Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 46, 49, 66, 218, 222, 224 💬
2 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 46, 49, 66, 218, 222, 224 💬
3 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Angiotensin II acetate 💬 Angiotensin II [7] 17, 46, 49, 66, 218, 222, 224 💬
4 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Azilsartan medoxomil 💬 Azilsartan medoxomil [1] 66 💬
5 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Azilsartan 💬 Azilsartan medoxomil [1] 66 💬
6 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Azilsartan kamedoxomil 💬 Azilsartan medoxomil [1] 66 💬
7 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Buloxibutid 💬 Buloxibutid [1] 85 💬
8 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Buloxibutid sodium 💬 Buloxibutid [1] 85 💬
9 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Candesartan 💬 Candesartan [2] 58, 67 💬
10 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
11 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Losartan potassium 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
12 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
13 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
14 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Telmisartan 💬 Telmisartan [2] 66, 67 💬
15 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [8] 57, 58, 66, 75, 86, 210, 222, 224 💬
16 Aldosterone synthesis and secretion 💬
 [4] ATP1A, ATP1A, ATP1A, ATP1A 💬 Digitoxin 💬 Digitoxin [1] 299 💬
17 Aldosterone synthesis and secretion 💬
 [4] ATP1A, ATP1A, ATP1A, ATP1A 💬 Digoxin 💬 Digoxin [3]  8 , 46, 210 💬
18 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine besylate 💬 Amlodipine [3] 51, 67, 298 💬
19 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine maleate 💬 Amlodipine [3] 51, 67, 298 💬
20 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [3] 51, 67, 298 💬
21 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine benzoate 💬 Amlodipine [3] 51, 67, 298 💬
22 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Bevantolol hydrochloride 💬 Bevantolol [1]  8  💬
23 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
24 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem hydrochloride 💬 Diltiazem [4] 51, 58, 86, 88 💬
25 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem malate 💬 Diltiazem [4] 51, 58, 86, 88 💬
26 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [4] 51, 58, 86, 88 💬
27 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
28 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine hydrochloride 💬 Nicardipine [2] 70, 86 💬
29 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
30 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [1] 81 💬
31 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
32 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline maleate 💬 Perhexiline [2] 58, 272 💬
33 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
34 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine hydrochloride 💬 Propiverine [1] 226 💬
35 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
36 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
37 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil hydrochloride 💬 Verapamil [4] 58, 96, 140, 167 💬
38 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
39 Aldosterone synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Suvecaltamide 💬 Suvecaltamide [1]  6  💬
40 Aldosterone synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Divalproex sodium 💬 Valproic acid [13]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
41 Aldosterone synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [13]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
42 Aldosterone synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproate sodium 💬 Valproic acid [13]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 89, 90, 127, 222, 331 💬
43 Aldosterone synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Zonisamide 💬 Zonisamide [1]  6  💬
44 Aldosterone synthesis and secretion 💬
 [1] CACNA1S 💬 Pinaverium bromide 💬 Pinaverium [1] 298 💬
45 Aldosterone synthesis and secretion 💬
 [1] CYP11A 💬 Levoketoconazole 💬 Levoketoconazole [1] 75 💬
46 Aldosterone synthesis and secretion 💬
 [1] CYP11B2 💬 Osilodrostat 💬 Osilodrostat [1] 75 💬
47 Aldosterone synthesis and secretion 💬
 [1] CYP11B2 💬 Osilodrostat phosphate 💬 Osilodrostat [1] 75 💬
48 Aldosterone synthesis and secretion 💬
 [1] KCNJ5 💬 Amiodarone hydrochloride 💬 Amiodarone [1] 127 💬
49 Aldosterone synthesis and secretion 💬
 [1] KCNJ5 💬 Amiodarone 💬 Amiodarone [1] 127 💬
50 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
51 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin, repository 💬 Corticotropin [11] 13, 46, 50, 66, 75, 78, 81, 84, 145, 205, 222 💬
52 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
53 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Tetracosactide acetate 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
54 Aldosterone synthesis and secretion 💬
 [1] NPR1 💬 Erythrityl tetranitrate 💬 Erythrityl tetranitrate [1] 46 💬
55 Aldosterone synthesis and secretion 💬
 [1] NPR1 💬 Nesiritide 💬 Nesiritide [1] 58 💬
56 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Aminophylline 💬 Aminophylline [1] 63 💬
57 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Aminophylline dihydrate 💬 Aminophylline [1] 63 💬
58 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Bucladesine 💬 Bucladesine [1] 246 💬
59 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
60 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
61 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Caffeine citrate 💬 Caffeine [8]  2 ,  6 , 13, 21, 46, 96, 97, 265 💬
62 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Flavoxate hydrochloride 💬 Flavoxate [1] 226 💬
63 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Flavoxate 💬 Flavoxate [1] 226 💬
64 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
65 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
66 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬
67 Aldosterone synthesis and secretion 💬
 [1] PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin [1] 168 💬
68 Aldosterone synthesis and secretion 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
69 Aldosterone synthesis and secretion 💬
 [1] PRKCE 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬
70 Aldosterone synthesis and secretion 💬
 [1] PRKCE 💬 Sotrastaurin acetate 💬 Sotrastaurin [1] 97 💬