Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Acute myeloid leukemia × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 1. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
2	Acute myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Acute myeloid leukemia × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 2. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
3	Acute myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Acute myeloid leukemia × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 3. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
4	Acute myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Acute myeloid leukemia × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 3. Acute myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
5	Acute myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Acute myeloid leukemia × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 5. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
6	Acute myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Acute myeloid leukemia × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 5. Acute myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
7	Alzheimer disease 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Alzheimer disease × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 7. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
8	Alzheimer disease 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Alzheimer disease × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 8. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
9	Alzheimer disease 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Alzheimer disease × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 9. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
10	Alzheimer disease 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Alzheimer disease × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 9. Alzheimer disease × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
11	Alzheimer disease 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Alzheimer disease × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 11. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
12	Alzheimer disease 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Alzheimer disease × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 11. Alzheimer disease × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
13	Apelin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Apelin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 13. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
14	Apelin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Apelin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 14. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
15	Apelin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Apelin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 15. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
16	Apelin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Apelin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 15. Apelin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
17	Apelin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Apelin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 17. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
18	Apelin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Apelin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 17. Apelin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
19	Apoptosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Apoptosis × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 19. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
20	Apoptosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Apoptosis × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 20. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
21	Apoptosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Apoptosis × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 21. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
22	Apoptosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Apoptosis × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 21. Apoptosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
23	Apoptosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Apoptosis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 23. Apoptosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
24	Apoptosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Apoptosis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 23. Apoptosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
25	Autophagy - animal 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Autophagy - animal × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 25. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
26	Autophagy - animal 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Autophagy - animal × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 26. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
27	Autophagy - animal 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Autophagy - animal × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 27. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
28	Autophagy - animal 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Autophagy - animal × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 27. Autophagy - animal × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
29	Autophagy - animal 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Autophagy - animal × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 29. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
30	Autophagy - animal 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Autophagy - animal × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 29. Autophagy - animal × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
31	B cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 B cell receptor signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 31. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
32	B cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 B cell receptor signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 32. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
33	B cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 B cell receptor signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 33. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
34	B cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 B cell receptor signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 33. B cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
35	B cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 B cell receptor signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 35. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
36	B cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 B cell receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 35. B cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
37	Bladder cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Bladder cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 37. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
38	Bladder cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Bladder cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 38. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
39	Bladder cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Bladder cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 39. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
40	Bladder cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Bladder cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 39. Bladder cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
41	Bladder cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Bladder cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 41. Bladder cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
42	Bladder cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Bladder cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 41. Bladder cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
43	Breast cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Breast cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 43. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
44	Breast cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Breast cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 44. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
45	Breast cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Breast cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 45. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
46	Breast cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Breast cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 45. Breast cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
47	Breast cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Breast cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 47. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
48	Breast cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Breast cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 47. Breast cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
49	Cadherin signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Cadherin signaling × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 49. Cadherin signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
50	Cadherin signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Cadherin signaling × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 50. Cadherin signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
51	Cadherin signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Cadherin signaling × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 51. Cadherin signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
52	Cadherin signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Cadherin signaling × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 51. Cadherin signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
53	Cadherin signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Cadherin signaling × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 53. Cadherin signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
54	Cadherin signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Cadherin signaling × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 53. Cadherin signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
55	cAMP signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 cAMP signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 55. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
56	cAMP signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 cAMP signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 56. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
57	cAMP signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 cAMP signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 57. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
58	cAMP signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 cAMP signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 57. cAMP signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
59	cAMP signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 cAMP signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 59. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
60	cAMP signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 cAMP signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 59. cAMP signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
61	Cellular senescence 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Cellular senescence × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 61. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
62	Cellular senescence 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Cellular senescence × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 62. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
63	Cellular senescence 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Cellular senescence × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 63. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
64	Cellular senescence 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Cellular senescence × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 63. Cellular senescence × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
65	Cellular senescence 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Cellular senescence × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 65. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
66	Cellular senescence 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Cellular senescence × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 65. Cellular senescence × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
67	Central carbon metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Central carbon metabolism in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 67. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
68	Central carbon metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Central carbon metabolism in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 68. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
69	Central carbon metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Central carbon metabolism in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 69. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
70	Central carbon metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Central carbon metabolism in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 69. Central carbon metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
71	Central carbon metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Central carbon metabolism in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 71. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
72	Central carbon metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Central carbon metabolism in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 71. Central carbon metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
73	cGMP-PKG signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 cGMP-PKG signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 73. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
74	cGMP-PKG signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 cGMP-PKG signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 74. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
75	cGMP-PKG signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 cGMP-PKG signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 75. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
76	cGMP-PKG signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 cGMP-PKG signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 75. cGMP-PKG signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
77	cGMP-PKG signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 cGMP-PKG signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 77. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
78	cGMP-PKG signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 cGMP-PKG signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 77. cGMP-PKG signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
79	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 79. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
80	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 80. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
81	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 81. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
82	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 81. Chemical carcinogenesis - reactive oxygen species × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
83	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 83. Chemical carcinogenesis - reactive oxygen species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
84	Chemical carcinogenesis - reactive oxygen species 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Chemical carcinogenesis - reactive oxygen species × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 83. Chemical carcinogenesis - reactive oxygen species × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
85	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 85. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
86	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 86. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
87	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 87. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
88	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Chemical carcinogenesis - receptor activation × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 87. Chemical carcinogenesis - receptor activation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
89	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Chemical carcinogenesis - receptor activation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 89. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
90	Chemical carcinogenesis - receptor activation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Chemical carcinogenesis - receptor activation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 89. Chemical carcinogenesis - receptor activation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
91	Choline metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Choline metabolism in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 91. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
92	Choline metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Choline metabolism in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 92. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
93	Choline metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Choline metabolism in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 93. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
94	Choline metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Choline metabolism in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 93. Choline metabolism in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
95	Choline metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Choline metabolism in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 95. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
96	Choline metabolism in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Choline metabolism in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 95. Choline metabolism in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
97	Chronic myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Chronic myeloid leukemia × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 97. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
98	Chronic myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Chronic myeloid leukemia × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 98. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
99	Chronic myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Chronic myeloid leukemia × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 99. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
100	Chronic myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Chronic myeloid leukemia × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 99. Chronic myeloid leukemia × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
101	Chronic myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Chronic myeloid leukemia × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 101. Chronic myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
102	Chronic myeloid leukemia 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Chronic myeloid leukemia × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 101. Chronic myeloid leukemia × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
103	Colorectal cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Colorectal cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 103. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
104	Colorectal cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Colorectal cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 104. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
105	Colorectal cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Colorectal cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 105. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
106	Colorectal cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Colorectal cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 105. Colorectal cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
107	Colorectal cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Colorectal cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 107. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
108	Colorectal cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Colorectal cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 107. Colorectal cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
109	Cushing syndrome 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Cushing syndrome × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 109. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
110	Cushing syndrome 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Cushing syndrome × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 110. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
111	Cushing syndrome 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Cushing syndrome × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 111. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
112	Cushing syndrome 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Cushing syndrome × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 111. Cushing syndrome × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
113	Cushing syndrome 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Cushing syndrome × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 113. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
114	Cushing syndrome 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Cushing syndrome × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 113. Cushing syndrome × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
115	Efferocytosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Efferocytosis × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 115. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
116	Efferocytosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Efferocytosis × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 116. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
117	Efferocytosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Efferocytosis × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 117. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
118	Efferocytosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Efferocytosis × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 117. Efferocytosis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
119	Efferocytosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Efferocytosis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 119. Efferocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
120	Efferocytosis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Efferocytosis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 119. Efferocytosis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
121	Endometrial cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Endometrial cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 121. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
122	Endometrial cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Endometrial cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 122. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
123	Endometrial cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Endometrial cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 123. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
124	Endometrial cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Endometrial cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 123. Endometrial cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
125	Endometrial cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Endometrial cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 125. Endometrial cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
126	Endometrial cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Endometrial cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 125. Endometrial cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
127	ErbB signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 ErbB signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 127. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
128	ErbB signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 ErbB signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 128. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
129	ErbB signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 ErbB signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 129. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
130	ErbB signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 ErbB signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 129. ErbB signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
131	ErbB signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 ErbB signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 131. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
132	ErbB signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 ErbB signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 131. ErbB signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
133	Estrogen signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Estrogen signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 133. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
134	Estrogen signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Estrogen signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 134. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
135	Estrogen signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Estrogen signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 135. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
136	Estrogen signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Estrogen signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 135. Estrogen signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
137	Estrogen signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Estrogen signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 137. Estrogen signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
138	Estrogen signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Estrogen signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 137. Estrogen signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
139	Fc epsilon RI signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Fc epsilon RI signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 139. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
140	Fc epsilon RI signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Fc epsilon RI signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 140. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
141	Fc epsilon RI signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Fc epsilon RI signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 141. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
142	Fc epsilon RI signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Fc epsilon RI signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 141. Fc epsilon RI signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
143	Fc epsilon RI signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Fc epsilon RI signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 143. Fc epsilon RI signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
144	Fc epsilon RI signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Fc epsilon RI signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 143. Fc epsilon RI signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
145	FoxO signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 FoxO signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 145. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
146	FoxO signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 FoxO signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 146. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
147	FoxO signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 FoxO signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 147. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
148	FoxO signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 FoxO signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 147. FoxO signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
149	FoxO signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 FoxO signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 149. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
150	FoxO signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 FoxO signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 149. FoxO signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
151	Gap junction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Gap junction × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 151. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
152	Gap junction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Gap junction × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 152. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
153	Gap junction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Gap junction × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 153. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
154	Gap junction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Gap junction × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 153. Gap junction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
155	Gap junction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Gap junction × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 155. Gap junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
156	Gap junction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Gap junction × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 155. Gap junction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
157	Gastric cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Gastric cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 157. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
158	Gastric cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Gastric cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 158. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
159	Gastric cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Gastric cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 159. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
160	Gastric cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Gastric cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 159. Gastric cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
161	Gastric cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Gastric cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 161. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
162	Gastric cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Gastric cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 161. Gastric cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
163	Glioma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Glioma × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 163. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
164	Glioma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Glioma × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 164. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
165	Glioma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Glioma × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 165. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
166	Glioma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Glioma × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 165. Glioma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
167	Glioma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Glioma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 167. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
168	Glioma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Glioma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 167. Glioma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
169	GnRH secretion 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 GnRH secretion × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 169. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
170	GnRH secretion 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 GnRH secretion × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 170. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
171	GnRH secretion 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 GnRH secretion × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 171. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
172	GnRH secretion 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 GnRH secretion × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 171. GnRH secretion × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
173	GnRH secretion 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 GnRH secretion × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 173. GnRH secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
174	GnRH secretion 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 GnRH secretion × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 173. GnRH secretion × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
175	GnRH signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 GnRH signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 175. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
176	GnRH signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 GnRH signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 176. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
177	GnRH signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 GnRH signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 177. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
178	GnRH signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 GnRH signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 177. GnRH signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
179	GnRH signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 GnRH signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 179. GnRH signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
180	GnRH signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 GnRH signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 179. GnRH signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
181	Growth hormone synthesis, secretion and action 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 181. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
182	Growth hormone synthesis, secretion and action 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 182. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
183	Growth hormone synthesis, secretion and action 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 183. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
184	Growth hormone synthesis, secretion and action 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Growth hormone synthesis, secretion and action × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 183. Growth hormone synthesis, secretion and action × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
185	Growth hormone synthesis, secretion and action 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Growth hormone synthesis, secretion and action × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 185. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
186	Growth hormone synthesis, secretion and action 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Growth hormone synthesis, secretion and action × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 185. Growth hormone synthesis, secretion and action × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
187	Hepatitis B 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Hepatitis B × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 187. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
188	Hepatitis B 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Hepatitis B × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 188. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
189	Hepatitis B 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Hepatitis B × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 189. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
190	Hepatitis B 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Hepatitis B × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 189. Hepatitis B × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
191	Hepatitis B 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Hepatitis B × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 191. Hepatitis B × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
192	Hepatitis B 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Hepatitis B × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 191. Hepatitis B × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
193	Hepatitis C 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Hepatitis C × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 193. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
194	Hepatitis C 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Hepatitis C × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 194. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
195	Hepatitis C 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Hepatitis C × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 195. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
196	Hepatitis C 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Hepatitis C × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 195. Hepatitis C × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
197	Hepatitis C 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Hepatitis C × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 197. Hepatitis C × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
198	Hepatitis C 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Hepatitis C × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 197. Hepatitis C × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
199	Hepatocellular carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Hepatocellular carcinoma × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 199. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
200	Hepatocellular carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Hepatocellular carcinoma × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 200. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
201	Hepatocellular carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Hepatocellular carcinoma × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 201. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
202	Hepatocellular carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Hepatocellular carcinoma × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 201. Hepatocellular carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
203	Hepatocellular carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Hepatocellular carcinoma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 203. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
204	Hepatocellular carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Hepatocellular carcinoma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 203. Hepatocellular carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
205	HIF-1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 HIF-1 signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 205. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
206	HIF-1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 HIF-1 signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 206. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
207	HIF-1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 HIF-1 signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 207. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
208	HIF-1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 HIF-1 signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 207. HIF-1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
209	HIF-1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 HIF-1 signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 209. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
210	HIF-1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 HIF-1 signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 209. HIF-1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
211	Human cytomegalovirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Human cytomegalovirus infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 211. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
212	Human cytomegalovirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Human cytomegalovirus infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 212. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
213	Human cytomegalovirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Human cytomegalovirus infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 213. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
214	Human cytomegalovirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Human cytomegalovirus infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 213. Human cytomegalovirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
215	Human cytomegalovirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Human cytomegalovirus infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 215. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
216	Human cytomegalovirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Human cytomegalovirus infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 215. Human cytomegalovirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
217	Human immunodeficiency virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 217. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
218	Human immunodeficiency virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 218. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
219	Human immunodeficiency virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 219. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
220	Human immunodeficiency virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Human immunodeficiency virus 1 infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 219. Human immunodeficiency virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
221	Human immunodeficiency virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Human immunodeficiency virus 1 infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 221. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
222	Human immunodeficiency virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Human immunodeficiency virus 1 infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 221. Human immunodeficiency virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
223	Human papillomavirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Human papillomavirus infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 223. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
224	Human papillomavirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Human papillomavirus infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 224. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
225	Human papillomavirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Human papillomavirus infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 225. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
226	Human papillomavirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Human papillomavirus infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 225. Human papillomavirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
227	Human papillomavirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Human papillomavirus infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 227. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
228	Human papillomavirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Human papillomavirus infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 227. Human papillomavirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
229	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 229. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
230	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 230. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
231	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 231. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
232	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Human T-cell leukemia virus 1 infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 231. Human T-cell leukemia virus 1 infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
233	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Human T-cell leukemia virus 1 infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 233. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
234	Human T-cell leukemia virus 1 infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Human T-cell leukemia virus 1 infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 233. Human T-cell leukemia virus 1 infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
235	IgSF CAM signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 IgSF CAM signaling × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 235. IgSF CAM signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
236	IgSF CAM signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 IgSF CAM signaling × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 236. IgSF CAM signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
237	IgSF CAM signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 IgSF CAM signaling × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 237. IgSF CAM signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
238	IgSF CAM signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 IgSF CAM signaling × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 237. IgSF CAM signaling × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
239	IgSF CAM signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 IgSF CAM signaling × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 239. IgSF CAM signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
240	IgSF CAM signaling 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 IgSF CAM signaling × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 239. IgSF CAM signaling × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
241	Influenza A 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Influenza A × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 241. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
242	Influenza A 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Influenza A × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 242. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
243	Influenza A 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Influenza A × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 243. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
244	Influenza A 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Influenza A × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 243. Influenza A × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
245	Influenza A 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Influenza A × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 245. Influenza A × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
246	Influenza A 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Influenza A × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 245. Influenza A × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
247	Insulin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Insulin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 247. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
248	Insulin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Insulin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 248. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
249	Insulin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Insulin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 249. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
250	Insulin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Insulin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 249. Insulin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
251	Insulin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Insulin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 251. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
252	Insulin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Insulin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 251. Insulin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
253	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 253. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
254	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 254. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
255	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 255. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
256	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 255. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
257	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 257. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
258	Kaposi sarcoma-associated herpesvirus infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Kaposi sarcoma-associated herpesvirus infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 257. Kaposi sarcoma-associated herpesvirus infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
259	Long-term depression 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Long-term depression × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 259. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
260	Long-term depression 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Long-term depression × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 260. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
261	Long-term depression 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Long-term depression × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 261. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
262	Long-term depression 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Long-term depression × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 261. Long-term depression × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
263	Long-term depression 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Long-term depression × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 263. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
264	Long-term depression 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Long-term depression × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 263. Long-term depression × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
265	Long-term potentiation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Long-term potentiation × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 265. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
266	Long-term potentiation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Long-term potentiation × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 266. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
267	Long-term potentiation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Long-term potentiation × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 267. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
268	Long-term potentiation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Long-term potentiation × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 267. Long-term potentiation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
269	Long-term potentiation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Long-term potentiation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 269. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
270	Long-term potentiation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Long-term potentiation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 269. Long-term potentiation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
271	MAPK signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 MAPK signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 271. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
272	MAPK signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 MAPK signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 272. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
273	MAPK signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 MAPK signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 273. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
274	MAPK signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 MAPK signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 273. MAPK signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
275	MAPK signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 MAPK signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 275. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
276	MAPK signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 MAPK signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 275. MAPK signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
277	Melanogenesis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Melanogenesis × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 277. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
278	Melanogenesis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Melanogenesis × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 278. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
279	Melanogenesis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Melanogenesis × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 279. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
280	Melanogenesis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Melanogenesis × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 279. Melanogenesis × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
281	Melanogenesis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Melanogenesis × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 281. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
282	Melanogenesis 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Melanogenesis × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 281. Melanogenesis × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
283	Melanoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Melanoma × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 283. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
284	Melanoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Melanoma × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 284. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
285	Melanoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Melanoma × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 285. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
286	Melanoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Melanoma × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 285. Melanoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
287	Melanoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Melanoma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 287. Melanoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
288	Melanoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Melanoma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 287. Melanoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
289	MicroRNAs in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 MicroRNAs in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 289. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
290	MicroRNAs in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 MicroRNAs in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 290. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
291	MicroRNAs in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 MicroRNAs in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 291. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
292	MicroRNAs in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 MicroRNAs in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 291. MicroRNAs in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
293	MicroRNAs in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 MicroRNAs in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 293. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
294	MicroRNAs in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 MicroRNAs in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 293. MicroRNAs in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
295	mTOR signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 mTOR signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 295. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
296	mTOR signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 mTOR signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 296. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
297	mTOR signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 mTOR signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 297. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
298	mTOR signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 mTOR signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 297. mTOR signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
299	mTOR signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 mTOR signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 299. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
300	mTOR signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 mTOR signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 299. mTOR signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
301	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 301. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
302	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 302. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
303	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 303. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
304	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Natural killer cell mediated cytotoxicity × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 303. Natural killer cell mediated cytotoxicity × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
305	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Natural killer cell mediated cytotoxicity × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 305. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
306	Natural killer cell mediated cytotoxicity 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Natural killer cell mediated cytotoxicity × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 305. Natural killer cell mediated cytotoxicity × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
307	Neurotrophin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Neurotrophin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 307. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
308	Neurotrophin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Neurotrophin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 308. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
309	Neurotrophin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Neurotrophin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 309. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
310	Neurotrophin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Neurotrophin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 309. Neurotrophin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
311	Neurotrophin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Neurotrophin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 311. Neurotrophin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
312	Neurotrophin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Neurotrophin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 311. Neurotrophin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
313	Neutrophil extracellular trap formation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Neutrophil extracellular trap formation × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 313. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
314	Neutrophil extracellular trap formation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Neutrophil extracellular trap formation × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 314. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
315	Neutrophil extracellular trap formation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Neutrophil extracellular trap formation × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 315. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
316	Neutrophil extracellular trap formation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Neutrophil extracellular trap formation × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 315. Neutrophil extracellular trap formation × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
317	Neutrophil extracellular trap formation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Neutrophil extracellular trap formation × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 317. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
318	Neutrophil extracellular trap formation 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Neutrophil extracellular trap formation × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 317. Neutrophil extracellular trap formation × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
319	Non-small cell lung cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Non-small cell lung cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 319. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
320	Non-small cell lung cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Non-small cell lung cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 320. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
321	Non-small cell lung cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Non-small cell lung cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 321. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
322	Non-small cell lung cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Non-small cell lung cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 321. Non-small cell lung cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
323	Non-small cell lung cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Non-small cell lung cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 323. Non-small cell lung cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
324	Non-small cell lung cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Non-small cell lung cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 323. Non-small cell lung cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
325	Oxytocin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Oxytocin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 325. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
326	Oxytocin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Oxytocin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 326. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
327	Oxytocin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Oxytocin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 327. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
328	Oxytocin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Oxytocin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 327. Oxytocin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
329	Oxytocin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Oxytocin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 329. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
330	Oxytocin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Oxytocin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 329. Oxytocin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
331	Pathways in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Pathways in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 331. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
332	Pathways in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Pathways in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 332. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
333	Pathways in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Pathways in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 333. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
334	Pathways in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Pathways in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 333. Pathways in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
335	Pathways in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Pathways in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 335. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
336	Pathways in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Pathways in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 335. Pathways in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
337	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 337. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
338	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 338. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
339	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 339. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
340	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 339. Pathways of neurodegeneration - multiple diseases × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
341	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 341. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
342	Pathways of neurodegeneration - multiple diseases 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Pathways of neurodegeneration - multiple diseases × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 341. Pathways of neurodegeneration - multiple diseases × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
343	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 343. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
344	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 344. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
345	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 345. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
346	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 345. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
347	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 347. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
348	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 PD-L1 expression and PD-1 checkpoint pathway in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 347. PD-L1 expression and PD-1 checkpoint pathway in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
349	Phospholipase D signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Phospholipase D signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 349. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
350	Phospholipase D signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Phospholipase D signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 350. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
351	Phospholipase D signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Phospholipase D signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 351. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
352	Phospholipase D signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Phospholipase D signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 351. Phospholipase D signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
353	Phospholipase D signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Phospholipase D signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 353. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
354	Phospholipase D signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Phospholipase D signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 353. Phospholipase D signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
355	PI3K-Akt signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 PI3K-Akt signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 355. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
356	PI3K-Akt signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 PI3K-Akt signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 356. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
357	PI3K-Akt signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 PI3K-Akt signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 357. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
358	PI3K-Akt signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 PI3K-Akt signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 357. PI3K-Akt signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
359	PI3K-Akt signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 PI3K-Akt signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 359. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
360	PI3K-Akt signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 PI3K-Akt signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 359. PI3K-Akt signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
361	Prolactin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Prolactin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 361. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
362	Prolactin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Prolactin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 362. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
363	Prolactin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Prolactin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 363. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
364	Prolactin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Prolactin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 363. Prolactin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
365	Prolactin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Prolactin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 365. Prolactin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
366	Prolactin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Prolactin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 365. Prolactin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
367	Prostate cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Prostate cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 367. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
368	Prostate cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Prostate cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 368. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
369	Prostate cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Prostate cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 369. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
370	Prostate cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Prostate cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 369. Prostate cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
371	Prostate cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Prostate cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 371. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
372	Prostate cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Prostate cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 371. Prostate cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
373	Proteoglycans in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Proteoglycans in cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 373. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
374	Proteoglycans in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Proteoglycans in cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 374. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
375	Proteoglycans in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Proteoglycans in cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 375. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
376	Proteoglycans in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Proteoglycans in cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 375. Proteoglycans in cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
377	Proteoglycans in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Proteoglycans in cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 377. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
378	Proteoglycans in cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Proteoglycans in cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 377. Proteoglycans in cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
379	Rap1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Rap1 signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 379. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
380	Rap1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Rap1 signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 380. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
381	Rap1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Rap1 signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 381. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
382	Rap1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Rap1 signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 381. Rap1 signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
383	Rap1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Rap1 signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 383. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
384	Rap1 signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Rap1 signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 383. Rap1 signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
385	Ras signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Ras signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 385. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
386	Ras signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Ras signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 386. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
387	Ras signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Ras signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 387. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
388	Ras signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Ras signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 387. Ras signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
389	Ras signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Ras signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 389. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
390	Ras signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Ras signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 389. Ras signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
391	Regulation of actin cytoskeleton 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Regulation of actin cytoskeleton × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 391. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
392	Regulation of actin cytoskeleton 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Regulation of actin cytoskeleton × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 392. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
393	Regulation of actin cytoskeleton 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Regulation of actin cytoskeleton × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 393. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
394	Regulation of actin cytoskeleton 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Regulation of actin cytoskeleton × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 393. Regulation of actin cytoskeleton × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
395	Regulation of actin cytoskeleton 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Regulation of actin cytoskeleton × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 395. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
396	Regulation of actin cytoskeleton 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Regulation of actin cytoskeleton × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 395. Regulation of actin cytoskeleton × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
397	Relaxin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Relaxin signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 397. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
398	Relaxin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Relaxin signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 398. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
399	Relaxin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Relaxin signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 399. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
400	Relaxin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Relaxin signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 399. Relaxin signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
401	Relaxin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Relaxin signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 401. Relaxin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
402	Relaxin signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Relaxin signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 401. Relaxin signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
403	Renal cell carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Renal cell carcinoma × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 403. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
404	Renal cell carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Renal cell carcinoma × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 404. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
405	Renal cell carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Renal cell carcinoma × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 405. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
406	Renal cell carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Renal cell carcinoma × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 405. Renal cell carcinoma × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
407	Renal cell carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Renal cell carcinoma × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 407. Renal cell carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
408	Renal cell carcinoma 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Renal cell carcinoma × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 407. Renal cell carcinoma × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
409	Salmonella infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Salmonella infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 409. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
410	Salmonella infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Salmonella infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 410. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
411	Salmonella infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Salmonella infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 411. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
412	Salmonella infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Salmonella infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 411. Salmonella infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
413	Salmonella infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Salmonella infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 413. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
414	Salmonella infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Salmonella infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 413. Salmonella infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
415	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 415. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
416	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 416. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
417	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 417. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
418	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 417. Signaling pathways regulating pluripotency of stem cells × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
419	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 419. Signaling pathways regulating pluripotency of stem cells × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
420	Signaling pathways regulating pluripotency of stem cells 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Signaling pathways regulating pluripotency of stem cells × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 419. Signaling pathways regulating pluripotency of stem cells × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
421	Sphingolipid signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Sphingolipid signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 421. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
422	Sphingolipid signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Sphingolipid signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 422. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
423	Sphingolipid signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Sphingolipid signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 423. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
424	Sphingolipid signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Sphingolipid signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 423. Sphingolipid signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
425	Sphingolipid signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Sphingolipid signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 425. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
426	Sphingolipid signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Sphingolipid signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 425. Sphingolipid signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
427	T cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 T cell receptor signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 427. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
428	T cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 T cell receptor signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 428. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
429	T cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 T cell receptor signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 429. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
430	T cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 T cell receptor signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 429. T cell receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
431	T cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 T cell receptor signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 431. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
432	T cell receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 T cell receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 431. T cell receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
433	Thyroid cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Thyroid cancer × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 433. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
434	Thyroid cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Thyroid cancer × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 434. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
435	Thyroid cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Thyroid cancer × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 435. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
436	Thyroid cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Thyroid cancer × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 435. Thyroid cancer × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
437	Thyroid cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Thyroid cancer × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 437. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
438	Thyroid cancer 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Thyroid cancer × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 437. Thyroid cancer × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
439	Thyroid hormone signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Thyroid hormone signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 439. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
440	Thyroid hormone signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Thyroid hormone signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 440. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
441	Thyroid hormone signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Thyroid hormone signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 441. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
442	Thyroid hormone signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Thyroid hormone signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 441. Thyroid hormone signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
443	Thyroid hormone signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Thyroid hormone signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 443. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
444	Thyroid hormone signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Thyroid hormone signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 443. Thyroid hormone signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
445	Toll-like receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Toll-like receptor signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 445. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
446	Toll-like receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Toll-like receptor signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 446. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
447	Toll-like receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Toll-like receptor signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 447. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
448	Toll-like receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Toll-like receptor signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 447. Toll-like receptor signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
449	Toll-like receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Toll-like receptor signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 449. Toll-like receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
450	Toll-like receptor signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Toll-like receptor signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 449. Toll-like receptor signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
451	Vascular smooth muscle contraction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Vascular smooth muscle contraction × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 451. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
452	Vascular smooth muscle contraction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Vascular smooth muscle contraction × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 452. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
453	Vascular smooth muscle contraction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Vascular smooth muscle contraction × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 453. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
454	Vascular smooth muscle contraction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Vascular smooth muscle contraction × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 453. Vascular smooth muscle contraction × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
455	Vascular smooth muscle contraction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Vascular smooth muscle contraction × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 455. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
456	Vascular smooth muscle contraction 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Vascular smooth muscle contraction × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 455. Vascular smooth muscle contraction × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
457	VEGF signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 VEGF signaling pathway × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 457. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
458	VEGF signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 VEGF signaling pathway × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 458. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
459	VEGF signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 VEGF signaling pathway × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 459. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
460	VEGF signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 VEGF signaling pathway × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 459. VEGF signaling pathway × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
461	VEGF signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 VEGF signaling pathway × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 461. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
462	VEGF signaling pathway 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 VEGF signaling pathway × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 461. VEGF signaling pathway × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
463	Yersinia infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Binimetinib 💬 Yersinia infection × Name Other Names Binimetinib Mektovi	Binimetinib	[1] 34 💬 463. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
464	Yersinia infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Mirdametinib 💬 Yersinia infection × Name Other Names Mirdametinib Gomekli Ezmekly	Mirdametinib	[4] 34, 278, 279, 280 💬 464. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 278 Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
465	Yersinia infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib 💬 Yersinia infection × Name Other Names Selumetinib Selumetinib	Selumetinib	[1] 34 💬 465. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
466	Yersinia infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Selumetinib sulfate 💬 Yersinia infection × Name Other Names Selumetinib sulfate Koselugo	Selumetinib	[1] 34 💬 465. Yersinia infection × Disease ID Name 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
467	Yersinia infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib 💬 Yersinia infection × Name Other Names Trametinib Trametinib	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 467. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;
468	Yersinia infection 💬	[1] MAP2K2 💬 Acute myeloid leukemia × Name Full Name MAP2K2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1	Trametinib dimethyl sulfoxide 💬 Yersinia infection × Name Other Names Trametinib dimethyl sulfoxide Mekinist Spexotras	Trametinib	[6]  2 , 34, 58, 195, 279, 280 💬 467. Yersinia infection × Disease ID Name  2  Amyotrophic lateral sclerosis;ALS; 34 Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2; 58 Hypertrophic cardiomyopathy;HCM; 195 Noonan syndrome; 279 Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation; 280 Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;

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