2. Amyotrophic lateral sclerosis Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 867 / Drugs : 820 - (DrugBank : 185) / Drug target genes : 189 - Drug target pathways : 237
Amyotrophic lateral sclerosis and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 2 | Amyotrophic lateral sclerosis | - |
| 13 | Multiple sclerosis/Neuromyelitis optica | 116.536 |
| 6 | Parkinson disease | 85.629 |
| 96 | Crohn disease | 75.223 |
| 46 | Malignant rheumatoid arthritis | 69.225 |
| 156 | Rett syndrome | 60.189 |
| 8 | Huntington disease | 53.019 |
| 5 | Progressive supranuclear palsy | 52.309 |
| 97 | Ulcerative colitis | 51.216 |
| 206 | Fragile X syndrome | 42.572 |
| 17 | Multiple system atrophy | 42.107 |
| 3 | Spinal muscular atrophy | 38.440 |
| 140 | Dorabe syndrome | 38.032 |
| 21 | Mitochondrial disease | 37.014 |
| 144 | Lennox-Gastaut syndrome | 35.902 |
| 65 | Primary immunodeficiency | 34.238 |
| 34 | Neurofibromatosis | 32.488 |
| 70 | Spinal stenosis | 30.457 |
| 18 | Spinocerebellar degeneration | 30.307 |
| 85 | Idiopathic interstitial pneumonia | 29.059 |
| 193 | Prader-Willi syndrome | 27.628 |
| 226 | Interstitial cystitis with Hunners ulcer | 27.220 |
| 36 | Epidermolysis bullosa | 27.035 |
| 49 | Systemic lupus erythematosus | 26.925 |
| 299 | Cystic fibrosis | 25.195 |
| 113 | Muscular dystrophy | 24.903 |
| 158 | Tuberous sclerosis | 24.867 |
| 26 | HTLV-1-associated myelopathy | 24.786 |
| 51 | Scleroderma | 24.006 |
| 86 | Pulmonary arterial hypertension | 23.588 |
| 145 | West syndrome | 23.417 |
| 98 | Eosinophilic gastro-intestinal disorder | 23.355 |
| 22 | Moyamoya disease | 22.711 |
| 201 | Angelman syndrome | 22.000 |
| 205 | Fragile X syndrome related disease | 21.406 |
| 127 | Frontotemporal lobar degeneration | 20.967 |
| 28 | Systemic amyloidosis | 20.774 |
| 231 | Alpha-1-antitrypsin deficiency | 20.325 |
| 84 | Sarcoidosis | 20.032 |
| 78 | Hypopituitarism | 18.206 |
| 298 | Hereditary pancreatitis | 18.082 |
| 107 | Juvenile idiopathic arthritis | 17.181 |
| 56 | Behcet disease | 17.116 |
| 152 | PCDH19-related syndrome | 16.000 |
| 42 | Polyarteritis nodosa | 15.921 |
| 296 | Biliary atresia | 15.504 |
| 331 | Idiopathic multicentric castleman disease | 15.053 |
| 90 | Retinitis pigmentosa | 14.535 |
| 63 | Idiopathic thrombocytopenic purpura | 14.363 |
| 75 | Cushing disease | 14.151 |
| 203 | 22q11.2 deletion syndrome | 14.000 |
| 53 | Sjogren syndrome | 13.346 |
| 222 | Primary nephrotic syndrome | 13.337 |
| 272 | Fibrodysplasia ossificans progressiva | 13.041 |
| 4 | Primary lateral sclerosis | 12.118 |
| 38 | Stevens-Johnson syndrome | 11.398 |
| 62 | Paroxysmal nocturnal hemoglobinuria | 11.088 |
| 58 | Hypertrophic cardiomyopathy | 10.630 |
| 254 | Porphyria | 10.616 |
| 265 | Lipodystrophy | 10.419 |
| 266 | Familial mediterranean fever | 10.405 |
| 11 | Myasthenia gravis | 10.181 |
| 149 | Hemiconvulsion hemiplegia epilepsy syndrome | 10.172 |
| 93 | Primary biliary cholangitis | 10.172 |
| 256 | Muscle glycogenosis | 10.081 |
| 1 | Spinal and bulbar muscular atrophy | 10.000 |
| 283 | Acquired pure red cell aplasia | 9.662 |
| 155 | Acquired aphasia with convulsive disorder | 9.495 |
| 50 | Dermatomyositis | 8.789 |
| 210 | Single Ventricle | 8.744 |
| 162 | Pemphigoid | 8.524 |
| 164 | Oculocutaneous albinism | 8.317 |
| 215 | Tetralogy of Fallot | 8.279 |
| 285 | Fanconi anemia | 8.154 |
| 66 | IgA nephropathy | 8.122 |
| 35 | Pemphigus | 8.084 |
| 95 | Autoimmune hepatitis | 7.887 |
| 89 | Lymphangioleiomyomatosis | 7.808 |
| 39 | Toxic epidermal necrolysis | 7.449 |
| 233 | Wolfram syndrome | 7.449 |
| 19 | Lysosomal storage disease | 7.449 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 7.309 |
| 61 | Autoimmune hemolytic anemia | 7.232 |
| 7 | Corticobasal degeneration | 7.152 |
| 60 | Aplastic anemia | 7.017 |
| 102 | Rubinstein-Taybi syndrome | 7.000 |
| 284 | Diamond-Blackfan anemia | 6.926 |
| 20 | Adrenoleukodystrophy | 6.926 |
| 224 | Purpura nephritis | 6.860 |
| 236 | Pseudohypoparathyroidism | 6.367 |
| 118 | Myelomeningocele | 6.161 |
| 151 | Rasmussen encephalitis | 6.000 |
| 45 | Eosinophilic granulomatosis with Polyangiitis | 5.814 |
| 228 | Bronchiolitis obliterans | 5.717 |
| 169 | Menkes disease | 5.508 |
| 170 | Occipital horn syndrome | 5.508 |
| 74 | Prolactin secreting pituitary adenoma | 5.269 |
| 302 | Leber hereditary optic neuropathy | 5.000 |
| 294 | Congenital diaphragmatic hernia | 5.000 |
| 10 | Charcot-Marie-Tooth disease | 4.558 |
| 269 | Pyogenic arthritis | 4.440 |
| 55 | Relapsing polychondritis | 4.202 |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) | 4.202 |
| 83 | Addison disease | 4.191 |
| 76 | Pituitary gonadotropin secretion hyperthyroidism | 4.191 |
| 64 | Thrombotic thrombocytopenic purpura | 4.186 |
| 41 | Giant cell arteritis | 4.136 |
| 271 | Ankylosing spondylitis | 4.104 |
| 168 | Ehlers-Danlos syndrome | 4.070 |
| 57 | Idiopathic dilated cardiomyopathy | 4.070 |
| 309 | Progressive myoclonus epilepsy | 4.000 |
| 246 | Methylmalonic acidemia | 3.962 |
| 227 | Osler disease | 3.808 |
| 160 | Congenital ichthyosis | 3.762 |
| 94 | Primary sclerosing cholangitis | 3.584 |
| 40 | Takayasu arteritis | 3.541 |
| 300 | IgG4-related disease | 3.419 |
| 15 | Inclusion body myositis | 3.368 |
| 157 | Sturge-Weber syndrome | 3.219 |
| 286 | Hereditary sideroblastic anemia | 3.180 |
| 81 | Congenital adrenal hyperplasia | 3.105 |
| 279 | Huge venous malformation with cervical, oral and pharyngeal diffuse lesion | 3.000 |
| 187 | Kabuki syndrome | 3.000 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 288 | Autoimmune acquired coagulation factor deficiency | 2.896 |
| 43 | Microscopic polyangiitis | 2.691 |
| 274 | Osteogenesis Imperfecta | 2.691 |
| 67 | Polycystic kidney disease | 2.491 |
| 71 | Idiopathic osteonecrosis of the femoral head | 2.263 |
| 212 | Tricuspid atresia | 2.047 |
| 77 | Growth hormone secreting pituitary adenoma | 2.000 |
| 282 | Congenital dyserythropoietic anemia | 2.000 |
| 307 | Canavan disease | 2.000 |
| 278 | Huge lymphatic malformation with cervicofacial lesion | 1.821 |
| 16 | Crow-Fukase syndrome | 1.821 |
| 211 | Hypoplastic left heart syndrome | 1.821 |
| 326 | Osteopetrosis | 1.662 |
| 47 | Buerger disease | 1.526 |
| 114 | Non-dystrophic myotonia syndrome | 1.494 |
| 14 | Chronic inflammatory demyelinating polyneuropathy | 1.395 |
| 225 | Congenital nephrogenic diabetes insipidus | 1.367 |
| 37 | Generalised pustular psoriasis | 1.359 |
| 44 | Wegener granulomatosis | 1.301 |
| 301 | Macular dystrophy | 1.035 |
| 179 | Williams syndrome | 1.035 |
| 87 | Pulmonary veno-occlusive disease | 1.012 |
| 106 | Cryopyrin-associated periodic syndrome | 1.012 |
| 251 | Urea cycle disorder | 1.012 |
| 137 | Focal cortical dysplasia | 1.000 |
| 192 | Cockayne syndrome | 1.000 |
| 277 | Lymphangiomatosis | 1.000 |
| 281 | Klippel-Trenaunay-Weber syndrome | 1.000 |
| 111 | Congenital myopathy | 1.000 |
| 54 | Adult still disease | 1.000 |
| 191 | Werner syndrome | 1.000 |
| 220 | Rapidly progressive glomerulonephritis | 1.000 |
| 30 | Distal myopathy | 1.000 |