Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Lisinopril 💬 Lisinopril [9] 19, 46, 49, 57, 66, 67, 113, 222, 223 💬
2 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Perindopril 💬 Perindopril [5] 57, 58, 113, 167, 222 💬
3 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Perindopril arginine 💬 Perindopril [5] 57, 58, 113, 167, 222 💬
4 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Perindopril erbumine 💬 Perindopril [5] 57, 58, 113, 167, 222 💬
5 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Captopril 💬 Captopril [3] 17, 57, 86 💬
6 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Enalapril 💬 Enalapril [10] 13, 19, 46, 57, 66, 113, 210, 222, 223, 279 💬
7 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Ramipril 💬 Ramipril [10] 46, 49, 57, 66, 67, 113, 218, 222, 223, 257 💬
8 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Enalapril maleate 💬 Enalapril [10] 13, 19, 46, 57, 66, 113, 210, 222, 223, 279 💬
9 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Benazepril hydrochloride 💬 Benazepril [5] 49, 57, 218, 222, 224 💬
10 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Lisinopril 💬 Lisinopril [9] 19, 46, 49, 57, 66, 67, 113, 222, 223 💬
11 ACE 💬 [6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy Benazepril 💬 Benazepril [5] 49, 57, 218, 222, 224 💬
12 ADORA1 💬 [8] cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Adenosine 💬 Adenosine [4] 13, 57, 58, 65 💬
13 ADORA2A 💬 [8] Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Regadenoson 💬 Regadenoson [2] 57, 58 💬
14 ADORA2A 💬 [8] Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Adenosine 💬 Adenosine [4] 13, 57, 58, 65 💬
15 ADORA2A 💬 [8] Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Regadenoson 💬 Regadenoson [2] 57, 58 💬
16 ADORA2B 💬 [6] Rap1 signaling pathway, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling, Vascular smooth muscle contraction, Alcoholism Adenosine 💬 Adenosine [4] 13, 57, 58, 65 💬
17 ADORA3 💬 [4] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Neuroactive ligand signaling Adenosine 💬 Adenosine [4] 13, 57, 58, 65 💬
18 ADRA1A 💬 [9] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol [7] 6, 46, 57, 58, 86, 113, 210 💬
19 ADRA1A 💬 [9] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Doxazosin mesylate 💬 Doxazosin [2] 57, 67 💬
20 ADRA1A 💬 [9] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol phosphate 💬 Carvedilol [7] 6, 46, 57, 58, 86, 113, 210 💬
21 ADRA1A 💬 [9] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Doxazosin 💬 Doxazosin [2] 57, 67 💬
22 ADRA1B 💬 [8] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol phosphate 💬 Carvedilol [7] 6, 46, 57, 58, 86, 113, 210 💬
23 ADRA1B 💬 [8] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Doxazosin mesylate 💬 Doxazosin [2] 57, 67 💬
24 ADRA1B 💬 [8] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol [7] 6, 46, 57, 58, 86, 113, 210 💬
25 ADRA1B 💬 [8] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Doxazosin 💬 Doxazosin [2] 57, 67 💬
26 ADRA1D 💬 [8] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol phosphate 💬 Carvedilol [7] 6, 46, 57, 58, 86, 113, 210 💬
27 ADRA1D 💬 [8] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Carvedilol 💬 Carvedilol [7] 6, 46, 57, 58, 86, 113, 210 💬
28 ADRA1D 💬 [8] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Doxazosin 💬 Doxazosin [2] 57, 67 💬
29 ADRA1D 💬 [8] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion Doxazosin mesylate 💬 Doxazosin [2] 57, 67 💬
30 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Metoprolol 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
31 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Carvedilol 💬 Carvedilol [7] 6, 46, 57, 58, 86, 113, 210 💬
32 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Metoprolol fumarate 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
33 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Carvedilol phosphate 💬 Carvedilol [7] 6, 46, 57, 58, 86, 113, 210 💬
34 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Dobutamine tartrate 💬 Dobutamine [5] 28, 57, 58, 86, 215 💬
35 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Dobutamine hydrochloride 💬 Dobutamine [5] 28, 57, 58, 86, 215 💬
36 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Metoprolol tartrate 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
37 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Bisoprolol 💬 Bisoprolol [5] 57, 58, 67, 86, 113 💬
38 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Dobutamine 💬 Dobutamine [5] 28, 57, 58, 86, 215 💬
39 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Bisoprolol fumarate 💬 Bisoprolol [5] 57, 58, 67, 86, 113 💬
40 ADRB1 💬 [13] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Gap junction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy Metoprolol succinate 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
41 ADRB2 💬 [11] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Carvedilol 💬 Carvedilol [7] 6, 46, 57, 58, 86, 113, 210 💬
42 ADRB2 💬 [11] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Carvedilol phosphate 💬 Carvedilol [7] 6, 46, 57, 58, 86, 113, 210 💬
43 ADRB2 💬 [11] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Clenbuterol hydrochloride 💬 Clenbuterol [6] 1, 2, 6, 57, 113, 256 💬
44 ADRB2 💬 [11] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation Clenbuterol 💬 Clenbuterol [6] 1, 2, 6, 57, 113, 256 💬
45 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease, Pathways in cancer, Diabetic cardiomyopathy Valsartan 💬 Valsartan [11] 28, 57, 58, 66, 75, 86, 210, 218, 222, 223, 224 💬
46 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease, Pathways in cancer, Diabetic cardiomyopathy Losartan 💬 Losartan [20] 17, 19, 36, 46, 57, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 223, 299 💬
47 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease, Pathways in cancer, Diabetic cardiomyopathy Candesartan 💬 Candesartan [4] 57, 58, 67, 222 💬
48 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease, Pathways in cancer, Diabetic cardiomyopathy Olmesartan medoxomil 💬 Olmesartan [2] 57, 223 💬
49 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease, Pathways in cancer, Diabetic cardiomyopathy Irbesartan 💬 Irbesartan [6] 57, 66, 167, 168, 222, 223 💬
50 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease, Pathways in cancer, Diabetic cardiomyopathy Telmisartan 💬 Telmisartan [5] 6, 57, 66, 67, 222 💬
51 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease, Pathways in cancer, Diabetic cardiomyopathy Olmesartan 💬 Olmesartan [2] 57, 223 💬
52 AGTR1 💬 [17] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Coronavirus disease, Pathways in cancer, Diabetic cardiomyopathy Losartan potassium 💬 Losartan [20] 17, 19, 36, 46, 57, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 223, 299 💬
53 AR 💬 [4] Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer Flutamide 💬 Flutamide [2] 57, 81 💬
54 ATP1A1 💬 [19] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin [7] 2, 8, 46, 57, 65, 67, 210 💬
55 ATP1A2 💬 [19] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin [7] 2, 8, 46, 57, 65, 67, 210 💬
56 ATP1A3 💬 [19] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin [7] 2, 8, 46, 57, 65, 67, 210 💬
57 ATP1A4 💬 [19] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Cytoskeleton in muscle cells, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption Digoxin 💬 Digoxin [7] 2, 8, 46, 57, 65, 67, 210 💬
58 CACNA1C 💬 [34] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Benidipine hydrochloride 💬 Benidipine [1] 57 💬
59 CACNA1C 💬 [34] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Verapamil hydrochloride 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
60 CACNA1C 💬 [34] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Verapamil 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
61 CACNA1C 💬 [34] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Benidipine 💬 Benidipine [1] 57 💬
62 CACNA1D 💬 [35] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Verapamil 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
63 CACNA1D 💬 [35] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Benidipine 💬 Benidipine [1] 57 💬
64 CACNA1D 💬 [35] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Benidipine hydrochloride 💬 Benidipine [1] 57 💬
65 CACNA1D 💬 [35] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Verapamil hydrochloride 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
66 CACNA1F 💬 [27] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Verapamil 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
67 CACNA1F 💬 [27] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Benidipine 💬 Benidipine [1] 57 💬
68 CACNA1F 💬 [27] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Benidipine hydrochloride 💬 Benidipine [1] 57 💬
69 CACNA1F 💬 [27] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Verapamil hydrochloride 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
70 CACNA1S 💬 [27] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Benidipine hydrochloride 💬 Benidipine [1] 57 💬
71 CACNA1S 💬 [27] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Benidipine 💬 Benidipine [1] 57 💬
72 CACNA1S 💬 [27] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Verapamil hydrochloride 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
73 CACNA1S 💬 [27] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Verapamil 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
74 CSF3R 💬 [5] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Pathways in cancer Lenograstim 💬 Lenograstim [8] 2, 13, 16, 18, 19, 57, 65, 97 💬
75 DRD2 💬 [10] Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Bromocriptine 💬 Bromocriptine [3] 6, 57, 74 💬
76 DRD2 💬 [10] Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Hormone signaling, Neuroactive ligand signaling, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Bromocriptine mesylate 💬 Bromocriptine [3] 6, 57, 74 💬
77 HCN1 💬 [1] GnRH secretion Ivabradine 💬 Ivabradine [1] 57 💬
78 HCN1 💬 [1] GnRH secretion Ivabradine hydrochloride 💬 Ivabradine [1] 57 💬
79 HCN2 💬 [2] cAMP signaling pathway, GnRH secretion Ivabradine hydrochloride 💬 Ivabradine [1] 57 💬
80 HCN2 💬 [2] cAMP signaling pathway, GnRH secretion Ivabradine 💬 Ivabradine [1] 57 💬
81 HCN3 💬 [1] GnRH secretion Ivabradine 💬 Ivabradine [1] 57 💬
82 HCN3 💬 [1] GnRH secretion Ivabradine hydrochloride 💬 Ivabradine [1] 57 💬
83 HCN4 💬 [2] cAMP signaling pathway, Taste transduction Ivabradine 💬 Ivabradine [1] 57 💬
84 HCN4 💬 [2] cAMP signaling pathway, Taste transduction Ivabradine hydrochloride 💬 Ivabradine [1] 57 💬
85 HMGCR 💬 [3] Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Rosuvastatin calcium 💬 Rosuvastatin [16] 6, 18, 46, 49, 51, 56, 57, 62, 65, 67, 79, 94, 96, 97, 271, 299 💬
86 HMGCR 💬 [3] Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Rosuvastatin 💬 Rosuvastatin [16] 6, 18, 46, 49, 51, 56, 57, 62, 65, 67, 79, 94, 96, 97, 271, 299 💬
87 HMGCR 💬 [3] Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Simvastatin 💬 Simvastatin [22] 6, 13, 15, 34, 46, 49, 51, 57, 66, 79, 86, 89, 94, 158, 160, 162, 195, 223, 265, 298, 299, 310 💬
88 IL1R1 💬 [13] MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Hematopoietic cell lineage, Th17 cell differentiation, Inflammatory mediator regulation of TRP channels, Pathogenic Escherichia coli infection, Shigellosis, Amoebiasis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Fluid shear stress and atherosclerosis Anakinra 💬 Anakinra [22] 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 57, 84, 86, 97, 106, 107, 149, 153, 266, 299 💬
89 IL1R2 💬 [7] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Amoebiasis, Human T-cell leukemia virus 1 infection, Transcriptional misregulation in cancer, Prostate cancer, Fluid shear stress and atherosclerosis Anakinra 💬 Anakinra [22] 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 57, 84, 86, 97, 106, 107, 149, 153, 266, 299 💬
90 IMPDH1 💬 [2] Purine metabolism, Drug metabolism - other enzymes Mycophenolate mofetil 💬 Mycophenolate mofetil [38] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 46, 49, 51, 53, 57, 60, 61, 62, 63, 65, 66, 93, 95, 96, 118, 162, 164, 222, 223, 224, 226, 234, 283, 284, 285, 300 💬
91 IMPDH1 💬 [2] Purine metabolism, Drug metabolism - other enzymes Mycophenolate mofetil hydrochloride 💬 Mycophenolate mofetil [38] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 46, 49, 51, 53, 57, 60, 61, 62, 63, 65, 66, 93, 95, 96, 118, 162, 164, 222, 223, 224, 226, 234, 283, 284, 285, 300 💬
92 IMPDH2 💬 [2] Purine metabolism, Drug metabolism - other enzymes Mycophenolate mofetil 💬 Mycophenolate mofetil [38] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 46, 49, 51, 53, 57, 60, 61, 62, 63, 65, 66, 93, 95, 96, 118, 162, 164, 222, 223, 224, 226, 234, 283, 284, 285, 300 💬
93 IMPDH2 💬 [2] Purine metabolism, Drug metabolism - other enzymes Mycophenolate mofetil hydrochloride 💬 Mycophenolate mofetil [38] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 46, 49, 51, 53, 57, 60, 61, 62, 63, 65, 66, 93, 95, 96, 118, 162, 164, 222, 223, 224, 226, 234, 283, 284, 285, 300 💬
94 MTOR 💬 [52] ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, Lysosome biogenesis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Integrated stress response (ISR) signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Integrin signaling, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Sirolimus 💬 Sirolimus [46] 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 54, 57, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 97, 98, 111, 127, 137, 157, 158, 192, 222, 223, 227, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
95 NPR1 💬 [10] Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, Hormone signaling, Vascular smooth muscle contraction, Thermogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Aldosterone synthesis and secretion Nesiritide 💬 Nesiritide [1] 57 💬
96 NR3C1 💬 [1] Neuroactive ligand-receptor interaction Prednisolone 💬 Prednisolone [48] 3, 11, 13, 14, 18, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 54, 56, 57, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 111, 113, 145, 162, 222, 223, 251, 269, 271, 296, 299, 300 💬
97 NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption Eplerenone 💬 Eplerenone [5] 57, 75, 113, 210, 215 💬
98 NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption Aldosterone 💬 Aldosterone [3] 57, 75, 222 💬
99 NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption Spironolactone 💬 Spironolactone [12] 46, 57, 58, 67, 86, 113, 210, 214, 218, 222, 223, 225 💬
100 PDE3A 💬 [5] Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Levosimendan 💬 Levosimendan [2] 2, 57 💬
101 PDE3B 💬 [10] Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Levosimendan 💬 Levosimendan [2] 2, 57 💬
102 PPARG 💬 [12] PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Rosiglitazone 💬 Rosiglitazone [7] 46, 57, 75, 77, 97, 222, 265 💬
103 PPARG 💬 [12] PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Rosiglitazone maleate 💬 Rosiglitazone [7] 46, 57, 75, 77, 97, 222, 265 💬
104 PPP3CA 💬 [33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Tacrolimus 💬 Tacrolimus [37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
105 PPP3CA 💬 [33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Tacrolimus 💬 Tacrolimus [37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
106 PPP3CB 💬 [33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Tacrolimus 💬 Tacrolimus [37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
107 PPP3CB 💬 [33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Tacrolimus 💬 Tacrolimus [37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
108 PPP3CC 💬 [33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Tacrolimus 💬 Tacrolimus [37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
109 PPP3CC 💬 [33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Tacrolimus 💬 Tacrolimus [37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
110 PPP3R1 💬 [32] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Tacrolimus 💬 Tacrolimus [37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
111 PPP3R1 💬 [32] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Tacrolimus 💬 Tacrolimus [37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
112 PPP3R2 💬 [32] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Tacrolimus 💬 Tacrolimus [37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
113 PPP3R2 💬 [32] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Tacrolimus 💬 Tacrolimus [37] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 57, 60, 61, 62, 63, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 223, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
114 PRL 💬 [6] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin signaling pathway Bromocriptine 💬 Bromocriptine [3] 6, 57, 74 💬
115 PRL 💬 [6] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, Hormone signaling, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin signaling pathway Bromocriptine mesylate 💬 Bromocriptine [3] 6, 57, 74 💬
116 SLC12A2 💬 [3] Salivary secretion, Pancreatic secretion, Vibrio cholerae infection Furosemide 💬 Furosemide [5] 6, 57, 77, 86, 222 💬
117 SLC12A2 💬 [3] Salivary secretion, Pancreatic secretion, Vibrio cholerae infection Bumetanide 💬 Bumetanide [4] 6, 57, 115, 158 💬
118 XDH 💬 [4] Purine metabolism, Caffeine metabolism, Drug metabolism - other enzymes, Peroxisome Allopurinol sodium 💬 Allopurinol [7] 6, 46, 57, 60, 66, 96, 97 💬
119 XDH 💬 [4] Purine metabolism, Caffeine metabolism, Drug metabolism - other enzymes, Peroxisome Allopurinol 💬 Allopurinol [7] 6, 46, 57, 60, 66, 96, 97 💬