Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Cholinergic synapse 💬
 [1] ACHE 💬 Donepezil 💬 Donepezil [9]  5 ,  6 , 13, 46, 78, 124, 127, 156, 206 💬
2 Cholinergic synapse 💬
 [1] ACHE 💬 Galantamine 💬 Galantamine [2]  6 , 127 💬
3 Cholinergic synapse 💬
 [1] ACHE 💬 Latrepirdine 💬 Latrepirdine [1]  8  💬
4 Cholinergic synapse 💬
 [1] ACHE 💬 Rivastigmine 💬 Rivastigmine [3]  5 ,  6 , 13 💬
5 Cholinergic synapse 💬
 [1] ACHE 💬 Tacrine 💬 Tacrine [2] 46, 271 💬
6 Cholinergic synapse 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
7 Cholinergic synapse 💬
 [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
8 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
9 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
10 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
11 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
12 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
13 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
14 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
15 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
16 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
17 Cholinergic synapse 💬
 [9] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Propiverine 💬 Propiverine [1] 226 💬
18 Cholinergic synapse 💬
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Atropine 💬 Atropine [2]  2 , 299 💬
19 Cholinergic synapse 💬
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Blarcamesine 💬 Blarcamesine [1] 156 💬
20 Cholinergic synapse 💬
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
21 Cholinergic synapse 💬
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Oxybutynin 💬 Oxybutynin [3]  6 , 13, 53 💬
22 Cholinergic synapse 💬
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Scopolamine 💬 Scopolamine [1]  2  💬
23 Cholinergic synapse 💬
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Trihexyphenidyl 💬 Trihexyphenidyl [2]  5 ,  6  💬
24 Cholinergic synapse 💬
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Tropicamide 💬 Tropicamide [1]  6  💬
25 Cholinergic synapse 💬
 [2] CHRM2, CHRM3 💬 Fesoterodine 💬 Fesoterodine [1]  6  💬
26 Cholinergic synapse 💬
 [2] CHRM2, CHRM3 💬 Pilocarpine 💬 Pilocarpine [3]  6 , 53, 299 💬
27 Cholinergic synapse 💬
 [1] CHRM3 💬 Cevimeline 💬 Cevimeline [1] 53 💬
28 Cholinergic synapse 💬
 [1] CHRM3 💬 Darifenacin 💬 Darifenacin [2]  6 , 13 💬
29 Cholinergic synapse 💬
 [1] CHRM3 💬 Solifenacin 💬 Solifenacin [3]  6 , 13, 53 💬
30 Cholinergic synapse 💬
 [1] CHRM3 💬 Tolterodine 💬 Tolterodine [2] 17, 53 💬
31 Cholinergic synapse 💬
 [6] CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4 💬 Nicotine 💬 Nicotine [3]  6 , 13, 84 💬
32 Cholinergic synapse 💬
 [2] CHRNA4, CHRNB2 💬 Varenicline 💬 Varenicline [3]  6 , 18, 53 💬
33 Cholinergic synapse 💬
 [1] FYN 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
34 Cholinergic synapse 💬
 [1] FYN 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
35 Cholinergic synapse 💬
 [1] JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
36 Cholinergic synapse 💬
 [1] JAK2 💬 Peficitinib 💬 Peficitinib [1] 46 💬
37 Cholinergic synapse 💬
 [1] JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬
38 Cholinergic synapse 💬
 [1] JAK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
39 Cholinergic synapse 💬
 [3] KCNJ12, KCNJ3, KCNQ1 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
40 Cholinergic synapse 💬
 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 Ezogabine 💬 Ezogabine [2]  2 , 144 💬
41 Cholinergic synapse 💬
 [1] MAP2K1 💬 Binimetinib 💬 Binimetinib [1] 34 💬
42 Cholinergic synapse 💬
 [1] MAP2K1 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
43 Cholinergic synapse 💬
 [1] MAP2K1 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
44 Cholinergic synapse 💬
 [1] MAP2K1 💬 Selumetinib 💬 Selumetinib [1] 34 💬
45 Cholinergic synapse 💬
 [1] MAP2K1 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
46 Cholinergic synapse 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
47 Cholinergic synapse 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
48 Cholinergic synapse 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
49 Cholinergic synapse 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬