Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [2] 66, 222 💬
2 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [2] 66, 222 💬
3 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Angiotensin II acetate 💬 Angiotensin II [2] 66, 222 💬
4 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Azilsartan 💬 Azilsartan [1] 66 💬
5 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Buloxibutid 💬 Buloxibutid [1] 85 💬
6 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Buloxibutid sodium 💬 Buloxibutid [1] 85 💬
7 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Candesartan 💬 Candesartan [4] 57, 58, 67, 222 💬
8 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [6] 57, 66, 167, 168, 222, 223 💬
9 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Losartan potassium 💬 Losartan [20] 17, 19, 36, 46, 57, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 223, 299 💬
10 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [20] 17, 19, 36, 46, 57, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 223, 299 💬
11 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Olmesartan medoxomil 💬 Olmesartan [2] 57, 223 💬
12 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Olmesartan 💬 Olmesartan [2] 57, 223 💬
13 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [4] 66, 218, 222, 223 💬
14 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Telmisartan 💬 Telmisartan [5]  6 , 57, 66, 67, 222 💬
15 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [11] 28, 57, 58, 66, 75, 86, 210, 218, 222, 223, 224 💬
16 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine besylate 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
17 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine maleate 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
18 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
19 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine benzoate 💬 Amlodipine [6] 51, 67, 79, 113, 222, 298 💬
20 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Benidipine hydrochloride 💬 Benidipine [1] 57 💬
21 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Benidipine 💬 Benidipine [1] 57 💬
22 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Bevantolol hydrochloride 💬 Bevantolol [1]  8  💬
23 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
24 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem hydrochloride 💬 Diltiazem [4] 51, 58, 86, 88 💬
25 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem malate 💬 Diltiazem [4] 51, 58, 86, 88 💬
26 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [4] 51, 58, 86, 88 💬
27 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
28 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine hydrochloride 💬 Nicardipine [2] 70, 86 💬
29 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
30 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
31 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
32 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline maleate 💬 Perhexiline [2] 58, 272 💬
33 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
34 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine hydrochloride 💬 Propiverine [1] 226 💬
35 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
36 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
37 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil hydrochloride 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
38 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [5] 57, 58, 96, 140, 167 💬
39 Cortisol synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Suvecaltamide 💬 Suvecaltamide [1]  6  💬
40 Cortisol synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Divalproex sodium 💬 Valproic acid [11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬
41 Cortisol synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬
42 Cortisol synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproate sodium 💬 Valproic acid [11]  3 ,  5 , 26, 34, 51, 65, 89, 90, 145, 222, 331 💬
43 Cortisol synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Zonisamide 💬 Zonisamide [1]  6  💬
44 Cortisol synthesis and secretion 💬
 [1] CACNA1S 💬 Pinaverium bromide 💬 Pinaverium [1] 298 💬
45 Cortisol synthesis and secretion 💬
 [3] CYP11A1, CYP11B1, CYP17A1 💬 Levoketoconazole 💬 Levoketoconazole [1] 75 💬
46 Cortisol synthesis and secretion 💬
 [1] CYP11B1 💬 Metyrapone 💬 Metyrapone [2] 75, 193 💬
47 Cortisol synthesis and secretion 💬
 [1] CYP17A1 💬 Abiraterone acetate 💬 Abiraterone [2] 75, 81 💬
48 Cortisol synthesis and secretion 💬
 [1] KCNA4 💬 Amifampridine 💬 Amifampridine [3]  3 , 11, 12 💬
49 Cortisol synthesis and secretion 💬
 [1] KCNA4 💬 Amifampridine phosphate 💬 Amifampridine [3]  3 , 11, 12 💬
50 Cortisol synthesis and secretion 💬
 [1] KCNA4 💬 Dalfampridine 💬 Dalfampridine [2]  4 , 13 💬
51 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Atumelnant 💬 Atumelnant [2] 75, 81 💬
52 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬
53 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin, repository 💬 Corticotropin [10]  2 , 13, 46, 75, 78, 81, 84, 145, 205, 222 💬
54 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [4] 83, 113, 145, 222 💬
55 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Tetracosactide acetate 💬 Tetracosactide [4] 83, 113, 145, 222 💬
56 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
57 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Aminophylline dihydrate 💬 Aminophylline [1] 63 💬
58 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
59 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Flavoxate hydrochloride 💬 Flavoxate [1] 226 💬
60 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
61 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
62 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
63 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Theophylline sodium glycinate 💬 Theophylline [2] 236, 299 💬