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Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Cholinergic synapse 💬

[1] ACHE 💬

Donepezil hydrochloride 💬

Donepezil

[8] 5 , 6 , 13, 46, 124, 127, 156, 206 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;
156	Rett syndrome;
206	Fragile X syndrome;

Cholinergic synapse 💬

[1] ACHE 💬

Donepezil 💬

Donepezil

[8] 5 , 6 , 13, 46, 124, 127, 156, 206 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;
156	Rett syndrome;
206	Fragile X syndrome;

Cholinergic synapse 💬

[1] ACHE 💬

Galantamine hydrobromide 💬

Galantamine

[3] 6 , 11, 127 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
11	Myasthenia gravis;MG;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;

Cholinergic synapse 💬

[1] ACHE 💬

Galantamine 💬

Galantamine

[3] 6 , 11, 127 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
11	Myasthenia gravis;MG;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;

Cholinergic synapse 💬

[1] ACHE 💬

Latrepirdine 💬

Latrepirdine

[1] 8 💬

Cholinergic synapse 💬

[1] ACHE 💬

Latrepirdine dihydrochloride 💬

Latrepirdine

[1] 8 💬

Cholinergic synapse 💬

[1] ACHE 💬

Neostigmine bromide 💬

Neostigmine

[1] 11 💬

Cholinergic synapse 💬

[1] ACHE 💬

Neostigmine methylsulfate 💬

Neostigmine

[1] 11 💬

Cholinergic synapse 💬

[1] ACHE 💬

Neostigmine 💬

Neostigmine

[1] 11 💬

Cholinergic synapse 💬

[1] ACHE 💬

Buntanetap 💬

Posiphen

[1] 6 💬

Cholinergic synapse 💬

[1] ACHE 💬

Pyridostigmine bromide 💬

Pyridostigmine

[5] 3 , 6 , 11, 51, 256 💬

Disease ID	Name
3	Spinal muscular atrophy;SMA;Myelopathic muscular atrophy;Werdnig-Hoffman disease;Dubowitz disease;Kugelberg-Welander disease;Dubowitz syndrome;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
11	Myasthenia gravis;MG;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;Glycogen storage disease type 0;GSD0;Glycogen synthase deficiency;Glycogen storage disease type II;GSDII;Pompe disease;Pompe syndrome;Alpha-1,4-glucosidase acid deficiency;Glycogen storage disease type III;GSDIII;Cori disease;Cori syndrome;Forbes disease;Forbes syndrome;Glycogen debranching enzyme deficiency;Glycogen storage disease type IV;GSDIV;Andersen disease;Glycogen-branching enzyme deficiency;GBED;Glycogen storage disease type V;GSDV;McArdle disease;Muscle phosphorylase deficiency;Muscular phosphorylase deficiency;Glycogen storage disease type VII;GSDVII;Tarui disease;Tarui syndrome;Phosphofructokinase deficiency;PFK deficiency;Glycogen storage disease type IXd;GSDIXd;Phosphorylase kinase deficiency;Phosphoglycerate kinase deficiency;PGK deficiency;Glycogen storage disease type X;GSDX;Phosphoglycerate mutase deficiency;Glycogen storage diseass type XI;GSDXI;Kanno disease;Lactate dehydrogenase deficiency;Glycogen storage diseass type XII;GSDXII;Aldolase A deficiency;Glycogen storage diseass type XIII;GSDXIII;Beta-enolase deficiency;Glycogen storage diseass type XIV;GSDXIV;Phosphoglucomutase deficiency;Glycogen storage diseass type XV;GSDXV;Glycogenin 1 deficiency;

Cholinergic synapse 💬

[1] ACHE 💬

Rivastigmine tartrate 💬

Rivastigmine

[3] 5 , 6 , 13 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;

Cholinergic synapse 💬

[1] ACHE 💬

Rivastigmine 💬

Rivastigmine

[3] 5 , 6 , 13 💬

Disease ID	Name
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;

Cholinergic synapse 💬

[1] BCL2 💬

Obatoclax mesylate 💬

Obatoclax

[1] 60 💬

Cholinergic synapse 💬

[1] BCL2 💬

Sonrotoclax 💬

Sonrotoclax

[1] 28 💬

Disease ID

Name

Systemic amyloidosis;Immunoglobulin light chain amyloidosis;Amyloid light-chain amyloidosis;AL amyloidosis;Immunoglobulin light chain amyloidosis;Immunoglobulin-related amyloidosis;Amyloid heavy-chain amyloidosis;Amyloid heavy-chain amyloidosis;AH amyloidosis;Systemic wild-type transthyretin amyloidosis;Senile systemic amyloidosis;SSA;Transthyretin amyloid cardiomyopathy;ATTR-CM;Hereditary transthyretin amyloidosis;Familial amyloidosis;Familial amyloid polyneuropathy;FAP;Transthyretin amyloid cardiomyopathy;ATTR-CM;Hereditary systemic amyloidosis;

Cholinergic synapse 💬

[1] BCL2 💬

Venetoclax 💬

Venetoclax

[2] 28, 85 💬

Disease ID

Name

Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE;

Cholinergic synapse 💬

[5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1B	voltage-dependent N-type calcium channel subunit alpha-1B isoform 1
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Cilnidipine 💬

Cilnidipine

[1] 67 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Amlodipine besylate 💬

Amlodipine

[6] 51, 67, 79, 113, 222, 298 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
79	Homozygous familial hypercholesterolemia;Familial hypercholesterolemia;Familial hypercholesterolaemia;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
222	Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
298	Hereditary pancreatitis;Chronic pancreatitis;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Amlodipine maleate 💬

Amlodipine

[6] 51, 67, 79, 113, 222, 298 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
79	Homozygous familial hypercholesterolemia;Familial hypercholesterolemia;Familial hypercholesterolaemia;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
222	Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
298	Hereditary pancreatitis;Chronic pancreatitis;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Amlodipine 💬

Amlodipine

[6] 51, 67, 79, 113, 222, 298 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
79	Homozygous familial hypercholesterolemia;Familial hypercholesterolemia;Familial hypercholesterolaemia;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
222	Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
298	Hereditary pancreatitis;Chronic pancreatitis;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Amlodipine benzoate 💬

Amlodipine

[6] 51, 67, 79, 113, 222, 298 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
79	Homozygous familial hypercholesterolemia;Familial hypercholesterolemia;Familial hypercholesterolaemia;
113	Muscular dystrophy;Dystrophinopathies;Duchenne muscular dystrophy;DMD;Becker muscular dystrophy;BMD;Limb-girdle muscular dystrophy;LGMD;Congenital muscular dystrophy;CMD;Fukuyama-type congenital muscular dystrophy;FCMD;Walker-Warburg syndrome;WWS;Muscle-Eye-Brain disease;MEB disease;α-dystroglycanopathy;Integrin α7 deficient CMD;CIntegrin α7 deficient ongenital muscular dystrophy;Merosin-deficient congenital muscular dystrophy;Ullrich congenital muscular dystrophy;Laminopathy;Rigid spine syndrome;Dynamin 2 deficient congenital muscular dystrophy;Telesonin-deficient congenital muscular dystrophy;Congenital muscular dystrophy with mitochondrial structural abnormalities;Facioscapulohumeral muscular dystrophy;FSMD;Myotonic dystrophy;Dystrophia myotonica;DM;Emery-Dreifuss muscular dystrophy;EDMD;Oculopharyngeal muscular dystrophy;OPMD;Myotilinopathy;Caveolinopathy;Limb gridle muscular dystrophy 1C;LGMD1C;Desminopathy;Sarcoglycanopathy;
222	Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
298	Hereditary pancreatitis;Chronic pancreatitis;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Benidipine hydrochloride 💬

Benidipine

[1] 57 💬

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Benidipine 💬

Benidipine

[1] 57 💬

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Bevantolol hydrochloride 💬

Bevantolol

[1] 8 💬

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Diltiazem hydrochloride 💬

Name	Other Names
Diltiazem hydrochloride	Cardizem Cartia XT Dilacor XR Dilt-CD CARDIZEM CD CARDIZEM LA DILTIAZEM HYDROCHLORIDE IN SODIUM CHLORIDE TIAZAC CARTIA DILTIAZEM HCI DILTIAZEM HCL ER DILTIAZEM HYDROCHLORIDE EXTENDED RELEASE DILTIAZEM HYDROCHLORIDE EXTENDED-RELEASE MATZIM LA TIADYLT ER

Diltiazem

[4] 51, 58, 86, 88 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
58	Hypertrophic cardiomyopathy;HCM;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Diltiazem malate 💬

Diltiazem

[4] 51, 58, 86, 88 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
58	Hypertrophic cardiomyopathy;HCM;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Diltiazem 💬

Diltiazem

[4] 51, 58, 86, 88 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
58	Hypertrophic cardiomyopathy;HCM;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Isradipine 💬

Isradipine

[1] 6 💬

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Nicardipine hydrochloride 💬

Nicardipine

[2] 70, 86 💬

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Nicardipine 💬

Nicardipine

[2] 70, 86 💬

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Nifedipine 💬

Nifedipine

[2] 50, 81 💬

Disease ID	Name
50	Dermatomyositis;Polymyositis;Idiopathic inflammatory myositis;IIM;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;Aldosterone synthase deficiency;Congenital Lipoid Adrenal Hyperplasia;3β-Hydroxysteroid Dehydrogenase Deficiency;21-Hydroxylase deficiency;21-OHD;11β-Hydroxylase deficiency;17α-Hydroxylase deficiency;P450 oxidoreductase deficiency;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Nilvadipine 💬

Nilvadipine

[1] 90 💬

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Perhexiline maleate 💬

Perhexiline

[2] 58, 272 💬

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Perhexiline 💬

Perhexiline

[2] 58, 272 💬

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
156	Rett syndrome;
193	Prader-Willi syndrome;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Verapamil hydrochloride 💬

Verapamil

[5] 57, 58, 96, 140, 167 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM;
58	Hypertrophic cardiomyopathy;HCM;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
167	Marfan syndrome;Loeys-Dietz syndrome;LDS;

Cholinergic synapse 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S

Verapamil 💬

Verapamil

[5] 57, 58, 96, 140, 167 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;Dilated cardiomyopathy;DCM;
58	Hypertrophic cardiomyopathy;HCM;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
140	Dorabe syndrome;Dravet syndrome;
167	Marfan syndrome;Loeys-Dietz syndrome;LDS;

Cholinergic synapse 💬

[9] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Propiverine hydrochloride 💬

Propiverine

[1] 226 💬

Cholinergic synapse 💬

[9] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CACNA1C	voltage-dependent L-type calcium channel subunit alpha-1C isoform 18
CACNA1D	voltage-dependent L-type calcium channel subunit alpha-1D isoform b
CACNA1F	voltage-dependent L-type calcium channel subunit alpha-1F isoform 1
CACNA1S	voltage-dependent L-type calcium channel subunit alpha-1S
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Propiverine 💬

Propiverine

[1] 226 💬

Cholinergic synapse 💬

[1] CACNA1S 💬

Pinaverium bromide 💬

Pinaverium

[1] 298 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Atropine 💬

Atropine

[1] 2 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Atropine sulfate 💬

Atropine

[1] 2 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Bethanechol chloride 💬

Bethanechol

[1] 98 💬

Disease ID	Name
98	Eosinophilic gastro-intestinal disorder;Eosinophilic gastrointestinal disorder;EGID;Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Neonatal food-protein induced enterocolitis syndrome;Neonatal food-protein induced enterocolitis;N-FPIES;Eosinophilic esophagitis;EoE;Eosinophilic gastroenteritis;EGE;

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Blarcamesine 💬

Blarcamesine

[1] 156 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Blarcamesine hydrochloride 💬

Blarcamesine

[1] 156 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Chlorpromazine 💬

Chlorpromazine

[2] 120, 254 💬

Disease ID

Name

120

Hereditary dystonia;Primary dystonia;X-linked dystonia parkinsonism;Lubag;Segawa syndrome;SS;Dopa-responsive dystonia;DRD;Paroxysmal nonkinesigenic dyskinesia 1;PNKD1;Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity;Paroxysmal choreoathetosis and episodic ataxia and spasticity;CSE;Episodic kinesigenic dyskinesia 1;EKD1;Myoclonus-dystonia syndrome;MDS;Rapid-onset dystonia-parkinsonism;RDP;Alternating hemiplegia of childhood;AHC;Cerebellar ataxia, areflexia, pes cavus, optic atropy, and sensorineural hearing loss;CAPOS;Paroxysmal execise-induced dyskinesia;PED;Episodic kinesigenic dyskinesia 2;EKD2;Paroxysmal nonkinesigenic dyskinesia 2;PNKD2;MEPAN syndrome;

254

Porphyria;Acute intermittent porphyria;AIP;Hereditary coproporphyria;HCP;Variegate porphyria;VP;Erythropoietic protoporphyria;EPP;Porphyria cutanea tarda;PCT;Congenital erythropoietic porphyria;CEP;X-linked dominant protoporphyria;XLDP;Hepatoerythropoietic porphyria;HEP;

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Chlorpromazine hydrochloride 💬

Chlorpromazine

[2] 120, 254 💬

Disease ID

Name

120

254

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Methacholine chloride 💬

Methacholine

[2] 96, 340 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Oxybutynin 💬

Oxybutynin

[3] 6 , 13, 53 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Oxybutynin chloride 💬

Oxybutynin

[3] 6 , 13, 53 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Propantheline bromide 💬

Propantheline

[1] 26 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Scopolamine 💬

Scopolamine

[1] 2 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Scopolamine hydrobromide 💬

Scopolamine

[1] 2 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Trihexyphenidyl hydrochloride 💬

Trihexyphenidyl

[2] 5 , 6 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Trihexyphenidyl 💬

Trihexyphenidyl

[2] 5 , 6 💬

Cholinergic synapse 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5

Tropicamide 💬

Tropicamide

[2] 6 , 19 💬

Disease ID

Name

Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;

Lysosomal storage disease;Lysosomal disease;Gaucher disease;Niemann-Pick disease type A/B;Niemann-Pick type A;NPD-A;NPA;Niemann-Pick type B;NPD-B;NPB;Acid sphingomyelinase deficiency;ASMD;Niemann-Pick disease type C;Niemann-Pick type C;NPD-C;NPC;GM1-gangliosidosis;GM1-gangliosidoses;GM2-gangliosidosis;GM2-gangliosidoses;Tay-Sachs disease;Sandhoff disease;Krabbe disease;Krabbe syndrome;Metachromatic leukodystrophy;MLD;Multiple-sulfatase deficiency;Farber disease;Mucopolysaccharidosis type I;Mucopolysaccharidosis I;MPS I;Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;Mucopolysaccharidosis type II;Mucopolysaccharidosis II;MPS II;Hunter syndrome;Mucopolysaccharidosis type III;Mucopolysaccharidosis III;MPS III;Sanfilippo syndrome;Mucopolysaccharidosis type IV;Mucopolysaccharidosis IV;MPS IV;MPS IVA;Morquio syndrome;Morquio A syndrome;Mucopolysaccharidosis type VI;Mucopolysaccharidosis VI;MPS VI;Maroteaux-Lamy syndrome;Mucopolysaccharidosis type VII;Mucopolysaccharidosis VII;MPS VII;Sly syndrome;Mucopolysaccharidosis type IX;Mucopolysaccharidosis IX;MPS IX;Hyaluronidase deficiency;Sialidosis;Galactosialidosis;Mucolipidosis II;Mucolipidosis type II;I-cell disease;Mucolipidosis III;Mucolipidosis type III;Alpha-Mannosidosis;Alpha-Mannosidase Deficiency;Beta-Mannosidosis;Beta-Mannosidase Deficiency;Fucosidosis;Aspartylglucosaminuria;Schindler disease;Schindler syndrome;Kanzaki disease;Kanzaki syndrome;Pompe disease;Pompe syndrome;Acid lipase deficiency;Wolman disease;Cholesterol ester storage disease;Danon disease;Danon syndrome;Free sialic acid storage disease;Infantile sialic acid storage disease;ISSD;Salla disease;Salla syndrome;Ceroid lipofuscinosis;Fabry disease;Cystinosis;

Cholinergic synapse 💬

[11] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5
CHRNA3	neuronal acetylcholine receptor subunit alpha-3 isoform 1 precursor
CHRNA4	neuronal acetylcholine receptor subunit alpha-4 isoform 1 precursor
CHRNA6	neuronal acetylcholine receptor subunit alpha-6 isoform 1 precursor
CHRNA7	neuronal acetylcholine receptor subunit alpha-7 isoform 1 precursor
CHRNB2	neuronal acetylcholine receptor subunit beta-2 precursor
CHRNB4	neuronal acetylcholine receptor subunit beta-4 isoform 1 precursor

Acetylcholine chloride 💬

Acetylcholine

[1] 11 💬

Cholinergic synapse 💬

[11] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4 💬

Name	Full Name
CHRM1	muscarinic acetylcholine receptor M1
CHRM2	muscarinic acetylcholine receptor M2
CHRM3	muscarinic acetylcholine receptor M3
CHRM4	muscarinic acetylcholine receptor M4
CHRM5	muscarinic acetylcholine receptor M5
CHRNA3	neuronal acetylcholine receptor subunit alpha-3 isoform 1 precursor
CHRNA4	neuronal acetylcholine receptor subunit alpha-4 isoform 1 precursor
CHRNA6	neuronal acetylcholine receptor subunit alpha-6 isoform 1 precursor
CHRNA7	neuronal acetylcholine receptor subunit alpha-7 isoform 1 precursor
CHRNB2	neuronal acetylcholine receptor subunit beta-2 precursor
CHRNB4	neuronal acetylcholine receptor subunit beta-4 isoform 1 precursor

Rocuronium bromide 💬

Rocuronium

[2] 70, 296 💬

Cholinergic synapse 💬

[2] CHRM2, CHRM3 💬

Fesoterodine 💬

Fesoterodine

[1] 6 💬

Cholinergic synapse 💬

[2] CHRM2, CHRM3 💬

Fesoterodine fumarate 💬

Fesoterodine

[1] 6 💬

Cholinergic synapse 💬

[2] CHRM2, CHRM3 💬

Pilocarpine 💬

Pilocarpine

[3] 6 , 53, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
299	Cystic fibrosis;CF;

Cholinergic synapse 💬

[2] CHRM2, CHRM3 💬

Pilocarpine hydrochloride 💬

Pilocarpine

[3] 6 , 53, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
299	Cystic fibrosis;CF;

Cholinergic synapse 💬

[2] CHRM2, CHRM3 💬

Pilocarpine nitrate 💬

Pilocarpine

[3] 6 , 53, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
299	Cystic fibrosis;CF;

Cholinergic synapse 💬

[1] CHRM3 💬

Cevimeline hydrochloride 💬

Cevimeline

[1] 53 💬

Cholinergic synapse 💬

[1] CHRM3 💬

Cevimeline 💬

Cevimeline

[1] 53 💬

Cholinergic synapse 💬

[1] CHRM3 💬

Darifenacin hydrobromide 💬

Darifenacin

[4] 2 , 6 , 13, 26 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM;

Cholinergic synapse 💬

[1] CHRM3 💬

Darifenacin 💬

Darifenacin

[4] 2 , 6 , 13, 26 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I;HAM;

Cholinergic synapse 💬

[1] CHRM3 💬

Solifenacin succinate 💬

Solifenacin

[3] 6 , 13, 53 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;

Cholinergic synapse 💬

[1] CHRM3 💬

Solifenacin 💬

Solifenacin

[3] 6 , 13, 53 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;

Cholinergic synapse 💬

[1] CHRM3 💬

Tiotropium bromide hydrate 💬

Tiotropium

[3] 55, 85, 299 💬

Disease ID	Name
55	Relapsing polychondritis;
85	Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE;
299	Cystic fibrosis;CF;

Cholinergic synapse 💬

[1] CHRM3 💬

Tolterodine 💬

Tolterodine

[2] 17, 53 💬

Disease ID	Name
17	Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;

Cholinergic synapse 💬

[1] CHRM3 💬

Tolterodine tartrate 💬

Tolterodine

[2] 17, 53 💬

Disease ID	Name
17	Multiple system atrophy;MSA;Olivopontocerebellar atrophy;OPCA;Striatonigral degeneration;Shy-Drager syndrome;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;

Cholinergic synapse 💬

[6] CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4 💬

Name	Full Name
CHRNA3	neuronal acetylcholine receptor subunit alpha-3 isoform 1 precursor
CHRNA4	neuronal acetylcholine receptor subunit alpha-4 isoform 1 precursor
CHRNA6	neuronal acetylcholine receptor subunit alpha-6 isoform 1 precursor
CHRNA7	neuronal acetylcholine receptor subunit alpha-7 isoform 1 precursor
CHRNB2	neuronal acetylcholine receptor subunit beta-2 precursor
CHRNB4	neuronal acetylcholine receptor subunit beta-4 isoform 1 precursor

Nicotine 💬

Nicotine

[3] 6 , 13, 84 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
84	Sarcoidosis;

Cholinergic synapse 💬

[6] CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4 💬

Name	Full Name
CHRNA3	neuronal acetylcholine receptor subunit alpha-3 isoform 1 precursor
CHRNA4	neuronal acetylcholine receptor subunit alpha-4 isoform 1 precursor
CHRNA6	neuronal acetylcholine receptor subunit alpha-6 isoform 1 precursor
CHRNA7	neuronal acetylcholine receptor subunit alpha-7 isoform 1 precursor
CHRNB2	neuronal acetylcholine receptor subunit beta-2 precursor
CHRNB4	neuronal acetylcholine receptor subunit beta-4 isoform 1 precursor

Nicotine bitartrate 💬

Nicotine

[3] 6 , 13, 84 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
84	Sarcoidosis;

Cholinergic synapse 💬

[6] CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4 💬

Name	Full Name
CHRNA3	neuronal acetylcholine receptor subunit alpha-3 isoform 1 precursor
CHRNA4	neuronal acetylcholine receptor subunit alpha-4 isoform 1 precursor
CHRNA6	neuronal acetylcholine receptor subunit alpha-6 isoform 1 precursor
CHRNA7	neuronal acetylcholine receptor subunit alpha-7 isoform 1 precursor
CHRNB2	neuronal acetylcholine receptor subunit beta-2 precursor
CHRNB4	neuronal acetylcholine receptor subunit beta-4 isoform 1 precursor

Nicotine polacrilex 💬

Nicotine

[3] 6 , 13, 84 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
84	Sarcoidosis;

Cholinergic synapse 💬

[2] CHRNA4, CHRNB2 💬

Varenicline tartrate 💬

Varenicline

[4] 6 , 18, 53, 298 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
18	Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
298	Hereditary pancreatitis;Chronic pancreatitis;

Cholinergic synapse 💬

[2] CHRNA4, CHRNB2 💬

Varenicline 💬

Varenicline

[4] 6 , 18, 53, 298 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;Parkinson syndrome;Parkinsonian syndrome;
18	Spinocerebellar degeneration;SCD;Spinocerebellar ataxia;SCA;Machado-Joseph disease;MJD;Dentatorubural pallidoluysian atrophy;Dentatorubropallidoluysian atrophy;DRPLA;Naito-Koyanagi disease;Early-onset ataxia with ocular motor ataxia and hypoalbuminemia;EAOH;Ataxia with vitamin E deficiency;AVED;Aprataxin deficiency;APTX deficiency;Friedreich ataxia;FRDA;Senataxin deficiency;SETX deficiency;Autosomal recessive spastic ataxia of Charlevoix-Saguenay;Spastic ataxia;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
298	Hereditary pancreatitis;Chronic pancreatitis;

Cholinergic synapse 💬

[1] FYN 💬

Dasatinib 💬

Dasatinib

[3] 13, 51, 85 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
85	Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE;

Cholinergic synapse 💬

[1] FYN 💬

Dasatinib 💬

Dasatinib

[3] 13, 51, 85 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
85	Idiopathic interstitial pneumonia;IIPs;Idiopathic pulmonary fibrosis;IPF;Idiopathic non-specific interstitial pneumonia;Idiopathic NSIP;Respiratory bronchiolitis - associated interstitial lung disease;RB-ILD;Desquamative interstitial pneumonia;DIP;Cryptogenic organizing pneumonia;COP;Acute interstitial pneumonia;AIP;Idiopathic lymphocytic interstitial pneumonia;Idiopathic LIP;Idiopathic PPFE;

Cholinergic synapse 💬

[1] JAK2 💬

Baricitinib 💬

Baricitinib

[24] 2 , 13, 40, 41, 46, 49, 50, 51, 53, 54, 56, 63, 65, 84, 93, 107, 135, 162, 265, 268, 269, 300, 325, 345 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;Idiopathic inflammatory myositis;IIM;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
54	Adult still disease;Adult-onset Still's disease;
56	Behcet disease;Behçet disease;BD;Behçet syndrome;Silk Road disease;
63	Idiopathic thrombocytopenic purpura;Immune thrombocytopenia;Primary immune thrombocytopenia;Autoimmune thrombocytopenic purpura;Immune thrombocytopenic purpura;
65	Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3;
84	Sarcoidosis;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
107	Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA;
135	Aicardi syndrome;
162	Pemphigoid;Bullous pemphigoid;BP;Epidermolysis bullosa acquisita;Acquired epidermolysis bullosa;
265	Lipodystrophy;
268	Nakajo-Nishimura syndrome;Autoinflammation, lipodystrophy, and dermatosis syndrome;Autoinflammation lipodystrophy and dermatosis syndrome;CANDLE syndrome;JMP syndrome;Nakajo syndrome;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
300	IgG4-related disease;Immunoglobulin G4-related disease;IgG4-related disease;Autoimmune pancreatitis;IgG4-related sclerosing cholangitis;IgG4-related lacrimal gland, orbital, and salivary gland lesions;IgG4-related kidney disease;
325	Hereditary autoinflammatory syndrome;Inherited autoinflammatory disease;NLRC4 abnormality;Adenosine deaminase 2 deficiency;ADA2 deficiency;DADA2;Aicardi-Goutieres syndrome;AGS;A20 haploinsufficiency;HA20;
345	Stimulator of interferon genes(STING)-associated vasculopathy with onset in infancy;STING (stimulator of interferon genes)-associated vasculopathy with onset in infancy;STING-associated vasculopathy with onset in infancy;SAVI;

Cholinergic synapse 💬

[1] JAK2 💬

Delgocitinib 💬

Delgocitinib

[1] 50 💬

Cholinergic synapse 💬

[1] JAK2 💬

Filgotinib maleate 💬

Filgotinib

[10] 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;Behçet syndrome;Silk Road disease;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
107	Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA;
222	Primary nephrotic syndrome;Nephrotic syndrome;Glomerulonephritis;Minimal change nephrotic syndrome;MCNS;Membranous nephropathy;Focal segmental glomerulosclerosis;FSGS;Crescentic glomerulonephritis;CGN;CrGN;Endocapillary proliferative glomerulonephritis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;Immunoglobulin G4-related disease;IgG4-related disease;Autoimmune pancreatitis;IgG4-related sclerosing cholangitis;IgG4-related lacrimal gland, orbital, and salivary gland lesions;IgG4-related kidney disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Cholinergic synapse 💬

[1] JAK2 💬

Gusacitinib 💬

Gusacitinib

[1] 49 💬

Cholinergic synapse 💬

[1] JAK2 💬

Pacritinib 💬

Pacritinib

[1] 331 💬

Cholinergic synapse 💬

[1] JAK2 💬

Peficitinib 💬

Peficitinib

[1] 46 💬

Cholinergic synapse 💬

[1] JAK2 💬

Ruxolitinib 💬

Ruxolitinib

[7] 13, 15, 50, 60, 65, 228, 331 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
15	Inclusion body myositis;
50	Dermatomyositis;Polymyositis;Idiopathic inflammatory myositis;IIM;
60	Aplastic anemia;
65	Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Cholinergic synapse 💬

[1] JAK2 💬

Ruxolitinib phosphate 💬

Ruxolitinib

[7] 13, 15, 50, 60, 65, 228, 331 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;Multiple sclerosis;Neuromyelitis optica;Neuromyelitis optica spectrum disorder;NMOSD;Balo concentric sclerosis;Baló concentric sclerosis;
15	Inclusion body myositis;
50	Dermatomyositis;Polymyositis;Idiopathic inflammatory myositis;IIM;
60	Aplastic anemia;
65	Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Cholinergic synapse 💬

[1] JAK2 💬

Tofacitinib citrate 💬

Tofacitinib

[23] 2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 56, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
35	Pemphigus;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;Idiopathic inflammatory myositis;IIM;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;Behçet syndrome;Silk Road disease;
65	Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;Glomerulonephritis;
84	Sarcoidosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
107	Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA;
110	Blau syndrome;Early-onset sarcoidosis;Systemic granulomatous diseases;Systemic inflammatory granulomatous disease;Juvenile onset sarcoidosis;Early-onset childhood sarcoidosis;Childhood sarcoidosis;Early onset sarcoidosis;EOS;
162	Pemphigoid;Bullous pemphigoid;BP;Epidermolysis bullosa acquisita;Acquired epidermolysis bullosa;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;Immunoglobulin G4-related disease;IgG4-related disease;Autoimmune pancreatitis;IgG4-related sclerosing cholangitis;IgG4-related lacrimal gland, orbital, and salivary gland lesions;IgG4-related kidney disease;

Cholinergic synapse 💬

[1] JAK2 💬

Tofacitinib 💬

Tofacitinib

[23] 2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 56, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
35	Pemphigus;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;Systemic rheumatoid vasculitis;SRV;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;Idiopathic inflammatory myositis;IIM;
51	Scleroderma;Systemic sclerosis;SSc;Diffuse cutaneous SSc;dcSSc;Limited cutaneous SSc;lcSSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;Behçet syndrome;Silk Road disease;
65	Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;Glomerulonephritis;
84	Sarcoidosis;
96	Crohn disease;CD;Terminal ileitis;Inflammatory bowel disease;IBD;
97	Ulcerative colitis;UC;Inflammatory bowel disease;IBD;
107	Juvenile idiopathic arthritis;JIA;Systemic juvenile idiopathic arthritis;Systemic-onset juvenile idiopathic arthritis;sJIA;Joint-type juvenile idiopathic arthritis;Joint-type juvenile idiopathic arthritis;Joint-type JIA;
110	Blau syndrome;Early-onset sarcoidosis;Systemic granulomatous diseases;Systemic inflammatory granulomatous disease;Juvenile onset sarcoidosis;Early-onset childhood sarcoidosis;Childhood sarcoidosis;Early onset sarcoidosis;EOS;
162	Pemphigoid;Bullous pemphigoid;BP;Epidermolysis bullosa acquisita;Acquired epidermolysis bullosa;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;Immunoglobulin G4-related disease;IgG4-related disease;Autoimmune pancreatitis;IgG4-related sclerosing cholangitis;IgG4-related lacrimal gland, orbital, and salivary gland lesions;IgG4-related kidney disease;

Cholinergic synapse 💬

[3] KCNJ12, KCNJ3, KCNQ1 💬

Name	Full Name
KCNJ12	ATP-sensitive inward rectifier potassium channel 12
KCNJ3	G protein-activated inward rectifier potassium channel 1 isoform 1
KCNQ1	potassium voltage-gated channel subfamily KQT member 1 isoform 1

Amiodarone hydrochloride 💬

Amiodarone

[3] 28, 67, 127 💬

Disease ID	Name
28	Systemic amyloidosis;Immunoglobulin light chain amyloidosis;Amyloid light-chain amyloidosis;AL amyloidosis;Immunoglobulin light chain amyloidosis;Immunoglobulin-related amyloidosis;Amyloid heavy-chain amyloidosis;Amyloid heavy-chain amyloidosis;AH amyloidosis;Systemic wild-type transthyretin amyloidosis;Senile systemic amyloidosis;SSA;Transthyretin amyloid cardiomyopathy;ATTR-CM;Hereditary transthyretin amyloidosis;Familial amyloidosis;Familial amyloid polyneuropathy;FAP;Transthyretin amyloid cardiomyopathy;ATTR-CM;Hereditary systemic amyloidosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;

Cholinergic synapse 💬

[3] KCNJ12, KCNJ3, KCNQ1 💬

Name	Full Name
KCNJ12	ATP-sensitive inward rectifier potassium channel 12
KCNJ3	G protein-activated inward rectifier potassium channel 1 isoform 1
KCNQ1	potassium voltage-gated channel subfamily KQT member 1 isoform 1

Amiodarone 💬

Amiodarone

[3] 28, 67, 127 💬

Disease ID	Name
28	Systemic amyloidosis;Immunoglobulin light chain amyloidosis;Amyloid light-chain amyloidosis;AL amyloidosis;Immunoglobulin light chain amyloidosis;Immunoglobulin-related amyloidosis;Amyloid heavy-chain amyloidosis;Amyloid heavy-chain amyloidosis;AH amyloidosis;Systemic wild-type transthyretin amyloidosis;Senile systemic amyloidosis;SSA;Transthyretin amyloid cardiomyopathy;ATTR-CM;Hereditary transthyretin amyloidosis;Familial amyloidosis;Familial amyloid polyneuropathy;FAP;Transthyretin amyloid cardiomyopathy;ATTR-CM;Hereditary systemic amyloidosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;Autosomal dominant polycystic kidney disease;Autosomal dominant PKD;ADPKD;Autosomal recessive polycystic kidney disease;Autosomal recessive PKD;ARPKD;
127	Frontotemporal lobar degeneration;Frontotemporal dementia, behavioral abnormal type;Frontotemporal dementia;Semantic dementia;

Cholinergic synapse 💬

[5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬

Name	Full Name
KCNQ1	potassium voltage-gated channel subfamily KQT member 1 isoform 1
KCNQ2	potassium voltage-gated channel subfamily KQT member 2 isoform a
KCNQ3	potassium voltage-gated channel subfamily KQT member 3 isoform 1
KCNQ4	potassium voltage-gated channel subfamily KQT member 4 isoform a
KCNQ5	potassium voltage-gated channel subfamily KQT member 5 isoform 1

Ezogabine 💬

Ezogabine

[2] 2 , 144 💬

Cholinergic synapse 💬

[1] MAP2K1 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

Cholinergic synapse 💬

[1] MAP2K1 💬

Mirdametinib 💬

Mirdametinib

[4] 34, 278, 279, 280 💬

Disease ID	Name
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;

Cholinergic synapse 💬

[1] MAP2K1 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

Cholinergic synapse 💬

[1] MAP2K1 💬

Selumetinib sulfate 💬

Selumetinib

[1] 34 💬

Cholinergic synapse 💬

[1] MAP2K1 💬

Trametinib 💬

Trametinib

[6] 2 , 34, 58, 195, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
58	Hypertrophic cardiomyopathy;HCM;
195	Noonan syndrome;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;

Cholinergic synapse 💬

[1] MAP2K1 💬

Trametinib dimethyl sulfoxide 💬

Trametinib

[6] 2 , 34, 58, 195, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;Neurofibromatosis type 1;NF1;Recklinghausen disease;Neurofibromatosis type 2;NF2;
58	Hypertrophic cardiomyopathy;HCM;
195	Noonan syndrome;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;

Cholinergic synapse 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[4] 138, 278, 279, 280 💬

Disease ID	Name
138	Nerve cell migration disorder;Lissencephaly;Neuronal migration defect;Neuronal migration disorder;Lissencephaly;Ectopic gray matter;Polymicrogyria;Cortical dysplasia with cobblestone appearance;Schizencephaly;orencephaly;Miller-Dieker syndrome;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;Lymphangioma;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;Gigantic venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;Gigantic arteriovenous malformation;

100

Cholinergic synapse 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
PIK3CB	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1
PIK3CD	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

Disease ID

Name

Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;

Primary immunodeficiency;X-linked severe combined immunodeficiency;X-SCID;Reticular dysgenesis;Adenosine deaminase deficiency;Omenn syndrome;Purine nucleoside phosphorylase deficiency;CD8 deficiency;ZAP-70 deficiency;MHC class I deficiency;MHC class II deficiency;Other combined immunodeficiencies;Wiskott-Aldrich syndrome;WAS;Ataxia telangiectasia;Nijmegen breakage syndrome;Bloom syndrome;Immunodeficiency, centromere region instability, facial anomalies syndrome;ICF syndrome;PMS2 deficiency;Radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome;RIDDLE syndrome;Schimke syndrome;Netherton syndrome;Thymic hypoplasia;DiGeorge syndrome;22q11.2 deletion syndrome;Hyper-IgE syndrome;Hepatic venoocclusive immunodeficiency;Immunodeficiency with central hepatic vein atresia;Dyskeratosis congenita;X-linked agammaglobulinaemia;Common variable immunodeficiency;Hyper-IgM syndrome;Isolated IgG subclass deficiency;Selective IgA deficiency;Specific antibody production deficiency;Infant transient hypogammaglobulinemia;Other predominantly antibody deficiencies;Chédiak-Higashi syndrome;Chediak-Higashi syndrome;X-linked lymphoproliferative syndrome;SAP deficiency;SH2D1A/SLAM-associated protein deficiency;XIAP deficiency;X-linked inhibitor of apoptosis deficiency;Autoimmune lymphoproliferative syndrome;ALPS;Other diseases of immune dysregulation;Familial hemophagocytic syndrome;FHPS;Familial hemophagocytic lymphohistiocytosis;FHL;Perforin deficiency;Munc13-4 deficiency;Syntaxin 11 deficiency;Munc18-2 deficiency;Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy;APECED;Autoimmune polyglandular syndrome;Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome;IPEX syndrome;CD25 deficiency;ITCH deficiency;Severe congenital neutropenia;Cyclic neutropenia;Other congenital defects of neutrophil function;p14 deficiency;Glycogen storage disease type Ib;Leukocyte adhesion deficiency;Shwachman-Diamond syndrome;Chronic granulomatous disease;Myeloperoxidase deficiency;Mendelian susceptibility to mycobacterial disease;MSMD;Other congenital defects of phagocyte function;Anhidrotic ectodermal dysplasia with immunodeficiency;EDA-ID;Interleukin-1 receptor-associated kinase-4 deficiency;IRAK4 deficiency;MyD88 deficiency;Chronic mucocutaneous candidiasis;Other defects in innate immunity;Warts, hypogammaglobulinemia, infections, myelokathexis syndrome;WHIM syndrome;Congenital complement deficiency;C1q deficiency;C1r deficiency;C1s deficiency;C2 deficiency;C3 deficiency;C4 deficiency;C5 deficiency;C6 deficiency;C7 deficiency;C8 deficiency;C9 deficiency;Hereditary angioedema;C1 inhibitor deficiency;Inherited deficiency of complement system;Factor D deficiency;Factor I deficiency;Factor H deficiency;Properdin deficiency;MASP1 deficiency;MASP2 deficiency;3MC syndrome;Immunodeficiency associated with FCN3 mutation;FCN3;

101

Cholinergic synapse 💬

[2] PIK3CA, PIK3CD 💬

Copanlisib 💬

Copanlisib

[1] 121 💬

Disease ID

Name

121

Neurodegeneration with brain iron accumulation;NBIA;Neuroferritinopathy;FTL;NBIA3;Pantothenate kinase-associated neurodegeneration;PKAN;NBIA1;Infantile neuroaxonal dystrophy;INAD;NBIA2;Calcium-independent phospholipase A2 group VI (PLA2G6) associated neurodegeneration;PLAN;NBIA/DYT/PARK-PLA2G6;Neuroferritinopathy;FTL;NBIA3;Mitochondrial membrane protein-associated neurodegeneration;MPAN;NBIA4;Static encephalopathy of childhood with neurodegeneration in adulthood;Beta-propeller protein-associated neurodegeneration;BPAN;NBIA5;Coenzyme A synthase (COASY) protein-associated neurodegeneration;CoPAN;NBIA6;Aceruloplaminemia;Hereditary ceruloplasmin deficiency;Fatty Acid Hydroxylase-associated neurodegeneration;FAHN;Dysmyelinating leukodystrophy and spastic paraparesis with or without dystonia、 spastic paraplegia 35;Kufor-Rakeb syndrome;KRS;Woodhouse-Sakati syndrome;DDB1 and CLUL4 associated factor 17;DCAF17;Hypogonadism, alopecia, diabetes mellitus, intellectual disability, and extrapyramidal syndrome;

102

Cholinergic synapse 💬

[1] PIK3CD 💬

Leniolisib phosphate 💬

Leniolisib

[2] 53, 65 💬

Disease ID

Name

Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;

103

Cholinergic synapse 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

Disease ID	Name
35	Pemphigus;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;Autoimmune exocrinopathy;
61	Autoimmune hemolytic anemia;AIHA;Cold agglutinin disease;CAD;Paroxysmal cold hemoglobinuria;Evans syndrome;

104

Cholinergic synapse 💬

[1] PRKCB 💬

Enzastaurin hydrochloride 💬

Enzastaurin

[1] 168 💬

Disease ID

Name

168

Ehlers-Danlos syndrome;EDS;Classic EDS;Classical EDS;cEDS;Classical-like Ehlers-Danlos syndrome;Classical-like EDS;clEDS;Cardiac-valvular Ehlers-Danlos syndrome;cvEDS;Vascular Ehlers-Danlos syndrome;Vascular EDS;vEDS;Hypermobile Ehlers-Danlos syndrome;Hypermobile EDS;hEDS;Arthrochalasia Ehlers-Danlos syndrome;Arthrochalasia EDS;aEDS;Dermatosparaxis Ehlers-Danlos syndrome;Dermatosparaxis EDS;dEDS;Kyphoscoliosis Ehlers-Danlos syndrome;Kyphoscoliosis EDS;kEDS;Brittle cornea syndrome;BCS;Spondylodysplastic Ehlers-Danlos Syndrome;spEDS;Musculocontractural Ehlers-Danlos Syndrome;mEDS;D4ST1-deficient Ehlers-Danlos syndrome;Dermatan 4-0-sulfotransferase 1-deficient EDS;D4ST1-deficient EDS;DDEDS;Myopathic Ehlers-Danlos Syndrome;mEDS;Periodontal Ehlers-Danlos Syndrome;pEDS;

105

Cholinergic synapse 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

Disease ID

Name

168