1 infection 💬	[2] LTA, TNF 💬 Herpes simplex virus 1 infection × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 Herpes simplex virus 1 infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 153. Herpes simplex virus 1 infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
154	Herpes simplex virus 1 infection 💬	[1] MTOR 💬 Herpes simplex virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Herpes simplex virus 1 infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 154. Herpes simplex virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
155	Herpes simplex virus 1 infection 💬	[1] PIK3CD 💬 Herpes simplex virus 1 infection × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Herpes simplex virus 1 infection × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 155. Herpes simplex virus 1 infection × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
156	Herpes simplex virus 1 infection 💬	[1] TNF 💬 Herpes simplex virus 1 infection × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Herpes simplex virus 1 infection × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 156. Herpes simplex virus 1 infection × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
157	HIF-1 signaling pathway 💬	[1] MTOR 💬 HIF-1 signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 HIF-1 signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 157. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
158	HIF-1 signaling pathway 💬	[1] PIK3CD 💬 HIF-1 signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 HIF-1 signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 158. HIF-1 signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
159	Human cytomegalovirus infection 💬	[1] MTOR 💬 Human cytomegalovirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human cytomegalovirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 159. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
160	Human cytomegalovirus infection 💬	[1] PDGFRA 💬 Human cytomegalovirus infection × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Human cytomegalovirus infection × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 160. Human cytomegalovirus infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
161	Human cytomegalovirus infection 💬	[1] PIK3CD 💬 Human cytomegalovirus infection × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Human cytomegalovirus infection × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 161. Human cytomegalovirus infection × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
162	Human cytomegalovirus infection 💬	[1] PTGS2 💬 Human cytomegalovirus infection × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Human cytomegalovirus infection × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 162. Human cytomegalovirus infection × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
163	Human cytomegalovirus infection 💬	[1] TNF 💬 Human cytomegalovirus infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Human cytomegalovirus infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 163. Human cytomegalovirus infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
164	Human cytomegalovirus infection 💬	[1] TNF 💬 Human cytomegalovirus infection × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Human cytomegalovirus infection × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 164. Human cytomegalovirus infection × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
165	Human immunodeficiency virus 1 infection 💬	[1] MTOR 💬 Human immunodeficiency virus 1 infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human immunodeficiency virus 1 infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 165. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
166	Human immunodeficiency virus 1 infection 💬	[1] PIK3CD 💬 Human immunodeficiency virus 1 infection × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Human immunodeficiency virus 1 infection × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 166. Human immunodeficiency virus 1 infection × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
167	Human immunodeficiency virus 1 infection 💬	[1] TNF 💬 Human immunodeficiency virus 1 infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Human immunodeficiency virus 1 infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 167. Human immunodeficiency virus 1 infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
168	Human immunodeficiency virus 1 infection 💬	[1] TNF 💬 Human immunodeficiency virus 1 infection × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Human immunodeficiency virus 1 infection × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 168. Human immunodeficiency virus 1 infection × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
169	Human papillomavirus infection 💬	[1] MTOR 💬 Human papillomavirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Human papillomavirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 169. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
170	Human papillomavirus infection 💬	[1] PIK3CD 💬 Human papillomavirus infection × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Human papillomavirus infection × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 170. Human papillomavirus infection × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
171	Human papillomavirus infection 💬	[1] PTGS2 💬 Human papillomavirus infection × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Human papillomavirus infection × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 171. Human papillomavirus infection × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
172	Human papillomavirus infection 💬	[1] TNF 💬 Human papillomavirus infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Human papillomavirus infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 172. Human papillomavirus infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
173	Human papillomavirus infection 💬	[1] TNF 💬 Human papillomavirus infection × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Human papillomavirus infection × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 173. Human papillomavirus infection × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
174	Human T-cell leukemia virus 1 infection 💬	[3] IL2RA, IL2RB, IL2RG 💬 Human T-cell leukemia virus 1 infection × Name Full Name IL2RA interleukin 2 receptor subunit alpha IL2RB interleukin 2 receptor subunit beta IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 Human T-cell leukemia virus 1 infection × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 174. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
175	Human T-cell leukemia virus 1 infection 💬	[2] LTA, TNF 💬 Human T-cell leukemia virus 1 infection × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 Human T-cell leukemia virus 1 infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 175. Human T-cell leukemia virus 1 infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
176	Human T-cell leukemia virus 1 infection 💬	[1] PIK3CD 💬 Human T-cell leukemia virus 1 infection × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 176. Human T-cell leukemia virus 1 infection × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
177	Human T-cell leukemia virus 1 infection 💬	[1] TNF 💬 Human T-cell leukemia virus 1 infection × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Human T-cell leukemia virus 1 infection × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 177. Human T-cell leukemia virus 1 infection × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
178	Human T-cell leukemia virus 1 infection 💬	[1] TNFRSF13C 💬 Human T-cell leukemia virus 1 infection × Name Full Name TNFRSF13C TNF receptor superfamily member 13C	Ianalumab 💬 Human T-cell leukemia virus 1 infection × Name Other Names Ianalumab Ianalumab (USAN/INN)	Ianalumab	[7] 35, 46, 49, 53, 61, 63, 95 💬 178. Human T-cell leukemia virus 1 infection × Disease ID Name 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 95 Autoimmune hepatitis;
179	Huntington disease 💬	[1] MTOR 💬 Huntington disease × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Huntington disease × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 179. Huntington disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
180	Hypertrophic cardiomyopathy 💬	[1] TNF 💬 Hypertrophic cardiomyopathy × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Hypertrophic cardiomyopathy × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 180. Hypertrophic cardiomyopathy × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
181	Hypertrophic cardiomyopathy 💬	[1] TNF 💬 Hypertrophic cardiomyopathy × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Hypertrophic cardiomyopathy × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 181. Hypertrophic cardiomyopathy × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
182	IL-17 signaling pathway 💬	[1] PTGS2 💬 IL-17 signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 IL-17 signaling pathway × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 182. IL-17 signaling pathway × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
183	IL-17 signaling pathway 💬	[1] TNF 💬 IL-17 signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 IL-17 signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 183. IL-17 signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
184	IL-17 signaling pathway 💬	[1] TNF 💬 IL-17 signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 IL-17 signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 184. IL-17 signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
185	Inflammatory bowel disease 💬	[1] IL2RG 💬 Inflammatory bowel disease × Name Full Name IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 Inflammatory bowel disease × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 185. Inflammatory bowel disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
186	Inflammatory bowel disease 💬	[1] TNF 💬 Inflammatory bowel disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Inflammatory bowel disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 186. Inflammatory bowel disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
187	Inflammatory bowel disease 💬	[1] TNF 💬 Inflammatory bowel disease × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Inflammatory bowel disease × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 187. Inflammatory bowel disease × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
188	Inflammatory mediator regulation of TRP channels 💬	[1] HRH1 💬 Inflammatory mediator regulation of TRP channels × Name Full Name HRH1 histamine receptor H1	Cetirizine 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Cetirizine Cetirizine (INN) Cetiderm (TN)	Cetirizine	[4] 13, 28, 35, 300 💬 188. Inflammatory mediator regulation of TRP channels × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 300 IgG4-related disease;
189	Inflammatory mediator regulation of TRP channels 💬	[1] PIK3CD 💬 Inflammatory mediator regulation of TRP channels × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Inflammatory mediator regulation of TRP channels × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 189. Inflammatory mediator regulation of TRP channels × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
190	Influenza A 💬	[1] PIK3CD 💬 Influenza A × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Influenza A × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 190. Influenza A × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
191	Influenza A 💬	[1] TNF 💬 Influenza A × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Influenza A × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 191. Influenza A × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
192	Influenza A 💬	[1] TNF 💬 Influenza A × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Influenza A × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 192. Influenza A × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
193	Inositol phosphate metabolism 💬	[1] PIK3CD 💬 Inositol phosphate metabolism × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Inositol phosphate metabolism × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 193. Inositol phosphate metabolism × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
194	Insulin resistance 💬	[1] MTOR 💬 Insulin resistance × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Insulin resistance × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 194. Insulin resistance × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
195	Insulin resistance 💬	[1] PIK3CD 💬 Insulin resistance × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Insulin resistance × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 195. Insulin resistance × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
196	Insulin resistance 💬	[1] TNF 💬 Insulin resistance × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Insulin resistance × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 196. Insulin resistance × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
197	Insulin resistance 💬	[1] TNF 💬 Insulin resistance × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Insulin resistance × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 197. Insulin resistance × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
198	Insulin signaling pathway 💬	[1] MTOR 💬 Insulin signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Insulin signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 198. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
199	Insulin signaling pathway 💬	[1] PIK3CD 💬 Insulin signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Insulin signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 199. Insulin signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
200	Intestinal immune network for IgA production 💬	[1] TNFRSF13C 💬 Intestinal immune network for IgA production × Name Full Name TNFRSF13C TNF receptor superfamily member 13C	Ianalumab 💬 Intestinal immune network for IgA production × Name Other Names Ianalumab Ianalumab (USAN/INN)	Ianalumab	[7] 35, 46, 49, 53, 61, 63, 95 💬 200. Intestinal immune network for IgA production × Disease ID Name 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 95 Autoimmune hepatitis;
201	JAK-STAT signaling pathway 💬	[1] CSF3R 💬 JAK-STAT signaling pathway × Name Full Name CSF3R colony stimulating factor 3 receptor	Filgrastim 💬 JAK-STAT signaling pathway × Name Other Names Filgrastim Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO	Filgrastim	[35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 201. JAK-STAT signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 16 Crow-Fukase syndrome;POEMS syndrome; 22 Moyamoya disease;Occlusive disease in circle of Willis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 47 Buerger disease;Thromboangiitis obliterans; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 57 Idiopathic dilated cardiomyopathy; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 113 Muscular dystrophy; 164 Oculocutaneous albinism; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
202	JAK-STAT signaling pathway 💬	[3] IL2RA, IL2RB, IL2RG 💬 JAK-STAT signaling pathway × Name Full Name IL2RA interleukin 2 receptor subunit alpha IL2RB interleukin 2 receptor subunit beta IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 JAK-STAT signaling pathway × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 202. JAK-STAT signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
203	JAK-STAT signaling pathway 💬	[1] MTOR 💬 JAK-STAT signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 JAK-STAT signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 203. JAK-STAT signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
204	JAK-STAT signaling pathway 💬	[1] PDGFRA 💬 JAK-STAT signaling pathway × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 JAK-STAT signaling pathway × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 204. JAK-STAT signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
205	JAK-STAT signaling pathway 💬	[1] PIK3CD 💬 JAK-STAT signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 JAK-STAT signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 205. JAK-STAT signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
206	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MTOR 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 206. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
207	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PIK3CD 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 207. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
208	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬 Kaposi sarcoma-associated herpesvirus infection × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 208. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
209	Legionellosis 💬	[1] TNF 💬 Legionellosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Legionellosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 209. Legionellosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
210	Legionellosis 💬	[1] TNF 💬 Legionellosis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Legionellosis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 210. Legionellosis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
211	Leishmaniasis 💬	[1] PTGS2 💬 Leishmaniasis × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Leishmaniasis × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 211. Leishmaniasis × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
212	Leishmaniasis 💬	[1] TNF 💬 Leishmaniasis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Leishmaniasis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 212. Leishmaniasis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
213	Leishmaniasis 💬	[1] TNF 💬 Leishmaniasis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Leishmaniasis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 213. Leishmaniasis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
214	Leukocyte transendothelial migration 💬	[1] PIK3CD 💬 Leukocyte transendothelial migration × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Leukocyte transendothelial migration × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 214. Leukocyte transendothelial migration × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
215	Lipid and atherosclerosis 💬	[1] PIK3CD 💬 Lipid and atherosclerosis × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Lipid and atherosclerosis × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 215. Lipid and atherosclerosis × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
216	Lipid and atherosclerosis 💬	[1] TNF 💬 Lipid and atherosclerosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Lipid and atherosclerosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 216. Lipid and atherosclerosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
217	Lipid and atherosclerosis 💬	[1] TNF 💬 Lipid and atherosclerosis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Lipid and atherosclerosis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 217. Lipid and atherosclerosis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
218	Longevity regulating pathway 💬	[1] MTOR 💬 Longevity regulating pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Longevity regulating pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 218. Longevity regulating pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
219	Longevity regulating pathway 💬	[1] PIK3CD 💬 Longevity regulating pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Longevity regulating pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 219. Longevity regulating pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
220	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬 Longevity regulating pathway - multiple species × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Longevity regulating pathway - multiple species × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 220. Longevity regulating pathway - multiple species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
221	Longevity regulating pathway - multiple species 💬	[1] PIK3CD 💬 Longevity regulating pathway - multiple species × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Longevity regulating pathway - multiple species × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 221. Longevity regulating pathway - multiple species × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
222	Malaria 💬	[1] TNF 💬 Malaria × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Malaria × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 222. Malaria × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
223	Malaria 💬	[1] TNF 💬 Malaria × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Malaria × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 223. Malaria × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
224	MAPK signaling pathway 💬	[2] KIT, PDGFRA 💬 MAPK signaling pathway × Name Full Name KIT KIT proto-oncogene, receptor tyrosine kinase PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 MAPK signaling pathway × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 224. MAPK signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
225	MAPK signaling pathway 💬	[1] TNF 💬 MAPK signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 MAPK signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 225. MAPK signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
226	MAPK signaling pathway 💬	[1] TNF 💬 MAPK signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 MAPK signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 226. MAPK signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
227	Measles 💬	[3] IL2RA, IL2RB, IL2RG 💬 Measles × Name Full Name IL2RA interleukin 2 receptor subunit alpha IL2RB interleukin 2 receptor subunit beta IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 Measles × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 227. Measles × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
228	Measles 💬	[1] PIK3CD 💬 Measles × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Measles × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 228. Measles × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
229	Melanogenesis 💬	[1] KIT 💬 Melanogenesis × Name Full Name KIT KIT proto-oncogene, receptor tyrosine kinase	Imatinib 💬 Melanogenesis × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 229. Melanogenesis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
230	Melanoma 💬	[1] PDGFRA 💬 Melanoma × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Melanoma × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 230. Melanoma × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
231	Melanoma 💬	[1] PIK3CD 💬 Melanoma × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Melanoma × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 231. Melanoma × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
232	Metabolic pathways 💬	[2] DHFR, DHFR2 💬 Metabolic pathways × Name Full Name DHFR dihydrofolate reductase DHFR2 dihydrofolate reductase 2	Methotrexate 💬 Metabolic pathways × Name Other Names Methotrexate Methotrexate (JP18/USP/INN) Otrexup (TN) Xatmep (TN) REDITREX	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 232. Metabolic pathways × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 84 Sarcoidosis; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 172 Hypophosphatasia; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
233	Metabolic pathways 💬	[2] IMPDH1, IMPDH2 💬 Metabolic pathways × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolate mofetil 💬 Metabolic pathways × Name Other Names Mycophenolate mofetil Mycophenolate mofetil (JAN/USP) Cellcept (TN)	Mycophenolate mofetil	[34]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 233. Metabolic pathways × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
234	Metabolic pathways 💬	[2] IMPDH1, IMPDH2 💬 Metabolic pathways × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolic acid 💬 Metabolic pathways × Name Other Names Mycophenolic acid Mycophenolic acid (USAN/INN) Mycophenolic acid (TN)	Mycophenolic acid	[36]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 234. Metabolic pathways × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
235	Metabolic pathways 💬	[1] PIK3CD 💬 Metabolic pathways × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Metabolic pathways × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 235. Metabolic pathways × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
236	Metabolic pathways 💬	[2] PTGS1, PTGS2 💬 Metabolic pathways × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Metabolic pathways × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 236. Metabolic pathways × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
237	MicroRNAs in cancer 💬	[2] ABL1, PDGFRA 💬 MicroRNAs in cancer × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 MicroRNAs in cancer × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 237. MicroRNAs in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
238	MicroRNAs in cancer 💬	[1] MTOR 💬 MicroRNAs in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 MicroRNAs in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 238. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
239	MicroRNAs in cancer 💬	[1] PIK3CD 💬 MicroRNAs in cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 MicroRNAs in cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 239. MicroRNAs in cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
240	MicroRNAs in cancer 💬	[1] PTGS2 💬 MicroRNAs in cancer × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 MicroRNAs in cancer × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 240. MicroRNAs in cancer × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
241	mTOR signaling pathway 💬	[1] MTOR 💬 mTOR signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 mTOR signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 241. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
242	mTOR signaling pathway 💬	[1] PIK3CD 💬 mTOR signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 mTOR signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 242. mTOR signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
243	mTOR signaling pathway 💬	[1] TNF 💬 mTOR signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 mTOR signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 243. mTOR signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
244	mTOR signaling pathway 💬	[1] TNF 💬 mTOR signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 mTOR signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 244. mTOR signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
245	Natural killer cell mediated cytotoxicity 💬	[1] PIK3CD 💬 Natural killer cell mediated cytotoxicity × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 245. Natural killer cell mediated cytotoxicity × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
246	Natural killer cell mediated cytotoxicity 💬	[1] TNF 💬 Natural killer cell mediated cytotoxicity × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Natural killer cell mediated cytotoxicity × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 246. Natural killer cell mediated cytotoxicity × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
247	Natural killer cell mediated cytotoxicity 💬	[1] TNF 💬 Natural killer cell mediated cytotoxicity × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Natural killer cell mediated cytotoxicity × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 247. Natural killer cell mediated cytotoxicity × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
248	Necroptosis 💬	[1] TNF 💬 Necroptosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Necroptosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 248. Necroptosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
249	Necroptosis 💬	[1] TNF 💬 Necroptosis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Necroptosis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 249. Necroptosis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
250	Neuroactive ligand-receptor interaction 💬	[1] HRH1 💬 Neuroactive ligand-receptor interaction × Name Full Name HRH1 histamine receptor H1	Cetirizine 💬 Neuroactive ligand-receptor interaction × Name Other Names Cetirizine Cetirizine (INN) Cetiderm (TN)	Cetirizine	[4] 13, 28, 35, 300 💬 250. Neuroactive ligand-receptor interaction × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 300 IgG4-related disease;
251	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Dexamethasone 💬 Neuroactive ligand-receptor interaction × Name Other Names Dexamethasone Dexamethasone (JP18/USP/INN) Decadron (TN) Maxidex (TN) DEXTENZA DEXYCU HEMADY OZURDEX DEXAMETHASONE 6-DAY DEXAMETHASONE INTENSOL TAPERDEX 12-DAY TAPERDEX 6-DAY TAPERDEX 7-DAY	Dexamethasone	[22] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299 💬 251. Neuroactive ligand-receptor interaction × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 16 Crow-Fukase syndrome;POEMS syndrome; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 70 Spinal stenosis;Extensive spinal canal stenosis; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 84 Sarcoidosis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 162 Pemphigoid; 222 Primary nephrotic syndrome; 235 Hypoparathyroidism;Accessory thyroid hypergasia disease; 257 Hepatic glycogenosis;Liver glycogenosis;Hepatic glycogen storage disease;Liver glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 296 Biliary atresia; 299 Cystic fibrosis;
252	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Methylprednisolone 💬 Neuroactive ligand-receptor interaction × Name Other Names Methylprednisolone Methylprednisolone (JP18/USP/INN) Medrol (TN) METHYLPRED DP	Methylprednisolone	[46]  2 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 252. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 18 Spinocerebellar degeneration;SCD; 19 Lysosomal storage disease;Lysosomal disease; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 83 Addison disease;Primary chronic adrenocortical insufficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 145 West syndrome;Infantile spasm; 162 Pemphigoid; 164 Oculocutaneous albinism; 211 Hypoplastic left heart syndrome;HLHS; 220 Rapidly progressive glomerulonephritis; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia;
253	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Prednisolone 💬 Neuroactive ligand-receptor interaction × Name Other Names Prednisolone Prednisolone (JP18/USP/INN) Delta-cortef (TN)	Prednisolone	[42]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬 253. Neuroactive ligand-receptor interaction × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 75 Cushing disease;Cushing; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 113 Muscular dystrophy; 145 West syndrome;Infantile spasm; 162 Pemphigoid; 222 Primary nephrotic syndrome; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 296 Biliary atresia; 299 Cystic fibrosis; 300 IgG4-related disease;
254	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Prednisone 💬 Neuroactive ligand-receptor interaction × Name Other Names Prednisone Prednisone (USP) Prednisone monohydrate Deltasone (TN) Meticorten (TN) Rayos (TN)	Prednisone	[45]  2 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬 254. Neuroactive ligand-receptor interaction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 14 Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy; 19 Lysosomal storage disease;Lysosomal disease; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 64 Thrombotic thrombocytopenic purpura;TTP; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 79 Homozygous familial hypercholesterolemia; 81 Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 113 Muscular dystrophy; 162 Pemphigoid; 164 Oculocutaneous albinism; 205 Fragile X syndrome related disease;Fragile X-associated tremor/ataxia syndrome;FXTAS; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 288 Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency; 299 Cystic fibrosis; 300 IgG4-related disease; 307 Canavan disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
255	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Prednisone acetate 💬 Neuroactive ligand-receptor interaction × Name Other Names Prednisone acetate Prednisone acetate Prednisone 21-acetate	Prednisone acetate	[6] 35, 41, 46, 49, 162, 224 💬 255. Neuroactive ligand-receptor interaction × Disease ID Name 35 Pemphigus; 41 Giant cell arteritis;Temporal arteritis; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 162 Pemphigoid; 224 Purpura nephritis;
256	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬 Neuroactive ligand-receptor interaction × Name Full Name NR3C1 nuclear receptor subfamily 3 group C member 1	Triamcinolone 💬 Neuroactive ligand-receptor interaction × Name Other Names Triamcinolone Triamcinolone (JP18/USP/INN) Aristocort (TN) Kenacort (TN)	Triamcinolone	[11] 35, 46, 53, 56, 70, 90, 96, 107, 162, 226, 298 💬 256. Neuroactive ligand-receptor interaction × Disease ID Name 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 70 Spinal stenosis;Extensive spinal canal stenosis; 90 Retinitis pigmentosa; 96 Crohn disease;Terminal ileitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 298 Hereditary pancreatitis;Chronic pancreatitis;
257	Neurotrophin signaling pathway 💬	[1] ABL1 💬 Neurotrophin signaling pathway × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase	Imatinib 💬 Neurotrophin signaling pathway × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 257. Neurotrophin signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
258	Neurotrophin signaling pathway 💬	[1] PIK3CD 💬 Neurotrophin signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Neurotrophin signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 258. Neurotrophin signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
259	Neutrophil extracellular trap formation 💬	[1] MTOR 💬 Neutrophil extracellular trap formation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Neutrophil extracellular trap formation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 259. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
260	Neutrophil extracellular trap formation 💬	[1] PIK3CD 💬 Neutrophil extracellular trap formation × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Neutrophil extracellular trap formation × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 260. Neutrophil extracellular trap formation × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
261	NF-kappa B signaling pathway 💬	[2] LTA, TNF 💬 NF-kappa B signaling pathway × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 NF-kappa B signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 261. NF-kappa B signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
262	NF-kappa B signaling pathway 💬	[1] PTGS2 💬 NF-kappa B signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 NF-kappa B signaling pathway × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 262. NF-kappa B signaling pathway × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
263	NF-kappa B signaling pathway 💬	[1] TNF 💬 NF-kappa B signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 NF-kappa B signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 263. NF-kappa B signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
264	NF-kappa B signaling pathway 💬	[1] TNFRSF13C 💬 NF-kappa B signaling pathway × Name Full Name TNFRSF13C TNF receptor superfamily member 13C	Ianalumab 💬 NF-kappa B signaling pathway × Name Other Names Ianalumab Ianalumab (USAN/INN)	Ianalumab	[7] 35, 46, 49, 53, 61, 63, 95 💬 264. NF-kappa B signaling pathway × Disease ID Name 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 95 Autoimmune hepatitis;
265	NOD-like receptor signaling pathway 💬	[1] TNF 💬 NOD-like receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 NOD-like receptor signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 265. NOD-like receptor signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
266	NOD-like receptor signaling pathway 💬	[1] TNF 💬 NOD-like receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 NOD-like receptor signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 266. NOD-like receptor signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
267	Non-alcoholic fatty liver disease 💬	[1] PIK3CD 💬 Non-alcoholic fatty liver disease × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Non-alcoholic fatty liver disease × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 267. Non-alcoholic fatty liver disease × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
268	Non-alcoholic fatty liver disease 💬	[1] TNF 💬 Non-alcoholic fatty liver disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Non-alcoholic fatty liver disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 268. Non-alcoholic fatty liver disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
269	Non-alcoholic fatty liver disease 💬	[1] TNF 💬 Non-alcoholic fatty liver disease × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Non-alcoholic fatty liver disease × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 269. Non-alcoholic fatty liver disease × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
270	Non-small cell lung cancer 💬	[1] PIK3CD 💬 Non-small cell lung cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Non-small cell lung cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 270. Non-small cell lung cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
271	Nucleotide metabolism 💬	[2] IMPDH1, IMPDH2 💬 Nucleotide metabolism × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolate mofetil 💬 Nucleotide metabolism × Name Other Names Mycophenolate mofetil Mycophenolate mofetil (JAN/USP) Cellcept (TN)	Mycophenolate mofetil	[34]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 271. Nucleotide metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
272	Nucleotide metabolism 💬	[2] IMPDH1, IMPDH2 💬 Nucleotide metabolism × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolic acid 💬 Nucleotide metabolism × Name Other Names Mycophenolic acid Mycophenolic acid (USAN/INN) Mycophenolic acid (TN)	Mycophenolic acid	[36]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 272. Nucleotide metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
273	One carbon pool by folate 💬	[2] DHFR, DHFR2 💬 One carbon pool by folate × Name Full Name DHFR dihydrofolate reductase DHFR2 dihydrofolate reductase 2	Methotrexate 💬 One carbon pool by folate × Name Other Names Methotrexate Methotrexate (JP18/USP/INN) Otrexup (TN) Xatmep (TN) REDITREX	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 273. One carbon pool by folate × Disease ID Name 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 84 Sarcoidosis; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 172 Hypophosphatasia; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 286 Hereditary sideroblastic anemia;Congenital sideroblastic anemia;Sideroblastic anemia; 326 Osteopetrosis; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
274	Oocyte meiosis 💬	[1] PGR 💬 Oocyte meiosis × Name Full Name PGR progesterone receptor	Medroxyprogesterone acetate 💬 Oocyte meiosis × Name Other Names Medroxyprogesterone acetate Medroxyprogesterone acetate (JP18/USP) Depo-provera (TN) Depo-subq provera 104 (TN) Provera (TN) DEPO-SUBQ PROVERA MEDROXYPROGESTERONE	Medroxyprogesterone acetate	[8] 13, 35, 46, 49, 50, 51, 60, 107 💬 274. Oocyte meiosis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 107 Juvenile idiopathic arthritis;JIA;
275	Osteoclast differentiation 💬	[1] PIK3CD 💬 Osteoclast differentiation × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Osteoclast differentiation × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 275. Osteoclast differentiation × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
276	Osteoclast differentiation 💬	[1] TNF 💬 Osteoclast differentiation × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Osteoclast differentiation × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 276. Osteoclast differentiation × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
277	Osteoclast differentiation 💬	[1] TNF 💬 Osteoclast differentiation × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Osteoclast differentiation × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 277. Osteoclast differentiation × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
278	Ovarian steroidogenesis 💬	[1] PTGS2 💬 Ovarian steroidogenesis × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Ovarian steroidogenesis × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 278. Ovarian steroidogenesis × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
279	Oxytocin signaling pathway 💬	[1] PTGS2 💬 Oxytocin signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Oxytocin signaling pathway × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 279. Oxytocin signaling pathway × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
280	Pancreatic cancer 💬	[1] MTOR 💬 Pancreatic cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pancreatic cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 280. Pancreatic cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
281	Pancreatic cancer 💬	[1] PIK3CD 💬 Pancreatic cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Pancreatic cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 281. Pancreatic cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
282	Pathogenic Escherichia coli infection 💬	[1] ABL1 💬 Pathogenic Escherichia coli infection × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase	Imatinib 💬 Pathogenic Escherichia coli infection × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 282. Pathogenic Escherichia coli infection × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
283	Pathogenic Escherichia coli infection 💬	[1] TNF 💬 Pathogenic Escherichia coli infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Pathogenic Escherichia coli infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 283. Pathogenic Escherichia coli infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
284	Pathogenic Escherichia coli infection 💬	[1] TNF 💬 Pathogenic Escherichia coli infection × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Pathogenic Escherichia coli infection × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 284. Pathogenic Escherichia coli infection × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
285	Pathways in cancer 💬	[3] ABL1, KIT, PDGFRA 💬 Pathways in cancer × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase KIT KIT proto-oncogene, receptor tyrosine kinase PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Pathways in cancer × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 285. Pathways in cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
286	Pathways in cancer 💬	[1] CSF3R 💬 Pathways in cancer × Name Full Name CSF3R colony stimulating factor 3 receptor	Filgrastim 💬 Pathways in cancer × Name Other Names Filgrastim Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO	Filgrastim	[35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 286. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 16 Crow-Fukase syndrome;POEMS syndrome; 22 Moyamoya disease;Occlusive disease in circle of Willis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 47 Buerger disease;Thromboangiitis obliterans; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 57 Idiopathic dilated cardiomyopathy; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 113 Muscular dystrophy; 164 Oculocutaneous albinism; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
287	Pathways in cancer 💬	[3] IL2RA, IL2RB, IL2RG 💬 Pathways in cancer × Name Full Name IL2RA interleukin 2 receptor subunit alpha IL2RB interleukin 2 receptor subunit beta IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 Pathways in cancer × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 287. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
288	Pathways in cancer 💬	[1] MTOR 💬 Pathways in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pathways in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 288. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
289	Pathways in cancer 💬	[1] PIK3CD 💬 Pathways in cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Pathways in cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 289. Pathways in cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
290	Pathways in cancer 💬	[1] PTGS2 💬 Pathways in cancer × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Pathways in cancer × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 290. Pathways in cancer × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
291	Pathways of neurodegeneration - multiple diseases 💬	[1] MTOR 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 291. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
292	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 292. Pathways of neurodegeneration - multiple diseases × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
293	Pathways of neurodegeneration - multiple diseases 💬	[1] TNF 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 293. Pathways of neurodegeneration - multiple diseases × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
294	Pathways of neurodegeneration - multiple diseases 💬	[1] TNF 💬 Pathways of neurodegeneration - multiple diseases × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 294. Pathways of neurodegeneration - multiple diseases × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
295	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MTOR 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 295. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
296	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] PIK3CD 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 296. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
297	Pertussis 💬	[1] TNF 💬 Pertussis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Pertussis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 297. Pertussis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
298	Pertussis 💬	[1] TNF 💬 Pertussis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Pertussis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 298. Pertussis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
299	Phosphatidylinositol signaling system 💬	[1] PIK3CD 💬 Phosphatidylinositol signaling system × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Phosphatidylinositol signaling system × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 299. Phosphatidylinositol signaling system × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
300	Phospholipase D signaling pathway 💬	[2] KIT, PDGFRA 💬 Phospholipase D signaling pathway × Name Full Name KIT KIT proto-oncogene, receptor tyrosine kinase PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Phospholipase D signaling pathway × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 300. Phospholipase D signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
301	Phospholipase D signaling pathway 💬	[1] MTOR 💬 Phospholipase D signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Phospholipase D signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 301. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
302	Phospholipase D signaling pathway 💬	[1] PIK3CD 💬 Phospholipase D signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Phospholipase D signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 302. Phospholipase D signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
303	PI3K-Akt signaling pathway 💬	[1] CSF3R 💬 PI3K-Akt signaling pathway × Name Full Name CSF3R colony stimulating factor 3 receptor	Filgrastim 💬 PI3K-Akt signaling pathway × Name Other Names Filgrastim Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO	Filgrastim	[35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 303. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 16 Crow-Fukase syndrome;POEMS syndrome; 22 Moyamoya disease;Occlusive disease in circle of Willis; 25 Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal; 26 HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 47 Buerger disease;Thromboangiitis obliterans; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 57 Idiopathic dilated cardiomyopathy; 60 Aplastic anemia; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 85 Idiopathic interstitial pneumonia;IIPs; 96 Crohn disease;Terminal ileitis; 113 Muscular dystrophy; 164 Oculocutaneous albinism; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 296 Biliary atresia; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
304	PI3K-Akt signaling pathway 💬	[3] IL2RA, IL2RB, IL2RG 💬 PI3K-Akt signaling pathway × Name Full Name IL2RA interleukin 2 receptor subunit alpha IL2RB interleukin 2 receptor subunit beta IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 PI3K-Akt signaling pathway × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 304. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
305	PI3K-Akt signaling pathway 💬	[2] KIT, PDGFRA 💬 PI3K-Akt signaling pathway × Name Full Name KIT KIT proto-oncogene, receptor tyrosine kinase PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 PI3K-Akt signaling pathway × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 305. PI3K-Akt signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
306	PI3K-Akt signaling pathway 💬	[1] MTOR 💬 PI3K-Akt signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 PI3K-Akt signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 306. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
307	PI3K-Akt signaling pathway 💬	[1] PIK3CD 💬 PI3K-Akt signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 PI3K-Akt signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 307. PI3K-Akt signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
308	Platelet activation 💬	[1] PIK3CD 💬 Platelet activation × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Platelet activation × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 308. Platelet activation × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
309	Platelet activation 💬	[1] PTGS1 💬 Platelet activation × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1	Acetaminophen 💬 Platelet activation × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 309. Platelet activation × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
310	Platinum drug resistance 💬	[1] PIK3CD 💬 Platinum drug resistance × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Platinum drug resistance × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 310. Platinum drug resistance × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
311	Primary immunodeficiency 💬	[1] IL2RG 💬 Primary immunodeficiency × Name Full Name IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 Primary immunodeficiency × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 311. Primary immunodeficiency × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
312	Primary immunodeficiency 💬	[1] TNFRSF13C 💬 Primary immunodeficiency × Name Full Name TNFRSF13C TNF receptor superfamily member 13C	Ianalumab 💬 Primary immunodeficiency × Name Other Names Ianalumab Ianalumab (USAN/INN)	Ianalumab	[7] 35, 46, 49, 53, 61, 63, 95 💬 312. Primary immunodeficiency × Disease ID Name 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 95 Autoimmune hepatitis;
313	Prion disease 💬	[1] PIK3CD 💬 Prion disease × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Prion disease × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 313. Prion disease × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
314	Prion disease 💬	[1] TNF 💬 Prion disease × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Prion disease × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 314. Prion disease × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
315	Prion disease 💬	[1] TNF 💬 Prion disease × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Prion disease × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 315. Prion disease × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
316	Progesterone-mediated oocyte maturation 💬	[1] PGR 💬 Progesterone-mediated oocyte maturation × Name Full Name PGR progesterone receptor	Medroxyprogesterone acetate 💬 Progesterone-mediated oocyte maturation × Name Other Names Medroxyprogesterone acetate Medroxyprogesterone acetate (JP18/USP) Depo-provera (TN) Depo-subq provera 104 (TN) Provera (TN) DEPO-SUBQ PROVERA MEDROXYPROGESTERONE	Medroxyprogesterone acetate	[8] 13, 35, 46, 49, 50, 51, 60, 107 💬 316. Progesterone-mediated oocyte maturation × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 51 Scleroderma;Systemic sclerosis;SSc; 60 Aplastic anemia; 107 Juvenile idiopathic arthritis;JIA;
317	Progesterone-mediated oocyte maturation 💬	[1] PIK3CD 💬 Progesterone-mediated oocyte maturation × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Progesterone-mediated oocyte maturation × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 317. Progesterone-mediated oocyte maturation × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
318	Prolactin signaling pathway 💬	[1] PIK3CD 💬 Prolactin signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Prolactin signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 318. Prolactin signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
319	Prostate cancer 💬	[1] MTOR 💬 Prostate cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Prostate cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 319. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
320	Prostate cancer 💬	[1] PDGFRA 💬 Prostate cancer × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Prostate cancer × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 320. Prostate cancer × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
321	Prostate cancer 💬	[1] PIK3CD 💬 Prostate cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Prostate cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 321. Prostate cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
322	Proteoglycans in cancer 💬	[1] MTOR 💬 Proteoglycans in cancer × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Proteoglycans in cancer × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 322. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
323	Proteoglycans in cancer 💬	[1] PIK3CD 💬 Proteoglycans in cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Proteoglycans in cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 323. Proteoglycans in cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
324	Proteoglycans in cancer 💬	[1] TNF 💬 Proteoglycans in cancer × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Proteoglycans in cancer × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 324. Proteoglycans in cancer × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
325	Proteoglycans in cancer 💬	[1] TNF 💬 Proteoglycans in cancer × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Proteoglycans in cancer × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 325. Proteoglycans in cancer × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
326	Purine metabolism 💬	[2] IMPDH1, IMPDH2 💬 Purine metabolism × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolate mofetil 💬 Purine metabolism × Name Other Names Mycophenolate mofetil Mycophenolate mofetil (JAN/USP) Cellcept (TN)	Mycophenolate mofetil	[34]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 326. Purine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
327	Purine metabolism 💬	[2] IMPDH1, IMPDH2 💬 Purine metabolism × Name Full Name IMPDH1 inosine monophosphate dehydrogenase 1 IMPDH2 inosine monophosphate dehydrogenase 2	Mycophenolic acid 💬 Purine metabolism × Name Other Names Mycophenolic acid Mycophenolic acid (USAN/INN) Mycophenolic acid (TN)	Mycophenolic acid	[36]  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 327. Purine metabolism × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 19 Lysosomal storage disease;Lysosomal disease; 20 Adrenoleukodystrophy;ALD; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 36 Epidermolysis bullosa; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 44 Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 93 Primary biliary cholangitis;Primary biliary cirrhosis;PBC; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 162 Pemphigoid; 164 Oculocutaneous albinism; 222 Primary nephrotic syndrome; 224 Purpura nephritis; 226 Interstitial cystitis with Hunners ulcer;Interstitial cystitis; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 234 Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 284 Diamond-Blackfan anemia; 285 Fanconi anemia; 300 IgG4-related disease;
328	Rap1 signaling pathway 💬	[2] KIT, PDGFRA 💬 Rap1 signaling pathway × Name Full Name KIT KIT proto-oncogene, receptor tyrosine kinase PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Rap1 signaling pathway × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 328. Rap1 signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
329	Rap1 signaling pathway 💬	[1] PIK3CD 💬 Rap1 signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Rap1 signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 329. Rap1 signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
330	Ras signaling pathway 💬	[3] ABL1, KIT, PDGFRA 💬 Ras signaling pathway × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase KIT KIT proto-oncogene, receptor tyrosine kinase PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Ras signaling pathway × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 330. Ras signaling pathway × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
331	Ras signaling pathway 💬	[1] PIK3CD 💬 Ras signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Ras signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 331. Ras signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
332	Regulation of actin cytoskeleton 💬	[1] PDGFRA 💬 Regulation of actin cytoskeleton × Name Full Name PDGFRA platelet derived growth factor receptor alpha	Imatinib 💬 Regulation of actin cytoskeleton × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 332. Regulation of actin cytoskeleton × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
333	Regulation of actin cytoskeleton 💬	[1] PIK3CD 💬 Regulation of actin cytoskeleton × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Regulation of actin cytoskeleton × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 333. Regulation of actin cytoskeleton × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
334	Regulation of lipolysis in adipocytes 💬	[1] PIK3CD 💬 Regulation of lipolysis in adipocytes × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Regulation of lipolysis in adipocytes × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 334. Regulation of lipolysis in adipocytes × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
335	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬 Regulation of lipolysis in adipocytes × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Regulation of lipolysis in adipocytes × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 335. Regulation of lipolysis in adipocytes × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
336	Relaxin signaling pathway 💬	[1] PIK3CD 💬 Relaxin signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Relaxin signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 336. Relaxin signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
337	Renal cell carcinoma 💬	[1] PIK3CD 💬 Renal cell carcinoma × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Renal cell carcinoma × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 337. Renal cell carcinoma × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
338	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬 Retrograde endocannabinoid signaling × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Retrograde endocannabinoid signaling × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 338. Retrograde endocannabinoid signaling × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
339	Rheumatoid arthritis 💬	[1] TNF 💬 Rheumatoid arthritis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Rheumatoid arthritis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 339. Rheumatoid arthritis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
340	Rheumatoid arthritis 💬	[1] TNF 💬 Rheumatoid arthritis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Rheumatoid arthritis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 340. Rheumatoid arthritis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
341	RIG-I-like receptor signaling pathway 💬	[1] TNF 💬 RIG-I-like receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 RIG-I-like receptor signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 341. RIG-I-like receptor signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
342	RIG-I-like receptor signaling pathway 💬	[1] TNF 💬 RIG-I-like receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 RIG-I-like receptor signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 342. RIG-I-like receptor signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
343	Salmonella infection 💬	[1] PIK3CD 💬 Salmonella infection × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Salmonella infection × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 343. Salmonella infection × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
344	Salmonella infection 💬	[1] TNF 💬 Salmonella infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Salmonella infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 344. Salmonella infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
345	Salmonella infection 💬	[1] TNF 💬 Salmonella infection × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Salmonella infection × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 345. Salmonella infection × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
346	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬 Serotonergic synapse × Name Full Name PTGS1 prostaglandin-endoperoxide synthase 1 PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Serotonergic synapse × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 346. Serotonergic synapse × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
347	Shigellosis 💬	[1] MTOR 💬 Shigellosis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Shigellosis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 347. Shigellosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
348	Shigellosis 💬	[1] PIK3CD 💬 Shigellosis × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Shigellosis × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 348. Shigellosis × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
349	Shigellosis 💬	[1] TNF 💬 Shigellosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Shigellosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 349. Shigellosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
350	Shigellosis 💬	[1] TNF 💬 Shigellosis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Shigellosis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 350. Shigellosis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
351	Signaling pathways regulating pluripotency of stem cells 💬	[1] PIK3CD 💬 Signaling pathways regulating pluripotency of stem cells × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 351. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
352	Small cell lung cancer 💬	[1] PIK3CD 💬 Small cell lung cancer × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Small cell lung cancer × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 352. Small cell lung cancer × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
353	Small cell lung cancer 💬	[1] PTGS2 💬 Small cell lung cancer × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 Small cell lung cancer × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 353. Small cell lung cancer × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
354	Sphingolipid signaling pathway 💬	[1] PIK3CD 💬 Sphingolipid signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Sphingolipid signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 354. Sphingolipid signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
355	Sphingolipid signaling pathway 💬	[1] TNF 💬 Sphingolipid signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Sphingolipid signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 355. Sphingolipid signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
356	Sphingolipid signaling pathway 💬	[1] TNF 💬 Sphingolipid signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Sphingolipid signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 356. Sphingolipid signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
357	Spinocerebellar ataxia 💬	[1] MTOR 💬 Spinocerebellar ataxia × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Spinocerebellar ataxia × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 357. Spinocerebellar ataxia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
358	Spinocerebellar ataxia 💬	[1] PIK3CD 💬 Spinocerebellar ataxia × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Spinocerebellar ataxia × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 358. Spinocerebellar ataxia × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
359	Systemic lupus erythematosus 💬	[1] TNF 💬 Systemic lupus erythematosus × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Systemic lupus erythematosus × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 359. Systemic lupus erythematosus × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
360	Systemic lupus erythematosus 💬	[1] TNF 💬 Systemic lupus erythematosus × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Systemic lupus erythematosus × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 360. Systemic lupus erythematosus × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
361	T cell receptor signaling pathway 💬	[1] PIK3CD 💬 T cell receptor signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 T cell receptor signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 361. T cell receptor signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
362	T cell receptor signaling pathway 💬	[1] TNF 💬 T cell receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 T cell receptor signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 362. T cell receptor signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
363	T cell receptor signaling pathway 💬	[1] TNF 💬 T cell receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 T cell receptor signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 363. T cell receptor signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
364	TGF-beta signaling pathway 💬	[1] TNF 💬 TGF-beta signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 TGF-beta signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 364. TGF-beta signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
365	TGF-beta signaling pathway 💬	[1] TNF 💬 TGF-beta signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 TGF-beta signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 365. TGF-beta signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
366	Th1 and Th2 cell differentiation 💬	[3] IL2RA, IL2RB, IL2RG 💬 Th1 and Th2 cell differentiation × Name Full Name IL2RA interleukin 2 receptor subunit alpha IL2RB interleukin 2 receptor subunit beta IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 Th1 and Th2 cell differentiation × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 366. Th1 and Th2 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
367	Th17 cell differentiation 💬	[3] IL2RA, IL2RB, IL2RG 💬 Th17 cell differentiation × Name Full Name IL2RA interleukin 2 receptor subunit alpha IL2RB interleukin 2 receptor subunit beta IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 Th17 cell differentiation × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 367. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
368	Th17 cell differentiation 💬	[1] MTOR 💬 Th17 cell differentiation × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Th17 cell differentiation × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 368. Th17 cell differentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
369	Thermogenesis 💬	[1] MTOR 💬 Thermogenesis × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Thermogenesis × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 369. Thermogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
370	Thyroid hormone signaling pathway 💬	[1] MTOR 💬 Thyroid hormone signaling pathway × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Thyroid hormone signaling pathway × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 370. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
371	Thyroid hormone signaling pathway 💬	[1] PIK3CD 💬 Thyroid hormone signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Thyroid hormone signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 371. Thyroid hormone signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
372	TNF signaling pathway 💬	[2] LTA, TNF 💬 TNF signaling pathway × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 TNF signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 372. TNF signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
373	TNF signaling pathway 💬	[1] PIK3CD 💬 TNF signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 TNF signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 373. TNF signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
374	TNF signaling pathway 💬	[1] PTGS2 💬 TNF signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 TNF signaling pathway × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 374. TNF signaling pathway × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
375	TNF signaling pathway 💬	[1] TNF 💬 TNF signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 TNF signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 375. TNF signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
376	Toll-like receptor signaling pathway 💬	[1] PIK3CD 💬 Toll-like receptor signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Toll-like receptor signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 376. Toll-like receptor signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
377	Toll-like receptor signaling pathway 💬	[1] TNF 💬 Toll-like receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Toll-like receptor signaling pathway × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 377. Toll-like receptor signaling pathway × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
378	Toll-like receptor signaling pathway 💬	[1] TNF 💬 Toll-like receptor signaling pathway × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Toll-like receptor signaling pathway × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 378. Toll-like receptor signaling pathway × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
379	Toxoplasmosis 💬	[1] TNF 💬 Toxoplasmosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Toxoplasmosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 379. Toxoplasmosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
380	Toxoplasmosis 💬	[1] TNF 💬 Toxoplasmosis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Toxoplasmosis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 380. Toxoplasmosis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
381	Transcriptional misregulation in cancer 💬	[1] IL2RB 💬 Transcriptional misregulation in cancer × Name Full Name IL2RB interleukin 2 receptor subunit beta	Aldesleukin 💬 Transcriptional misregulation in cancer × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 381. Transcriptional misregulation in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
382	Tuberculosis 💬	[1] TNF 💬 Tuberculosis × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Tuberculosis × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 382. Tuberculosis × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
383	Tuberculosis 💬	[1] TNF 💬 Tuberculosis × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Tuberculosis × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 383. Tuberculosis × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
384	Type I diabetes mellitus 💬	[2] LTA, TNF 💬 Type I diabetes mellitus × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 Type I diabetes mellitus × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 384. Type I diabetes mellitus × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
385	Type I diabetes mellitus 💬	[1] TNF 💬 Type I diabetes mellitus × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Type I diabetes mellitus × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 385. Type I diabetes mellitus × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
386	Type II diabetes mellitus 💬	[1] MTOR 💬 Type II diabetes mellitus × Name Full Name MTOR mechanistic target of rapamycin kinase	Sirolimus 💬 Type II diabetes mellitus × Name Other Names Sirolimus Sirolimus (JAN/USAN/INN) Rapamune (TN) Rapamycin (TN) FYARRO HYFTOR	Sirolimus	[40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 386. Type II diabetes mellitus × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 13 Multiple sclerosis/Neuromyelitis optica; 15 Inclusion body myositis; 17 Multiple system atrophy;MSA-C;MSA-P; 19 Lysosomal storage disease;Lysosomal disease; 34 Neurofibromatosis; 35 Pemphigus; 36 Epidermolysis bullosa; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 60 Aplastic anemia; 61 Autoimmune hemolytic anemia;AIHA; 62 Paroxysmal nocturnal hemoglobinuria;PNH; 63 Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia; 65 Primary immunodeficiency; 66 IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy; 67 Polycystic kidney disease;PKD;PCKD;Polycystic kidney; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 89 Lymphangioleiomyomatosis;LAM; 96 Crohn disease;Terminal ileitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 137 Focal cortical dysplasia;FCD; 157 Sturge-Weber syndrome;Síndrome de Sturge-Weber; 158 Tuberous sclerosis;Tuberous sclerosis complex; 192 Cockayne syndrome;CS; 193 Prader-Willi syndrome; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 277 Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation; 281 Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome; 283 Acquired pure red cell aplasia;Pure red cell aplasia; 300 IgG4-related disease; 331 Idiopathic multicentric castleman disease;iMCD;Castleman disease;
387	Type II diabetes mellitus 💬	[1] PIK3CD 💬 Type II diabetes mellitus × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Type II diabetes mellitus × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 387. Type II diabetes mellitus × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
388	Type II diabetes mellitus 💬	[1] TNF 💬 Type II diabetes mellitus × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Type II diabetes mellitus × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 388. Type II diabetes mellitus × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
389	Type II diabetes mellitus 💬	[1] TNF 💬 Type II diabetes mellitus × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Type II diabetes mellitus × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 389. Type II diabetes mellitus × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
390	VEGF signaling pathway 💬	[1] PIK3CD 💬 VEGF signaling pathway × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 VEGF signaling pathway × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 390. VEGF signaling pathway × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
391	VEGF signaling pathway 💬	[1] PTGS2 💬 VEGF signaling pathway × Name Full Name PTGS2 prostaglandin-endoperoxide synthase 2	Acetaminophen 💬 VEGF signaling pathway × Name Other Names Acetaminophen Acetaminophen (JP18/USP) Paracetamol (INN) Tylenol (TN) OFIRMEV GOOD NEIGHBOR PHARMACY PAIN RELIEF	Acetaminophen	[15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 391. VEGF signaling pathway × Disease ID Name  3  Spinal muscular atrophy;Myelopathic muscular atrophy;  6  Parkinson disease;Disease Parkinson's; 11 Myasthenia gravis;MG; 13 Multiple sclerosis/Neuromyelitis optica; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 51 Scleroderma;Systemic sclerosis;SSc; 70 Spinal stenosis;Extensive spinal canal stenosis; 86 Pulmonary arterial hypertension;PAH; 222 Primary nephrotic syndrome; 256 Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 337 Homocystinuria;
392	Viral carcinogenesis 💬	[1] PIK3CD 💬 Viral carcinogenesis × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Viral carcinogenesis × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 392. Viral carcinogenesis × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
393	Viral myocarditis 💬	[1] ABL1 💬 Viral myocarditis × Name Full Name ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase	Imatinib 💬 Viral myocarditis × Name Other Names Imatinib Imatinib (INN) Glamox (TN)	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 393. Viral myocarditis × Disease ID Name 13 Multiple sclerosis/Neuromyelitis optica; 28 Systemic amyloidosis;AL amyloidosis; 34 Neurofibromatosis; 35 Pemphigus; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 51 Scleroderma;Systemic sclerosis;SSc; 85 Idiopathic interstitial pneumonia;IIPs; 86 Pulmonary arterial hypertension;PAH; 87 Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis; 88 Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism; 89 Lymphangioleiomyomatosis;LAM; 162 Pemphigoid;
394	Viral protein interaction with cytokine and cytokine receptor 💬	[3] IL2RA, IL2RB, IL2RG 💬 Viral protein interaction with cytokine and cytokine receptor × Name Full Name IL2RA interleukin 2 receptor subunit alpha IL2RB interleukin 2 receptor subunit beta IL2RG interleukin 2 receptor subunit gamma	Aldesleukin 💬 Viral protein interaction with cytokine and cytokine receptor × Name Other Names Aldesleukin Aldesleukin (USAN/INN) Interleukin-2 Proleukin (TN)	Aldesleukin	[6]  2 , 35, 49, 65, 96, 97 💬 394. Viral protein interaction with cytokine and cytokine receptor × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 35 Pemphigus; 49 Systemic lupus erythematosus;SLE; 65 Primary immunodeficiency; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis;
395	Viral protein interaction with cytokine and cytokine receptor 💬	[2] LTA, TNF 💬 Viral protein interaction with cytokine and cytokine receptor × Name Full Name LTA lymphotoxin alpha TNF tumor necrosis factor	Etanercept 💬 Viral protein interaction with cytokine and cytokine receptor × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 395. Viral protein interaction with cytokine and cytokine receptor × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
396	Viral protein interaction with cytokine and cytokine receptor 💬	[1] TNF 💬 Viral protein interaction with cytokine and cytokine receptor × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Viral protein interaction with cytokine and cytokine receptor × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 396. Viral protein interaction with cytokine and cytokine receptor × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;
397	Yersinia infection 💬	[1] PIK3CD 💬 Yersinia infection × Name Full Name PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Parsaclisib 💬 Yersinia infection × Name Other Names Parsaclisib Parsaclisib (USAN/INN)	Parsaclisib	[3] 35, 53, 61 💬 397. Yersinia infection × Disease ID Name 35 Pemphigus; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 61 Autoimmune hemolytic anemia;AIHA;
398	Yersinia infection 💬	[1] TNF 💬 Yersinia infection × Name Full Name TNF tumor necrosis factor	Etanercept 💬 Yersinia infection × Name Other Names Etanercept Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 398. Yersinia infection × Disease ID Name 15 Inclusion body myositis; 28 Systemic amyloidosis;AL amyloidosis; 35 Pemphigus; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 50 Dermatomyositis;Polymyositis; 53 Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy; 56 Behcet disease;Behçet disease;BD; 60 Aplastic anemia; 85 Idiopathic interstitial pneumonia;IIPs; 107 Juvenile idiopathic arthritis;JIA; 228 Bronchiolitis obliterans;Obliterating bronchiolitis; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica; 285 Fanconi anemia;
399	Yersinia infection 💬	[1] TNF 💬 Yersinia infection × Name Full Name TNF tumor necrosis factor	Infliximab 💬 Yersinia infection × Name Other Names Infliximab Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 399. Yersinia infection × Disease ID Name 35 Pemphigus; 37 Generalised pustular psoriasis;Pustular psoriasis; 38 Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome; 39 Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN; 40 Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome; 41 Giant cell arteritis;Temporal arteritis; 42 Polyarteritis nodosa;PAN; 43 Microscopic polyangiitis;MPA; 45 Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS; 46 Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA; 49 Systemic lupus erythematosus;SLE; 50 Dermatomyositis;Polymyositis; 55 Relapsing polychondritis; 56 Behcet disease;Behçet disease;BD; 65 Primary immunodeficiency; 84 Sarcoidosis; 85 Idiopathic interstitial pneumonia;IIPs; 95 Autoimmune hepatitis; 96 Crohn disease;Terminal ileitis; 97 Ulcerative colitis; 98 Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID; 107 Juvenile idiopathic arthritis;JIA; 162 Pemphigoid; 164 Oculocutaneous albinism; 269 Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome; 270 Chronic recurrent multifocal osteomyelitis; 271 Ankylosing spondylitis;Spondylarthritis ankylopoietica;

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