Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Adrenergic signaling in cardiomyocytes 💬

[3] ADRA1A, ADRA1B, ADRA1D 💬

[2] 57, 67 💬

2

Adrenergic signaling in cardiomyocytes 💬

[5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬

Carvedilol 💬

[4] 57, 86, 113, 210 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

3

Adrenergic signaling in cardiomyocytes 💬

[1] ADRB1 💬

Dobutamine 💬

[4] 57, 58, 86, 215 💬

4

Adrenergic signaling in cardiomyocytes 💬

[1] ADRB1 💬

Metoprolol 💬

[6] 17, 57, 58, 113, 193, 226 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
113	Muscular dystrophy;
193	Prader-Willi syndrome;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;

5

Adrenergic signaling in cardiomyocytes 💬

[1] AGTR1 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

6

AGE-RAGE signaling pathway in diabetic complications 💬

[1] AGTR1 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

7

Aldosterone synthesis and secretion 💬

[1] AGTR1 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

8

AMPK signaling pathway 💬

[1] ADRA1A 💬

Carvedilol 💬

[4] 57, 86, 113, 210 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

9

AMPK signaling pathway 💬

[1] ADRA1A 💬

[2] 57, 67 💬

10

Apelin signaling pathway 💬

[1] AGTR1 💬

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

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