Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Amyotrophic lateral sclerosis 💬

[1] BCL2 💬

Venetoclax 💬

[1] 28 💬

2

Amyotrophic lateral sclerosis 💬

[1] CASP9 💬

[6] 19, 60, 65, 284, 285, 326 💬

3

Amyotrophic lateral sclerosis 💬

[1] ERBB4 💬

[1] 34 💬

4

Amyotrophic lateral sclerosis 💬

[2] GRIA1, GRIA2 💬

Perampanel 💬

[3] 2 , 6 , 144 💬

5

Amyotrophic lateral sclerosis 💬

[2] GRIA1, GRIA2 💬

Talampanel 💬

[2] 2 , 6 💬

6

Amyotrophic lateral sclerosis 💬

[2] GRIA1, GRIA2 💬

Topiramate 💬

[6] 6 , 97, 140, 144, 156, 193 💬

7

Amyotrophic lateral sclerosis 💬

[7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

[9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
18	Spinocerebellar degeneration;SCD;
203	22q11.2 deletion syndrome;
206	Fragile X syndrome;

8

Amyotrophic lateral sclerosis 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Acamprosate 💬

[2] 6 , 206 💬

9

Amyotrophic lateral sclerosis 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Amantadine 💬

[4] 6 , 8 , 13, 127 💬

10

Amyotrophic lateral sclerosis 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Esketamine 💬

[3] 2 , 4 , 70 💬

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