Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Phospholipase D signaling pathway 💬

[1] AGTR1 💬

Angiotensin II 💬

Angiotensin II

[7] 17, 19, 46, 66, 86, 222, 224 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Phospholipase D signaling pathway 💬

[1] AGTR1 💬

Angiotensin II 💬

Angiotensin II

[7] 17, 19, 46, 66, 86, 222, 224 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Phospholipase D signaling pathway 💬

[1] AGTR1 💬

Candesartan 💬

Candesartan

[2] 58, 67 💬

Phospholipase D signaling pathway 💬

[1] AGTR1 💬

Candesartan cilexetil 💬

Candesartan cilexetil

[1] 67 💬

Phospholipase D signaling pathway 💬

[1] AGTR1 💬

Irbesartan 💬

Irbesartan

[4] 66, 167, 168, 222 💬

Phospholipase D signaling pathway 💬

[1] AGTR1 💬

Losartan 💬

Losartan

[17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬

Disease ID	Name
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
36	Epidermolysis bullosa;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
113	Muscular dystrophy;
164	Oculocutaneous albinism;
167	Marfan syndrome;
179	Williams syndrome;
215	Tetralogy of Fallot;Fallot tetralogy;
222	Primary nephrotic syndrome;
299	Cystic fibrosis;

Phospholipase D signaling pathway 💬

[1] AGTR1 💬

Sparsentan 💬

Sparsentan

[3] 66, 218, 222 💬

Phospholipase D signaling pathway 💬

[1] AGTR1 💬

Telmisartan 💬

Telmisartan

[2] 66, 67 💬

Phospholipase D signaling pathway 💬

[1] AGTR1 💬

Valsartan 💬

Valsartan

[7] 57, 58, 66, 75, 218, 222, 224 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
58	Hypertrophic cardiomyopathy;HCM;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
75	Cushing disease;Cushing;
218	Alport syndrome;
222	Primary nephrotic syndrome;
224	Purpura nephritis;

Phospholipase D signaling pathway 💬

[3] AVPR1A, AVPR1B, AVPR2 💬

Terlipressin 💬

Terlipressin

[1] 299 💬

Phospholipase D signaling pathway 💬

[3] AVPR1A, AVPR1B, AVPR2 💬

Vasopressin 💬

Vasopressin

[1] 210 💬

Phospholipase D signaling pathway 💬

[2] AVPR1A, AVPR2 💬

Conivaptan 💬

Conivaptan

[1] 86 💬

Phospholipase D signaling pathway 💬

[1] AVPR2 💬

Desmopressin 💬

Desmopressin

[6] 6 , 64, 72, 75, 225, 288 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
64	Thrombotic thrombocytopenic purpura;TTP;
72	Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;
75	Cushing disease;Cushing;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;

Phospholipase D signaling pathway 💬

[1] AVPR2 💬

Lixivaptan 💬

Lixivaptan

[1] 67 💬

Phospholipase D signaling pathway 💬

[1] AVPR2 💬

Tolvaptan 💬

Tolvaptan

[4] 67, 72, 86, 225 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
72	Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;
86	Pulmonary arterial hypertension;PAH;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;

Phospholipase D signaling pathway 💬

[2] CXCR1, CXCR2 💬

Reparixin 💬

Reparixin

[2] 298, 299 💬

Phospholipase D signaling pathway 💬

[1] EGFR 💬

Cetuximab 💬

Cetuximab

[2] 51, 86 💬

Phospholipase D signaling pathway 💬

[1] EGFR 💬

Erlotinib 💬

Erlotinib

[1] 94 💬

Phospholipase D signaling pathway 💬

[1] EGFR 💬

Gefitinib 💬

Gefitinib

[1] 75 💬

Phospholipase D signaling pathway 💬

[1] EGFR 💬

Icotinib 💬

Icotinib

[1] 34 💬

Phospholipase D signaling pathway 💬

[1] EGFR 💬

Lapatinib 💬

Lapatinib

[3] 34, 74, 75 💬

Phospholipase D signaling pathway 💬

[1] EGFR 💬

Neratinib 💬

Neratinib

[1] 34 💬

Phospholipase D signaling pathway 💬

[1] EGFR 💬

Tesevatinib 💬

Tesevatinib

[1] 67 💬

Phospholipase D signaling pathway 💬

[1] F2 💬

Dabigatran 💬

Dabigatran

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Phospholipase D signaling pathway 💬

[1] F2 💬

Dabigatran etexilate 💬

Dabigatran etexilate

[2] 51, 75 💬

Phospholipase D signaling pathway 💬

[1] F2 💬

Thrombomodulin alfa 💬

Thrombomodulin Alfa

[1] 85 💬

Phospholipase D signaling pathway 💬

[1] FCER1A 💬

Omalizumab 💬

Omalizumab

[7] 46, 53, 65, 98, 162, 226, 299 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
65	Primary immunodeficiency;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
162	Pemphigoid;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
299	Cystic fibrosis;

Phospholipase D signaling pathway 💬

[3] FYN, KIT, PDGFRB 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Phospholipase D signaling pathway 💬

[3] FYN, KIT, PDGFRB 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Phospholipase D signaling pathway 💬

[1] INSR 💬

Insulin detemir 💬

Insulin detemir

[1] 299 💬

Phospholipase D signaling pathway 💬

[1] INSR 💬

Insulin glargine 💬

Name	Other Names
Insulin glargine	Insulin glargine (USAN/INN) Insulin glargine (genetical recombination) (JP18) Insulin glargine (genetical recombination) [Insulin glargin biosimilar 1] (JAN) Insulin glargine (genetical recombination) [Insulin glargin biosimilar 2] (JAN) Lantus (TN) BASAGLAR INSULIN GLARGINE SOLOSTAR LANTUS SOLOSTAR REZVOGLAR SEMGLEE TOUJEO TOUJEO MAX

Insulin glargine

[1] 299 💬

Phospholipase D signaling pathway 💬

[1] INSR 💬

Insulin human 💬

Insulin human

[2] 96, 156 💬

Phospholipase D signaling pathway 💬

[1] KIT 💬

Masitinib 💬

Masitinib

[6] 2 , 5 , 6 , 13, 46, 96 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
96	Crohn disease;Terminal ileitis;

Phospholipase D signaling pathway 💬

[1] KIT 💬

Pexidartinib 💬

Pexidartinib

[1] 34 💬

Phospholipase D signaling pathway 💬

[2] KIT, PDGFRA 💬

Imatinib 💬

Imatinib

[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
87	Pulmonary veno-occlusive disease;Pulmonary capillary hemangiomatosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
89	Lymphangioleiomyomatosis;LAM;
162	Pemphigoid;

Phospholipase D signaling pathway 💬

[3] KIT, PDGFRA, PDGFRB 💬

Nilotinib 💬

Nilotinib

[5] 6 , 8 , 34, 51, 86 💬

Phospholipase D signaling pathway 💬

[3] KIT, PDGFRA, PDGFRB 💬

Sunitinib 💬

Sunitinib

[2] 28, 34 💬

Phospholipase D signaling pathway 💬

[3] KIT, PDGFRB, RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

Phospholipase D signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

Phospholipase D signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

Phospholipase D signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

Phospholipase D signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

Phospholipase D signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

Phospholipase D signaling pathway 💬

[1] MTOR 💬

Everolimus 💬

Everolimus

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

Phospholipase D signaling pathway 💬

[1] MTOR 💬

Sirolimus 💬

Sirolimus

[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
17	Multiple system atrophy;MSA-C;MSA-P;
19	Lysosomal storage disease;Lysosomal disease;
34	Neurofibromatosis;
35	Pemphigus;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
192	Cockayne syndrome;CS;
193	Prader-Willi syndrome;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
281	Klippel-Trenaunay-Weber syndrome;Klippel-Trenauney-Weber syndrome;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Phospholipase D signaling pathway 💬

[1] MTOR 💬

Temsirolimus 💬

Temsirolimus

[1] 13 💬

Phospholipase D signaling pathway 💬

[2] PDGFRA, PDGFRB 💬

Nintedanib 💬

Nintedanib

[5] 51, 85, 89, 227, 228 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

Phospholipase D signaling pathway 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

Phospholipase D signaling pathway 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

Phospholipase D signaling pathway 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

Phospholipase D signaling pathway 💬

[1] PTGFR 💬

Tafluprost 💬

Tafluprost

[1] 299 💬

Phospholipase D signaling pathway 💬

[1] PTGFR 💬

Unoprostone 💬

Unoprostone

[1] 90 💬

Phospholipase D signaling pathway 💬

[1] SYK 💬

Fostamatinib 💬

Fostamatinib

[4] 46, 49, 61, 66 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
61	Autoimmune hemolytic anemia;AIHA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;