Target Gene/Pathway Pathway / Gene
Search results
No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related | KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
---|---|---|---|---|---|
1 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
BRAF [1] BRAF 💬
|
Dabrafenib Dabrafenib 💬
| Dabrafenib | 034 [1] 34 💬
|
2 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
BRAF [2] BRAF, RAF1 💬
|
Sorafenib Sorafenib 💬
| Sorafenib | 034 [2] 34, 86 💬
|
3 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
CSF2 [1] CSF2 💬
|
Otilimab Otilimab 💬
| Otilimab | 046 [1] 46 💬
|
4 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
FYN [2] FYN, LCK 💬
|
Dasatinib Dasatinib 💬
| Dasatinib | 051 [2] 51, 85 💬
|
5 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
FYN [2] FYN, LCK 💬
|
Dasatinib Dasatinib 💬
| Dasatinib | 051 [2] 51, 85 💬
|
6 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNA1 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬
|
Rontalizumab Rontalizumab 💬
| Rontalizumab | 049 [1] 49 💬
|
7 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNA1 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬
|
Sifalimumab Sifalimumab 💬
| Sifalimumab | 049 [1] 49 💬
|
8 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬
|
Anifrolumab Anifrolumab 💬
| Anifrolumab | 046 [3] 46, 49, 53 💬
|
9 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬
|
Interferon alfa Interferon alfa 💬
| Interferon alfa | 013 [6] 13, 25, 26, 28, 56, 96 💬
|
10 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬
|
Interferon alfa-2a Interferon alfa-2a 💬
| Interferon alfa-2a | 056 [1] 56 💬
|
11 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬
|
Interferon alfa-2b Interferon alfa-2b 💬
| Interferon alfa-2b | 025 [2] 25, 34 💬
|
12 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬
|
Interferon beta-1a Interferon beta-1a 💬
| Interferon beta-1a | 013 [4] 13, 26, 96, 97 💬
|
13 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬
|
Interferon beta-1b Interferon beta-1b 💬
| Interferon beta-1b | 013 [1] 13 💬
|
14 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬
|
Peginterferon beta-1a Peginterferon beta-1a 💬
| Peginterferon beta-1a | 013 [1] 13 💬
|
15 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNG [1] IFNG 💬
|
Emapalumab Emapalumab 💬
| Emapalumab | 049 [3] 49, 65, 107 💬
|
16 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNG [1] IFNG 💬
|
Fontolizumab Fontolizumab 💬
| Fontolizumab | 046 [1] 46 💬
|
17 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬
|
Interferon gamma-1b Interferon gamma-1b 💬
| Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬
|
18 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
ITGAL [1] ITGAL 💬
|
Efalizumab Efalizumab 💬
| Efalizumab | 011 [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
|
19 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬
|
Binimetinib Binimetinib 💬
| Binimetinib | 034 [1] 34 💬
|
20 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬
|
Cobimetinib Cobimetinib 💬
| Cobimetinib | 280 [1] 280 💬
|
21 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬
|
Mirdametinib Mirdametinib 💬
| Mirdametinib | 034 [1] 34 💬
|
22 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬
|
Selumetinib Selumetinib 💬
| Selumetinib | 034 [1] 34 💬
|
23 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬
|
Trametinib Trametinib 💬
| Trametinib | 002 [4] 2 , 34, 279, 280 💬
|
24 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PIK3CA [1] PIK3CA 💬
|
Alpelisib Alpelisib 💬
| Alpelisib | 138 [1] 138 💬
|
25 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PIK3CA [3] PIK3CA, PIK3CB, PIK3CD 💬
|
Leniolisib Leniolisib 💬
| Leniolisib | 053 [2] 53, 65 💬
|
26 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PIK3CD [1] PIK3CD 💬
|
Parsaclisib Parsaclisib 💬
| Parsaclisib | 035 [3] 35, 53, 61 💬
|
27 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬
|
Cyclosporine Cyclosporine 💬
| Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
|
28 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬
|
Pimecrolimus Pimecrolimus 💬
| Pimecrolimus | 160 [1] 160 💬
|
29 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬
|
Tacrolimus Tacrolimus 💬
| Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
|
30 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬
|
Tacrolimus Tacrolimus 💬
| Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
|
31 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬
|
Voclosporin Voclosporin 💬
| Voclosporin | 049 [2] 49, 222 💬
|
32 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PRKCB [1] PRKCB 💬
|
Enzastaurin Enzastaurin 💬
| Enzastaurin | 168 [1] 168 💬
|
33 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
SYK [1] SYK 💬
|
Fostamatinib Fostamatinib 💬
| Fostamatinib | 046 [4] 46, 49, 61, 66 💬
|
34 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Adalimumab Adalimumab 💬
| Adalimumab | 019 [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
|
35 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Certolizumab pegol Certolizumab pegol 💬
| Certolizumab pegol | 037 [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
|
36 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Etanercept Etanercept 💬
| Etanercept | 015 [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
|
37 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Golimumab Golimumab 💬
| Golimumab | 046 [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
|
38 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Infliximab Infliximab 💬
| Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
|
39 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Lenalidomide Lenalidomide 💬
| Lenalidomide | 016 [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
|
40 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Ozoralizumab Ozoralizumab 💬
| Ozoralizumab | 046 [1] 46 💬
|
41 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Pegsunercept Pegsunercept 💬
| Pegsunercept | 046 [1] 46 💬
|
42 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Pirfenidone Pirfenidone 💬
| Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
|
43 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Pomalidomide Pomalidomide 💬
| Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬
|
44 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬
|
Thalidomide Thalidomide 💬
| Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
|