Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 Diazoxide 💬 Diazoxide [2] 13, 193 💬
2 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 Diazoxide choline 💬 Diazoxide [2] 13, 193 💬
3 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 Minoxidil 💬 Minoxidil [1] 179 💬
4 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 Nicorandil 💬 Nicorandil [1] 46 💬
5 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 Repaglinide 💬 Repaglinide [4]  6 , 21, 46, 299 💬
6 Insulin secretion 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 Digitoxin 💬 Digitoxin [1] 299 💬
7 Insulin secretion 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 Digoxin 💬 Digoxin [7]  2 ,  8 , 46, 57, 65, 67, 210 💬
8 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine besylate 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
9 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine maleate 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
10 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
11 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine benzoate 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
12 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Benidipine hydrochloride 💬 Benidipine [1] 57 💬
13 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Benidipine 💬 Benidipine [1] 57 💬
14 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Bevantolol hydrochloride 💬 Bevantolol [1]  8  💬
15 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
16 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem hydrochloride 💬 Diltiazem [4] 51, 58, 86, 88 💬
17 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem malate 💬 Diltiazem [4] 51, 58, 86, 88 💬
18 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [4] 51, 58, 86, 88 💬
19 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
20 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine hydrochloride 💬 Nicardipine [2] 70, 86 💬
21 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
22 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
23 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
24 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline maleate 💬 Perhexiline [2] 58, 272 💬
25 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
26 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
27 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil hydrochloride 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
28 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
29 Insulin secretion 💬
 [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM3 💬 Propiverine hydrochloride 💬 Propiverine [1] 226 💬
30 Insulin secretion 💬
 [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM3 💬 Propiverine 💬 Propiverine [1] 226 💬
31 Insulin secretion 💬
 [1] CACNA1S 💬 Pinaverium bromide 💬 Pinaverium [1] 298 💬
32 Insulin secretion 💬
 [1] CHRM3 💬 Acetylcholine chloride 💬 Acetylcholine [1] 11 💬
33 Insulin secretion 💬
 [1] CHRM3 💬 Atropine 💬 Atropine [1]  2  💬
34 Insulin secretion 💬
 [1] CHRM3 💬 Atropine sulfate 💬 Atropine [1]  2  💬
35 Insulin secretion 💬
 [1] CHRM3 💬 Bethanechol chloride 💬 Bethanechol [1] 98 💬
36 Insulin secretion 💬
 [1] CHRM3 💬 Blarcamesine 💬 Blarcamesine [1] 156 💬
37 Insulin secretion 💬
 [1] CHRM3 💬 Blarcamesine hydrochloride 💬 Blarcamesine [1] 156 💬
38 Insulin secretion 💬
 [1] CHRM3 💬 Cevimeline hydrochloride 💬 Cevimeline [1] 53 💬
39 Insulin secretion 💬
 [1] CHRM3 💬 Cevimeline 💬 Cevimeline [1] 53 💬
40 Insulin secretion 💬
 [1] CHRM3 💬 Chlorpromazine 💬 Chlorpromazine [2] 120, 254 💬
41 Insulin secretion 💬
 [1] CHRM3 💬 Chlorpromazine hydrochloride 💬 Chlorpromazine [2] 120, 254 💬
42 Insulin secretion 💬
 [1] CHRM3 💬 Darifenacin hydrobromide 💬 Darifenacin [4]  2 ,  6 , 13, 26 💬
43 Insulin secretion 💬
 [1] CHRM3 💬 Darifenacin 💬 Darifenacin [4]  2 ,  6 , 13, 26 💬
44 Insulin secretion 💬
 [1] CHRM3 💬 Fesoterodine 💬 Fesoterodine [1]  6  💬
45 Insulin secretion 💬
 [1] CHRM3 💬 Fesoterodine fumarate 💬 Fesoterodine [1]  6  💬
46 Insulin secretion 💬
 [1] CHRM3 💬 Methacholine chloride 💬 Methacholine [2] 96, 340 💬
47 Insulin secretion 💬
 [1] CHRM3 💬 Oxybutynin 💬 Oxybutynin [3]  6 , 13, 53 💬
48 Insulin secretion 💬
 [1] CHRM3 💬 Oxybutynin chloride 💬 Oxybutynin [3]  6 , 13, 53 💬
49 Insulin secretion 💬
 [1] CHRM3 💬 Pilocarpine 💬 Pilocarpine [3]  6 , 53, 299 💬
50 Insulin secretion 💬
 [1] CHRM3 💬 Pilocarpine hydrochloride 💬 Pilocarpine [3]  6 , 53, 299 💬
51 Insulin secretion 💬
 [1] CHRM3 💬 Pilocarpine nitrate 💬 Pilocarpine [3]  6 , 53, 299 💬
52 Insulin secretion 💬
 [1] CHRM3 💬 Propantheline bromide 💬 Propantheline [1] 26 💬
53 Insulin secretion 💬
 [1] CHRM3 💬 Rocuronium bromide 💬 Rocuronium [2] 70, 296 💬
54 Insulin secretion 💬
 [1] CHRM3 💬 Scopolamine 💬 Scopolamine [1]  2  💬
55 Insulin secretion 💬
 [1] CHRM3 💬 Scopolamine hydrobromide 💬 Scopolamine [1]  2  💬
56 Insulin secretion 💬
 [1] CHRM3 💬 Solifenacin succinate 💬 Solifenacin [3]  6 , 13, 53 💬
57 Insulin secretion 💬
 [1] CHRM3 💬 Solifenacin 💬 Solifenacin [3]  6 , 13, 53 💬
58 Insulin secretion 💬
 [1] CHRM3 💬 Tiotropium bromide hydrate 💬 Tiotropium [3] 55, 85, 299 💬
59 Insulin secretion 💬
 [1] CHRM3 💬 Tolterodine 💬 Tolterodine [2] 17, 53 💬
60 Insulin secretion 💬
 [1] CHRM3 💬 Tolterodine tartrate 💬 Tolterodine [2] 17, 53 💬
61 Insulin secretion 💬
 [1] CHRM3 💬 Trihexyphenidyl hydrochloride 💬 Trihexyphenidyl [2]  5 ,  6  💬
62 Insulin secretion 💬
 [1] CHRM3 💬 Trihexyphenidyl 💬 Trihexyphenidyl [2]  5 ,  6  💬
63 Insulin secretion 💬
 [1] CHRM3 💬 Tropicamide 💬 Tropicamide [2]  6 , 19 💬
64 Insulin secretion 💬
 [1] GCK 💬 Dorzagliatin 💬 Dorzagliatin [1] 299 💬
65 Insulin secretion 💬
 [1] GLP1R 💬 Dulaglutide 💬 Dulaglutide [1] 299 💬
66 Insulin secretion 💬
 [1] GLP1R 💬 Exenatide 💬 Exenatide [6]  6 , 17, 72, 78, 193, 233 💬
67 Insulin secretion 💬
 [1] GLP1R 💬 Liraglutide 💬 Liraglutide [5]  6 , 13, 75, 77, 193 💬
68 Insulin secretion 💬
 [1] GLP1R 💬 Lixisenatide 💬 Lixisenatide [1]  6  💬
69 Insulin secretion 💬
 [1] GLP1R 💬 Semaglutide 💬 Semaglutide [5]  6 , 51, 84, 113, 299 💬
70 Insulin secretion 💬
 [1] GLP1R 💬 Tirzepatide 💬 Tirzepatide [6] 67, 96, 97, 193, 233, 265 💬
71 Insulin secretion 💬
 [1] KCNJ11 💬 Amiodarone hydrochloride 💬 Amiodarone [3] 28, 67, 127 💬
72 Insulin secretion 💬
 [1] KCNJ11 💬 Amiodarone 💬 Amiodarone [3] 28, 67, 127 💬
73 Insulin secretion 💬
 [1] KCNN4 💬 Senicapoc 💬 Senicapoc [1] 85 💬
74 Insulin secretion 💬
 [1] PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin [1] 168 💬
75 Insulin secretion 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
76 Insulin secretion 💬
 [1] SNAP25 💬 Botulinum toxin type A 💬 Botulinum toxin type A [13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 70, 113, 149, 171, 226 💬
77 Insulin secretion 💬
 [1] SNAP25 💬 Incobotulinumtoxin A 💬 Botulinum toxin type A [13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 70, 113, 149, 171, 226 💬
78 Insulin secretion 💬
 [1] SNAP25 💬 RimabotulinumtoxinB 💬 Botulinum toxin type B [3]  2 ,  6 , 51 💬