21. Mitochondrial disease Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 108 / Drugs : 107 - (DrugBank : 35) / Drug target genes : 48 - Drug target pathways : 110
Mitochondrial disease and other diseases between which drug repositioning (DR) might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Score (Drug repositionability)
| ID | Diseases (Sorted by score) | Score |
|---|---|---|
| 21 | Mitochondrial disease | - |
| 6 | Parkinson disease | 47.000 |
| 13 | Multiple sclerosis/Neuromyelitis optica | 45.191 |
| 96 | Crohn disease | 38.649 |
| 46 | Malignant rheumatoid arthritis | 38.546 |
| 2 | Amyotrophic lateral sclerosis | 37.014 |
| 97 | Ulcerative colitis | 35.709 |
| 8 | Huntington disease | 29.787 |
| 206 | Fragile X syndrome | 26.505 |
| 70 | Spinal stenosis | 22.774 |
| 5 | Progressive supranuclear palsy | 20.283 |
| 17 | Multiple system atrophy | 19.334 |
| 205 | Fragile X syndrome related disease | 19.141 |
| 22 | Moyamoya disease | 18.096 |
| 78 | Hypopituitarism | 17.395 |
| 18 | Spinocerebellar degeneration | 17.258 |
| 156 | Rett syndrome | 17.097 |
| 3 | Spinal muscular atrophy | 16.352 |
| 152 | PCDH19-related syndrome | 16.000 |
| 84 | Sarcoidosis | 14.550 |
| 201 | Angelman syndrome | 14.534 |
| 34 | Neurofibromatosis | 14.360 |
| 145 | West syndrome | 12.981 |
| 298 | Hereditary pancreatitis | 12.846 |
| 231 | Alpha-1-antitrypsin deficiency | 12.605 |
| 158 | Tuberous sclerosis | 12.605 |
| 272 | Fibrodysplasia ossificans progressiva | 11.941 |
| 193 | Prader-Willi syndrome | 11.898 |
| 98 | Eosinophilic gastro-intestinal disorder | 11.770 |
| 155 | Acquired aphasia with convulsive disorder | 11.269 |
| 140 | Dorabe syndrome | 11.059 |
| 296 | Biliary atresia | 10.248 |
| 75 | Cushing disease | 10.118 |
| 299 | Cystic fibrosis | 9.921 |
| 144 | Lennox-Gastaut syndrome | 9.914 |
| 36 | Epidermolysis bullosa | 8.893 |
| 113 | Muscular dystrophy | 7.384 |
| 226 | Interstitial cystitis with Hunners ulcer | 7.181 |
| 265 | Lipodystrophy | 6.139 |
| 236 | Pseudohypoparathyroidism | 6.064 |
| 179 | Williams syndrome | 5.676 |
| 4 | Primary lateral sclerosis | 5.170 |
| 294 | Congenital diaphragmatic hernia | 5.000 |
| 63 | Idiopathic thrombocytopenic purpura | 4.634 |
| 246 | Methylmalonic acidemia | 4.486 |
| 107 | Juvenile idiopathic arthritis | 4.357 |
| 215 | Tetralogy of Fallot | 4.312 |
| 171 | Wilson disease | 3.000 |
| 323 | Aromatic L-amino acid decarboxylase deficiency | 3.000 |
| 51 | Scleroderma | 2.824 |
| 49 | Systemic lupus erythematosus | 2.818 |
| 271 | Ankylosing spondylitis | 2.657 |
| 65 | Primary immunodeficiency | 2.451 |
| 85 | Idiopathic interstitial pneumonia | 2.385 |
| 212 | Tricuspid atresia | 2.170 |
| 203 | 22q11.2 deletion syndrome | 2.128 |
| 127 | Frontotemporal lobar degeneration | 2.085 |
| 337 | Homocystinuria | 2.000 |
| 282 | Congenital dyserythropoietic anemia | 2.000 |
| 254 | Porphyria | 1.708 |
| 187 | Kabuki syndrome | 1.362 |
| 225 | Congenital nephrogenic diabetes insipidus | 1.277 |
| 118 | Myelomeningocele | 1.245 |
| 169 | Menkes disease | 1.128 |
| 170 | Occipital horn syndrome | 1.128 |
| 86 | Pulmonary arterial hypertension | 1.080 |
| 251 | Urea cycle disorder | 1.043 |
| 71 | Idiopathic osteonecrosis of the femoral head | 1.043 |
| 11 | Myasthenia gravis | 1.028 |