206. Fragile X syndrome Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 118 / Drugs : 75 - (DrugBank : 30) / Drug target genes : 58 - Drug target pathways : 83
Fragile X syndrome and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 206 | Fragile X syndrome | - |
| 6 | Parkinson disease | 50.607 |
| 13 | Multiple sclerosis | 45.299 |
| 8 | Huntington disease | 44.316 |
| 2 | Amyotrophic lateral sclerosis | 42.572 |
| 17 | Multiple system atrophy | 36.430 |
| 5 | Progressive supranuclear palsy | 36.011 |
| 97 | Ulcerative colitis | 33.960 |
| 18 | Spinocerebellar degeneration | 33.600 |
| 156 | Rett syndrome | 32.297 |
| 46 | Malignant rheumatoid arthritis | 29.053 |
| 3 | Spinal muscular atrophy | 28.157 |
| 21 | Mitochondrial disease | 26.505 |
| 140 | Dorabe syndrome | 26.324 |
| 96 | Crohn disease | 23.956 |
| 144 | Lennox-Gastaut syndrome | 23.520 |
| 193 | Prader-Willi syndrome | 23.208 |
| 70 | Spinal stenosis | 22.727 |
| 22 | Moyamoya disease | 22.095 |
| 205 | Fragile X syndrome related disease | 18.947 |
| 158 | Tuberous sclerosis | 18.473 |
| 145 | West syndrome | 16.735 |
| 152 | PCDH19 related syndrome | 16.000 |
| 201 | Angelman syndrome | 15.818 |
| 34 | Neurofibromatosis | 14.345 |
| 203 | 22q11.2 deletion syndrome | 14.000 |
| 298 | Hereditary pancreatitis | 13.252 |
| 231 | Alpha-1-antitrypsin deficiency | 12.171 |
| 272 | Fibrodysplasia ossificans progressiva | 11.670 |
| 155 | Acquired aphasia with convulsive disorder | 10.953 |
| 75 | Cushing disease | 10.459 |
| 36 | Epidermolysis bullosa | 10.408 |
| 98 | Eosinophilic gastro-intestinal disorder | 10.182 |
| 296 | Biliary atresia | 9.752 |
| 84 | Sarcoidosis | 9.539 |
| 113 | Muscular dystrophy | 8.708 |
| 127 | Frontotemporal lobar degeneration | 7.259 |
| 118 | Myelomeningocele | 6.238 |
| 4 | Primary lateral sclerosis | 6.140 |
| 78 | Hypopituitarism | 6.046 |
| 169 | Menkes disease | 4.222 |
| 170 | Occipital horn syndrome | 4.222 |
| 179 | Williams syndrome | 4.222 |
| 215 | Tetralogy of Fallot | 4.214 |
| 280 | Huge arteriovenous malformation with cervicofacial or limb lesion | 3.954 |
| 49 | Systemic lupus erythematosus | 3.649 |
| 288 | Autoimmune acquired coagulation factor deficiency | 3.277 |
| 299 | Cystic fibrosis | 3.244 |
| 86 | Pulmonary arterial hypertension | 3.204 |
| 226 | Interstitial cystitis with Hunners ulcer | 3.125 |
| 11 | Myasthenia gravis | 3.000 |
| 171 | Wilson disease | 3.000 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 65 | Primary immunodeficiency | 2.250 |
| 85 | Idiopathic interstitial pneumonia | 2.182 |
| 337 | Homocystinuria | 2.000 |
| 120 | Hereditary dystonia | 2.000 |
| 77 | Growth hormone secreting pituitary adenoma | 2.000 |
| 254 | Porphyria | 1.657 |
| 67 | Polycystic kidney disease | 1.509 |
| 271 | Ankylosing spondylitis | 1.447 |
| 187 | Kabuki syndrome | 1.358 |
| 58 | Hypertrophic cardiomyopathy | 1.333 |
| 212 | Tricuspid atresia | 1.229 |
| 225 | Congenital nephrogenic diabetes insipidus | 1.219 |
| 210 | Single Ventricle | 1.172 |
| 149 | Hemiconvulsion hemiplegia epilepsy syndrome | 1.168 |
| 57 | Idiopathic dilated cardiomyopathy | 1.111 |
| 251 | Urea cycle disorder | 1.037 |
| 309 | Progressive myoclonus epilepsy | 1.037 |