Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Estrogen signaling pathway 💬
 [1] BCL2 💬 Obatoclax mesylate 💬 Obatoclax [1] 60 💬
2 Estrogen signaling pathway 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [2] 28, 85 💬
3 Estrogen signaling pathway 💬
 [1] EGFR 💬 Afatinib 💬 Afatinib [1] 285 💬
4 Estrogen signaling pathway 💬
 [1] EGFR 💬 Afatinib dimaleate 💬 Afatinib [1] 285 💬
5 Estrogen signaling pathway 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
6 Estrogen signaling pathway 💬
 [1] EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib [2] 94, 160 💬
7 Estrogen signaling pathway 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [2] 94, 160 💬
8 Estrogen signaling pathway 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
9 Estrogen signaling pathway 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
10 Estrogen signaling pathway 💬
 [1] EGFR 💬 Lapatinib ditosylate 💬 Lapatinib [3] 34, 74, 75 💬
11 Estrogen signaling pathway 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
12 Estrogen signaling pathway 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
13 Estrogen signaling pathway 💬
 [1] EGFR 💬 Neratinib maleate 💬 Neratinib [1] 34 💬
14 Estrogen signaling pathway 💬
 [1] EGFR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
15 Estrogen signaling pathway 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
16 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Bazedoxifene acetate 💬 Bazedoxifene [1] 13 💬
17 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Clomiphene citrate 💬 Clomifene [2] 74, 77 💬
18 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [2] 74, 77 💬
19 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
20 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
21 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [3] 13, 76, 299 💬
22 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estradiol hemihydrate 💬 Estradiol [3] 13, 76, 299 💬
23 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
24 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
25 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [1] 86 💬
26 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
27 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Raloxifene hydrochloride 💬 Raloxifene [2] 46, 77 💬
28 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [2] 46, 77 💬
29 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Tamoxifen citrate 💬 Tamoxifen [4]  2 , 86, 113, 227 💬
30 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [4]  2 , 86, 113, 227 💬
31 Estrogen signaling pathway 💬
 [2] ESR1, PGR 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
32 Estrogen signaling pathway 💬
 [2] ESR1, PGR 💬 Desogestrel 💬 Desogestrel [1] 230 💬
33 Estrogen signaling pathway 💬
 [2] GABBR, GABBR 💬 Arbaclofen placarbil 💬 Arbaclofen Placarbil [1] 13 💬
34 Estrogen signaling pathway 💬
 [2] GABBR, GABBR 💬 Valiloxybate 💬 Valiloxibic acid [1]  6  💬
35 Estrogen signaling pathway 💬
 [2] GABBR, GABBR 💬 gamma-Aminobutyric acid 💬 gamma-Aminobutyric acid [1] 140 💬
36 Estrogen signaling pathway 💬
 [2] GABBR, GABBR 💬 Arbaclofen 💬 Arbaclofen [2] 13, 206 💬
37 Estrogen signaling pathway 💬
 [2] GABBR, GABBR 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬
38 Estrogen signaling pathway 💬
 [2] KCNJ3, KCNJ5 💬 Amiodarone hydrochloride 💬 Amiodarone [1] 127 💬
39 Estrogen signaling pathway 💬
 [2] KCNJ3, KCNJ5 💬 Amiodarone 💬 Amiodarone [1] 127 💬
40 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
41 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
42 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib [1] 280 💬
43 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [4] 34, 278, 279, 280 💬
44 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
45 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib [1] 34 💬
46 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [6]  2 , 34, 58, 195, 279, 280 💬
47 Estrogen signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib [6]  2 , 34, 58, 195, 279, 280 💬
48 Estrogen signaling pathway 💬
 [1] MMP9 💬 Andecaliximab 💬 Andecaliximab [5] 46, 96, 97, 272, 299 💬
49 Estrogen signaling pathway 💬
 [1] NOS3 💬 Tilarginine acetate 💬 Tilarginine [1] 67 💬
50 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Buprenorphine hydrochloride 💬 Buprenorphine [3] 46, 70, 298 💬
51 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Buprenorphine 💬 Buprenorphine [3] 46, 70, 298 💬
52 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Dezocine 💬 Dezocine [1] 46 💬
53 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Dihydrocodeine phosphate 💬 Dihydrocodeine [1] 310 💬
54 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Dihydrocodeine bitartrate 💬 Dihydrocodeine [1] 310 💬
55 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Dihydrocodeine 💬 Dihydrocodeine [1] 310 💬
56 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Dihydrocodeine thiocyanate 💬 Dihydrocodeine [1] 310 💬
57 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Fentanyl 💬 Fentanyl [6] 46, 70, 97, 215, 231, 298 💬
58 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Fentanyl citrate 💬 Fentanyl [6] 46, 70, 97, 215, 231, 298 💬
59 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Fentanyl hydrochloride 💬 Fentanyl [6] 46, 70, 97, 215, 231, 298 💬
60 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Hydromorphone hydrochloride 💬 Hydromorphone [1] 70 💬
61 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Hydromorphone 💬 Hydromorphone [1] 70 💬
62 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Loperamide hydrochloride 💬 Loperamide [2] 13, 97 💬
63 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Loperamide 💬 Loperamide [2] 13, 97 💬
64 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Meperidine hydrochloride 💬 Meperidine [2] 97, 298 💬
65 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Pethidine 💬 Meperidine [2] 97, 298 💬
66 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Methadone hydrochloride 💬 Methadone [1] 60 💬
67 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Methadone 💬 Methadone [1] 60 💬
68 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Morphine sulfate 💬 Morphine [6] 36, 46, 70, 85, 86, 298 💬
69 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Morphine hydrochloride hydrate 💬 Morphine [6] 36, 46, 70, 85, 86, 298 💬
70 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Morphine 💬 Morphine [6] 36, 46, 70, 85, 86, 298 💬
71 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Morphine tartrate 💬 Morphine [6] 36, 46, 70, 85, 86, 298 💬
72 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Nalbuphine hydrochloride 💬 Nalbuphine [1] 85 💬
73 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Nalbuphine 💬 Nalbuphine [1] 85 💬
74 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Nalmefene hydrochloride 💬 Nalmefene [2]  6 , 93 💬
75 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Nalmefene 💬 Nalmefene [2]  6 , 93 💬
76 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Nalmefene hydrochloride hydrate 💬 Nalmefene [2]  6 , 93 💬
77 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Naloxone hydrochloride 💬 Naloxone [2]  6 , 226 💬
78 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Naloxone 💬 Naloxone [2]  6 , 226 💬
79 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Naloxone hydrochloride dihydrate 💬 Naloxone [2]  6 , 226 💬
80 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Naltrexone hydrochloride 💬 Naltrexone [12]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
81 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Naltrexone 💬 Naltrexone [12]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
82 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Oxycodone hydrochloride 💬 Oxycodone [6]  6 , 46, 70, 226, 231, 298 💬
83 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Oxycodone terephthalate 💬 Oxycodone [6]  6 , 46, 70, 226, 231, 298 💬
84 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Oxycodone 💬 Oxycodone [6]  6 , 46, 70, 226, 231, 298 💬
85 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Remifentanil hydrochloride 💬 Remifentanil [3]  6 , 22, 70 💬
86 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Remifentanil 💬 Remifentanil [3]  6 , 22, 70 💬
87 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Sufentanil citrate 💬 Sufentanil [4] 11, 22, 70, 280 💬
88 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Sufentanil 💬 Sufentanil [4] 11, 22, 70, 280 💬
89 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Tramadol hydrochloride 💬 Tramadol [4] 46, 70, 226, 271 💬
90 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Tramadol 💬 Tramadol [4] 46, 70, 226, 271 💬
91 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Trimebutine maleate 💬 Trimebutine [1] 51 💬
92 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Trimebutine 💬 Trimebutine [1] 51 💬
93 Estrogen signaling pathway 💬
 [1] PGR 💬 Dydrogesterone 💬 Dydrogesterone [1] 13 💬
94 Estrogen signaling pathway 💬
 [1] PGR 💬 Levonorgestrel 💬 Levonorgestrel [1] 13 💬
95 Estrogen signaling pathway 💬
 [1] PGR 💬 Medroxyprogesterone acetate 💬 Medroxyprogesterone acetate [8] 13, 35, 46, 49, 50, 51, 60, 107 💬
96 Estrogen signaling pathway 💬
 [1] PGR 💬 Megestrol 💬 Megestrol [2]  2 , 76 💬
97 Estrogen signaling pathway 💬
 [1] PGR 💬 Megestrol acetate 💬 Megestrol acetate [1] 76 💬
98 Estrogen signaling pathway 💬
 [1] PGR 💬 Mifepristone 💬 Mifepristone [1] 75 💬
99 Estrogen signaling pathway 💬
 [1] PGR 💬 Nomegestrol 💬 Nomegestrol [1] 13 💬
100 Estrogen signaling pathway 💬
 [1] PGR 💬 Nomegestrol acetate 💬 Nomegestrol acetate [1] 13 💬
101 Estrogen signaling pathway 💬
 [1] PGR 💬 Norethindrone 💬 Norethisterone [4] 13, 46, 49, 299 💬
102 Estrogen signaling pathway 💬
 [1] PGR 💬 Norethindrone acetate 💬 Norethisterone [4] 13, 46, 49, 299 💬
103 Estrogen signaling pathway 💬
 [1] PGR 💬 Progesterone 💬 Progesterone [2] 76, 299 💬
104 Estrogen signaling pathway 💬
 [1] PGR 💬 Ulipristal 💬 Ulipristal [1] 10 💬
105 Estrogen signaling pathway 💬
 [1] PGR 💬 Ulipristal acetate 💬 Ulipristal [1] 10 💬
106 Estrogen signaling pathway 💬
 [1] PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib [4] 138, 278, 279, 280 💬
107 Estrogen signaling pathway 💬
 [1] PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib [2] 53, 65 💬
108 Estrogen signaling pathway 💬
 [1] PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
109 Estrogen signaling pathway 💬
 [2] PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib [1] 121 💬
110 Estrogen signaling pathway 💬
 [3] PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
111 Estrogen signaling pathway 💬
 [1] PRKCD 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬
112 Estrogen signaling pathway 💬
 [1] PRKCD 💬 Sotrastaurin acetate 💬 Sotrastaurin [1] 97 💬
113 Estrogen signaling pathway 💬
 [1] RAF1 💬 Sorafenib tosylate 💬 Sorafenib [2] 34, 86 💬
114 Estrogen signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
115 Estrogen signaling pathway 💬
 [1] RARA 💬 Acitretin 💬 Acitretin [1] 37 💬
116 Estrogen signaling pathway 💬
 [1] RARA 💬 Alitretinoin 💬 Alitretinoin [1] 49 💬
117 Estrogen signaling pathway 💬
 [1] RARA 💬 Fenretinide 💬 Fenretinide [1] 299 💬
118 Estrogen signaling pathway 💬
 [1] RARA 💬 Isotretinoin 💬 Isotretinoin [4] 36, 39, 159, 160 💬
119 Estrogen signaling pathway 💬
 [1] RARA 💬 Tamibarotene 💬 Tamibarotene [3] 26, 67, 96 💬
120 Estrogen signaling pathway 💬
 [1] RARA 💬 Tazarotene 💬 Tazarotene [1] 85 💬
121 Estrogen signaling pathway 💬
 [1] RARA 💬 Tretinoin 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
122 Estrogen signaling pathway 💬
 [1] RARA 💬 Vitamin A 💬 Vitamin A [3] 13, 53, 90 💬
123 Estrogen signaling pathway 💬
 [1] SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
124 Estrogen signaling pathway 💬
 [1] SRC 💬 Bosutinib hydrate 💬 Bosutinib [2]  2 , 67 💬
125 Estrogen signaling pathway 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
126 Estrogen signaling pathway 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
127 Estrogen signaling pathway 💬
 [1] SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬