Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Cadherin signaling 💬
 [4] APH1A, NCSTN, PSEN1, PSENEN 💬 Tarenflurbil 💬 Tarenflurbil [1] 13 💬
2 Cadherin signaling 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
3 Cadherin signaling 💬
 [1] EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib [2] 94, 160 💬
4 Cadherin signaling 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [2] 94, 160 💬
5 Cadherin signaling 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
6 Cadherin signaling 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
7 Cadherin signaling 💬
 [2] EGFR, ERBB2 💬 Afatinib 💬 Afatinib [1] 285 💬
8 Cadherin signaling 💬
 [2] EGFR, ERBB2 💬 Afatinib dimaleate 💬 Afatinib [1] 285 💬
9 Cadherin signaling 💬
 [2] EGFR, ERBB2 💬 Lapatinib ditosylate 💬 Lapatinib [3] 34, 74, 75 💬
10 Cadherin signaling 💬
 [2] EGFR, ERBB2 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
11 Cadherin signaling 💬
 [2] EGFR, ERBB2 💬 Neratinib 💬 Neratinib [1] 34 💬
12 Cadherin signaling 💬
 [2] EGFR, ERBB2 💬 Neratinib maleate 💬 Neratinib [1] 34 💬
13 Cadherin signaling 💬
 [4] EGFR, ERBB2, FLT4, KDR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
14 Cadherin signaling 💬
 [1] FGFR1 💬 Infigratinib 💬 Infigratinib [1] 276 💬
15 Cadherin signaling 💬
 [1] FGFR1 💬 Infigratinib phosphate 💬 Infigratinib [1] 276 💬
16 Cadherin signaling 💬
 [5] FGFR1, FLT4, KDR, PDGFRA, PDGFRB 💬 Catequentinib 💬 Anlotinib [1] 85 💬
17 Cadherin signaling 💬
 [5] FGFR1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib esylate 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
18 Cadherin signaling 💬
 [5] FGFR1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib [7] 51, 84, 85, 89, 227, 228, 331 💬
19 Cadherin signaling 💬
 [2] FLT4, KDR 💬 Axitinib 💬 Axitinib [1] 34 💬
20 Cadherin signaling 💬
 [2] FLT4, KDR 💬 Cediranib 💬 Cediranib [1] 34 💬
21 Cadherin signaling 💬
 [2] FLT4, KDR 💬 Cediranib maleate 💬 Cediranib [1] 34 💬
22 Cadherin signaling 💬
 [4] FLT4, KDR, PDGFRA, PDGFRB 💬 Pazopanib hydrochloride 💬 Pazopanib [1] 227 💬
23 Cadherin signaling 💬
 [4] FLT4, KDR, PDGFRA, PDGFRB 💬 Sunitinib malate 💬 Sunitinib [2] 28, 34 💬
24 Cadherin signaling 💬
 [4] FLT4, KDR, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
25 Cadherin signaling 💬
 [4] FLT4, KDR, PDGFRB, RAF1 💬 Sorafenib tosylate 💬 Sorafenib [2] 34, 86 💬
26 Cadherin signaling 💬
 [4] FLT4, KDR, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
27 Cadherin signaling 💬
 [1] GABRA1 💬 Etomidate 💬 Etomidate [2]  6 , 11 💬
28 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Alprazolam 💬 Alprazolam [2]  8 , 75 💬
29 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clobazam 💬 Clobazam [2] 140, 144 💬
30 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clonazepam 💬 Clonazepam [1]  6  💬
31 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Diazepam 💬 Diazepam [3] 46, 155, 298 💬
32 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Eszopiclone 💬 Eszopiclone [3]  6 , 13, 46 💬
33 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Flumazenil 💬 Flumazenil [5]  6 , 13, 17, 18, 206 💬
34 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Fospropofol disodium 💬 Fospropofol [1] 226 💬
35 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Gaboxadol 💬 Gaboxadol [2] 201, 206 💬
36 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Ganaxolone 💬 Ganaxolone [4] 145, 152, 158, 206 💬
37 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Lorazepam 💬 Lorazepam [2] 36, 231 💬
38 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Midazolam 💬 Midazolam [14]  2 ,  3 ,  6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬
39 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Midazolam hydrochloride 💬 Midazolam [14]  2 ,  3 ,  6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬
40 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Midazolam maleate 💬 Midazolam [14]  2 ,  3 ,  6 , 13, 21, 46, 67, 70, 96, 97, 231, 272, 298, 299 💬
41 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Nitrazepam 💬 Nitrazepam [1] 145 💬
42 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Propofol 💬 Propofol [10]  3 ,  6 , 21, 22, 34, 46, 70, 97, 98, 296 💬
43 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Remimazolam besylate 💬 Remimazolam [3]  6 , 22, 97 💬
44 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Remimazolam 💬 Remimazolam [3]  6 , 22, 97 💬
45 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Zolpidem tartrate 💬 Zolpidem [3]  5 ,  6 , 46 💬
46 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Zolpidem 💬 Zolpidem [3]  5 ,  6 , 46 💬
47 Cadherin signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Zopiclone 💬 Zopiclone [1]  6  💬
48 Cadherin signaling 💬
 [17] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, SCN5A 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
49 Cadherin signaling 💬
 [1] GABRA5 💬 Alogabat 💬 Alogabat [1] 201 💬
50 Cadherin signaling 💬
 [1] IGF1R 💬 Linsitinib 💬 Linsitinib [1] 232 💬
51 Cadherin signaling 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [4] 96, 168, 265, 299 💬
52 Cadherin signaling 💬
 [1] IGF1R 💬 Mecasermin rinfabate 💬 Mecasermin [4] 96, 168, 265, 299 💬
53 Cadherin signaling 💬
 [1] IGF1R 💬 Teprotumumab 💬 Teprotumumab [1] 49 💬
54 Cadherin signaling 💬
 [2] KDR, MET 💬 Cabozantinib 💬 Cabozantinib [9] 13, 34, 46, 49, 50, 51, 53, 96, 97 💬
55 Cadherin signaling 💬
 [2] KDR, MET 💬 Cabozantinib s-malate 💬 Cabozantinib [9] 13, 34, 46, 49, 50, 51, 53, 96, 97 💬
56 Cadherin signaling 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
57 Cadherin signaling 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [4] 34, 278, 279, 280 💬
58 Cadherin signaling 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
59 Cadherin signaling 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib [1] 34 💬
60 Cadherin signaling 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [6]  2 , 34, 58, 195, 279, 280 💬
61 Cadherin signaling 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib [6]  2 , 34, 58, 195, 279, 280 💬
62 Cadherin signaling 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
63 Cadherin signaling 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
64 Cadherin signaling 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [7] 46, 49, 51, 53, 63, 271, 300 💬
65 Cadherin signaling 💬
 [1] PDGFRA 💬 Imatinib mesylate 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
66 Cadherin signaling 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
67 Cadherin signaling 💬
 [2] PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
68 Cadherin signaling 💬
 [2] PDGFRA, PDGFRB 💬 Seralutinib 💬 Seralutinib [1] 86 💬
69 Cadherin signaling 💬
 [1] PDGFRB 💬 Dasatinib 💬 Dasatinib [3] 13, 51, 85 💬
70 Cadherin signaling 💬
 [1] PDGFRB 💬 Dasatinib 💬 Dasatinib [3] 13, 51, 85 💬
71 Cadherin signaling 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
72 Cadherin signaling 💬
 [2] ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil [5]  2 ,  5 ,  6 ,  7 , 51 💬
73 Cadherin signaling 💬
 [2] ROCK1, ROCK2 💬 Fasudil 💬 Fasudil [5]  2 ,  5 ,  6 ,  7 , 51 💬
74 Cadherin signaling 💬
 [1] ROCK2 💬 Belumosudil 💬 Belumosudil [3] 51, 85, 228 💬
75 Cadherin signaling 💬
 [1] ROCK2 💬 Belumosudil mesylate 💬 Belumosudil [3] 51, 85, 228 💬
76 Cadherin signaling 💬
 [1] SCN5A 💬 Amiodarone hydrochloride 💬 Amiodarone [3] 28, 67, 127 💬
77 Cadherin signaling 💬
 [1] SCN5A 💬 Amiodarone 💬 Amiodarone [3] 28, 67, 127 💬
78 Cadherin signaling 💬
 [1] SCN5A 💬 Bupivacaine hydrochloride 💬 Bupivacaine [10] 46, 51, 53, 70, 71, 96, 97, 168, 226, 298 💬
79 Cadherin signaling 💬
 [1] SCN5A 💬 Bupivacaine 💬 Bupivacaine [10] 46, 51, 53, 70, 71, 96, 97, 168, 226, 298 💬
80 Cadherin signaling 💬
 [1] SCN5A 💬 Carbamazepine 💬 Carbamazepine [6]  6 , 13, 137, 145, 158, 231 💬
81 Cadherin signaling 💬
 [1] SCN5A 💬 Eleclazine 💬 Eleclazine [1] 58 💬
82 Cadherin signaling 💬
 [1] SCN5A 💬 Flecainide acetate 💬 Flecainide [2]  6 , 115 💬
83 Cadherin signaling 💬
 [1] SCN5A 💬 Flecainide 💬 Flecainide [2]  6 , 115 💬
84 Cadherin signaling 💬
 [1] SCN5A 💬 Lamotrigine 💬 Lamotrigine [7] 13, 34, 38, 113, 114, 115, 144 💬
85 Cadherin signaling 💬
 [1] SCN5A 💬 Levobupivacaine hydrochloride 💬 Levobupivacaine [1] 46 💬
86 Cadherin signaling 💬
 [1] SCN5A 💬 Levobupivacaine 💬 Levobupivacaine [1] 46 💬
87 Cadherin signaling 💬
 [1] SCN5A 💬 Lidocaine 💬 Lidocaine [14]  6 , 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
88 Cadherin signaling 💬
 [1] SCN5A 💬 Lidocaine hydrochloride 💬 Lidocaine [14]  6 , 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
89 Cadherin signaling 💬
 [1] SCN5A 💬 Lidocaine hydrochloride monohydrate 💬 Lidocaine [14]  6 , 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256, 298 💬
90 Cadherin signaling 💬
 [1] SCN5A 💬 Mexiletine hydrochloride 💬 Mexiletine [6]  1 ,  2 , 10, 113, 114, 115 💬
91 Cadherin signaling 💬
 [1] SCN5A 💬 Mexiletine 💬 Mexiletine [6]  1 ,  2 , 10, 113, 114, 115 💬
92 Cadherin signaling 💬
 [1] SCN5A 💬 Oxcarbazepine 💬 Oxcarbazepine [1] 13 💬
93 Cadherin signaling 💬
 [1] SCN5A 💬 Benoxinate hydrochloride 💬 Oxybuprocaine [1]  6  💬
94 Cadherin signaling 💬
 [1] SCN5A 💬 Oxybuprocaine 💬 Oxybuprocaine [1]  6  💬
95 Cadherin signaling 💬
 [1] SCN5A 💬 Phenytoin 💬 Phenytoin [1] 13 💬
96 Cadherin signaling 💬
 [1] SCN5A 💬 Phenytoin sodium 💬 Phenytoin [1] 13 💬
97 Cadherin signaling 💬
 [1] SCN5A 💬 Quinidine gluconate 💬 Quinidine [3]  2 ,  8 , 13 💬
98 Cadherin signaling 💬
 [1] SCN5A 💬 Quinidine polygalacturonate 💬 Quinidine [3]  2 ,  8 , 13 💬
99 Cadherin signaling 💬
 [1] SCN5A 💬 Quinidine sulfate 💬 Quinidine [3]  2 ,  8 , 13 💬
100 Cadherin signaling 💬
 [1] SCN5A 💬 Quinidine 💬 Quinidine [3]  2 ,  8 , 13 💬
101 Cadherin signaling 💬
 [1] SCN5A 💬 Ropivacaine hydrochloride 💬 Ropivacaine [7] 22, 36, 46, 63, 70, 71, 97 💬
102 Cadherin signaling 💬
 [1] SCN5A 💬 Ropivacaine 💬 Ropivacaine [7] 22, 36, 46, 63, 70, 71, 97 💬
103 Cadherin signaling 💬
 [1] SCN5A 💬 Rufinamide 💬 Rufinamide [1] 144 💬
104 Cadherin signaling 💬
 [1] SCN5A 💬 Zonisamide 💬 Zonisamide [1]  6  💬